Cycloheximide

Target genes for Cycloheximide is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
CycloheximideNR1H3ATG_DR4_LXR_CIS_dn
CycloheximideESR1ATG_ERE_CIS_dn
CycloheximideCCL26BSK_4H_Eotaxin3_down
CycloheximideCEBPBATG_C_EBP_CIS_up
CycloheximideCOL3A1BSK_hDFCGF_CollagenIII_down
CycloheximideCSF1BSK_LPS_MCSF_down
CycloheximideCSF1BSK_CASM3C_MCSF_down
CycloheximideCSF1BSK_hDFCGF_MCSF_down
CycloheximideCYP19A1TOX21_Aromatase_Inhibition
CycloheximideE2F1ATG_E2F_CIS_up
CycloheximideAHRATG_Ahr_CIS_up
CycloheximideESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
CycloheximideESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
CycloheximideESR1NVS_NR_hER
CycloheximideESR1ATG_ERE_CIS_dn
CycloheximideESRRATOX21_PGC_ERR_Antagonist
CycloheximideESRRATOX21_ERR_Antagonist
CycloheximideETS1ATG_Ets_CIS_dn
CycloheximideF3BSK_3C_TissueFactor_down
CycloheximideF3BSK_LPS_TissueFactor_down
CycloheximideFOXO1ATG_FoxO_CIS_dn
CycloheximideFOXO3ATG_FoxO_CIS_dn
CycloheximideFOSATG_AP_1_CIS_dn
CycloheximideNR3C1CEETOX_H295R_11DCORT_dn
CycloheximideNR3C1ATG_GR_TRANS_up
CycloheximideNR3C1TOX21_GR_BLA_Antagonist_ratio
CycloheximideNR3C1ATG_GRE_CIS_dn
CycloheximideNR3C1NVS_NR_hGR
CycloheximideHIF1AATG_HIF1a_CIS_dn
CycloheximideHLA-DRABSK_3C_HLADR_down
CycloheximideHLA-DRABSK_CASM3C_HLADR_down
CycloheximideHLA-DRABSK_BE3C_HLADR_down
CycloheximideHSF1ATG_HSE_CIS_dn
CycloheximideICAM1BSK_KF3CT_ICAM1_down
CycloheximideICAM1BSK_3C_ICAM1_down
CycloheximideIL1ABSK_KF3CT_IL1a_up
CycloheximideIL1ABSK_BE3C_IL1a_down
CycloheximideIL1ABSK_LPS_IL1a_down
CycloheximideIL6BSK_CASM3C_IL6_down
CycloheximideCXCL8BSK_LPS_IL8_down
CycloheximideCXCL8BSK_CASM3C_IL8_down
CycloheximideCXCL8BSK_3C_IL8_down
CycloheximideCXCL8BSK_hDFCGF_IL8_down
CycloheximideCXCL8BSK_SAg_IL8_down
CycloheximideCXCL10BSK_hDFCGF_IP10_down
CycloheximideCXCL10BSK_KF3CT_IP10_down
CycloheximideCXCL10BSK_BE3C_IP10_down
CycloheximideIRF1ATG_ISRE_CIS_dn
CycloheximideARTOX21_AR_BLA_Antagonist_ratio
CycloheximideARACEA_AR_agonist_80hr
CycloheximideARACEA_AR_antagonist_80hr
CycloheximideARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
CycloheximideARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
CycloheximideAROT_AR_ARSRC1_0960
CycloheximideAROT_AR_ARSRC1_0480
CycloheximideJUNATG_AP_1_CIS_dn
CycloheximideKDRBSK_4H_VEGFRII_down
CycloheximideLDLRBSK_CASM3C_LDLR_down
CycloheximideESR1ATG_ERE_CIS_dn
CycloheximideNAATG_ERE_CIS_dn
CycloheximideSMAD1ATG_BRE_CIS_up
CycloheximideCXCL9BSK_hDFCGF_MIG_down
CycloheximideCXCL9BSK_BE3C_MIG_down
CycloheximideCXCL9BSK_3C_MIG_down
CycloheximideCXCL9BSK_SAg_MIG_down
CycloheximideCXCL9BSK_CASM3C_MIG_down
