Apigenin

Target genes for Apigenin is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ApigeninNR1H3ATG_DR4_LXR_CIS_dn
ApigeninCREB3ATG_CRE_CIS_up
ApigeninCEBPBATG_C_EBP_CIS_up
ApigeninCYP19A1TOX21_Aromatase_Inhibition
ApigeninCYP24A1TOX21_VDR_BLA_antagonist_ratio
ApigeninEGR1ATG_EGR_CIS_up
ApigeninESR1OT_ER_ERaERb_0480
ApigeninESR1TOX21_ERa_BLA_Antagonist_ratio
ApigeninESR1OT_ER_ERaERa_0480
ApigeninESR1ACEA_ER_80hr
ApigeninESR1OT_ER_ERaERa_1440
ApigeninESR1OT_ERa_EREGFP_0120
ApigeninESR1TOX21_ERa_LUC_VM7_Agonist
ApigeninESR1OT_ERa_EREGFP_0480
ApigeninESR1NVS_NR_hER
ApigeninESR1ATG_ERE_CIS_up
ApigeninESR1ATG_ERa_TRANS_up
ApigeninESR1TOX21_ERa_BLA_Agonist_ratio
ApigeninESR1OT_ER_ERaERb_1440
ApigeninESR2OT_ER_ERaERb_1440
ApigeninESR2OT_ER_ERaERb_0480
ApigeninESR2TOX21_ERb_BLA_Agonist_ratio
ApigeninESR2TOX21_ERb_BLA_Antagonist_ratio
ApigeninESR2OT_ER_ERbERb_0480
ApigeninESR2OT_ER_ERbERb_1440
ApigeninESRRATOX21_PGC_ERR_Agonist
ApigeninESRRATOX21_ERR_Agonist
ApigeninETS1ATG_Ets_CIS_dn
ApigeninFOSATG_AP_1_CIS_up
ApigeninGATA1ATG_GATA_CIS_dn
ApigeninNR3C1CEETOX_H295R_DOC_dn
ApigeninNR3C1TOX21_GR_BLA_Antagonist_ratio
ApigeninNR3C1CEETOX_H295R_11DCORT_dn
ApigeninHDAC1TOX21_HDAC_Inhibition
ApigeninHIF1AATG_HIF1a_CIS_up
ApigeninONECUT1ATG_HNF6_CIS_up
ApigeninHSF1ATG_HSE_CIS_dn
ApigeninIRF1ATG_ISRE_CIS_dn
ApigeninARTOX21_AR_BLA_Antagonist_ratio
ApigeninAROT_AR_ARSRC1_0960
ApigeninARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ApigeninARTOX21_AR_BLA_Agonist_ratio
ApigeninARACEA_AR_antagonist_80hr
ApigeninJUNATG_AP_1_CIS_up
ApigeninNR3C2CEETOX_H295R_11DCORT_dn
ApigeninNR3C2CEETOX_H295R_DOC_dn
ApigeninMTF1ATG_MRE_CIS_up
ApigeninNFE2L2TOX21_ARE_BLA_agonist_ratio
ApigeninNFE2L2ATG_NRF2_ARE_CIS_up
ApigeninNFKB1ATG_NF_kB_CIS_up
ApigeninNRF1ATG_NRF1_CIS_dn
ApigeninPAX6ATG_Pax6_CIS_up
ApigeninLEF1ATG_TCF_b_cat_CIS_dn
ApigeninPGRTOX21_PR_BLA_Antagonist_ratio
ApigeninPGRCEETOX_H295R_OHPROG_up
ApigeninPOU2F1ATG_Oct_MLP_CIS_up
ApigeninPPARAATG_PPRE_CIS_up
ApigeninPPARDTOX21_PPARd_BLA_antagonist_ratio
ApigeninPPARDATG_PPRE_CIS_up
ApigeninPPARGATG_PPRE_CIS_up
ApigeninPPARGTOX21_PPARg_BLA_antagonist_ratio
ApigeninPPARGATG_PPARg_TRANS_up
ApigeninSOX1ATG_Sox_CIS_up
ApigeninTCF7ATG_TCF_b_cat_CIS_dn
ApigeninTCF7L2ATG_TCF_b_cat_CIS_dn
ApigeninTFAP2AATG_AP_2_CIS_dn
ApigeninTFAP2BATG_AP_2_CIS_dn
ApigeninTP53TOX21_p53_BLA_p3_ratio
ApigeninTP53TOX21_p53_BLA_p4_ratio
ApigeninTP53TOX21_p53_BLA_p2_ratio
ApigeninTP53ATG_p53_CIS_up
ApigeninTP53TOX21_p53_BLA_p5_ratio
ApigeninTP53TOX21_p53_BLA_p1_ratio
ApigeninNR1H2ATG_DR4_LXR_CIS_dn
ApigeninVDRATG_VDRE_CIS_up
ApigeninVDRTOX21_VDR_BLA_antagonist_ratio
ApigeninXBP1ATG_Xbp1_CIS_up
ApigeninATAD5TOX21_ELG1_LUC_Agonist
ApigeninTCF7L1ATG_TCF_b_cat_CIS_dn
ApigeninTFAP2DATG_AP_2_CIS_dn
ApigeninNR1I2ATG_PXRE_CIS_dn
ApigeninNR1I3TOX21_CAR_Agonist
ApigeninNR1H4TOX21_FXR_BLA_antagonist_ratio
ApigeninNR1H4ATG_IR1_CIS_dn

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.