Tamoxifen citrate

Target genes for Tamoxifen citrate is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Tamoxifen citrateNR1H3ATG_DR4_LXR_CIS_dn
Tamoxifen citrateNACEETOX_H295R_PROG_dn
Tamoxifen citrateESR1ATG_ERE_CIS_dn
Tamoxifen citrateCCL26BSK_4H_Eotaxin3_down
Tamoxifen citratePDE10ANVS_ENZ_hPDE10
Tamoxifen citrateCHRM1NVS_GPCR_hM1
Tamoxifen citrateCHRM2NVS_GPCR_hM2
Tamoxifen citrateCHRM3NVS_GPCR_hM3
Tamoxifen citrateCHRM4NVS_GPCR_hM4
Tamoxifen citrateCHUKNVS_ENZ_hIKKa
Tamoxifen citrateCOL3A1BSK_hDFCGF_CollagenIII_down
Tamoxifen citrateCSF1BSK_CASM3C_MCSF_down
Tamoxifen citrateCSF1BSK_hDFCGF_MCSF_down
Tamoxifen citrateCSF1BSK_LPS_MCSF_down
Tamoxifen citrateCYP19A1TOX21_Aromatase_Inhibition
Tamoxifen citrateCYP24A1TOX21_VDR_BLA_agonist_ratio
Tamoxifen citrateCYP24A1TOX21_VDR_BLA_antagonist_ratio
Tamoxifen citrateDIO1NHEERL_MED_hDIO1_dn
Tamoxifen citrateDRD1NVS_GPCR_hDRD1
Tamoxifen citrateESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
Tamoxifen citrateESR1OT_ERa_EREGFP_0120
Tamoxifen citrateESR1OT_ER_ERaERb_0480
Tamoxifen citrateESR1OT_ER_ERaERb_1440
Tamoxifen citrateESR1ATG_ERE_CIS_dn
Tamoxifen citrateESR1ACEA_ER_80hr
Tamoxifen citrateESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
Tamoxifen citrateESR1TOX21_ERa_BLA_Agonist_ratio
Tamoxifen citrateESR1OT_ERa_EREGFP_0480
Tamoxifen citrateESR1OT_ER_ERaERa_1440
Tamoxifen citrateESR1NVS_NR_hER
Tamoxifen citrateESR1TOX21_ERa_BLA_Antagonist_ratio
Tamoxifen citrateESR1OT_ER_ERaERa_0480
Tamoxifen citrateESR2OT_ER_ERaERb_1440
Tamoxifen citrateESR2TOX21_ERb_BLA_Antagonist_ratio
Tamoxifen citrateESR2TOX21_ERb_BLA_Agonist_ratio
Tamoxifen citrateESR2OT_ER_ERbERb_0480
Tamoxifen citrateESR2OT_ER_ERaERb_0480
Tamoxifen citrateESR2OT_ER_ERbERb_1440
Tamoxifen citrateESRRATOX21_PGC_ERR_Antagonist
Tamoxifen citrateESRRATOX21_ERR_Antagonist
Tamoxifen citrateESRRAATG_ERRa_TRANS_dn
Tamoxifen citrateF3BSK_LPS_TissueFactor_down
Tamoxifen citrateF3BSK_3C_TissueFactor_down
Tamoxifen citrateFGFR1NVS_ENZ_hFGFR1
Tamoxifen citrateATF6TOX21_ESRE_BLA_ratio
Tamoxifen citrateSIRT3NVS_ENZ_hSIRT3
Tamoxifen citrateFYNNVS_ENZ_hFyn
Tamoxifen citrateNR3C1CEETOX_H295R_DOC_dn
Tamoxifen citrateNR3C1TOX21_GR_BLA_Agonist_ratio
Tamoxifen citrateNR3C1CEETOX_H295R_11DCORT_dn
Tamoxifen citrateHIF1ATOX21_HRE_BLA_Agonist_ratio
Tamoxifen citrateHLA-DRABSK_CASM3C_HLADR_down
Tamoxifen citrateHLA-DRABSK_BE3C_HLADR_down
Tamoxifen citrateHLA-DRABSK_3C_HLADR_down
Tamoxifen citrateHSF1TOX21_HSE_BLA_agonist_ratio
Tamoxifen citrateHTR2ANVS_GPCR_h5HT2A
Tamoxifen citrateHTR5ANVS_GPCR_h5HT5A
Tamoxifen citrateHTR7NVS_GPCR_h5HT7
Tamoxifen citrateICAM1BSK_3C_ICAM1_down
Tamoxifen citrateICAM1BSK_KF3CT_ICAM1_down
Tamoxifen citrateIL1ABSK_KF3CT_IL1a_down