CycloheximideNR3C2CEETOX_H295R_11DCORT_dn
CycloheximideMMP1BSK_BE3C_MMP1_down
CycloheximideMMP1BSK_hDFCGF_MMP1_down
CycloheximideMMP9BSK_KF3CT_MMP9_down
CycloheximideMTF1ATG_MRE_CIS_up
CycloheximideNFIAATG_NFI_CIS_up
CycloheximideNFE2L2ATG_NRF2_ARE_CIS_dn
CycloheximideNFKB1ATG_NF_kB_CIS_up
CycloheximideSERPINE1BSK_BE3C_PAI1_down
CycloheximideSERPINE1BSK_hDFCGF_PAI1_down
CycloheximideLEF1ATG_TCF_b_cat_CIS_dn
CycloheximidePGRTOX21_PR_BLA_Antagonist_ratio
CycloheximidePGRCEETOX_H295R_OHPROG_dn
CycloheximidePGRCEETOX_H295R_OHPREG_dn
CycloheximidePLATBSK_BE3C_tPA_down
CycloheximidePLAUBSK_BE3C_uPA_down
CycloheximidePLAUBSK_KF3CT_uPA_down
CycloheximidePLAURBSK_4H_uPAR_down
CycloheximidePLAURBSK_BE3C_uPAR_down
CycloheximidePLAURBSK_3C_uPAR_down
CycloheximidePLAURBSK_CASM3C_uPAR_down
CycloheximidePOU2F1ATG_Oct_MLP_CIS_up
CycloheximidePTGER2BSK_LPS_PGE2_down
CycloheximideRARAATG_RARa_TRANS_dn
CycloheximideRARAATG_DR5_CIS_up
CycloheximideRARBATG_DR5_CIS_up
CycloheximideRARGATG_DR5_CIS_up
CycloheximideRORBATG_RORb_TRANS_dn
CycloheximideSAA1BSK_CASM3C_SAA_down
CycloheximideCCL2BSK_LPS_MCP1_down
CycloheximideCCL2BSK_SAg_MCP1_down
CycloheximideCCL2BSK_CASM3C_MCP1_down
CycloheximideCCL2BSK_3C_MCP1_down
CycloheximideCCL2BSK_4H_MCP1_down
CycloheximideCCL2BSK_KF3CT_MCP1_down
CycloheximideSELEBSK_SAg_Eselectin_down
CycloheximideSELEBSK_3C_Eselectin_down
CycloheximideSELEBSK_LPS_Eselectin_down
CycloheximideSELPBSK_4H_Pselectin_down
CycloheximideTCF7ATG_TCF_b_cat_CIS_dn
CycloheximideTCF7L2ATG_TCF_b_cat_CIS_dn
CycloheximideTFAP2AATG_AP_2_CIS_dn
CycloheximideTFAP2BATG_AP_2_CIS_dn
CycloheximideTGFB1BSK_BE3C_TGFb1_down
CycloheximideTGFB1BSK_KF3CT_TGFb1_down
CycloheximideTGFB1ATG_TGFb_CIS_up
CycloheximideTHBDBSK_CASM3C_Thrombomodulin_up
CycloheximideTIMP1BSK_hDFCGF_TIMP1_down
CycloheximideTIMP2BSK_KF3CT_TIMP2_down
CycloheximideTNFBSK_LPS_TNFa_down
CycloheximideTP53APR_HepG2_p53Act_72h_up
CycloheximideTP53ATG_p53_CIS_dn
CycloheximideTP53APR_HepG2_p53Act_24h_up
CycloheximideNR1H2ATG_DR4_LXR_CIS_dn
CycloheximideUSF1ATG_E_Box_CIS_up
CycloheximideVCAM1BSK_LPS_VCAM1_down
CycloheximideVCAM1BSK_hDFCGF_VCAM1_down
CycloheximideVCAM1BSK_3C_VCAM1_down
CycloheximideVCAM1BSK_4H_VCAM1_down
CycloheximideVCAM1BSK_CASM3C_VCAM1_down
CycloheximideTCF7L1ATG_TCF_b_cat_CIS_dn
CycloheximideTFAP2DATG_AP_2_CIS_dn
CycloheximideNR1I2ATG_PXRE_CIS_dn
CycloheximideCD38BSK_SAg_CD38_down
CycloheximideCD40BSK_SAg_CD40_down
CycloheximideCD40BSK_LPS_CD40_down
CycloheximideCD69BSK_SAg_CD69_down
CycloheximideNR1I3TOX21_CAR_Antagonist
CycloheximideNR1I3ATG_PBREM_CIS_up
CycloheximideNR1I3ATG_CAR_TRANS_dn

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.