Mifepristone

Target genes for Mifepristone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
MifepristoneNR1H3ATG_DR4_LXR_CIS_dn
MifepristoneNACEETOX_H295R_PROG_up
MifepristoneNACEETOX_H295R_ANDR_dn
MifepristoneCREB3ATG_CRE_CIS_up
MifepristoneCOL3A1BSK_hDFCGF_CollagenIII_down
MifepristoneADORA2ANVS_GPCR_hAdoRA2a
MifepristoneCSF1BSK_LPS_MCSF_down
MifepristoneCYP2C19NVS_ADME_hCYP2C19
MifepristoneCYP2C9NVS_ADME_hCYP2C9
MifepristoneCYP3A4NVS_ADME_hCYP3A4
MifepristoneCYP19A1TOX21_Aromatase_Inhibition
MifepristoneEGR1ATG_EGR_CIS_up
MifepristoneAHRATG_Ahr_CIS_up
MifepristoneELANENVS_ENZ_hElastase
MifepristoneESR1OT_ER_ERaERa_1440
MifepristoneESR1NVS_NR_hER
MifepristoneESR1OT_ERa_EREGFP_0480
MifepristoneESR1OT_ERa_EREGFP_0120
MifepristoneESR1OT_ER_ERaERa_0480
MifepristoneESR1TOX21_ERa_BLA_Antagonist_ratio
MifepristoneESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
MifepristoneESR1OT_ER_ERaERb_1440
MifepristoneESR1OT_ER_ERaERb_0480
MifepristoneESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
MifepristoneESR1ACEA_ER_80hr
MifepristoneESR2OT_ER_ERbERb_0480
MifepristoneESR2TOX21_ERb_BLA_Antagonist_ratio
MifepristoneESR2OT_ER_ERaERb_1440
MifepristoneESR2OT_ER_ERbERb_1440
MifepristoneESR2OT_ER_ERaERb_0480
MifepristoneESRRATOX21_ERR_Antagonist
MifepristoneESRRATOX21_PGC_ERR_Antagonist
MifepristoneF3BSK_LPS_TissueFactor_up
MifepristoneFOSATG_AP_1_CIS_up
MifepristoneGLI1ATG_GLI_CIS_up
MifepristoneNR3C1NVS_NR_hGR
MifepristoneNR3C1CEETOX_H295R_CORTISOL_dn
MifepristoneNR3C1CEETOX_H295R_DOC_dn
MifepristoneNR3C1CEETOX_H295R_CORTIC_dn
MifepristoneNR3C1CEETOX_H295R_11DCORT_dn
MifepristoneNR3C1TOX21_GR_BLA_Antagonist_ratio
MifepristoneHIF1AATG_HIF1a_CIS_up
MifepristoneFOXA2ATG_FoxA2_CIS_up
MifepristoneHSF1ATG_HSE_CIS_up
MifepristoneHTR7NVS_GPCR_h5HT7
MifepristoneICAM1BSK_KF3CT_ICAM1_up
MifepristoneIL1ABSK_LPS_IL1a_down
MifepristoneIL1ABSK_BE3C_IL1a_down
MifepristoneIL6BSK_CASM3C_IL6_down
MifepristoneCXCL8BSK_CASM3C_IL8_down
MifepristoneCXCL8BSK_SAg_IL8_down
MifepristoneCXCL8BSK_3C_IL8_down
MifepristoneCXCL10BSK_BE3C_IP10_down
MifepristoneIRF1ATG_ISRE_CIS_dn
MifepristoneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
MifepristoneAROT_AR_ARSRC1_0960
MifepristoneARNVS_NR_hAR
MifepristoneARTOX21_AR_BLA_Antagonist_ratio
MifepristoneARCEETOX_H295R_ANDR_dn
MifepristoneARACEA_AR_antagonist_80hr
MifepristoneARTOX21_AR_LUC_MDAKB2_Agonist_3uM_Nilutamide
MifepristoneAROT_AR_ARSRC1_0480
MifepristoneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
MifepristoneARTOX21_AR_LUC_MDAKB2_Agonist
MifepristoneJUNATG_AP_1_CIS_up
MifepristoneSMAD1ATG_BRE_CIS_up
MifepristoneARCEETOX_H295R_ANDR_dn
MifepristoneCXCL9BSK_SAg_MIG_down
MifepristoneCXCL9BSK_3C_MIG_down
MifepristoneACHENVS_ENZ_hAChE
MifepristoneNR3C2CEETOX_H295R_DOC_dn
MifepristoneNR3C2CEETOX_H295R_CORTISOL_dn
MifepristoneNR3C2CEETOX_H295R_CORTIC_dn
MifepristoneNR3C2CEETOX_H295R_11DCORT_dn
