Toxaphene

Target genes for Toxaphene is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ToxapheneCYP19A1TOX21_Aromatase_Inhibition
ToxapheneCYP24A1TOX21_VDR_BLA_agonist_ratio
ToxapheneCYP24A1TOX21_VDR_BLA_antagonist_ratio
ToxapheneESR1TOX21_ERa_LUC_VM7_Agonist
ToxapheneESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ToxapheneESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ToxapheneESR1TOX21_ERa_BLA_Agonist_ratio
ToxapheneESR1TOX21_ERa_BLA_Antagonist_ratio
ToxapheneESR2TOX21_ERb_BLA_Antagonist_ratio
ToxapheneESRRATOX21_PGC_ERR_Antagonist
ToxapheneESRRATOX21_ERR_Antagonist
ToxapheneATF6TOX21_ESRE_BLA_ratio
ToxapheneNR3C1TOX21_GR_BLA_Agonist_ratio
ToxapheneNR3C1TOX21_GR_BLA_Antagonist_ratio
ToxapheneHIF1ATOX21_HRE_BLA_Agonist_ratio
ToxapheneHSF1TOX21_HSE_BLA_agonist_ratio
ToxapheneARTOX21_AR_BLA_Agonist_ratio
ToxapheneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ToxapheneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ToxapheneARTOX21_AR_BLA_Antagonist_ratio
ToxapheneJUNTOX21_AP1_BLA_Agonist_ratio
ToxapheneFOSTOX21_AP1_BLA_Agonist_ratio
ToxapheneNFE2L2TOX21_ARE_BLA_agonist_ratio
ToxapheneNFKB1TOX21_NFkB_BLA_agonist_ratio
ToxaphenePGRTOX21_PR_BLA_Antagonist_ratio
ToxaphenePPARDTOX21_PPARd_BLA_agonist_ratio
ToxaphenePPARGTOX21_PPARg_BLA_Agonist_ratio
ToxaphenePPARGTOX21_PPARg_BLA_antagonist_ratio
ToxapheneTP53TOX21_p53_BLA_p3_ratio
ToxapheneTP53TOX21_p53_BLA_p4_ratio
ToxapheneTP53TOX21_p53_BLA_p2_ratio
ToxapheneTP53TOX21_p53_BLA_p1_ratio
ToxapheneTP53TOX21_p53_BLA_p5_ratio
ToxapheneTSHRTOX21_TSHR_Agonist_ratio
ToxapheneVDRTOX21_VDR_BLA_agonist_ratio
ToxapheneVDRTOX21_VDR_BLA_antagonist_ratio
ToxapheneNR1I3TOX21_CAR_Agonist
ToxapheneNR1H4TOX21_FXR_BLA_antagonist_ratio
ToxapheneNR1H4TOX21_FXR_BLA_agonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.