Mancozeb

Target genes for Mancozeb is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
MancozebAKT3NVS_ENZ_hAKT3
MancozebHDAC6NVS_ENZ_hHDAC6
MancozebNR1H3ATG_DR4_LXR_CIS_dn
MancozebCDK2NVS_ENZ_hCDK2
MancozebCDK6NVS_ENZ_hCDK6
MancozebPAK4NVS_ENZ_hPAK4
MancozebCREB3ATG_CRE_CIS_up
MancozebPDE10ANVS_ENZ_hPDE10
MancozebCHUKNVS_ENZ_hIKKa
MancozebCSF1RNVS_ENZ_hCSF1R
MancozebCSNK1A1NVS_ENZ_hCK1a
MancozebCSNK1DNVS_ENZ_hCK1D
MancozebCSNK2A1NVS_ENZ_hCK2a2b2
MancozebCYP1A1CLD_CYP1A1_48hr
MancozebCYP1A1CLD_CYP1A1_6hr
MancozebCYP1A2CLD_CYP1A2_6hr
MancozebCYP2B6CLD_CYP2B6_6hr
MancozebCYP2C19NVS_ADME_hCYP2C19
MancozebCYP2C9NVS_ADME_hCYP2C9
MancozebCYP2C18NVS_ADME_hCYP2C18
MancozebCYP3A4CLD_CYP3A4_6hr
MancozebDIO1NHEERL_MED_hDIO1_dn
MancozebDUSP3NVS_ENZ_hDUSP3
MancozebDYRK1ANVS_ENZ_hDYRK1a
MancozebEGFRNVS_ENZ_hEGFR
MancozebEGR1ATG_EGR_CIS_up
MancozebAHRATG_Ahr_CIS_up
MancozebEPHA2NVS_ENZ_hEphA2_Activator
MancozebELANENVS_ENZ_hElastase
MancozebEPHA1NVS_ENZ_hEphA1
MancozebEPHB2NVS_ENZ_hEphB2_Activator
MancozebAKT1NVS_ENZ_hAKT1
MancozebAKT2NVS_ENZ_hAKT2
MancozebESR2TOX21_ERb_BLA_Antagonist_ratio
MancozebESRRATOX21_PGC_ERR_Agonist
MancozebESRRATOX21_ERR_Antagonist
MancozebF3BSK_CASM3C_TissueFactor_up
MancozebF3BSK_3C_TissueFactor_up
MancozebFGFR1NVS_ENZ_hFGFR1
MancozebFGFR3NVS_ENZ_hFGFR3
MancozebSIRT2NVS_ENZ_hSIRT2
MancozebFLT1NVS_ENZ_hVEGFR1
MancozebFLT4NVS_ENZ_hVEGFR3
MancozebSIRT1NVS_ENZ_hSIRT1
MancozebFOSATG_AP_1_CIS_up
MancozebBACE1NVS_ENZ_hBACE
MancozebABL1NVS_ENZ_hAbl_Activator
MancozebFYNNVS_ENZ_hFyn_Activator
MancozebNR3C1NVS_NR_hGR
MancozebGSK3BNVS_ENZ_hGSK3b
MancozebHIF1AATG_HIF1a_CIS_up
MancozebHLA-DRABSK_3C_HLADR_down
MancozebHTR2ANVS_GPCR_h5HT2A
MancozebHTR7NVS_GPCR_h5HT7
MancozebIGF1RNVS_ENZ_hIGF1R_Activator
MancozebINSRNVS_ENZ_hInsR_Activator
MancozebIRF1ATG_ISRE_CIS_dn
MancozebARACEA_AR_agonist_80hr
MancozebAROT_AR_ARSRC1_0960
MancozebAROT_AR_ARSRC1_0480
MancozebJAK2NVS_ENZ_hJak2
MancozebJUNTOX21_AP1_BLA_Agonist_ratio
MancozebJUNATG_AP_1_CIS_up
MancozebKDRNVS_ENZ_hVEGFR2
MancozebLCKNVS_ENZ_hLck_Activator
MancozebFOSTOX21_AP1_BLA_Agonist_ratio
MancozebLYNNVS_ENZ_hLynA_Activator
MancozebMARK1NVS_ENZ_hMARK1
MancozebMETNVS_ENZ_hMet
MancozebMMP3NVS_ENZ_hMMP3
MancozebMMP9NVS_ENZ_hMMP9_Activator
MancozebMMP13NVS_ENZ_hMMP13
MancozebMTF1ATG_MRE_CIS_up
MancozebNEK2NVS_ENZ_hNEK2_Activator
MancozebNFE2L2ATG_NRF2_ARE_CIS_up
