Clomiphene citrate

Target genes for Clomiphene citrate is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Clomiphene citrateNR1H3ATG_DR4_LXR_CIS_dn
Clomiphene citrateNACEETOX_H295R_PROG_dn
Clomiphene citrateESR1CEETOX_H295R_TESTO_dn
Clomiphene citrateESR1ATG_ERE_CIS_dn
Clomiphene citrateNACEETOX_H295R_TESTO_dn
Clomiphene citrateNACEETOX_H295R_ANDR_dn
Clomiphene citrateCCL26BSK_4H_Eotaxin3_down
Clomiphene citrateCHRM1NVS_GPCR_hM1
Clomiphene citrateCHRM2NVS_GPCR_hM2
Clomiphene citrateCHRM3NVS_GPCR_hM3
Clomiphene citrateCHRM4NVS_GPCR_hM4
Clomiphene citrateCHRM5NVS_GPCR_hM5
Clomiphene citrateCOL3A1BSK_hDFCGF_CollagenIII_down
Clomiphene citrateADORA1NVS_GPCR_hAdoRA1
Clomiphene citrateADORA2ANVS_GPCR_hAdoRA2a
Clomiphene citrateCSF1BSK_CASM3C_MCSF_down
Clomiphene citrateCSF1BSK_LPS_MCSF_down
Clomiphene citrateCSF1BSK_hDFCGF_MCSF_down
Clomiphene citrateADRA2ANVS_GPCR_hAdra2A
Clomiphene citrateADRA2CNVS_GPCR_hAdra2C
Clomiphene citrateADRB1NVS_GPCR_hAdrb1
Clomiphene citrateADRB2NVS_GPCR_hAdrb2
Clomiphene citrateADRB3NVS_GPCR_hAdrb3
Clomiphene citrateCYP2B6NVS_ADME_hCYP2B6
Clomiphene citrateCYP2C19NVS_ADME_hCYP2C19
Clomiphene citrateCYP2C9NVS_ADME_hCYP2C9
Clomiphene citrateCYP2C18NVS_ADME_hCYP2C18
Clomiphene citrateCYP2D6NVS_ADME_hCYP2D6
Clomiphene citrateCYP2J2NVS_ADME_hCYP2J2
Clomiphene citrateCYP3A4NVS_ADME_hCYP3A4
Clomiphene citrateCYP19A1TOX21_Aromatase_Inhibition
Clomiphene citrateCYP24A1TOX21_VDR_BLA_antagonist_ratio
Clomiphene citrateDIO1NHEERL_MED_hDIO1_dn
Clomiphene citrateDRD1NVS_GPCR_hDRD1
Clomiphene citrateDRD2NVS_GPCR_hDRD2s
Clomiphene citrateDRD4NVS_GPCR_hDRD4.4
Clomiphene citrateEDNRANVS_GPCR_hETA
Clomiphene citrateEDNRBNVS_GPCR_hETB
Clomiphene citrateESR1NVS_NR_hER
Clomiphene citrateESR1OT_ERa_EREGFP_0480
Clomiphene citrateESR1OT_ER_ERaERa_0480
Clomiphene citrateESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
Clomiphene citrateESR1OT_ERa_EREGFP_0120
Clomiphene citrateESR1ACEA_ER_80hr
Clomiphene citrateESR1OT_ER_ERaERa_1440
Clomiphene citrateESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
Clomiphene citrateESR1ATG_ERE_CIS_dn
Clomiphene citrateESR1OT_ER_ERaERb_1440
Clomiphene citrateESR1TOX21_ERa_BLA_Antagonist_ratio
Clomiphene citrateESR1OT_ER_ERaERb_0480
Clomiphene citrateESR2OT_ER_ERbERb_0480
Clomiphene citrateESR2OT_ER_ERaERb_1440