Tamoxifen citrateIL1ABSK_LPS_IL1a_down
Tamoxifen citrateIL1ABSK_BE3C_IL1a_down
Tamoxifen citrateIL6BSK_CASM3C_IL6_down
Tamoxifen citrateCXCL8BSK_LPS_IL8_down
Tamoxifen citrateCXCL8BSK_CASM3C_IL8_down
Tamoxifen citrateCXCL8BSK_hDFCGF_IL8_down
Tamoxifen citrateCXCL8BSK_3C_IL8_down
Tamoxifen citrateCXCL8BSK_SAg_IL8_down
Tamoxifen citrateCXCL10BSK_KF3CT_IP10_down
Tamoxifen citrateCXCL10BSK_BE3C_IP10_down
Tamoxifen citrateCXCL10BSK_hDFCGF_IP10_down
Tamoxifen citrateARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Tamoxifen citrateARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
Tamoxifen citrateARTOX21_AR_BLA_Agonist_ratio
Tamoxifen citrateAROT_AR_ARSRC1_0480
Tamoxifen citrateARACEA_AR_antagonist_80hr
Tamoxifen citrateARTOX21_AR_BLA_Antagonist_ratio
Tamoxifen citrateAROT_AR_ARSRC1_0960
Tamoxifen citrateJAK2NVS_ENZ_hJak2
Tamoxifen citrateJUNTOX21_AP1_BLA_Agonist_ratio
Tamoxifen citrateKDRBSK_4H_VEGFRII_down
Tamoxifen citrateLDLRBSK_CASM3C_LDLR_down
Tamoxifen citrateESR1ATG_ERE_CIS_dn
Tamoxifen citrateFOSTOX21_AP1_BLA_Agonist_ratio
Tamoxifen citrateNAATG_ERE_CIS_dn
Tamoxifen citrateCXCL9BSK_BE3C_MIG_down
Tamoxifen citrateCXCL9BSK_hDFCGF_MIG_down
Tamoxifen citrateCXCL9BSK_SAg_MIG_down
Tamoxifen citrateCXCL9BSK_3C_MIG_down
Tamoxifen citrateCXCL9BSK_CASM3C_MIG_down
Tamoxifen citrateACHENVS_ENZ_hAChE
Tamoxifen citrateNR3C2CEETOX_H295R_DOC_dn
Tamoxifen citrateNR3C2CEETOX_H295R_11DCORT_dn
Tamoxifen citrateMMP1BSK_hDFCGF_MMP1_down
Tamoxifen citrateMMP1BSK_BE3C_MMP1_down
Tamoxifen citrateMMP9BSK_KF3CT_MMP9_down
Tamoxifen citrateMMP13NVS_ENZ_hMMP13
Tamoxifen citrateNFE2L2ATG_NRF2_ARE_CIS_up
Tamoxifen citrateNFKB1TOX21_NFkB_BLA_agonist_ratio
Tamoxifen citrateNPY2RNVS_GPCR_hNPY2
Tamoxifen citrateNR4A2ATG_NURR1_TRANS_dn
Tamoxifen citrateOPRL1NVS_GPCR_hORL1
Tamoxifen citrateOPRM1NVS_GPCR_hOpiate_mu
Tamoxifen citrateSERPINE1BSK_BE3C_PAI1_down
Tamoxifen citrateSERPINE1BSK_hDFCGF_PAI1_down
Tamoxifen citratePDE4ANVS_ENZ_hPDE4A1
Tamoxifen citratePGRCEETOX_H295R_OHPREG_dn
Tamoxifen citratePGRTOX21_PR_BLA_Antagonist_ratio
Tamoxifen citratePGRCEETOX_H295R_OHPROG_dn
Tamoxifen citratePGRCEETOX_H295R_PROG_dn
Tamoxifen citratePGRTOX21_PR_BLA_Agonist_ratio
Tamoxifen citratePIK3CANVS_ENZ_hPI3Ka
Tamoxifen citratePLATBSK_BE3C_tPA_down
Tamoxifen citratePLAUBSK_BE3C_uPA_down
Tamoxifen citratePLAUBSK_KF3CT_uPA_down
Tamoxifen citratePLAURBSK_BE3C_uPAR_down
Tamoxifen citratePLAURBSK_4H_uPAR_down
Tamoxifen citratePLAURBSK_CASM3C_uPAR_down
Tamoxifen citratePLAURBSK_3C_uPAR_down
Tamoxifen citratePPARANVS_NR_hPPARa
Tamoxifen citratePPARAATG_PPARa_TRANS_dn
Tamoxifen citratePPARDTOX21_PPARd_BLA_antagonist_ratio
Tamoxifen citratePPARDTOX21_PPARd_BLA_agonist_ratio
