Zearalenone

Target genes for Zearalenone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ZearalenoneNR1H3ATG_DR4_LXR_CIS_dn
ZearalenoneNACEETOX_H295R_PROG_noMTC_up
ZearalenoneESR1CEETOX_H295R_ESTRONE_noMTC_dn
ZearalenoneESR1CEETOX_H295R_ESTRADIOL_noMTC_dn
ZearalenoneESR1CEETOX_H295R_TESTO_noMTC_dn
ZearalenoneNACEETOX_H295R_TESTO_noMTC_dn
ZearalenoneNACEETOX_H295R_ANDR_noMTC_dn
ZearalenoneCYP19A1TOX21_Aromatase_Inhibition
ZearalenoneEGR1ATG_EGR_CIS_up
ZearalenoneAHRATG_Ahr_CIS_dn
ZearalenoneESR1OT_ERa_EREGFP_0120
ZearalenoneESR1OT_ER_ERaERb_0480
ZearalenoneESR1ACEA_ER_80hr
ZearalenoneESR1OT_ERa_EREGFP_0480
ZearalenoneESR1NVS_NR_hER
ZearalenoneESR1OT_ER_ERaERa_0480
ZearalenoneESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ZearalenoneESR1CEETOX_H295R_TESTO_noMTC_dn
ZearalenoneESR1ATG_ERa_TRANS_up
ZearalenoneESR1OT_ER_ERaERa_1440
ZearalenoneESR1TOX21_ERa_LUC_VM7_Agonist
ZearalenoneESR1TOX21_ERa_BLA_Agonist_ratio
ZearalenoneESR1CEETOX_H295R_ESTRONE_noMTC_dn
ZearalenoneESR1OT_ER_ERaERb_1440
ZearalenoneESR1ATG_ERE_CIS_up
ZearalenoneESR1TOX21_ERa_BLA_Antagonist_ratio
ZearalenoneESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ZearalenoneESR1CEETOX_H295R_ESTRADIOL_noMTC_dn
ZearalenoneESR2OT_ER_ERaERb_0480
ZearalenoneESR2TOX21_ERb_BLA_Antagonist_ratio
ZearalenoneESR2OT_ER_ERbERb_1440
ZearalenoneESR2OT_ER_ERbERb_0480
ZearalenoneESR2CEETOX_H295R_ESTRONE_noMTC_dn
ZearalenoneESR2CEETOX_H295R_TESTO_noMTC_dn
ZearalenoneESR2OT_ER_ERaERb_1440
ZearalenoneESR2CEETOX_H295R_ESTRADIOL_noMTC_dn
ZearalenoneESRRATOX21_ERR_Antagonist
ZearalenoneESRRATOX21_PGC_ERR_Antagonist
ZearalenoneETS1ATG_Ets_CIS_dn
ZearalenoneFOXO1ATG_FoxO_CIS_dn
ZearalenoneFOXO3ATG_FoxO_CIS_dn
ZearalenoneNR3C1CEETOX_H295R_11DCORT_noMTC_dn
ZearalenoneNR3C1TOX21_GR_BLA_Antagonist_ratio
ZearalenoneNR3C1CEETOX_H295R_CORTISOL_noMTC_dn
ZearalenoneNR3C1CEETOX_H295R_CORTIC_noMTC_dn
ZearalenoneNR3C1CEETOX_H295R_DOC_noMTC_dn
ZearalenoneHSF1ATG_HSE_CIS_up
ZearalenoneHSF1TOX21_HSE_BLA_agonist_ratio
ZearalenoneIRF1ATG_ISRE_CIS_dn
ZearalenoneARTOX21_AR_BLA_Antagonist_ratio
ZearalenoneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ZearalenoneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ZearalenoneARCEETOX_H295R_ANDR_noMTC_dn
ZearalenoneARCEETOX_H295R_TESTO_noMTC_dn
ZearalenoneARACEA_AR_antagonist_80hr
ZearalenoneESR1CEETOX_H295R_ESTRONE_noMTC_dn
ZearalenoneESR1CEETOX_H295R_TESTO_noMTC_dn
ZearalenoneESR1CEETOX_H295R_ESTRADIOL_noMTC_dn
ZearalenoneNACEETOX_H295R_TESTO_noMTC_dn
ZearalenoneNACEETOX_H295R_ESTRONE_noMTC_dn
ZearalenoneNACEETOX_H295R_ESTRADIOL_noMTC_dn
ZearalenoneSMAD1ATG_BRE_CIS_up
ZearalenoneARCEETOX_H295R_TESTO_noMTC_dn
ZearalenoneARCEETOX_H295R_ANDR_noMTC_dn
ZearalenoneNR3C2CEETOX_H295R_11DCORT_noMTC_dn
ZearalenoneNR3C2CEETOX_H295R_CORTISOL_noMTC_dn
ZearalenoneNR3C2CEETOX_H295R_CORTIC_noMTC_dn
ZearalenoneNR3C2CEETOX_H295R_DOC_noMTC_dn
ZearalenoneMTF1ATG_MRE_CIS_up
ZearalenoneNFE2L2TOX21_ARE_BLA_agonist_ratio
ZearalenoneNRF1ATG_NRF1_CIS_dn
ZearalenoneNR4A2ATG_NURR1_TRANS_up
ZearalenonePAX6ATG_Pax6_CIS_up
ZearalenonePGRCEETOX_H295R_PROG_noMTC_up
ZearalenonePGRTOX21_PR_BLA_Antagonist_ratio
ZearalenonePOU2F1ATG_Oct_MLP_CIS_up
ZearalenonePPARAATG_PPRE_CIS_up
ZearalenonePPARDTOX21_PPARd_BLA_antagonist_ratio
ZearalenonePPARDATG_PPRE_CIS_up
ZearalenonePPARGATG_PPRE_CIS_up
ZearalenonePPARGNVS_NR_hPPARg
ZearalenonePPARGTOX21_PPARg_BLA_antagonist_ratio
ZearalenoneRARAATG_DR5_CIS_up
ZearalenoneRARBATG_DR5_CIS_up
ZearalenoneRARGATG_DR5_CIS_up
ZearalenoneRXRBATG_RXRb_TRANS_up
ZearalenoneTSPONVS_MP_hPBR
ZearalenoneTP53TOX21_p53_BLA_p4_ratio
ZearalenoneTP53TOX21_p53_BLA_p1_ratio
ZearalenoneTP53TOX21_p53_BLA_p2_ratio
ZearalenoneTP53TOX21_p53_BLA_p3_ratio
ZearalenoneTP53TOX21_p53_BLA_p5_ratio
ZearalenoneNR1H2ATG_DR4_LXR_CIS_dn
ZearalenoneVDRATG_VDRE_CIS_up
ZearalenoneNACEETOX_H295R_TESTO_noMTC_dn
ZearalenoneNACEETOX_H295R_ANDR_noMTC_dn
ZearalenoneNR1I2ATG_PXR_TRANS_up
ZearalenoneNR1I2ATG_PXRE_CIS_up
ZearalenoneNR1I2CEETOX_H295R_OHPROG_noMTC_up
ZearalenoneNR1I2NVS_NR_hPXR
ZearalenoneNR1I3TOX21_CAR_Antagonist
ZearalenoneNR1I3ATG_PBREM_CIS_up
ZearalenoneNR1H4TOX21_FXR_BLA_antagonist_ratio

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.