Fenhexamid

Target genes for Fenhexamid is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
FenhexamidNR1H3ATG_LXRa_TRANS_up
FenhexamidNACEETOX_H295R_PROG_dn
FenhexamidESR1CEETOX_H295R_TESTO_dn
FenhexamidNACEETOX_H295R_TESTO_dn
FenhexamidNACEETOX_H295R_ANDR_dn
FenhexamidCREB3ATG_CRE_CIS_up
FenhexamidCEBPBATG_C_EBP_CIS_up
FenhexamidCYP2C19NVS_ADME_hCYP2C19
FenhexamidCYP2C9NVS_ADME_hCYP2C9
FenhexamidEGR1ATG_EGR_CIS_up
FenhexamidESR1OT_ER_ERaERb_1440
FenhexamidESR1ATG_ERE_CIS_up
FenhexamidESR1TOX21_ERa_BLA_Antagonist_ratio
FenhexamidESR1TOX21_ERa_BLA_Agonist_ratio
FenhexamidESR1TOX21_ERa_LUC_VM7_Agonist
FenhexamidESR1OT_ER_ERaERa_1440
FenhexamidESR1OT_ER_ERaERa_0480
FenhexamidESR1OT_ERa_EREGFP_0480
FenhexamidESR1ATG_ERa_TRANS_up
FenhexamidESR1ACEA_ER_80hr
FenhexamidESR1OT_ERa_EREGFP_0120
FenhexamidESR1OT_ER_ERaERb_0480
FenhexamidESR2OT_ER_ERbERb_0480
FenhexamidESR2OT_ER_ERaERb_1440
FenhexamidESR2OT_ER_ERbERb_1440
FenhexamidESR2OT_ER_ERaERb_0480
FenhexamidESR2TOX21_ERb_BLA_Antagonist_ratio
FenhexamidESRRATOX21_ERR_Antagonist
FenhexamidFOSATG_AP_1_CIS_up
FenhexamidNR3C1CEETOX_H295R_11DCORT_dn
FenhexamidNR3C1TOX21_GR_BLA_Antagonist_ratio
FenhexamidNR3C1CEETOX_H295R_DOC_dn
FenhexamidNR3C1CEETOX_H295R_CORTISOL_dn
FenhexamidIL1ABSK_BE3C_IL1a_up
FenhexamidCXCL8BSK_SAg_IL8_down
FenhexamidARNVS_NR_hAR
FenhexamidARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
FenhexamidARACEA_AR_antagonist_80hr
FenhexamidARCEETOX_H295R_TESTO_dn
FenhexamidARTOX21_AR_BLA_Antagonist_ratio
FenhexamidARCEETOX_H295R_ANDR_dn
FenhexamidARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
FenhexamidJUNTOX21_AP1_BLA_Agonist_ratio
FenhexamidJUNATG_AP_1_CIS_up
FenhexamidESR1CEETOX_H295R_TESTO_dn
FenhexamidFOSTOX21_AP1_BLA_Agonist_ratio
FenhexamidNACEETOX_H295R_TESTO_dn
FenhexamidSMAD1ATG_BRE_CIS_up
FenhexamidARCEETOX_H295R_ANDR_dn
FenhexamidARCEETOX_H295R_TESTO_dn
FenhexamidNR3C2CEETOX_H295R_11DCORT_dn
FenhexamidNR3C2CEETOX_H295R_CORTISOL_dn
FenhexamidNR3C2CEETOX_H295R_DOC_dn
FenhexamidMTF1ATG_MRE_CIS_up
FenhexamidNFE2L2ATG_NRF2_ARE_CIS_up
FenhexamidNFE2L2TOX21_ARE_BLA_agonist_ratio
FenhexamidPAX6ATG_Pax6_CIS_up
FenhexamidPGRTOX21_PR_BLA_Antagonist_ratio
FenhexamidPGRCEETOX_H295R_PROG_dn
FenhexamidPGRCEETOX_H295R_OHPROG_dn
FenhexamidPGRCEETOX_H295R_OHPREG_up
FenhexamidPLAURBSK_BE3C_uPAR_up
FenhexamidPOU2F1ATG_Oct_MLP_CIS_up
FenhexamidPPARAATG_PPRE_CIS_up
FenhexamidPPARDATG_PPRE_CIS_up
FenhexamidPPARGATG_PPARg_TRANS_up
FenhexamidPPARGATG_PPRE_CIS_up
FenhexamidPTGER2BSK_LPS_PGE2_down
FenhexamidRORAATG_RORE_CIS_up
FenhexamidRORBATG_RORE_CIS_up
FenhexamidRORCATG_RORE_CIS_up
FenhexamidSELEBSK_LPS_Eselectin_down
FenhexamidSLC6A3NVS_TR_hDAT
FenhexamidSREBF1ATG_SREBP_CIS_up
FenhexamidTACR2NVS_GPCR_hNK2
FenhexamidTSPONVS_MP_hPBR
FenhexamidVCAM1BSK_LPS_VCAM1_down
FenhexamidVDRATG_VDRE_CIS_up
FenhexamidNACEETOX_H295R_TESTO_dn
FenhexamidNACEETOX_H295R_ANDR_dn
FenhexamidNR1I2ATG_PXRE_CIS_up
FenhexamidNR1I2ATG_PXR_TRANS_up
FenhexamidNR1I3NVS_NR_hCAR_Antagonist
FenhexamidNR1I3ATG_PBREM_CIS_up
FenhexamidNR1H4OT_FXR_FXRSRC1_0480

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.