Chlordecone

Target genes for Chlordecone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ChlordeconeNR1H3ATG_DR4_LXR_CIS_dn
ChlordeconeCCL26BSK_4H_Eotaxin3_down
ChlordeconeCOL3A1BSK_hDFCGF_CollagenIII_down
ChlordeconeADORA2ANVS_GPCR_hAdoRA2a
ChlordeconeCSF1BSK_CASM3C_MCSF_down
ChlordeconeCSF1BSK_LPS_MCSF_down
ChlordeconeCSF1BSK_hDFCGF_MCSF_down
ChlordeconeADRB1NVS_GPCR_hAdrb1
ChlordeconeCYP2B6NVS_ADME_hCYP2B6
ChlordeconeCYP2C19NVS_ADME_hCYP2C19
ChlordeconeCYP2C9NVS_ADME_hCYP2C9
ChlordeconeCYP2C18NVS_ADME_hCYP2C18
ChlordeconeCYP19A1TOX21_Aromatase_Inhibition
ChlordeconeCYP24A1TOX21_VDR_BLA_agonist_ratio
ChlordeconeCYP24A1TOX21_VDR_BLA_antagonist_ratio
ChlordeconeDIO1NHEERL_MED_hDIO1_dn
ChlordeconeDRD1NVS_GPCR_hDRD1
ChlordeconeEGFRBSK_hDFCGF_EGFR_down
ChlordeconeESR1OT_ERa_EREGFP_0120
ChlordeconeESR1ATG_ERa_TRANS_up
ChlordeconeESR1OT_ERa_EREGFP_0480
ChlordeconeESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ChlordeconeESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ChlordeconeESR1OT_ER_ERaERb_1440
ChlordeconeESR1TOX21_ERa_LUC_VM7_Agonist
ChlordeconeESR1TOX21_ERa_BLA_Agonist_ratio
ChlordeconeESR1TOX21_ERa_BLA_Antagonist_ratio
ChlordeconeESR1NVS_NR_hER
ChlordeconeESR1ATG_ERE_CIS_up
ChlordeconeESR2TOX21_ERb_BLA_Antagonist_ratio
ChlordeconeESR2OT_ER_ERaERb_1440
ChlordeconeESRRATOX21_ERR_Antagonist
ChlordeconeESRRATOX21_PGC_ERR_Antagonist
ChlordeconeF3BSK_LPS_TissueFactor_down
ChlordeconeF3BSK_3C_TissueFactor_down
ChlordeconeF3BSK_CASM3C_TissueFactor_down
ChlordeconeATF6TOX21_ESRE_BLA_ratio
ChlordeconeFOSATG_AP_1_CIS_up
ChlordeconeGLI1ATG_GLI_CIS_up
ChlordeconeNR3C1TOX21_GR_BLA_Agonist_ratio
ChlordeconeNR3C1TOX21_GR_BLA_Antagonist_ratio
ChlordeconeNR3C1NVS_NR_hGR
ChlordeconeNR3C1ATG_GRE_CIS_dn
ChlordeconeHIF1ATOX21_HRE_BLA_Agonist_ratio
ChlordeconeHLA-DRABSK_CASM3C_HLADR_down
ChlordeconeHLA-DRABSK_3C_HLADR_down
ChlordeconeHLA-DRABSK_BE3C_HLADR_down
ChlordeconeHSF1TOX21_HSE_BLA_agonist_ratio
ChlordeconeHTR5ANVS_GPCR_h5HT5A
ChlordeconeHTR7NVS_GPCR_h5HT7
ChlordeconeICAM1BSK_3C_ICAM1_down
ChlordeconeICAM1BSK_KF3CT_ICAM1_down
ChlordeconeIL1ABSK_KF3CT_IL1a_down
ChlordeconeIL1ABSK_BE3C_IL1a_down
ChlordeconeIL1ABSK_LPS_IL1a_down
ChlordeconeIL6BSK_CASM3C_IL6_down
ChlordeconeCXCL8BSK_hDFCGF_IL8_down
ChlordeconeCXCL8BSK_SAg_IL8_down
ChlordeconeCXCL8BSK_3C_IL8_down
ChlordeconeCXCL8BSK_LPS_IL8_down
ChlordeconeCXCL8BSK_CASM3C_IL8_down
ChlordeconeCXCL10BSK_hDFCGF_IP10_down
ChlordeconeCXCL10BSK_KF3CT_IP10_down
ChlordeconeCXCL10BSK_BE3C_IP10_down
ChlordeconeARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ChlordeconeARTOX21_AR_BLA_Antagonist_ratio
ChlordeconeAROT_AR_ARSRC1_0960
ChlordeconeARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ChlordeconeARACEA_AR_antagonist_80hr
ChlordeconeAROT_AR_ARSRC1_0480
ChlordeconeARTOX21_AR_BLA_Agonist_ratio
ChlordeconeJUNTOX21_AP1_BLA_Agonist_ratio
ChlordeconeJUNATG_AP_1_CIS_up
ChlordeconeKDRBSK_4H_VEGFRII_down
ChlordeconeLDLRBSK_CASM3C_LDLR_down