Tamoxifen citratePPARGTOX21_PPARg_BLA_Agonist_ratio
Tamoxifen citratePRKAA1NVS_ENZ_hAMPKa1
Tamoxifen citratePTGER2BSK_LPS_PGE2_down
Tamoxifen citratePTPN1NVS_ENZ_hPTPN1_Activator
Tamoxifen citratePTPN9NVS_ENZ_hPTPN9_Activator
Tamoxifen citratePTPN13NVS_ENZ_hPTPN13
Tamoxifen citratePTPRMNVS_ENZ_hPTPRM
Tamoxifen citrateRARANVS_NR_hRAR_Antagonist
Tamoxifen citrateRARBATG_RARb_TRANS_dn
Tamoxifen citrateRXRATOX21_RXR_BLA_Agonist_ratio
Tamoxifen citrateRXRAOT_NURR1_NURR1RXRa_1440
Tamoxifen citrateRXRAATG_RXRa_TRANS_up
Tamoxifen citrateSAA1BSK_CASM3C_SAA_down
Tamoxifen citrateCCL2BSK_4H_MCP1_down
Tamoxifen citrateCCL2BSK_LPS_MCP1_down
Tamoxifen citrateCCL2BSK_SAg_MCP1_down
Tamoxifen citrateCCL2BSK_3C_MCP1_down
Tamoxifen citrateCCL2BSK_CASM3C_MCP1_down
Tamoxifen citrateCCL2BSK_KF3CT_MCP1_down
Tamoxifen citrateSELEBSK_SAg_Eselectin_down
Tamoxifen citrateSELEBSK_LPS_Eselectin_down
Tamoxifen citrateSELEBSK_3C_Eselectin_down
Tamoxifen citrateSELPBSK_4H_Pselectin_down
Tamoxifen citrateSLC5A5NIS_RAIU_inhibition
Tamoxifen citrateSLC6A3NVS_TR_hDAT
Tamoxifen citrateSREBF1ATG_SREBP_CIS_up
Tamoxifen citrateTACR2NVS_GPCR_hNK2
Tamoxifen citrateTGFB1BSK_KF3CT_TGFb1_down
Tamoxifen citrateTGFB1BSK_BE3C_TGFb1_down
Tamoxifen citrateTHBDBSK_CASM3C_Thrombomodulin_up
Tamoxifen citrateTIMP1BSK_hDFCGF_TIMP1_down
Tamoxifen citrateTIMP2BSK_KF3CT_TIMP2_down
Tamoxifen citrateTNFBSK_LPS_TNFa_down
Tamoxifen citrateTP53TOX21_p53_BLA_p3_ratio
Tamoxifen citrateTP53TOX21_p53_BLA_p1_ratio
Tamoxifen citrateTP53APR_HepG2_p53Act_24h_up
Tamoxifen citrateTP53TOX21_p53_BLA_p5_ratio
Tamoxifen citrateTP53TOX21_p53_BLA_p4_ratio
Tamoxifen citrateTP53TOX21_p53_BLA_p2_ratio
Tamoxifen citrateTP53APR_HepG2_p53Act_72h_up
Tamoxifen citrateTSHRTOX21_TSHR_Antagonist_ratio
Tamoxifen citrateNR1H2ATG_DR4_LXR_CIS_dn
Tamoxifen citrateVCAM1BSK_hDFCGF_VCAM1_down
Tamoxifen citrateVCAM1BSK_CASM3C_VCAM1_down
Tamoxifen citrateVCAM1BSK_LPS_VCAM1_down
Tamoxifen citrateVCAM1BSK_4H_VCAM1_down
Tamoxifen citrateVCAM1BSK_3C_VCAM1_down
Tamoxifen citrateVDRTOX21_VDR_BLA_antagonist_ratio
Tamoxifen citrateVDRTOX21_VDR_BLA_agonist_ratio
Tamoxifen citrateNR1I2ATG_PXR_TRANS_up
Tamoxifen citrateNR1I2ATG_PXRE_CIS_up
Tamoxifen citrateMAPKAPK2NVS_ENZ_hMAPKAPK2_Activator
Tamoxifen citrateCD38BSK_SAg_CD38_down
Tamoxifen citrateCD40BSK_SAg_CD40_down
Tamoxifen citrateCD40BSK_LPS_CD40_down
Tamoxifen citrateCD69BSK_SAg_CD69_down
Tamoxifen citrateNR1I3TOX21_CAR_Antagonist
Tamoxifen citrateNR1I3NVS_NR_hCAR_Antagonist
Tamoxifen citrateNR1H4NVS_NR_hFXR_Antagonist
Tamoxifen citrateNR1H4TOX21_FXR_BLA_agonist_ratio
Tamoxifen citrateNR1H4OT_FXR_FXRSRC1_0480
Tamoxifen citrateNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.