Tamoxifen

Target genes for Tamoxifen is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
TamoxifenNR1H3ATG_DR4_LXR_CIS_dn
TamoxifenESR1ATG_ERE_CIS_dn
TamoxifenCCL26BSK_4H_Eotaxin3_down
TamoxifenCHRM5NVS_GPCR_hM5
TamoxifenCOL3A1BSK_hDFCGF_CollagenIII_down
TamoxifenCSF1BSK_LPS_MCSF_down
TamoxifenCSF1BSK_CASM3C_MCSF_down
TamoxifenCSF1BSK_hDFCGF_MCSF_down
TamoxifenADRA2CNVS_GPCR_hAdra2C
TamoxifenCYP2C19NVS_ADME_hCYP2C19
TamoxifenCYP2C9NVS_ADME_hCYP2C9
TamoxifenCYP19A1TOX21_Aromatase_Inhibition
TamoxifenCYP24A1TOX21_VDR_BLA_agonist_ratio
TamoxifenDIO1NHEERL_MED_hDIO1_dn
TamoxifenDRD1NVS_GPCR_hDRD1
TamoxifenAKT1NVS_ENZ_hAKT1
TamoxifenESR1TOX21_ERa_BLA_Agonist_ratio
TamoxifenESR1OT_ERa_EREGFP_0480
TamoxifenESR1ATG_ERE_CIS_dn
TamoxifenESR1OT_ER_ERaERb_1440
TamoxifenESR1TOX21_ERa_BLA_Antagonist_ratio
TamoxifenESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
TamoxifenESR1OT_ERa_EREGFP_0120
TamoxifenESR1OT_ER_ERaERa_1440
TamoxifenESR1OT_ER_ERaERb_0480
TamoxifenESR1ACEA_ER_80hr
TamoxifenESR1OT_ER_ERaERa_0480
TamoxifenESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
TamoxifenESR1TOX21_ERa_LUC_VM7_Agonist
TamoxifenESR1NVS_NR_hER
TamoxifenESR2OT_ER_ERaERb_1440
TamoxifenESR2OT_ER_ERbERb_1440
TamoxifenESR2TOX21_ERb_BLA_Antagonist_ratio
TamoxifenESR2OT_ER_ERbERb_0480
TamoxifenESR2OT_ER_ERaERb_0480
TamoxifenESR2TOX21_ERb_BLA_Agonist_ratio
TamoxifenESRRATOX21_ERR_Antagonist
TamoxifenESRRATOX21_PGC_ERR_Antagonist
TamoxifenF3BSK_CASM3C_TissueFactor_down
TamoxifenF3BSK_LPS_TissueFactor_down
TamoxifenF3BSK_3C_TissueFactor_down
TamoxifenATF6TOX21_ESRE_BLA_ratio
TamoxifenNR3C1TOX21_GR_BLA_Antagonist_ratio
TamoxifenNR3C1NVS_NR_hGR
TamoxifenNR3C1TOX21_GR_BLA_Agonist_ratio
TamoxifenHIF1ATOX21_HRE_BLA_Agonist_ratio
TamoxifenHLA-DRABSK_3C_HLADR_down
TamoxifenHLA-DRABSK_CASM3C_HLADR_down
TamoxifenHLA-DRABSK_BE3C_HLADR_down
TamoxifenHSF1TOX21_HSE_BLA_agonist_ratio
TamoxifenHTR6NVS_GPCR_h5HT6
TamoxifenICAM1BSK_KF3CT_ICAM1_down
TamoxifenICAM1BSK_3C_ICAM1_down
TamoxifenIL1ABSK_BE3C_IL1a_down
TamoxifenIL1ABSK_KF3CT_IL1a_down
TamoxifenIL1ABSK_LPS_IL1a_down
TamoxifenIL6BSK_CASM3C_IL6_down
TamoxifenCXCL8BSK_3C_IL8_down
TamoxifenCXCL8BSK_SAg_IL8_down
TamoxifenCXCL8BSK_CASM3C_IL8_down
TamoxifenCXCL8BSK_LPS_IL8_down
TamoxifenCXCL8BSK_hDFCGF_IL8_down
TamoxifenCXCL10BSK_hDFCGF_IP10_down
TamoxifenCXCL10BSK_BE3C_IP10_down
TamoxifenCXCL10BSK_KF3CT_IP10_down
TamoxifenARTOX21_AR_BLA_Agonist_ratio
TamoxifenAROT_AR_ARSRC1_0480
TamoxifenARACEA_AR_antagonist_80hr
TamoxifenARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
TamoxifenAROT_AR_ARSRC1_0960
TamoxifenARTOX21_AR_BLA_Antagonist_ratio
TamoxifenARNVS_NR_hAR
TamoxifenJUNTOX21_AP1_BLA_Agonist_ratio
TamoxifenKCNH2NVS_IC_hKhERGCh
TamoxifenKDRBSK_4H_VEGFRII_down
