Chlorpyrifos

Target genes for Chlorpyrifos is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ChlorpyrifosNR1H3ATG_DR4_LXR_CIS_dn
ChlorpyrifosNACEETOX_H295R_PROG_up
ChlorpyrifosESR1CEETOX_H295R_TESTO_dn
ChlorpyrifosNACEETOX_H295R_TESTO_dn
ChlorpyrifosNACEETOX_H295R_ANDR_dn
ChlorpyrifosCCL26BSK_4H_Eotaxin3_down
ChlorpyrifosCOL3A1BSK_hDFCGF_CollagenIII_down
ChlorpyrifosCSF1BSK_LPS_MCSF_down
ChlorpyrifosCSF1BSK_hDFCGF_MCSF_down
ChlorpyrifosDUSP3NVS_ENZ_hDUSP3
ChlorpyrifosE2F1ATG_E2F_CIS_dn
ChlorpyrifosAHRATG_Ahr_CIS_up
ChlorpyrifosAHRTOX21_AhR_LUC_Agonist
ChlorpyrifosESR1OT_ER_ERaERb_1440
ChlorpyrifosESR1ATG_ERa_TRANS_up
ChlorpyrifosESR1OT_ER_ERaERa_1440
ChlorpyrifosESR1ATG_ERE_CIS_up
ChlorpyrifosESR1OT_ER_ERaERa_0480
ChlorpyrifosESR1OT_ER_ERaERb_0480
ChlorpyrifosESR2OT_ER_ERaERb_0480
ChlorpyrifosESR2OT_ER_ERaERb_1440
ChlorpyrifosESR2OT_ER_ERbERb_0480
ChlorpyrifosETS1ATG_Ets_CIS_dn
ChlorpyrifosFOSATG_AP_1_CIS_up
ChlorpyrifosGATA1ATG_GATA_CIS_dn
ChlorpyrifosGLI1ATG_GLI_CIS_up
ChlorpyrifosNR3C1CEETOX_H295R_CORTISOL_dn
ChlorpyrifosNR3C1CEETOX_H295R_11DCORT_dn
ChlorpyrifosHLA-DRABSK_BE3C_HLADR_down
ChlorpyrifosHLA-DRABSK_3C_HLADR_down
ChlorpyrifosCXCL8BSK_SAg_IL8_down
ChlorpyrifosCXCL8BSK_3C_IL8_down
ChlorpyrifosCXCL10BSK_hDFCGF_IP10_down
ChlorpyrifosIRF1ATG_ISRE_CIS_dn
ChlorpyrifosARCEETOX_H295R_ANDR_dn
ChlorpyrifosARCEETOX_H295R_TESTO_dn
ChlorpyrifosARACEA_AR_antagonist_80hr
ChlorpyrifosAROT_AR_ARSRC1_0960
ChlorpyrifosAROT_AR_ARSRC1_0480
ChlorpyrifosJUNATG_AP_1_CIS_up
ChlorpyrifosJUNTOX21_AP1_BLA_Agonist_ratio
ChlorpyrifosLDLRBSK_CASM3C_LDLR_up
ChlorpyrifosESR1CEETOX_H295R_TESTO_dn
ChlorpyrifosFOSTOX21_AP1_BLA_Agonist_ratio
ChlorpyrifosNACEETOX_H295R_TESTO_dn
ChlorpyrifosSMAD1ATG_BRE_CIS_up
ChlorpyrifosARCEETOX_H295R_TESTO_dn
ChlorpyrifosARCEETOX_H295R_ANDR_dn
ChlorpyrifosNR3C2CEETOX_H295R_11DCORT_dn
ChlorpyrifosNR3C2CEETOX_H295R_CORTISOL_dn
ChlorpyrifosMMP1BSK_hDFCGF_MMP1_up
ChlorpyrifosMTF1ATG_MRE_CIS_up
ChlorpyrifosNFIAATG_NFI_CIS_up
ChlorpyrifosNFE2L2TOX21_ARE_BLA_agonist_ratio
ChlorpyrifosNFE2L2ATG_NRF2_ARE_CIS_up
ChlorpyrifosNRF1ATG_NRF1_CIS_up
ChlorpyrifosSERPINE1BSK_hDFCGF_PAI1_down
ChlorpyrifosPGRCEETOX_H295R_PROG_up
ChlorpyrifosPGRCEETOX_H295R_OHPREG_dn
ChlorpyrifosPGRTOX21_PR_BLA_Antagonist_ratio
ChlorpyrifosPLAURBSK_3C_uPAR_down
ChlorpyrifosPOU2F1ATG_Oct_MLP_CIS_up
ChlorpyrifosPPARGATG_PPARg_TRANS_up
ChlorpyrifosBCHENVS_ENZ_hES
ChlorpyrifosRXRAOT_NURR1_NURR1RXRa_0480
ChlorpyrifosRXRAOT_NURR1_NURR1RXRa_1440
ChlorpyrifosRXRBATG_RXRb_TRANS_up
ChlorpyrifosCCL2BSK_3C_MCP1_down
ChlorpyrifosCCL2BSK_KF3CT_MCP1_down
ChlorpyrifosCCL2BSK_SAg_MCP1_down
ChlorpyrifosSELEBSK_SAg_Eselectin_down
ChlorpyrifosSELEBSK_3C_Eselectin_down
ChlorpyrifosSELPBSK_4H_Pselectin_down
ChlorpyrifosSLC5A5NIS_RAIU_inhibition
ChlorpyrifosSP1ATG_Sp1_CIS_up
ChlorpyrifosSREBF1ATG_SREBP_CIS_up
ChlorpyrifosTHBDBSK_CASM3C_Thrombomodulin_up
ChlorpyrifosTSHRTOX21_TSHR_Antagonist_ratio
ChlorpyrifosNR1H2ATG_DR4_LXR_CIS_dn
ChlorpyrifosVCAM1BSK_3C_VCAM1_down
ChlorpyrifosVCAM1BSK_hDFCGF_VCAM1_down
ChlorpyrifosVCAM1BSK_LPS_VCAM1_down
ChlorpyrifosVCAM1BSK_4H_VCAM1_down
ChlorpyrifosVDRATG_VDRE_CIS_up
ChlorpyrifosNACEETOX_H295R_TESTO_dn
ChlorpyrifosNACEETOX_H295R_ANDR_dn
ChlorpyrifosXBP1ATG_Xbp1_CIS_up
ChlorpyrifosNR1I2ATG_PXRE_CIS_up
ChlorpyrifosNR1I2ATG_PXR_TRANS_up
ChlorpyrifosCD38BSK_SAg_CD38_down
ChlorpyrifosCD40BSK_LPS_CD40_down
ChlorpyrifosCD40BSK_SAg_CD40_down
ChlorpyrifosCD69BSK_SAg_CD69_down
ChlorpyrifosNR1I3TOX21_CAR_Agonist
ChlorpyrifosNR1H4OT_FXR_FXRSRC1_1440
ChlorpyrifosNR1H4OT_FXR_FXRSRC1_0480
ChlorpyrifosNR1H4ATG_IR1_CIS_dn

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.