Spironolactone

Target genes for Spironolactone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
SpironolactoneNR1H3ATG_DR4_LXR_CIS_dn
SpironolactoneESR1CEETOX_H295R_TESTO_dn
SpironolactoneNACEETOX_H295R_ANDR_dn
SpironolactoneNACEETOX_H295R_TESTO_dn
SpironolactoneCCL26BSK_4H_Eotaxin3_down
SpironolactoneCREB3ATG_CRE_CIS_up
SpironolactonePDE10ANVS_ENZ_hPDE10
SpironolactoneCSF1BSK_hDFCGF_MCSF_down
SpironolactoneCSF1BSK_LPS_MCSF_down
SpironolactoneCYP2C19NVS_ADME_hCYP2C19
SpironolactoneCYP19A1TOX21_Aromatase_Inhibition
SpironolactoneCYP24A1TOX21_VDR_BLA_antagonist_ratio
SpironolactoneESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
SpironolactoneESR1ACEA_ER_80hr
SpironolactoneESR1TOX21_ERa_BLA_Antagonist_ratio
SpironolactoneESR2TOX21_ERb_BLA_Antagonist_ratio
SpironolactoneESRRATOX21_PGC_ERR_Antagonist
SpironolactoneESRRATOX21_ERR_Antagonist
SpironolactoneF3BSK_LPS_TissueFactor_down
SpironolactoneF3BSK_3C_TissueFactor_down
SpironolactoneNR3C1CEETOX_H295R_11DCORT_dn
SpironolactoneNR3C1TOX21_GR_BLA_Antagonist_ratio
SpironolactoneNR3C1NVS_NR_hGR
SpironolactoneNR3C1CEETOX_H295R_CORTIC_dn
SpironolactoneNR3C1CEETOX_H295R_CORTISOL_dn
SpironolactoneHIF1AATG_HIF1a_CIS_up
SpironolactoneHLA-DRABSK_CASM3C_HLADR_down
SpironolactoneHLA-DRABSK_3C_HLADR_down
SpironolactoneIL1ABSK_LPS_IL1a_down
SpironolactoneIL1ABSK_KF3CT_IL1a_down
SpironolactoneIL6BSK_CASM3C_IL6_down
SpironolactoneCXCL8BSK_LPS_IL8_down
SpironolactoneCXCL8BSK_hDFCGF_IL8_down
SpironolactoneCXCL8BSK_CASM3C_IL8_down
SpironolactoneCXCL8BSK_SAg_IL8_down
SpironolactoneCXCL8BSK_3C_IL8_down
SpironolactoneCXCL10BSK_hDFCGF_IP10_down
SpironolactoneCXCL10BSK_KF3CT_IP10_down
SpironolactoneCXCL10BSK_BE3C_IP10_down
SpironolactoneIRF1ATG_ISRE_CIS_dn
SpironolactoneARACEA_AR_agonist_80hr
SpironolactoneARTOX21_AR_BLA_Agonist_ratio
SpironolactoneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
SpironolactoneAROT_AR_ARSRC1_0960
SpironolactoneARCEETOX_H295R_ANDR_dn
SpironolactoneAROT_AR_ARSRC1_0480
SpironolactoneARNVS_NR_hAR
SpironolactoneARCEETOX_H295R_TESTO_dn
SpironolactoneARACEA_AR_antagonist_80hr
SpironolactoneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
SpironolactoneARTOX21_AR_LUC_MDAKB2_Agonist
SpironolactoneARTOX21_AR_LUC_MDAKB2_Agonist_3uM_Nilutamide
SpironolactoneARTOX21_AR_BLA_Antagonist_ratio
SpironolactoneESR1CEETOX_H295R_TESTO_dn
SpironolactoneNACEETOX_H295R_TESTO_dn
SpironolactoneSMAD1ATG_BRE_CIS_up
SpironolactoneARCEETOX_H295R_ANDR_dn