TamoxifenLDLRBSK_CASM3C_LDLR_down
TamoxifenESR1ATG_ERE_CIS_dn
TamoxifenFOSTOX21_AP1_BLA_Agonist_ratio
TamoxifenNAATG_ERE_CIS_dn
TamoxifenCXCL9BSK_3C_MIG_down
TamoxifenCXCL9BSK_BE3C_MIG_down
TamoxifenCXCL9BSK_hDFCGF_MIG_down
TamoxifenCXCL9BSK_SAg_MIG_down
TamoxifenCXCL9BSK_CASM3C_MIG_down
TamoxifenMMP1BSK_BE3C_MMP1_down
TamoxifenMMP1BSK_hDFCGF_MMP1_down
TamoxifenMMP9BSK_KF3CT_MMP9_down
TamoxifenNFE2L2ATG_NRF2_ARE_CIS_up
TamoxifenNFE2L2TOX21_ARE_BLA_agonist_ratio
TamoxifenNFKB1TOX21_NFkB_BLA_agonist_ratio
TamoxifenSERPINE1BSK_hDFCGF_PAI1_down
TamoxifenSERPINE1BSK_BE3C_PAI1_down
TamoxifenPGRTOX21_PR_BLA_Antagonist_ratio
TamoxifenPGRTOX21_PR_BLA_Agonist_ratio
TamoxifenPLATBSK_BE3C_tPA_down
TamoxifenPLAUBSK_KF3CT_uPA_down
TamoxifenPLAUBSK_BE3C_uPA_down
TamoxifenPLAURBSK_BE3C_uPAR_down
TamoxifenPLAURBSK_4H_uPAR_down
TamoxifenPLAURBSK_3C_uPAR_down
TamoxifenPLAURBSK_CASM3C_uPAR_down
TamoxifenPPARDTOX21_PPARd_BLA_agonist_ratio
TamoxifenPPARDTOX21_PPARd_BLA_antagonist_ratio
TamoxifenPPARGTOX21_PPARg_BLA_Agonist_ratio
TamoxifenPPARGTOX21_PPARg_BLA_antagonist_ratio
TamoxifenPTGER2BSK_LPS_PGE2_down
TamoxifenRXRAOT_NURR1_NURR1RXRa_1440
TamoxifenRXRATOX21_RXR_BLA_Agonist_ratio
TamoxifenRXRAOT_NURR1_NURR1RXRa_0480
TamoxifenSAA1BSK_CASM3C_SAA_down
TamoxifenCCL2BSK_3C_MCP1_down
TamoxifenCCL2BSK_LPS_MCP1_down
TamoxifenCCL2BSK_KF3CT_MCP1_down
TamoxifenCCL2BSK_SAg_MCP1_down
TamoxifenCCL2BSK_4H_MCP1_down
TamoxifenCCL2BSK_CASM3C_MCP1_down
TamoxifenSELEBSK_LPS_Eselectin_down
TamoxifenSELEBSK_3C_Eselectin_down
TamoxifenSELEBSK_SAg_Eselectin_down
TamoxifenSELPBSK_4H_Pselectin_down
TamoxifenSLC5A5NIS_RAIU_inhibition
TamoxifenSLC6A2NVS_TR_hNET
TamoxifenSLC6A3NVS_TR_hDAT
TamoxifenTGFB1BSK_KF3CT_TGFb1_down
TamoxifenTGFB1BSK_BE3C_TGFb1_down
TamoxifenTHBDBSK_3C_Thrombomodulin_up
TamoxifenTHBDBSK_CASM3C_Thrombomodulin_up
TamoxifenTIMP1BSK_hDFCGF_TIMP1_down
TamoxifenTIMP2BSK_KF3CT_TIMP2_down
TamoxifenTNFBSK_LPS_TNFa_down
TamoxifenTP53APR_HepG2_p53Act_24h_up
TamoxifenTP53APR_HepG2_p53Act_72h_up
TamoxifenTP53TOX21_p53_BLA_p5_ratio
TamoxifenTP53TOX21_p53_BLA_p3_ratio
TamoxifenTP53TOX21_p53_BLA_p1_ratio
TamoxifenTSHRTOX21_TSHR_Antagonist_ratio
TamoxifenNR1H2ATG_DR4_LXR_CIS_dn
TamoxifenVCAM1BSK_3C_VCAM1_down
TamoxifenVCAM1BSK_4H_VCAM1_down
TamoxifenVCAM1BSK_hDFCGF_VCAM1_down
TamoxifenVCAM1BSK_CASM3C_VCAM1_down
TamoxifenVCAM1BSK_LPS_VCAM1_down
TamoxifenVDRTOX21_VDR_BLA_agonist_ratio
TamoxifenNR1I2ATG_PXRE_CIS_up
TamoxifenCD38BSK_SAg_CD38_down
TamoxifenCD40BSK_SAg_CD40_down
TamoxifenCD40BSK_LPS_CD40_down
TamoxifenCD69BSK_SAg_CD69_down
TamoxifenNR1I3TOX21_CAR_Antagonist
TamoxifenNR1H4TOX21_FXR_BLA_antagonist_ratio
TamoxifenNR1H4TOX21_FXR_BLA_agonist_ratio
TamoxifenNR1H4OT_FXR_FXRSRC1_0480

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.