Napropamide

Target genes for Napropamide is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
NapropamideESR1CEETOX_H295R_ESTRONE_up
NapropamideNACEETOX_H295R_ANDR_dn
NapropamideCCL26BSK_4H_Eotaxin3_down
NapropamideCREB3ATG_CRE_CIS_up
NapropamideCEBPBATG_C_EBP_CIS_up
NapropamideCOL3A1BSK_hDFCGF_CollagenIII_down
NapropamideCSF1BSK_LPS_MCSF_down
NapropamideCSF1RNVS_ENZ_hCSF1R
NapropamideCYP1A1CLD_CYP1A1_6hr
NapropamideCYP1A1CLD_CYP1A1_48hr
NapropamideCYP1A2CLD_CYP1A2_24hr
NapropamideCYP1A2CLD_CYP1A2_6hr
NapropamideCYP1A2CLD_CYP1A2_48hr
NapropamideCYP2B6CLD_CYP2B6_6hr
NapropamideCYP2B6CLD_CYP2B6_48hr
NapropamideCYP2B6NVS_ADME_hCYP2B6
NapropamideCYP2C19NVS_ADME_hCYP2C19
NapropamideCYP2C9NVS_ADME_hCYP2C9
NapropamideCYP2C18NVS_ADME_hCYP2C18
NapropamideCYP3A4CLD_CYP3A4_48hr
NapropamideCYP19A1TOX21_Aromatase_Inhibition
NapropamideEGR1ATG_EGR_CIS_up
NapropamideAHRTOX21_AhR_LUC_Agonist
NapropamideAHRATG_Ahr_CIS_up
NapropamideESR1CEETOX_H295R_ESTRONE_up
NapropamideESR1ATG_ERE_CIS_up
NapropamideESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
NapropamideESR1ATG_ERa_TRANS_up
NapropamideESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
NapropamideESR2TOX21_ERb_BLA_Antagonist_ratio
NapropamideESR2CEETOX_H295R_ESTRONE_up
NapropamideESRRATOX21_ERR_Antagonist
NapropamideESRRATOX21_PGC_ERR_Antagonist
NapropamideNR3C1ATG_GRE_CIS_dn
NapropamideHIF1AATG_HIF1a_CIS_up
NapropamideONECUT1ATG_HNF6_CIS_dn
NapropamideCXCL10BSK_hDFCGF_IP10_down
NapropamideARNVS_NR_hAR
NapropamideARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
NapropamideARACEA_AR_antagonist_80hr
NapropamideARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
NapropamideARTOX21_AR_BLA_Antagonist_ratio
NapropamideARCEETOX_H295R_ANDR_dn
NapropamideJUNTOX21_AP1_BLA_Agonist_ratio
NapropamideESR1CEETOX_H295R_ESTRONE_up
NapropamideFOSTOX21_AP1_BLA_Agonist_ratio
NapropamideNACEETOX_H295R_ESTRONE_up
NapropamideSMAD1ATG_BRE_CIS_up
NapropamideARCEETOX_H295R_ANDR_dn
NapropamideMMP1BSK_BE3C_MMP1_up
NapropamideMTF1ATG_MRE_CIS_up
NapropamideNFE2L2TOX21_ARE_BLA_agonist_ratio
NapropamideNFE2L2ATG_NRF2_ARE_CIS_up
NapropamideOPRM1NVS_GPCR_hOpiate_mu
NapropamidePGRTOX21_PR_BLA_Antagonist_ratio
NapropamidePOU2F1ATG_Oct_MLP_CIS_up
NapropamidePPARAATG_PPRE_CIS_up
NapropamideUGT1A1CLD_UGT1A1_48hr
NapropamidePPARDATG_PPRE_CIS_up
NapropamidePPARGATG_PPARg_TRANS_up
NapropamidePPARGATG_PPRE_CIS_up
NapropamideBCHENVS_ENZ_hES
NapropamideRARAATG_RARa_TRANS_up
NapropamideRARAATG_DR5_CIS_up
NapropamideRARBATG_DR5_CIS_up
NapropamideRARGATG_DR5_CIS_up
NapropamideRORAATG_RORE_CIS_up
NapropamideRORBATG_RORE_CIS_up
NapropamideRORCATG_RORE_CIS_up
NapropamideRXRATOX21_RXR_BLA_Agonist_ratio
NapropamideSLC6A3NVS_TR_hDAT
NapropamideSREBF1ATG_SREBP_CIS_up
NapropamideSULT2A1CLD_SULT2A_48hr
NapropamideTBXA2RNVS_GPCR_hTXA2
NapropamideTHBDBSK_CASM3C_Thrombomodulin_up
NapropamideTSPONVS_MP_hPBR
NapropamideTSHRTOX21_TSHR_Agonist_ratio
NapropamideUSF1ATG_E_Box_CIS_dn
NapropamideVDRATG_VDRE_CIS_up
NapropamideNACEETOX_H295R_ANDR_dn
NapropamideNR1I2ATG_PXR_TRANS_up
NapropamideNR1I2ATG_PXRE_CIS_up
NapropamideNR1I3TOX21_CAR_Agonist
NapropamideNR1I3NVS_NR_hCAR_Antagonist
NapropamideNR1I3ATG_PBREM_CIS_up
NapropamideNR1I3ATG_CAR_TRANS_up
NapropamideNR1H4OT_FXR_FXRSRC1_0480
NapropamideNR1H4OT_FXR_FXRSRC1_1440

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.