Trenbolone

Target genes for Trenbolone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
TrenboloneNACEETOX_H295R_PROG_dn
TrenboloneESR1CEETOX_H295R_ESTRONE_dn
TrenboloneESR1CEETOX_H295R_TESTO_dn
TrenboloneNACEETOX_H295R_TESTO_dn
TrenboloneNACEETOX_H295R_ANDR_dn
TrenboloneCOL3A1BSK_hDFCGF_CollagenIII_down
TrenboloneCSF1BSK_LPS_MCSF_down
TrenboloneCYP2C19NVS_ADME_hCYP2C19
TrenboloneEGR1ATG_EGR_CIS_up
TrenboloneAHRATG_Ahr_CIS_dn
TrenboloneSLC29A1NVS_TR_hAdoT
TrenboloneESR1ATG_ERE_CIS_up
TrenboloneESR1OT_ERa_EREGFP_0480
TrenboloneESR1ATG_ERa_TRANS_up
TrenboloneESR1TOX21_ERa_LUC_VM7_Agonist
TrenboloneESR1OT_ERa_EREGFP_0120
TrenboloneESR1TOX21_ERa_BLA_Agonist_ratio
TrenboloneESR1OT_ER_ERaERb_1440
TrenboloneESR1ACEA_ER_80hr
TrenboloneESR1OT_ER_ERaERb_0480
TrenboloneESR1OT_ER_ERaERa_1440
TrenboloneESR1CEETOX_H295R_ESTRONE_dn
TrenboloneESR1OT_ER_ERaERa_0480
TrenboloneESR1NVS_NR_hER
TrenboloneESR2TOX21_ERb_BLA_Agonist_ratio
TrenboloneESR2OT_ER_ERbERb_1440
TrenboloneESR2OT_ER_ERaERb_0480
TrenboloneESR2OT_ER_ERbERb_0480
TrenboloneESR2OT_ER_ERaERb_1440
TrenboloneESR2CEETOX_H295R_ESTRONE_dn
TrenboloneESRRATOX21_ERR_Antagonist
TrenboloneF3BSK_CASM3C_TissueFactor_down
TrenboloneF3BSK_3C_TissueFactor_down
TrenboloneNR3C1CEETOX_H295R_CORTIC_dn
TrenboloneNR3C1CEETOX_H295R_CORTISOL_dn
TrenboloneNR3C1ATG_GRE_CIS_dn
TrenboloneNR3C1CEETOX_H295R_11DCORT_dn
TrenboloneNR3C1CEETOX_H295R_DOC_dn
TrenboloneNR3C1NVS_NR_hGR
TrenboloneNR3C1TOX21_GR_BLA_Antagonist_ratio
TrenboloneHDAC1TOX21_HDAC_Inhibition
TrenboloneHLA-DRABSK_3C_HLADR_down
TrenboloneHLA-DRABSK_BE3C_HLADR_down
TrenboloneIL6BSK_CASM3C_IL6_down
TrenboloneCXCL8BSK_CASM3C_IL8_down
TrenboloneCXCL10BSK_BE3C_IP10_down
TrenboloneIRF1ATG_ISRE_CIS_dn
TrenboloneARACEA_AR_agonist_80hr
TrenboloneAROT_AR_ARSRC1_0480
TrenboloneARTOX21_AR_BLA_Agonist_ratio
TrenboloneARCEETOX_H295R_TESTO_dn
TrenboloneARCEETOX_H295R_ANDR_dn
TrenboloneARATG_AR_TRANS_up
TrenboloneARNVS_NR_hAR
TrenboloneARTOX21_AR_LUC_MDAKB2_Agonist_3uM_Nilutamide
TrenboloneAROT_AR_ARSRC1_0960
TrenboloneARTOX21_AR_LUC_MDAKB2_Agonist
TrenboloneARTOX21_AR_BLA_Antagonist_ratio
TrenboloneESR1CEETOX_H295R_ESTRONE_dn
TrenboloneESR1CEETOX_H295R_TESTO_dn
TrenboloneNACEETOX_H295R_TESTO_dn
