Nordihydroguaiaretic acid

Target genes for Nordihydroguaiaretic acid is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Nordihydroguaiaretic acidNR1H3ATG_DR4_LXR_CIS_dn
Nordihydroguaiaretic acidNACEETOX_H295R_PROG_up
Nordihydroguaiaretic acidESR1CEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidNACEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidNACEETOX_H295R_ANDR_dn
Nordihydroguaiaretic acidCREB3ATG_CRE_CIS_up
Nordihydroguaiaretic acidDIO1NHEERL_MED_hDIO1_dn
Nordihydroguaiaretic acidE2F1ATG_E2F_CIS_dn
Nordihydroguaiaretic acidEGR1ATG_EGR_CIS_up
Nordihydroguaiaretic acidESR1OT_ERa_EREGFP_0480
Nordihydroguaiaretic acidESR1ATG_ERE_CIS_up
Nordihydroguaiaretic acidESR1TOX21_ERa_BLA_Antagonist_ratio
Nordihydroguaiaretic acidESR1OT_ER_ERaERa_1440
Nordihydroguaiaretic acidESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
Nordihydroguaiaretic acidESR1NVS_NR_hER
Nordihydroguaiaretic acidESR1OT_ER_ERaERa_0480
Nordihydroguaiaretic acidESR1OT_ERa_EREGFP_0120
Nordihydroguaiaretic acidESR1TOX21_ERa_BLA_Agonist_ratio
Nordihydroguaiaretic acidESR1OT_ER_ERaERb_1440
Nordihydroguaiaretic acidESR1OT_ER_ERaERb_0480
Nordihydroguaiaretic acidESR1ATG_ERa_TRANS_up
Nordihydroguaiaretic acidESR2OT_ER_ERbERb_0480
Nordihydroguaiaretic acidESR2OT_ER_ERaERb_0480
Nordihydroguaiaretic acidESR2OT_ER_ERaERb_1440
Nordihydroguaiaretic acidESR2TOX21_ERb_BLA_Antagonist_ratio
Nordihydroguaiaretic acidESR2OT_ER_ERbERb_1440
Nordihydroguaiaretic acidESRRATOX21_PGC_ERR_Antagonist
Nordihydroguaiaretic acidESRRATOX21_ERR_Antagonist
Nordihydroguaiaretic acidATF6TOX21_ESRE_BLA_ratio
Nordihydroguaiaretic acidGLI1ATG_GLI_CIS_up
Nordihydroguaiaretic acidNR3C1CEETOX_H295R_DOC_dn
Nordihydroguaiaretic acidNR3C1TOX21_GR_BLA_Antagonist_ratio
Nordihydroguaiaretic acidNR3C1NVS_NR_hGR
Nordihydroguaiaretic acidNR3C1CEETOX_H295R_CORTIC_up
Nordihydroguaiaretic acidNR3C1CEETOX_H295R_11DCORT_dn
Nordihydroguaiaretic acidNR3C1CEETOX_H295R_CORTISOL_dn
Nordihydroguaiaretic acidNR3C1CEETOX_H295R_DOC_up
Nordihydroguaiaretic acidHIF1ATOX21_HRE_BLA_Agonist_ratio
Nordihydroguaiaretic acidHSF1TOX21_HSE_BLA_agonist_ratio
Nordihydroguaiaretic acidHSF1ATG_HSE_CIS_up
Nordihydroguaiaretic acidARACEA_AR_antagonist_80hr
Nordihydroguaiaretic acidAROT_AR_ARSRC1_0960
Nordihydroguaiaretic acidARCEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidARCEETOX_H295R_ANDR_dn
Nordihydroguaiaretic acidARTOX21_AR_BLA_Antagonist_ratio
Nordihydroguaiaretic acidARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Nordihydroguaiaretic acidARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
Nordihydroguaiaretic acidAROT_AR_ARSRC1_0480