MifepristoneMMP1BSK_hDFCGF_MMP1_down
MifepristoneMMP1BSK_BE3C_MMP1_up
MifepristoneMMP9BSK_KF3CT_MMP9_down
MifepristoneMTF1ATG_MRE_CIS_up
MifepristoneMYCATG_Myc_CIS_up
MifepristoneNFIAATG_NFI_CIS_up
MifepristoneNFE2L2TOX21_ARE_BLA_agonist_ratio
MifepristoneNFE2L2ATG_NRF2_ARE_CIS_up
MifepristoneNRF1ATG_NRF1_CIS_dn
MifepristoneOPRM1NVS_GPCR_hOpiate_mu
MifepristoneSERPINE1BSK_hDFCGF_PAI1_down
MifepristoneSERPINE1BSK_BE3C_PAI1_down
MifepristonePAX6ATG_Pax6_CIS_up
MifepristoneLEF1ATG_TCF_b_cat_CIS_dn
MifepristonePGRCEETOX_H295R_OHPROG_up
MifepristonePGRNVS_NR_hPR
MifepristonePGRCEETOX_H295R_PROG_up
MifepristonePGRTOX21_PR_BLA_Antagonist_ratio
MifepristonePLATBSK_BE3C_tPA_down
MifepristonePLAURBSK_3C_uPAR_down
MifepristonePLAURBSK_CASM3C_uPAR_down
MifepristonePLAURBSK_4H_uPAR_down
MifepristonePOU2F1ATG_Oct_MLP_CIS_up
MifepristonePPARAATG_PPRE_CIS_up
MifepristonePPARANVS_NR_hPPARa
MifepristonePPARDATG_PPRE_CIS_up
MifepristonePPARDTOX21_PPARd_BLA_antagonist_ratio
MifepristonePPARGATG_PPRE_CIS_up
MifepristonePPARGTOX21_PPARg_BLA_antagonist_ratio
MifepristonePPARGATG_PPARg_TRANS_up
MifepristonePTGER2BSK_LPS_PGE2_up
MifepristoneBCHENVS_ENZ_hES
MifepristoneRARAATG_RARa_TRANS_dn
MifepristoneRARBATG_RARb_TRANS_dn
MifepristoneRORAATG_RORE_CIS_up
MifepristoneRORBATG_RORE_CIS_up
MifepristoneRORBATG_RORb_TRANS_dn
MifepristoneRORCATG_RORE_CIS_up
MifepristoneRORCATG_RORg_TRANS_dn
MifepristoneSAA1BSK_CASM3C_SAA_up
MifepristoneCCL2BSK_LPS_MCP1_down
MifepristoneCCL2BSK_SAg_MCP1_down
MifepristoneCCL2BSK_4H_MCP1_down
MifepristoneCCL2BSK_3C_MCP1_down
MifepristoneSELEBSK_LPS_Eselectin_down
MifepristoneSELEBSK_SAg_Eselectin_up
MifepristoneSELEBSK_3C_Eselectin_down
MifepristoneSELPBSK_4H_Pselectin_down
MifepristoneSP1ATG_Sp1_CIS_up
MifepristoneSREBF1ATG_SREBP_CIS_up
MifepristoneTCF7ATG_TCF_b_cat_CIS_dn
MifepristoneTCF7L2ATG_TCF_b_cat_CIS_dn
MifepristoneTGFB1ATG_TGFb_CIS_up
MifepristoneTP53TOX21_p53_BLA_p4_ratio
MifepristoneTP53TOX21_p53_BLA_p5_ratio
MifepristoneTP53ATG_p53_CIS_dn
MifepristoneTP53TOX21_p53_BLA_p1_ratio
MifepristoneTP53TOX21_p53_BLA_p2_ratio
MifepristoneTP53TOX21_p53_BLA_p3_ratio
MifepristoneNR1H2ATG_DR4_LXR_CIS_dn
MifepristoneVCAM1BSK_LPS_VCAM1_down
MifepristoneVCAM1BSK_3C_VCAM1_down
MifepristoneVCAM1BSK_4H_VCAM1_down
MifepristoneVDRATG_VDRE_CIS_up
MifepristoneNACEETOX_H295R_ANDR_dn
MifepristoneXBP1ATG_Xbp1_CIS_up
MifepristoneTCF7L1ATG_TCF_b_cat_CIS_dn
MifepristoneNR1I2ATG_PXR_TRANS_up
MifepristoneNR1I2ATG_PXRE_CIS_up
MifepristoneCD38BSK_SAg_CD38_down
MifepristoneCD40BSK_LPS_CD40_down
MifepristoneCD40BSK_SAg_CD40_down
MifepristoneCD69BSK_SAg_CD69_down
MifepristoneNR1I3ATG_CAR_TRANS_dn
MifepristoneNR1I3ATG_PBREM_CIS_up
MifepristoneNR1I3TOX21_CAR_Antagonist
MifepristoneNR1H4NVS_NR_hFXR_Antagonist
MifepristoneNR1H4OT_FXR_FXRSRC1_0480
MifepristoneNR1H4ATG_IR1_CIS_dn
MifepristoneNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.