Reserpine

Target genes for Reserpine is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ReserpineNR1H3ATG_DR4_LXR_CIS_dn
ReserpineESR1ATG_ERE_CIS_dn
ReserpineESR1ATG_ERa_TRANS_dn
ReserpineCCL26BSK_4H_Eotaxin3_down
ReserpineCREB3ATG_CRE_CIS_up
ReserpineCEBPBATG_C_EBP_CIS_dn
ReserpineCHRM1NVS_GPCR_hM1
ReserpineCSF1BSK_LPS_MCSF_down
ReserpineADRB2NVS_GPCR_hAdrb2
ReserpineCYP2C19NVS_ADME_hCYP2C19
ReserpineCYP19A1TOX21_Aromatase_Inhibition
ReserpineDUSP3NVS_ENZ_hDUSP3
ReserpineEGR1ATG_EGR_CIS_up
ReserpineAHRATG_Ahr_CIS_up
ReserpineAHRTOX21_AhR_LUC_Agonist
ReserpineSLC29A1NVS_TR_hAdoT
ReserpineESR1OT_ER_ERaERb_1440
ReserpineESR1TOX21_ERa_BLA_Antagonist_ratio
ReserpineESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ReserpineESR1OT_ER_ERaERa_0480
ReserpineESR1OT_ER_ERaERa_1440
ReserpineESR1OT_ER_ERaERb_0480
ReserpineESR1ATG_ERa_TRANS_dn
ReserpineESR1OT_ERa_EREGFP_0480
ReserpineESR1ATG_ERE_CIS_dn
ReserpineESR1OT_ERa_EREGFP_0120
ReserpineESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ReserpineESR2OT_ER_ERbERb_0480
ReserpineESR2OT_ER_ERbERb_1440
ReserpineESR2TOX21_ERb_BLA_Antagonist_ratio
ReserpineESR2OT_ER_ERaERb_1440
ReserpineESR2OT_ER_ERaERb_0480
ReserpineESRRATOX21_ERR_Antagonist
ReserpineESRRATOX21_PGC_ERR_Antagonist
ReserpineF3BSK_LPS_TissueFactor_up
ReserpineF3BSK_3C_TissueFactor_up
ReserpineFOSATG_AP_1_CIS_up
ReserpineHIF1AATG_HIF1a_CIS_up
ReserpineHLA-DRABSK_3C_HLADR_down
ReserpineIL1ABSK_LPS_IL1a_down
ReserpineCXCL8BSK_3C_IL8_down
ReserpineCXCL8BSK_SAg_IL8_down
ReserpineIRF1ATG_ISRE_CIS_dn
ReserpineAROT_AR_ARSRC1_0960
ReserpineARTOX21_AR_BLA_Antagonist_ratio
ReserpineARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ReserpineARACEA_AR_antagonist_80hr
ReserpineAROT_AR_ARSRC1_0480
ReserpineARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ReserpineJUNATG_AP_1_CIS_up
ReserpineLDLRBSK_CASM3C_LDLR_up
ReserpineESR1ATG_ERa_TRANS_dn
ReserpineESR1ATG_ERE_CIS_dn
ReserpineNAATG_ERa_TRANS_dn
ReserpineNAATG_ERE_CIS_dn
ReserpineCXCL9BSK_SAg_MIG_down
ReserpineMTF1ATG_MRE_CIS_up
ReserpineNFIAATG_NFI_CIS_dn
ReserpineNFE2L2ATG_NRF2_ARE_CIS_up
ReserpineOPRM1NVS_GPCR_hOpiate_mu
ReserpinePAX6ATG_Pax6_CIS_up
ReserpineLEF1ATG_TCF_b_cat_CIS_dn
ReserpinePLAURBSK_4H_uPAR_down
ReserpinePLAURBSK_3C_uPAR_down
ReserpinePPARAATG_PPARa_TRANS_up
ReserpinePPARDATG_PPARd_TRANS_up
ReserpinePPARGOT_PPARg_PPARgSRC1_0480
ReserpinePPARGOT_PPARg_PPARgSRC1_1440
ReserpinePPARGTOX21_PPARg_BLA_antagonist_ratio
ReserpinePTPRCNVS_ENZ_hPTPRC
ReserpineRORAATG_RORE_CIS_up
ReserpineRORBATG_RORE_CIS_up
ReserpineRORCATG_RORE_CIS_up
ReserpineRXRAOT_NURR1_NURR1RXRa_1440
ReserpineRXRAOT_NURR1_NURR1RXRa_0480
ReserpineCCL2BSK_SAg_MCP1_down
ReserpineCCL2BSK_4H_MCP1_down
ReserpineCCL2BSK_LPS_MCP1_down
ReserpineCCL2BSK_3C_MCP1_down
ReserpineSELEBSK_3C_Eselectin_down
ReserpineSELPBSK_4H_Pselectin_down
ReserpineSLC6A2NVS_TR_hNET
ReserpineSP1ATG_Sp1_CIS_up
ReserpineSREBF1ATG_SREBP_CIS_up
ReserpineTCF7ATG_TCF_b_cat_CIS_dn
ReserpineTCF7L2ATG_TCF_b_cat_CIS_dn
ReserpineTHBDBSK_CASM3C_Thrombomodulin_up
ReserpineTNFBSK_LPS_TNFa_down
ReserpineTP53ATG_p53_CIS_dn
ReserpineTP53APR_HepG2_p53Act_24h_up
ReserpineTP53APR_HepG2_p53Act_72h_up
ReserpineTSHRTOX21_TSHR_Agonist_ratio
ReserpineNR1H2ATG_DR4_LXR_CIS_dn
ReserpineUSF1ATG_E_Box_CIS_dn
ReserpineVCAM1BSK_4H_VCAM1_down
ReserpineVCAM1BSK_3C_VCAM1_down
ReserpineVCAM1BSK_LPS_VCAM1_down
ReserpineVCAM1BSK_hDFCGF_VCAM1_down
ReserpineVDRATG_VDR_TRANS_up
ReserpineVDRATG_VDRE_CIS_up
ReserpineTCF7L1ATG_TCF_b_cat_CIS_dn
ReserpineNR1I2ATG_PXR_TRANS_up
ReserpineNR1I2ATG_PXRE_CIS_up
ReserpineCD38BSK_SAg_CD38_down
ReserpineCD40BSK_SAg_CD40_down
ReserpineCD40BSK_LPS_CD40_down
ReserpineCD69BSK_SAg_CD69_down
ReserpineNR1I3TOX21_CAR_Agonist
ReserpineNR1H4TOX21_FXR_BLA_antagonist_ratio
ReserpineNR1H4OT_FXR_FXRSRC1_1440
ReserpineNR1H4ATG_IR1_CIS_dn
ReserpineNR1H4OT_FXR_FXRSRC1_0480

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