Nordihydroguaiaretic acidESR1CEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidNACEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidARCEETOX_H295R_ANDR_dn
Nordihydroguaiaretic acidARCEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidNR3C2CEETOX_H295R_DOC_dn
Nordihydroguaiaretic acidNR3C2CEETOX_H295R_CORTISOL_dn
Nordihydroguaiaretic acidNR3C2CEETOX_H295R_CORTIC_up
Nordihydroguaiaretic acidNR3C2CEETOX_H295R_11DCORT_dn
Nordihydroguaiaretic acidNR3C2CEETOX_H295R_DOC_up
Nordihydroguaiaretic acidMTF1ATG_MRE_CIS_up
Nordihydroguaiaretic acidNFIAATG_NFI_CIS_up
Nordihydroguaiaretic acidNFE2L2ATG_NRF2_ARE_CIS_up
Nordihydroguaiaretic acidNFKB1ATG_NF_kB_CIS_up
Nordihydroguaiaretic acidNR4A2ATG_NURR1_TRANS_up
Nordihydroguaiaretic acidPAX6ATG_Pax6_CIS_up
Nordihydroguaiaretic acidLEF1ATG_TCF_b_cat_CIS_dn
Nordihydroguaiaretic acidPGRTOX21_PR_BLA_Antagonist_ratio
Nordihydroguaiaretic acidPGRCEETOX_H295R_OHPROG_up
Nordihydroguaiaretic acidPGRCEETOX_H295R_PROG_up
Nordihydroguaiaretic acidPOU2F1ATG_Oct_MLP_CIS_up
Nordihydroguaiaretic acidPPARAATG_PPARa_TRANS_up
Nordihydroguaiaretic acidPPARANVS_NR_hPPARa
Nordihydroguaiaretic acidPPARAATG_PPRE_CIS_up
Nordihydroguaiaretic acidPPARDATG_PPRE_CIS_up
Nordihydroguaiaretic acidPPARGATG_PPARg_TRANS_up
Nordihydroguaiaretic acidPPARGTOX21_PPARg_BLA_antagonist_ratio
Nordihydroguaiaretic acidPPARGNVS_NR_hPPARg
Nordihydroguaiaretic acidPPARGATG_PPRE_CIS_up
Nordihydroguaiaretic acidRARANVS_NR_hRAR_Antagonist
Nordihydroguaiaretic acidRORAATG_RORE_CIS_up
Nordihydroguaiaretic acidRORBATG_RORE_CIS_up
Nordihydroguaiaretic acidRORCATG_RORE_CIS_up
Nordihydroguaiaretic acidRXRAOT_NURR1_NURR1RXRa_0480
Nordihydroguaiaretic acidSOX1ATG_Sox_CIS_up
Nordihydroguaiaretic acidSP1ATG_Sp1_CIS_up
Nordihydroguaiaretic acidSREBF1ATG_SREBP_CIS_up
Nordihydroguaiaretic acidTCF7ATG_TCF_b_cat_CIS_dn
Nordihydroguaiaretic acidTCF7L2ATG_TCF_b_cat_CIS_dn
Nordihydroguaiaretic acidTSPONVS_MP_hPBR
Nordihydroguaiaretic acidTP53TOX21_p53_BLA_p3_ratio
Nordihydroguaiaretic acidTP53TOX21_p53_BLA_p5_ratio
Nordihydroguaiaretic acidTP53TOX21_p53_BLA_p1_ratio
Nordihydroguaiaretic acidTP53TOX21_p53_BLA_p2_ratio
Nordihydroguaiaretic acidTP53TOX21_p53_BLA_p4_ratio
Nordihydroguaiaretic acidNR1H2ATG_DR4_LXR_CIS_dn
Nordihydroguaiaretic acidVDRATG_VDRE_CIS_up
Nordihydroguaiaretic acidNACEETOX_H295R_TESTO_dn
Nordihydroguaiaretic acidNACEETOX_H295R_ANDR_dn
Nordihydroguaiaretic acidXBP1ATG_Xbp1_CIS_up
Nordihydroguaiaretic acidTCF7L1ATG_TCF_b_cat_CIS_dn
Nordihydroguaiaretic acidNR1I2ATG_PXRE_CIS_up
Nordihydroguaiaretic acidNR1I2ATG_PXR_TRANS_up
Nordihydroguaiaretic acidNR1I2NVS_NR_hPXR
Nordihydroguaiaretic acidNR1I3ATG_PBREM_CIS_up
Nordihydroguaiaretic acidNR1H4ATG_IR1_CIS_dn

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.