SpironolactoneARCEETOX_H295R_TESTO_dn
SpironolactoneCXCL9BSK_SAg_MIG_down
SpironolactoneCXCL9BSK_hDFCGF_MIG_down
SpironolactoneNR3C2CEETOX_H295R_11DCORT_dn
SpironolactoneNR3C2CEETOX_H295R_CORTIC_dn
SpironolactoneNR3C2CEETOX_H295R_CORTISOL_dn
SpironolactoneMMP1BSK_hDFCGF_MMP1_down
SpironolactoneMMP9BSK_KF3CT_MMP9_down
SpironolactoneMTF1ATG_MRE_CIS_up
SpironolactoneOPRD1NVS_GPCR_hOpiate_D1
SpironolactoneSERPINE1BSK_hDFCGF_PAI1_down
SpironolactoneSERPINE1BSK_BE3C_PAI1_down
SpironolactonePAX6ATG_Pax6_CIS_up
SpironolactonePGRCEETOX_H295R_OHPREG_up
SpironolactonePGRTOX21_PR_BLA_Agonist_ratio
SpironolactonePGRNVS_NR_hPR
SpironolactonePGRTOX21_PR_BLA_Antagonist_ratio
SpironolactonePLAURBSK_3C_uPAR_down
SpironolactonePLAURBSK_4H_uPAR_down
SpironolactonePOU2F1ATG_Oct_MLP_CIS_up
SpironolactonePPARDTOX21_PPARd_BLA_antagonist_ratio
SpironolactonePPARGTOX21_PPARg_BLA_Agonist_ratio
SpironolactonePPARGTOX21_PPARg_BLA_antagonist_ratio
SpironolactonePTGER2BSK_LPS_PGE2_down
SpironolactoneCCL2BSK_3C_MCP1_down
SpironolactoneCCL2BSK_CASM3C_MCP1_down
SpironolactoneCCL2BSK_SAg_MCP1_down
SpironolactoneCCL2BSK_LPS_MCP1_down
SpironolactoneCCL2BSK_4H_MCP1_down
SpironolactoneSELEBSK_LPS_Eselectin_down
SpironolactoneSELEBSK_SAg_Eselectin_down
SpironolactoneSELEBSK_3C_Eselectin_down
SpironolactoneSELPBSK_4H_Pselectin_down
SpironolactoneSP1ATG_Sp1_CIS_up
SpironolactoneSREBF1ATG_SREBP_CIS_up
SpironolactoneTIMP1BSK_hDFCGF_TIMP1_down
SpironolactoneTNFBSK_LPS_TNFa_down
SpironolactoneTP53ATG_p53_CIS_dn
SpironolactoneTP53TOX21_p53_BLA_p1_ratio
SpironolactoneTP53APR_HepG2_p53Act_72h_up
SpironolactoneTP53TOX21_p53_BLA_p2_ratio
SpironolactoneTP53APR_HepG2_p53Act_24h_up
SpironolactoneNR1H2ATG_DR4_LXR_CIS_dn
SpironolactoneUSF1ATG_E_Box_CIS_dn
SpironolactoneVCAM1BSK_3C_VCAM1_down
SpironolactoneVCAM1BSK_4H_VCAM1_down
SpironolactoneVCAM1BSK_CASM3C_VCAM1_up
SpironolactoneVCAM1BSK_LPS_VCAM1_down
SpironolactoneVCAM1BSK_hDFCGF_VCAM1_down
SpironolactoneVDRTOX21_VDR_BLA_antagonist_ratio
SpironolactoneVDRATG_VDRE_CIS_up
SpironolactoneNACEETOX_H295R_ANDR_dn
SpironolactoneNACEETOX_H295R_TESTO_dn
SpironolactoneXBP1ATG_Xbp1_CIS_up
SpironolactoneNR1I2ATG_PXRE_CIS_up
SpironolactoneNR1I2NVS_NR_hPXR
SpironolactoneCD38BSK_SAg_CD38_down
SpironolactoneCD40BSK_SAg_CD40_down
SpironolactoneCD40BSK_LPS_CD40_down
SpironolactoneCD69BSK_SAg_CD69_down
SpironolactoneNR1I3TOX21_CAR_Antagonist
SpironolactoneNR1H4ATG_IR1_CIS_dn
SpironolactoneNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.