Clomiphene citrateESR2OT_ER_ERbERb_1440
Clomiphene citrateESR2TOX21_ERb_BLA_Antagonist_ratio
Clomiphene citrateESR2OT_ER_ERaERb_0480
Clomiphene citrateESRRATOX21_PGC_ERR_Antagonist
Clomiphene citrateESRRATOX21_ERR_Antagonist
Clomiphene citrateF3BSK_LPS_TissueFactor_down
Clomiphene citrateF3BSK_3C_TissueFactor_down
Clomiphene citrateF3BSK_CASM3C_TissueFactor_down
Clomiphene citrateFGFR1NVS_ENZ_hFGFR1
Clomiphene citrateATF6TOX21_ESRE_BLA_ratio
Clomiphene citrateSIRT2NVS_ENZ_hSIRT2
Clomiphene citrateBACE1NVS_ENZ_hBACE
Clomiphene citrateFYNNVS_ENZ_hFyn
Clomiphene citrateGLI1ATG_GLI_CIS_up
Clomiphene citrateNR3C1CEETOX_H295R_CORTIC_dn
Clomiphene citrateNR3C1TOX21_GR_BLA_Agonist_ratio
Clomiphene citrateNR3C1NVS_NR_hGR
Clomiphene citrateNR3C1CEETOX_H295R_DOC_dn
Clomiphene citrateNR3C1CEETOX_H295R_11DCORT_dn
Clomiphene citrateHIF1ATOX21_HRE_BLA_Agonist_ratio
Clomiphene citrateHLA-DRABSK_BE3C_HLADR_down
Clomiphene citrateHLA-DRABSK_CASM3C_HLADR_down
Clomiphene citrateHLA-DRABSK_3C_HLADR_down
Clomiphene citrateHRH1NVS_GPCR_hH1
Clomiphene citrateHSF1TOX21_HSE_BLA_agonist_ratio
Clomiphene citrateHTR5ANVS_GPCR_h5HT5A
Clomiphene citrateHTR6NVS_GPCR_h5HT6
Clomiphene citrateHTR7NVS_GPCR_h5HT7
Clomiphene citrateICAM1BSK_KF3CT_ICAM1_down
Clomiphene citrateICAM1BSK_3C_ICAM1_down
Clomiphene citrateIL1ABSK_BE3C_IL1a_down
Clomiphene citrateIL1ABSK_LPS_IL1a_down
Clomiphene citrateIL1ABSK_KF3CT_IL1a_down
Clomiphene citrateCXCL8BSK_3C_IL8_down
Clomiphene citrateCXCL8BSK_hDFCGF_IL8_down
Clomiphene citrateCXCL8BSK_SAg_IL8_down
Clomiphene citrateCXCL8BSK_LPS_IL8_down
Clomiphene citrateCXCL10BSK_hDFCGF_IP10_down
Clomiphene citrateCXCL10BSK_BE3C_IP10_down
Clomiphene citrateCXCL10BSK_KF3CT_IP10_down
Clomiphene citrateARNVS_NR_hAR
Clomiphene citrateARTOX21_AR_BLA_Antagonist_ratio
Clomiphene citrateAROT_AR_ARSRC1_0960
Clomiphene citrateARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Clomiphene citrateARCEETOX_H295R_TESTO_dn
Clomiphene citrateARACEA_AR_antagonist_80hr
Clomiphene citrateAROT_AR_ARSRC1_0480
Clomiphene citrateARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
Clomiphene citrateARCEETOX_H295R_ANDR_dn
Clomiphene citrateJUNTOX21_AP1_BLA_Agonist_ratio
Clomiphene citrateKCNH2NVS_IC_hKhERGCh
Clomiphene citrateKDRBSK_4H_VEGFRII_down
Clomiphene citrateLDLRBSK_CASM3C_LDLR_up
