Mitotane

Target genes for Mitotane is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
MitotaneNR1H3ATG_DR4_LXR_CIS_dn
MitotaneCREB3ATG_CRE_CIS_dn
MitotaneCYP19A1TOX21_Aromatase_Inhibition
MitotaneAHRATG_Ahr_CIS_dn
MitotaneESR1TOX21_ERa_BLA_Agonist_ratio
MitotaneESR1ATG_ERE_CIS_up
MitotaneESR1TOX21_ERa_LUC_VM7_Agonist
MitotaneESR1OT_ERa_EREGFP_0480
MitotaneESR1OT_ER_ERaERb_0480
MitotaneESR1OT_ER_ERaERa_1440
MitotaneESR1ACEA_ER_80hr
MitotaneESR1NVS_NR_hER
MitotaneESR1TOX21_ERa_BLA_Antagonist_ratio
MitotaneESR1OT_ERa_EREGFP_0120
MitotaneESR1ATG_ERa_TRANS_up
MitotaneESR1OT_ER_ERaERb_1440
MitotaneESR1OT_ER_ERaERa_0480
MitotaneESR2OT_ER_ERbERb_1440
MitotaneESR2OT_ER_ERaERb_1440
MitotaneESR2OT_ER_ERbERb_0480
MitotaneESR2TOX21_ERb_BLA_Antagonist_ratio
MitotaneESR2OT_ER_ERaERb_0480
MitotaneESRRATOX21_ERR_Antagonist
MitotaneESRRATOX21_PGC_ERR_Antagonist
MitotaneATF6TOX21_ESRE_BLA_ratio
MitotaneFOXO1ATG_FoxO_CIS_dn
MitotaneFOXO3ATG_FoxO_CIS_dn
MitotaneFOSATG_AP_1_CIS_up
MitotaneGLI1ATG_GLI_CIS_up
MitotaneNR3C1TOX21_GR_BLA_Agonist_ratio
MitotaneNR3C1TOX21_GR_BLA_Antagonist_ratio
MitotaneHIF1AATG_HIF1a_CIS_up
MitotaneHIF1ATOX21_HRE_BLA_Agonist_ratio
MitotaneFOXA2ATG_FoxA2_CIS_dn
MitotaneONECUT1ATG_HNF6_CIS_up
MitotaneHSF1ATG_HSE_CIS_up
MitotaneIRF1ATG_ISRE_CIS_up
MitotaneARACEA_AR_antagonist_80hr
MitotaneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
MitotaneAROT_AR_ARSRC1_0480
MitotaneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
MitotaneAROT_AR_ARSRC1_0960
MitotaneARACEA_AR_agonist_80hr
MitotaneARTOX21_AR_BLA_Antagonist_ratio
MitotaneJUNATG_AP_1_CIS_up
MitotaneJUNTOX21_AP1_BLA_Agonist_ratio
MitotaneFOSTOX21_AP1_BLA_Agonist_ratio
MitotaneMTF1ATG_MRE_CIS_up
MitotaneNFIAATG_NFI_CIS_up
MitotaneNFE2L2TOX21_ARE_BLA_agonist_ratio
MitotaneNFE2L2ATG_NRF2_ARE_CIS_up
MitotaneNFKB1TOX21_NFkB_BLA_agonist_ratio
MitotaneNRF1ATG_NRF1_CIS_up
MitotaneLEF1ATG_TCF_b_cat_CIS_up
MitotanePGRTOX21_PR_BLA_Antagonist_ratio
MitotanePOU2F1ATG_Oct_MLP_CIS_dn
MitotanePPARAATG_PPRE_CIS_dn
MitotanePPARDATG_PPRE_CIS_dn
MitotanePPARGATG_PPRE_CIS_dn
MitotaneRARAATG_RARa_TRANS_dn
MitotaneRARBATG_RARb_TRANS_dn
MitotaneRORAATG_RORE_CIS_dn
MitotaneRORBATG_RORE_CIS_dn
MitotaneRORCATG_RORE_CIS_dn
MitotaneRXRAOT_NURR1_NURR1RXRa_0480
MitotaneRXRBATG_RXRb_TRANS_up
MitotaneSOX1ATG_Sox_CIS_dn
MitotaneSP1ATG_Sp1_CIS_up
MitotaneSTAT3ATG_STAT3_CIS_up
MitotaneTCF7ATG_TCF_b_cat_CIS_up
MitotaneTCF7L2ATG_TCF_b_cat_CIS_up
MitotaneTGFB1ATG_TGFb_CIS_dn
MitotaneTP53TOX21_p53_BLA_p2_ratio
MitotaneTP53TOX21_p53_BLA_p5_ratio
MitotaneTP53TOX21_p53_BLA_p4_ratio
MitotaneTP53TOX21_p53_BLA_p1_ratio
MitotaneTP53TOX21_p53_BLA_p3_ratio
MitotaneTSHRTOX21_TSHR_Agonist_ratio
MitotaneNR1H2ATG_DR4_LXR_CIS_dn
MitotaneXBP1ATG_Xbp1_CIS_up
MitotaneTCF7L1ATG_TCF_b_cat_CIS_up
MitotaneNR1I2ATG_PXR_TRANS_up
MitotaneNR1I2ATG_PXRE_CIS_up
MitotaneNR1I3TOX21_CAR_Agonist
MitotaneNR1I3ATG_CAR_TRANS_dn
MitotaneNR1H4TOX21_FXR_BLA_antagonist_ratio
MitotaneNR1H4ATG_IR1_CIS_dn

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