5-Chloro-2-(2,4-dichlorophenoxy)phenol

Target genes for 5-Chloro-2-(2,4-dichlorophenoxy)phenol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H3ATG_DR4_LXR_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL26BSK_4H_Eotaxin3_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCOL3A1BSK_hDFCGF_CollagenIII_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCSF1BSK_LPS_MCSF_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCSF1BSK_CASM3C_MCSF_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCSF1BSK_hDFCGF_MCSF_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolADRA2CNVS_GPCR_hAdra2C
5-Chloro-2-(2,4-dichlorophenoxy)phenolADRB1NVS_GPCR_hAdrb1
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP1A2NVS_ADME_hCYP1A2
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP2C19NVS_ADME_hCYP2C19
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP2C8NVS_ADME_hCYP2C8
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP2C9NVS_ADME_hCYP2C9
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP19A1TOX21_Aromatase_Inhibition
5-Chloro-2-(2,4-dichlorophenoxy)phenolCYP24A1TOX21_VDR_BLA_antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolDIO1NHEERL_MED_hDIO1_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolEGFRBSK_hDFCGF_EGFR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolEGR1ATG_EGR_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolAKT2NVS_ENZ_hAKT2
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR1OT_ER_ERaERb_1440
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR1TOX21_ERa_LUC_VM7_Agonist
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR1TOX21_ERa_BLA_Antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR2OT_ER_ERaERb_1440
5-Chloro-2-(2,4-dichlorophenoxy)phenolESR2TOX21_ERb_BLA_Antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolESRRATOX21_PGC_ERR_Antagonist
5-Chloro-2-(2,4-dichlorophenoxy)phenolESRRATOX21_ERR_Antagonist
5-Chloro-2-(2,4-dichlorophenoxy)phenolF3BSK_3C_TissueFactor_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolF3BSK_CASM3C_TissueFactor_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolF3BSK_LPS_TissueFactor_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolATF6TOX21_ESRE_BLA_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolFOSATG_AP_1_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolBACE1NVS_ENZ_hBACE
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR3C1TOX21_GR_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolHIF1ATOX21_HRE_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolHLA-DRABSK_3C_HLADR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolHLA-DRABSK_BE3C_HLADR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolHLA-DRABSK_CASM3C_HLADR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolHSF1TOX21_HSE_BLA_agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolHTR7NVS_GPCR_h5HT7
5-Chloro-2-(2,4-dichlorophenoxy)phenolICAM1BSK_KF3CT_ICAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolICAM1BSK_3C_ICAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolIL1ABSK_LPS_IL1a_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolIL1ABSK_BE3C_IL1a_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolIL1ABSK_KF3CT_IL1a_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolIL6BSK_CASM3C_IL6_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL8BSK_CASM3C_IL8_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL8BSK_3C_IL8_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL8BSK_SAg_IL8_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL8BSK_LPS_IL8_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL8BSK_hDFCGF_IL8_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL10BSK_KF3CT_IP10_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL10BSK_BE3C_IP10_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL10BSK_hDFCGF_IP10_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolIRF1ATG_ISRE_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
5-Chloro-2-(2,4-dichlorophenoxy)phenolARNVS_NR_hAR
5-Chloro-2-(2,4-dichlorophenoxy)phenolARTOX21_AR_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
5-Chloro-2-(2,4-dichlorophenoxy)phenolARTOX21_AR_BLA_Antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolARACEA_AR_antagonist_80hr
5-Chloro-2-(2,4-dichlorophenoxy)phenolAROT_AR_ARSRC1_0480
5-Chloro-2-(2,4-dichlorophenoxy)phenolAROT_AR_ARSRC1_0960
5-Chloro-2-(2,4-dichlorophenoxy)phenolJUNATG_AP_1_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolJUNTOX21_AP1_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolKDRBSK_4H_VEGFRII_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolLCKNVS_ENZ_hLck_Activator
5-Chloro-2-(2,4-dichlorophenoxy)phenolLDLRBSK_CASM3C_LDLR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolFOSTOX21_AP1_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolSMAD1ATG_BRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL9BSK_SAg_MIG_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL9BSK_BE3C_MIG_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL9BSK_hDFCGF_MIG_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL9BSK_3C_MIG_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCXCL9BSK_CASM3C_MIG_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolMMP1BSK_hDFCGF_MMP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolMMP1BSK_BE3C_MMP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolMMP7NVS_ENZ_hMMP7
5-Chloro-2-(2,4-dichlorophenoxy)phenolMMP9BSK_KF3CT_MMP9_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolMTF1ATG_MRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolNFE2L2ATG_NRF2_ARE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolNFE2L2TOX21_ARE_BLA_agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolNFKB1TOX21_NFkB_BLA_agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolOPRD1NVS_GPCR_hOpiate_D1