Clomiphene citrateESR1CEETOX_H295R_TESTO_dn
Clomiphene citrateESR1ATG_ERE_CIS_dn
Clomiphene citrateFOSTOX21_AP1_BLA_Agonist_ratio
Clomiphene citrateLYNNVS_ENZ_hLynA
Clomiphene citrateNACEETOX_H295R_TESTO_dn
Clomiphene citrateNAATG_ERE_CIS_dn
Clomiphene citrateARCEETOX_H295R_TESTO_dn
Clomiphene citrateARCEETOX_H295R_ANDR_dn
Clomiphene citrateCXCL9BSK_SAg_MIG_down
Clomiphene citrateCXCL9BSK_hDFCGF_MIG_down
Clomiphene citrateCXCL9BSK_3C_MIG_down
Clomiphene citrateCXCL9BSK_BE3C_MIG_down
Clomiphene citrateNR3C2CEETOX_H295R_CORTIC_dn
Clomiphene citrateNR3C2CEETOX_H295R_DOC_dn
Clomiphene citrateNR3C2CEETOX_H295R_11DCORT_dn
Clomiphene citrateMMP1BSK_BE3C_MMP1_up
Clomiphene citrateMMP1BSK_hDFCGF_MMP1_down
Clomiphene citrateMMP9BSK_KF3CT_MMP9_down
Clomiphene citrateMTF1ATG_MRE_CIS_up
Clomiphene citrateNFE2L2TOX21_ARE_BLA_agonist_ratio
Clomiphene citrateNFE2L2ATG_NRF2_ARE_CIS_up
Clomiphene citrateNFKB1TOX21_NFkB_BLA_agonist_ratio
Clomiphene citrateNPY1RNVS_GPCR_hNPY1
Clomiphene citrateOPRD1NVS_GPCR_hOpiate_D1
Clomiphene citrateOPRL1NVS_GPCR_hORL1
Clomiphene citrateOPRM1NVS_GPCR_hOpiate_mu
Clomiphene citrateSERPINE1BSK_hDFCGF_PAI1_down
Clomiphene citrateSERPINE1BSK_BE3C_PAI1_down
Clomiphene citratePGRNVS_NR_hPR
Clomiphene citratePGRCEETOX_H295R_OHPREG_dn
Clomiphene citratePGRCEETOX_H295R_PROG_dn
Clomiphene citratePGRCEETOX_H295R_OHPROG_dn
Clomiphene citratePGRTOX21_PR_BLA_Antagonist_ratio
Clomiphene citratePLATBSK_BE3C_tPA_down
Clomiphene citratePLAUBSK_BE3C_uPA_down
Clomiphene citratePLAUBSK_KF3CT_uPA_down
Clomiphene citratePLAURBSK_BE3C_uPAR_down
Clomiphene citratePLAURBSK_CASM3C_uPAR_down
Clomiphene citratePLAURBSK_4H_uPAR_down
Clomiphene citratePLAURBSK_3C_uPAR_down
Clomiphene citratePPARDTOX21_PPARd_BLA_antagonist_ratio
Clomiphene citratePPARDTOX21_PPARd_BLA_agonist_ratio
Clomiphene citratePPARGTOX21_PPARg_BLA_antagonist_ratio
Clomiphene citratePRKAA1NVS_ENZ_hAMPKa1
Clomiphene citratePTGER2BSK_LPS_PGE2_down
Clomiphene citratePTPN1NVS_ENZ_hPTPN1_Activator
Clomiphene citrateRARANVS_NR_hRAR_Antagonist
Clomiphene citrateRARANVS_NR_hRARa_Agonist
Clomiphene citrateSAA1BSK_CASM3C_SAA_down
Clomiphene citrateCCL2BSK_SAg_MCP1_down
Clomiphene citrateCCL2BSK_LPS_MCP1_down
Clomiphene citrateCCL2BSK_KF3CT_MCP1_down
Clomiphene citrateCCL2BSK_4H_MCP1_down
