Benz(a)anthracene

Target genes for Benz(a)anthracene is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Benz(a)anthraceneNR1H3ATG_DR4_LXR_CIS_dn
Benz(a)anthraceneESR1CEETOX_H295R_TESTO_dn
Benz(a)anthraceneESR1CEETOX_H295R_ESTRONE_up
Benz(a)anthraceneESR1CEETOX_H295R_ESTRADIOL_up
Benz(a)anthraceneNACEETOX_H295R_ANDR_dn
Benz(a)anthraceneNACEETOX_H295R_TESTO_dn
Benz(a)anthraceneCCL26BSK_4H_Eotaxin3_down
Benz(a)anthraceneCYP1A2NVS_ADME_hCYP1A2
Benz(a)anthraceneDRD4NVS_GPCR_hDRD4.4
Benz(a)anthraceneAHRATG_Ahr_CIS_up
Benz(a)anthraceneAHRTOX21_AhR_LUC_Agonist
Benz(a)anthraceneELANENVS_ENZ_hElastase
Benz(a)anthraceneESR1CEETOX_H295R_ESTRADIOL_up
Benz(a)anthraceneESR1ATG_ERE_CIS_up
Benz(a)anthraceneESR1TOX21_ERa_BLA_Agonist_ratio
Benz(a)anthraceneESR1TOX21_ERa_LUC_VM7_Agonist
Benz(a)anthraceneESR1CEETOX_H295R_ESTRONE_up
Benz(a)anthraceneESR1ATG_ERa_TRANS_up
Benz(a)anthraceneESR1ACEA_ER_80hr
Benz(a)anthraceneESR1OT_ER_ERaERb_0480
Benz(a)anthraceneESR2OT_ER_ERbERb_1440
Benz(a)anthraceneESR2OT_ER_ERbERb_0480
Benz(a)anthraceneESR2OT_ER_ERaERb_0480
Benz(a)anthraceneESR2CEETOX_H295R_ESTRONE_up
Benz(a)anthraceneESR2CEETOX_H295R_ESTRADIOL_up
Benz(a)anthraceneESRRATOX21_PGC_ERR_Agonist
Benz(a)anthraceneESRRATOX21_ERR_Agonist
Benz(a)anthraceneF3BSK_LPS_TissueFactor_up
Benz(a)anthraceneNR3C1CEETOX_H295R_DOC_up
Benz(a)anthraceneNR3C1CEETOX_H295R_CORTIC_up
Benz(a)anthraceneHDAC1TOX21_HDAC_Inhibition
Benz(a)anthraceneHIF1AATG_HIF1a_CIS_up
Benz(a)anthraceneARNVS_NR_hAR
Benz(a)anthraceneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Benz(a)anthraceneARACEA_AR_antagonist_80hr
Benz(a)anthraceneARACEA_AR_agonist_80hr
Benz(a)anthraceneARCEETOX_H295R_TESTO_dn
Benz(a)anthraceneARCEETOX_H295R_ANDR_dn
Benz(a)anthraceneARTOX21_AR_LUC_MDAKB2_Agonist
Benz(a)anthraceneESR1CEETOX_H295R_TESTO_dn
Benz(a)anthraceneESR1CEETOX_H295R_ESTRONE_up
Benz(a)anthraceneESR1CEETOX_H295R_ESTRADIOL_up
Benz(a)anthraceneNACEETOX_H295R_TESTO_dn
Benz(a)anthraceneNACEETOX_H295R_ESTRONE_up
Benz(a)anthraceneNACEETOX_H295R_ESTRADIOL_up
Benz(a)anthraceneARCEETOX_H295R_TESTO_dn
Benz(a)anthraceneARCEETOX_H295R_ANDR_dn
Benz(a)anthraceneNR3C2CEETOX_H295R_CORTIC_up
Benz(a)anthraceneNR3C2CEETOX_H295R_DOC_up
Benz(a)anthraceneMMP1BSK_BE3C_MMP1_up
Benz(a)anthraceneNFE2L2ATG_NRF2_ARE_CIS_up
Benz(a)anthraceneNFE2L2TOX21_ARE_BLA_agonist_ratio
Benz(a)anthraceneSERPINE1BSK_BE3C_PAI1_down
Benz(a)anthracenePGRCEETOX_H295R_OHPROG_dn
Benz(a)anthracenePGRTOX21_PR_BLA_Antagonist_ratio
Benz(a)anthracenePOU2F1ATG_Oct_MLP_CIS_up
Benz(a)anthracenePPARGATG_PPARg_TRANS_up
Benz(a)anthraceneRXRATOX21_RXR_BLA_Agonist_ratio
Benz(a)anthraceneSLC5A5NIS_RAIU_inhibition
Benz(a)anthraceneSLC6A2NVS_TR_hNET
Benz(a)anthraceneTHBDBSK_CASM3C_Thrombomodulin_up
Benz(a)anthraceneTSPONVS_MP_hPBR
Benz(a)anthraceneTP53APR_HepG2_p53Act_24h_dn
Benz(a)anthraceneNR1H2ATG_DR4_LXR_CIS_dn
Benz(a)anthraceneUSF1ATG_E_Box_CIS_dn
Benz(a)anthraceneVDRATG_VDRE_CIS_up
Benz(a)anthraceneNACEETOX_H295R_ANDR_dn
Benz(a)anthraceneNACEETOX_H295R_TESTO_dn
Benz(a)anthraceneATAD5TOX21_ELG1_LUC_Agonist
Benz(a)anthraceneNR1I2ATG_PXRE_CIS_up
Benz(a)anthraceneNR1I3TOX21_CAR_Agonist
Benz(a)anthraceneNR1H4ATG_IR1_CIS_dn

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.