TrenboloneNACEETOX_H295R_ESTRONE_dn
TrenboloneARCEETOX_H295R_ANDR_dn
TrenboloneARCEETOX_H295R_TESTO_dn
TrenboloneNR3C2CEETOX_H295R_11DCORT_dn
TrenboloneNR3C2CEETOX_H295R_DOC_dn
TrenboloneNR3C2CEETOX_H295R_CORTIC_dn
TrenboloneNR3C2CEETOX_H295R_CORTISOL_dn
TrenboloneMMP1BSK_BE3C_MMP1_up
TrenboloneMTF1ATG_MRE_CIS_up
TrenboloneNFE2L2TOX21_ARE_BLA_agonist_ratio
TrenboloneNFKB1ATG_NF_kB_CIS_dn
TrenboloneSERPINE1BSK_hDFCGF_PAI1_up
TrenboloneLEF1ATG_TCF_b_cat_CIS_dn
TrenbolonePGRCEETOX_H295R_OHPROG_dn
TrenbolonePGRCEETOX_H295R_OHPREG_up
TrenbolonePGRNVS_NR_hPR
TrenbolonePGRTOX21_PR_BLA_Antagonist_ratio
TrenbolonePGRTOX21_PR_BLA_Agonist_ratio
TrenbolonePGRCEETOX_H295R_PROG_dn
TrenbolonePLATBSK_BE3C_tPA_down
TrenbolonePLAURBSK_3C_uPAR_down
TrenbolonePLAURBSK_4H_uPAR_down
TrenbolonePOU2F1ATG_Oct_MLP_CIS_up
TrenbolonePPARGTOX21_PPARg_BLA_antagonist_ratio
TrenbolonePPARGNVS_NR_hPPARg
TrenbolonePTGER2BSK_LPS_PGE2_down
TrenbolonePTPRCNVS_ENZ_hPTPRC
TrenboloneRARANVS_NR_hRARa_Agonist
TrenboloneRARBATG_RARb_TRANS_dn
TrenboloneRXRAOT_NURR1_NURR1RXRa_1440
TrenboloneCCL2BSK_SAg_MCP1_down
TrenboloneCCL2BSK_3C_MCP1_down
TrenboloneCCL2BSK_LPS_MCP1_down
TrenboloneSELEBSK_3C_Eselectin_down
TrenboloneSELEBSK_LPS_Eselectin_down
TrenboloneAURKANVS_ENZ_hAurA
TrenboloneTACR2NVS_GPCR_hNK2
TrenboloneTCF7ATG_TCF_b_cat_CIS_dn
TrenboloneTCF7L2ATG_TCF_b_cat_CIS_dn
TrenboloneTFAP2AATG_AP_2_CIS_dn
TrenboloneTFAP2BATG_AP_2_CIS_dn
TrenboloneTP53ATG_p53_CIS_dn
TrenboloneTP53APR_HepG2_p53Act_72h_up
TrenboloneVCAM1BSK_CASM3C_VCAM1_down
TrenboloneVCAM1BSK_4H_VCAM1_down
TrenboloneVCAM1BSK_LPS_VCAM1_down
TrenboloneVCAM1BSK_3C_VCAM1_down
TrenboloneVCAM1BSK_hDFCGF_VCAM1_down
TrenboloneNACEETOX_H295R_TESTO_dn
TrenboloneNACEETOX_H295R_ANDR_dn
TrenboloneXBP1ATG_Xbp1_CIS_up
TrenboloneTCF7L1ATG_TCF_b_cat_CIS_dn
TrenboloneTFAP2DATG_AP_2_CIS_dn
TrenbolonePDE5ANVS_ENZ_hPDE5
TrenboloneNR1I2ATG_PXRE_CIS_dn
TrenboloneCD38BSK_SAg_CD38_down
TrenboloneCD40BSK_SAg_CD40_down
TrenboloneCD40BSK_LPS_CD40_down
TrenboloneNR1I3TOX21_CAR_Agonist
TrenboloneNR1H4OT_FXR_FXRSRC1_1440
TrenboloneNR1H4TOX21_FXR_BLA_antagonist_ratio
TrenboloneNR1H4OT_FXR_FXRSRC1_0480

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.