Clomiphene citrateCCL2BSK_3C_MCP1_down
Clomiphene citrateSELEBSK_3C_Eselectin_down
Clomiphene citrateSELEBSK_SAg_Eselectin_down
Clomiphene citrateSELEBSK_LPS_Eselectin_down
Clomiphene citrateSELPBSK_4H_Pselectin_down
Clomiphene citrateSLC5A5NIS_RAIU_inhibition
Clomiphene citrateSLC6A2NVS_TR_hNET
Clomiphene citrateSLC6A3NVS_TR_hDAT
Clomiphene citrateSLC6A4NVS_TR_hSERT
Clomiphene citrateSP1ATG_Sp1_CIS_up
Clomiphene citrateSREBF1ATG_SREBP_CIS_up
Clomiphene citrateTACR2NVS_GPCR_hNK2
Clomiphene citrateTGFB1BSK_BE3C_TGFb1_down
Clomiphene citrateTGFB1BSK_KF3CT_TGFb1_down
Clomiphene citrateTHBDBSK_3C_Thrombomodulin_up
Clomiphene citrateTHBDBSK_CASM3C_Thrombomodulin_up
Clomiphene citrateTHRANVS_NR_hTRa_Antagonist
Clomiphene citrateTIMP1BSK_hDFCGF_TIMP1_down
Clomiphene citrateTIMP2BSK_KF3CT_TIMP2_down
Clomiphene citrateTNFBSK_LPS_TNFa_down
Clomiphene citrateTP53TOX21_p53_BLA_p5_ratio
Clomiphene citrateTP53TOX21_p53_BLA_p2_ratio
Clomiphene citrateTP53TOX21_p53_BLA_p3_ratio
Clomiphene citrateTP53TOX21_p53_BLA_p4_ratio
Clomiphene citrateTP53APR_HepG2_p53Act_72h_up
Clomiphene citrateTP53APR_HepG2_p53Act_24h_up
Clomiphene citrateTP53TOX21_p53_BLA_p1_ratio
Clomiphene citrateTSHRTOX21_TSHR_Agonist_ratio
Clomiphene citrateNR1H2ATG_DR4_LXR_CIS_dn
Clomiphene citrateUSF1ATG_E_Box_CIS_dn
Clomiphene citrateVCAM1BSK_3C_VCAM1_down
Clomiphene citrateVCAM1BSK_LPS_VCAM1_down
Clomiphene citrateVCAM1BSK_hDFCGF_VCAM1_down
Clomiphene citrateVCAM1BSK_4H_VCAM1_down
Clomiphene citrateVDRTOX21_VDR_BLA_antagonist_ratio
Clomiphene citrateVDRATG_VDRE_CIS_up
Clomiphene citrateNACEETOX_H295R_TESTO_dn
Clomiphene citrateNACEETOX_H295R_ANDR_dn
Clomiphene citrateHDAC3NVS_ENZ_hHDAC3
Clomiphene citrateNR1I2ATG_PXRE_CIS_up
Clomiphene citrateNR1I2ATG_PXR_TRANS_up
Clomiphene citrateNR1I2NVS_NR_hPXR
Clomiphene citrateCD38BSK_SAg_CD38_down
Clomiphene citrateCD40BSK_LPS_CD40_down
Clomiphene citrateCD40BSK_SAg_CD40_down
Clomiphene citrateCD69BSK_SAg_CD69_down
Clomiphene citrateNR1I3TOX21_CAR_Antagonist
Clomiphene citrateNR1I3ATG_CAR_TRANS_dn
Clomiphene citrateNR1I3NVS_NR_hCAR_Antagonist
Clomiphene citrateNR1H4ATG_IR1_CIS_dn
Clomiphene citrateNR1H4OT_FXR_FXRSRC1_0480
Clomiphene citrateNR1H4TOX21_FXR_BLA_antagonist_ratio
Clomiphene citrateNR1H4NVS_NR_hFXR_Antagonist

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.