ChlordeconeFOSTOX21_AP1_BLA_Agonist_ratio
ChlordeconeCXCL9BSK_SAg_MIG_down
ChlordeconeCXCL9BSK_BE3C_MIG_down
ChlordeconeCXCL9BSK_3C_MIG_down
ChlordeconeCXCL9BSK_CASM3C_MIG_down
ChlordeconeCXCL9BSK_hDFCGF_MIG_down
ChlordeconeMMP1BSK_hDFCGF_MMP1_down
ChlordeconeMMP1BSK_BE3C_MMP1_down
ChlordeconeMMP7NVS_ENZ_hMMP7
ChlordeconeMMP9BSK_KF3CT_MMP9_down
ChlordeconeMTF1ATG_MRE_CIS_up
ChlordeconeNFE2L2ATG_NRF2_ARE_CIS_up
ChlordeconeNFE2L2TOX21_ARE_BLA_agonist_ratio
ChlordeconeNFKB1TOX21_NFkB_BLA_agonist_ratio
ChlordeconeOPRM1NVS_GPCR_hOpiate_mu
ChlordeconeSERPINE1BSK_hDFCGF_PAI1_down
ChlordeconeSERPINE1BSK_BE3C_PAI1_down
ChlordeconePGRTOX21_PR_BLA_Antagonist_ratio
ChlordeconePLATBSK_BE3C_tPA_down
ChlordeconePLAUBSK_KF3CT_uPA_down
ChlordeconePLAUBSK_BE3C_uPA_down
ChlordeconePLAURBSK_3C_uPAR_down
ChlordeconePLAURBSK_CASM3C_uPAR_down
ChlordeconePLAURBSK_BE3C_uPAR_down
ChlordeconePLAURBSK_4H_uPAR_down
ChlordeconePPARDTOX21_PPARd_BLA_agonist_ratio
ChlordeconePPARDTOX21_PPARd_BLA_antagonist_ratio
ChlordeconePPARGTOX21_PPARg_BLA_Agonist_ratio
ChlordeconePTGER2BSK_LPS_PGE2_down
ChlordeconeRARGATG_RARg_TRANS_up
ChlordeconeRXRATOX21_RXR_BLA_Agonist_ratio
ChlordeconeRXRBATG_RXRb_TRANS_up
ChlordeconeSAA1BSK_CASM3C_SAA_down
ChlordeconeCCL2BSK_SAg_MCP1_down
ChlordeconeCCL2BSK_LPS_MCP1_down
ChlordeconeCCL2BSK_3C_MCP1_down
ChlordeconeCCL2BSK_KF3CT_MCP1_down
ChlordeconeCCL2BSK_4H_MCP1_down
ChlordeconeCCL2BSK_CASM3C_MCP1_down
ChlordeconeSELEBSK_3C_Eselectin_down
ChlordeconeSELEBSK_SAg_Eselectin_down
ChlordeconeSELEBSK_LPS_Eselectin_down
ChlordeconeSELPBSK_4H_Pselectin_down
ChlordeconeSLC6A2NVS_TR_hNET
ChlordeconeSOX1ATG_Sox_CIS_up
ChlordeconeSTAT3ATG_STAT3_CIS_dn
ChlordeconeTGFB1BSK_BE3C_TGFb1_down
ChlordeconeTGFB1BSK_KF3CT_TGFb1_down
ChlordeconeTHBDBSK_CASM3C_Thrombomodulin_down
ChlordeconeTHRAATG_THRa1_TRANS_up
ChlordeconeTIMP1BSK_hDFCGF_TIMP1_down
ChlordeconeTIMP2BSK_KF3CT_TIMP2_down
ChlordeconeTNFBSK_LPS_TNFa_down
ChlordeconeTP53TOX21_p53_BLA_p4_ratio
ChlordeconeTP53TOX21_p53_BLA_p3_ratio
ChlordeconeTP53TOX21_p53_BLA_p1_ratio
ChlordeconeTP53TOX21_p53_BLA_p2_ratio
ChlordeconeTP53APR_HepG2_p53Act_72h_up
ChlordeconeTP53TOX21_p53_BLA_p5_ratio
ChlordeconeTSHRTOX21_TSHR_Antagonist_ratio
ChlordeconeTSHRTOX21_TSHR_Agonist_ratio
ChlordeconeNR1H2ATG_DR4_LXR_CIS_dn
ChlordeconeUSF1ATG_E_Box_CIS_dn
ChlordeconeVCAM1BSK_LPS_VCAM1_down
ChlordeconeVCAM1BSK_4H_VCAM1_down
ChlordeconeVCAM1BSK_hDFCGF_VCAM1_down
ChlordeconeVCAM1BSK_3C_VCAM1_down
ChlordeconeVCAM1BSK_CASM3C_VCAM1_down
ChlordeconeVDRTOX21_VDR_BLA_agonist_ratio
ChlordeconeVDRATG_VDRE_CIS_up
ChlordeconeVDRTOX21_VDR_BLA_antagonist_ratio
ChlordeconeNR1I2ATG_PXRE_CIS_up
ChlordeconeNR1I2ATG_PXR_TRANS_up
ChlordeconeCD38BSK_SAg_CD38_down
ChlordeconeCD40BSK_LPS_CD40_down
ChlordeconeCD40BSK_SAg_CD40_down
ChlordeconeCD69BSK_SAg_CD69_down
ChlordeconeNR1I3TOX21_CAR_Antagonist
ChlordeconeNR1H4OT_FXR_FXRSRC1_0480
ChlordeconeNR1H4ATG_FXR_TRANS_up
ChlordeconeNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.