Colchicine

Target genes for Colchicine is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ColchicineESR1ATG_ERE_CIS_dn
ColchicineCCL26BSK_4H_Eotaxin3_down
ColchicineCSF1BSK_LPS_MCSF_down
ColchicineCYP19A1NVS_ADME_hCYP19A1_Activator
ColchicineESR1TOX21_ERa_BLA_Antagonist_ratio
ColchicineESR1ATG_ERE_CIS_dn
ColchicineESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ColchicineESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ColchicineESR1OT_ER_ERaERb_1440
ColchicineESR2OT_ER_ERaERb_1440
ColchicineFOSATG_AP_1_CIS_up
ColchicineHIF1AATG_HIF1a_CIS_dn
ColchicineHLA-DRABSK_3C_HLADR_down
ColchicineHLA-DRABSK_BE3C_HLADR_down
ColchicineHLA-DRABSK_CASM3C_HLADR_down
ColchicineIL1ABSK_LPS_IL1a_down
ColchicineIL6BSK_CASM3C_IL6_up
ColchicineCXCL10BSK_hDFCGF_IP10_down
ColchicineAROT_AR_ARSRC1_0480
ColchicineARTOX21_AR_BLA_Antagonist_ratio
ColchicineARTOX21_AR_BLA_Agonist_ratio
ColchicineARACEA_AR_antagonist_80hr
ColchicineAROT_AR_ARSRC1_0960
ColchicineJUNTOX21_AP1_BLA_Agonist_ratio
ColchicineJUNATG_AP_1_CIS_up
ColchicineESR1ATG_ERE_CIS_dn
ColchicineFOSTOX21_AP1_BLA_Agonist_ratio
ColchicineNAATG_ERE_CIS_dn
ColchicineSMAD1ATG_BRE_CIS_dn
ColchicineMMP1BSK_hDFCGF_MMP1_down
ColchicineMMP3NVS_ENZ_hMMP3
ColchicineMMP9BSK_KF3CT_MMP9_down
ColchicineMMP13NVS_ENZ_hMMP13
ColchicineNFIAATG_NFI_CIS_dn
ColchicineNFE2L2TOX21_ARE_BLA_agonist_ratio
ColchicineNRF1ATG_NRF1_CIS_dn
ColchicineSERPINE1BSK_BE3C_PAI1_down
ColchicineLEF1ATG_TCF_b_cat_CIS_dn
ColchicinePGRTOX21_PR_BLA_Antagonist_ratio
ColchicinePLAURBSK_4H_uPAR_down
ColchicinePLAURBSK_3C_uPAR_down
ColchicineRXRAOT_NURR1_NURR1RXRa_1440
ColchicineRXRAOT_NURR1_NURR1RXRa_0480
ColchicineSELPBSK_4H_Pselectin_down
ColchicineTCF7ATG_TCF_b_cat_CIS_dn
ColchicineTCF7L2ATG_TCF_b_cat_CIS_dn
ColchicineTFAP2AATG_AP_2_CIS_dn
ColchicineTFAP2BATG_AP_2_CIS_dn
ColchicineTNFBSK_LPS_TNFa_down
ColchicineTP53APR_HepG2_p53Act_72h_up
ColchicineTP53APR_HepG2_p53Act_24h_up
ColchicineTP53ATG_p53_CIS_dn
ColchicineUSF1ATG_E_Box_CIS_dn
ColchicineVCAM1BSK_3C_VCAM1_down
ColchicineVCAM1BSK_hDFCGF_VCAM1_down
ColchicineVCAM1BSK_CASM3C_VCAM1_down
ColchicineVCAM1BSK_LPS_VCAM1_down
ColchicineTCF7L1ATG_TCF_b_cat_CIS_dn
ColchicineCASP4NVS_ENZ_hCASP4
ColchicineTFAP2DATG_AP_2_CIS_dn
ColchicineNR1I2ATG_PXRE_CIS_dn
ColchicineCD38BSK_SAg_CD38_down
ColchicineCD40BSK_SAg_CD40_down
ColchicineCD40BSK_LPS_CD40_down
ColchicineCD69BSK_SAg_CD69_down
ColchicineNR1I3TOX21_CAR_Antagonist
ColchicineNR1H4OT_FXR_FXRSRC1_0480
ColchicineNR1H4TOX21_FXR_BLA_antagonist_ratio
ColchicineNR1H4ATG_IR1_CIS_dn
ColchicineNR1H4OT_FXR_FXRSRC1_1440

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.