MancozebNFE2L2TOX21_ARE_BLA_agonist_ratio
MancozebNPY1RNVS_GPCR_hNPY1
MancozebNTRK1NVS_ENZ_hTrkA_Activator
MancozebNTRK1NVS_ENZ_hTrkA
MancozebOPRL1NVS_GPCR_hORL1
MancozebOPRM1NVS_GPCR_hOpiate_mu
MancozebPAX6ATG_Pax6_CIS_up
MancozebLEF1ATG_TCF_b_cat_CIS_dn
MancozebPDE4ANVS_ENZ_hPDE4A1
MancozebACP1NVS_ENZ_hACP1
MancozebPGRTOX21_PR_BLA_Antagonist_ratio
MancozebABCB1CLD_ABCB1_24hr
MancozebABCB1CLD_ABCB1_48hr
MancozebPIK3CANVS_ENZ_hPI3Ka
MancozebPOU2F1ATG_Oct_MLP_CIS_up
MancozebUGT1A1CLD_UGT1A1_6hr
MancozebPPARGATG_PPARg_TRANS_up
MancozebPPM1ANVS_ENZ_hPPM1A_Activator
MancozebPRKAA1NVS_ENZ_hAMPKa1
MancozebPRKACANVS_ENZ_hPKA
MancozebMAPK1NVS_ENZ_hMAPK1
MancozebMAPK3NVS_ENZ_hMAPK3
MancozebMAPK11NVS_ENZ_hMAPK11
MancozebPTENNVS_ENZ_hPTEN
MancozebPTPN1NVS_ENZ_hPTPN1
MancozebPTPN2NVS_ENZ_hPTPN2
MancozebPTPN4NVS_ENZ_hPTPN4
MancozebPTPN6NVS_ENZ_hPTPN6
MancozebPTPN9NVS_ENZ_hPTPN9
MancozebPTPN11NVS_ENZ_hPTPN11
MancozebPTPN12NVS_ENZ_hPTPN12
MancozebPTPN13NVS_ENZ_hPTPN13
MancozebPTPN14NVS_ENZ_hPTPN14
MancozebPTPRBNVS_ENZ_hPTPRB
MancozebPTPRCNVS_ENZ_hPTPRC
MancozebPTPRFNVS_ENZ_hPTPRF
MancozebPTPRMNVS_ENZ_hPTPRM
MancozebRARANVS_NR_hRAR_Antagonist
MancozebSGK1NVS_ENZ_hSGK1
MancozebSLC5A5NIS_RAIU_inhibition
MancozebSLC6A2NVS_TR_hNET
MancozebSOX1ATG_Sox_CIS_up
MancozebSRCNVS_ENZ_hSRC
MancozebSRCNVS_ENZ_hSRC_Activator
MancozebAURKANVS_ENZ_hAurA
MancozebSYKNVS_ENZ_hSyk
MancozebTACR2NVS_GPCR_hNK2
MancozebTCF7ATG_TCF_b_cat_CIS_dn
MancozebTCF7L2ATG_TCF_b_cat_CIS_dn
MancozebBTKNVS_ENZ_hBTK_Activator
MancozebTEKNVS_ENZ_hTie2
MancozebTSPONVS_MP_hPBR
MancozebTHRANVS_NR_hTRa_Antagonist
MancozebNR1H2ATG_DR4_LXR_CIS_dn
MancozebUSF1ATG_E_Box_CIS_dn
MancozebVCAM1BSK_LPS_VCAM1_down
MancozebVCAM1BSK_3C_VCAM1_down
MancozebVDRATG_VDRE_CIS_up
MancozebXBP1ATG_Xbp1_CIS_up
MancozebTCF7L1ATG_TCF_b_cat_CIS_dn
MancozebCASP5NVS_ENZ_hCASP5
MancozebMAPKAPK5NVS_ENZ_hMAPKAPK5
MancozebPDE5ANVS_ENZ_hPDE5
MancozebHDAC3NVS_ENZ_hHDAC3
MancozebNR1I2ATG_PXRE_CIS_up
MancozebNR1I2NVS_NR_hPXR
MancozebNR1I2ATG_PXR_TRANS_up
MancozebRPS6KA5NVS_ENZ_hMsk1
MancozebMAPKAPK2NVS_ENZ_hMAPKAPK2
MancozebABCG2CLD_ABCG2_48hr
MancozebNR1I3NVS_NR_hCAR_Antagonist
MancozebNR1H4OT_FXR_FXRSRC1_1440
MancozebNR1H4TOX21_FXR_BLA_antagonist_ratio
MancozebNR1H4NVS_NR_hFXR_Antagonist
MancozebNR1H4OT_FXR_FXRSRC1_0480

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.