Indole-3-carbinol

Target genes for Indole-3-carbinol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Indole-3-carbinolNR1H3ATG_DR4_LXR_CIS_dn
Indole-3-carbinolCCL26BSK_4H_Eotaxin3_down
Indole-3-carbinolPDE10ANVS_ENZ_hPDE10
Indole-3-carbinolCSF1BSK_LPS_MCSF_down
Indole-3-carbinolCYP2C19NVS_ADME_hCYP2C19
Indole-3-carbinolCYP19A1TOX21_Aromatase_Inhibition
Indole-3-carbinolDUSP3NVS_ENZ_hDUSP3
Indole-3-carbinolEGR1ATG_EGR_CIS_up
Indole-3-carbinolAHRATG_Ahr_CIS_up
Indole-3-carbinolAHRTOX21_AhR_LUC_Agonist
Indole-3-carbinolESR1TOX21_ERa_BLA_Antagonist_ratio
Indole-3-carbinolESR1ATG_ERE_CIS_up
Indole-3-carbinolESR1ATG_ERa_TRANS_up
Indole-3-carbinolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
Indole-3-carbinolESR2TOX21_ERb_BLA_Antagonist_ratio
Indole-3-carbinolESRRATOX21_ERR_Antagonist
Indole-3-carbinolF3BSK_3C_TissueFactor_up
Indole-3-carbinolFLT1NVS_ENZ_hVEGFR1_Activator
Indole-3-carbinolFOSATG_AP_1_CIS_up
Indole-3-carbinolBACE1NVS_ENZ_hBACE
Indole-3-carbinolNR3C1CEETOX_H295R_DOC_dn
Indole-3-carbinolNR3C1NVS_NR_hGR
Indole-3-carbinolNR3C1CEETOX_H295R_CORTIC_dn
Indole-3-carbinolHIF1AATG_HIF1a_CIS_up
Indole-3-carbinolHLA-DRABSK_BE3C_HLADR_down
Indole-3-carbinolHLA-DRABSK_3C_HLADR_down
Indole-3-carbinolFOXA2ATG_FoxA2_CIS_up
Indole-3-carbinolHSF1ATG_HSE_CIS_up
Indole-3-carbinolCXCL8BSK_SAg_IL8_up
Indole-3-carbinolCXCL10BSK_BE3C_IP10_down
Indole-3-carbinolIRF1ATG_ISRE_CIS_dn
Indole-3-carbinolARTOX21_AR_BLA_Antagonist_ratio
Indole-3-carbinolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Indole-3-carbinolARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
Indole-3-carbinolJUNATG_AP_1_CIS_up
Indole-3-carbinolSMAD1ATG_BRE_CIS_up
Indole-3-carbinolNR3C2CEETOX_H295R_CORTIC_dn
Indole-3-carbinolNR3C2CEETOX_H295R_DOC_dn
Indole-3-carbinolMMP1BSK_BE3C_MMP1_up
Indole-3-carbinolMMP1BSK_hDFCGF_MMP1_up
Indole-3-carbinolMMP9BSK_KF3CT_MMP9_down
Indole-3-carbinolMTF1ATG_MRE_CIS_up
Indole-3-carbinolNFE2L2ATG_NRF2_ARE_CIS_up
Indole-3-carbinolNFE2L2TOX21_ARE_BLA_agonist_ratio
Indole-3-carbinolNRF1ATG_NRF1_CIS_dn
Indole-3-carbinolNR4A2ATG_NURR1_TRANS_up
Indole-3-carbinolSERPINE1BSK_hDFCGF_PAI1_down
Indole-3-carbinolSERPINE1BSK_BE3C_PAI1_down
Indole-3-carbinolPAX6ATG_Pax6_CIS_up
Indole-3-carbinolPGRTOX21_PR_BLA_Antagonist_ratio
Indole-3-carbinolPGRCEETOX_H295R_OHPROG_up
Indole-3-carbinolPGRCEETOX_H295R_OHPREG_dn
Indole-3-carbinolPIK3CANVS_ENZ_hPI3Ka
Indole-3-carbinolPLAURBSK_3C_uPAR_down
Indole-3-carbinolPPARAATG_PPRE_CIS_up
Indole-3-carbinolPPARDATG_PPRE_CIS_up
Indole-3-carbinolPPARGATG_PPARg_TRANS_up
Indole-3-carbinolPPARGATG_PPRE_CIS_up
Indole-3-carbinolPPARGTOX21_PPARg_BLA_antagonist_ratio
Indole-3-carbinolBCHENVS_ENZ_hES
Indole-3-carbinolRORAATG_RORE_CIS_up
Indole-3-carbinolRORBATG_RORE_CIS_up
Indole-3-carbinolRORCATG_RORE_CIS_up
Indole-3-carbinolCCL2BSK_4H_MCP1_down
Indole-3-carbinolCCL2BSK_CASM3C_MCP1_up
Indole-3-carbinolSELEBSK_3C_Eselectin_down
Indole-3-carbinolTACR2NVS_GPCR_hNK2
Indole-3-carbinolTHBDBSK_CASM3C_Thrombomodulin_up
Indole-3-carbinolTP53TOX21_p53_BLA_p4_ratio
Indole-3-carbinolTP53TOX21_p53_BLA_p2_ratio
Indole-3-carbinolNR1H2ATG_DR4_LXR_CIS_dn
Indole-3-carbinolVCAM1BSK_hDFCGF_VCAM1_down
Indole-3-carbinolVCAM1BSK_4H_VCAM1_down
Indole-3-carbinolVCAM1BSK_CASM3C_VCAM1_down
Indole-3-carbinolVDRATG_VDRE_CIS_up
Indole-3-carbinolCASP5NVS_ENZ_hCASP5
Indole-3-carbinolNR1I2ATG_PXR_TRANS_up
Indole-3-carbinolNR1I2ATG_PXRE_CIS_up
Indole-3-carbinolCD40BSK_SAg_CD40_down
Indole-3-carbinolCD40BSK_LPS_CD40_down
Indole-3-carbinolNR1I3ATG_PBREM_CIS_up
Indole-3-carbinolNR1I3TOX21_CAR_Agonist

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.