5-Chloro-2-(2,4-dichlorophenoxy)phenolOPRM1NVS_GPCR_hOpiate_mu
5-Chloro-2-(2,4-dichlorophenoxy)phenolSERPINE1BSK_hDFCGF_PAI1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSERPINE1BSK_BE3C_PAI1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPAX6ATG_Pax6_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolLEF1ATG_TCF_b_cat_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolPGRTOX21_PR_BLA_Antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLATBSK_BE3C_tPA_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAUBSK_KF3CT_uPA_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAUBSK_BE3C_uPA_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAURBSK_4H_uPAR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAURBSK_BE3C_uPAR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAURBSK_3C_uPAR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPLAURBSK_CASM3C_uPAR_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolPOU2F1ATG_Oct_MLP_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARAATG_PPRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARDATG_PPRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARDTOX21_PPARd_BLA_antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARGATG_PPRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARGTOX21_PPARg_BLA_antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARGNVS_NR_hPPARg
5-Chloro-2-(2,4-dichlorophenoxy)phenolPPARGATG_PPARg_TRANS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolPTGER2BSK_LPS_PGE2_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolRXRAATG_RXRa_TRANS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolRXRATOX21_RXR_BLA_Agonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolRXRBATG_RXRb_TRANS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolSAA1BSK_CASM3C_SAA_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_SAg_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_3C_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_CASM3C_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_KF3CT_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_LPS_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCCL2BSK_4H_MCP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSELEBSK_3C_Eselectin_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSELEBSK_SAg_Eselectin_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSELEBSK_LPS_Eselectin_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSELPBSK_4H_Pselectin_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolSLC5A5NIS_RAIU_inhibition
5-Chloro-2-(2,4-dichlorophenoxy)phenolSLC6A2NVS_TR_hNET
5-Chloro-2-(2,4-dichlorophenoxy)phenolSLC6A3NVS_TR_hDAT
5-Chloro-2-(2,4-dichlorophenoxy)phenolSOX1ATG_Sox_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolSP1ATG_Sp1_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolTACR2NVS_GPCR_hNK2
5-Chloro-2-(2,4-dichlorophenoxy)phenolTCF7ATG_TCF_b_cat_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolTCF7L2ATG_TCF_b_cat_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolTGFB1BSK_BE3C_TGFb1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolTGFB1BSK_KF3CT_TGFb1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolTIMP1BSK_hDFCGF_TIMP1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolTIMP2BSK_KF3CT_TIMP2_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolTNFBSK_LPS_TNFa_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53TOX21_p53_BLA_p3_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53TOX21_p53_BLA_p4_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53APR_HepG2_p53Act_72h_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53APR_HepG2_p53Act_24h_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53TOX21_p53_BLA_p5_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53TOX21_p53_BLA_p1_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolTP53TOX21_p53_BLA_p2_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H2ATG_DR4_LXR_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolVCAM1BSK_LPS_VCAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolVCAM1BSK_3C_VCAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolVCAM1BSK_4H_VCAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolVCAM1BSK_hDFCGF_VCAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolVCAM1BSK_CASM3C_VCAM1_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolVDRATG_VDRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolVDRTOX21_VDR_BLA_antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolXBP1ATG_Xbp1_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolTCF7L1ATG_TCF_b_cat_CIS_dn
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1I2ATG_PXR_TRANS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1I2NVS_NR_hPXR
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1I2ATG_PXRE_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolCD38BSK_SAg_CD38_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCD40BSK_SAg_CD40_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCD40BSK_LPS_CD40_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolCD69BSK_SAg_CD69_down
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1I3ATG_PBREM_CIS_up
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1I3TOX21_CAR_Antagonist
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H4TOX21_FXR_BLA_antagonist_ratio
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H4NVS_NR_hFXR_Agonist
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H4OT_FXR_FXRSRC1_1440
5-Chloro-2-(2,4-dichlorophenoxy)phenolNR1H4OT_FXR_FXRSRC1_0480
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.