Myclobutanil

Target genes for Myclobutanil is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
MyclobutanilNR1H3ATG_DR4_LXR_CIS_dn
MyclobutanilESR1CEETOX_H295R_TESTO_dn
MyclobutanilESR1CEETOX_H295R_ESTRADIOL_dn
MyclobutanilESR1CEETOX_H295R_ESTRONE_dn
MyclobutanilNACEETOX_H295R_ANDR_dn
MyclobutanilNACEETOX_H295R_TESTO_dn
MyclobutanilCHRM1NVS_GPCR_hM1
MyclobutanilCHRM2NVS_GPCR_hM2
MyclobutanilCHRM3NVS_GPCR_hM3
MyclobutanilCHRM4NVS_GPCR_hM4
MyclobutanilCOL3A1BSK_hDFCGF_CollagenIII_down
MyclobutanilCYP1A1CLD_CYP1A1_48hr
MyclobutanilCYP1A1NVS_ADME_hCYP1A1
MyclobutanilCYP1A1CLD_CYP1A1_24hr
MyclobutanilCYP1A2CLD_CYP1A2_48hr
MyclobutanilCYP1A2CLD_CYP1A2_24hr
MyclobutanilCYP2B6CLD_CYP2B6_48hr
MyclobutanilCYP2B6CLD_CYP2B6_24hr
MyclobutanilCYP2B6NVS_ADME_hCYP2B6
MyclobutanilCYP2B6CLD_CYP2B6_6hr
MyclobutanilCYP2C19NVS_ADME_hCYP2C19
MyclobutanilCYP2C9NVS_ADME_hCYP2C9
MyclobutanilCYP2C18NVS_ADME_hCYP2C18
MyclobutanilCYP3A4CLD_CYP3A4_48hr
MyclobutanilCYP3A4CLD_CYP3A4_6hr
MyclobutanilCYP3A4CLD_CYP3A4_24hr
MyclobutanilCYP19A1TOX21_Aromatase_Inhibition
MyclobutanilCYP19A1NVS_ADME_hCYP19A1
MyclobutanilESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
MyclobutanilESR1ATG_ERa_TRANS_up
MyclobutanilESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
MyclobutanilESR1ATG_ERE_CIS_up
MyclobutanilESR1CEETOX_H295R_ESTRONE_dn
MyclobutanilESR1CEETOX_H295R_ESTRADIOL_dn
MyclobutanilESR2CEETOX_H295R_ESTRONE_dn
MyclobutanilESR2CEETOX_H295R_ESTRADIOL_dn
MyclobutanilESRRATOX21_PGC_ERR_Antagonist
MyclobutanilESRRATOX21_ERR_Antagonist
MyclobutanilSIRT3NVS_ENZ_hSIRT3
MyclobutanilNR3C1CEETOX_H295R_11DCORT_dn
MyclobutanilNR3C1CEETOX_H295R_CORTISOL_dn
MyclobutanilNR3C1CEETOX_H295R_DOC_dn
MyclobutanilCXCL10BSK_KF3CT_IP10_up
MyclobutanilARCEETOX_H295R_TESTO_dn
MyclobutanilARCEETOX_H295R_ANDR_dn
MyclobutanilARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
MyclobutanilARACEA_AR_antagonist_80hr
MyclobutanilARTOX21_AR_BLA_Antagonist_ratio
MyclobutanilESR1CEETOX_H295R_TESTO_dn
MyclobutanilESR1CEETOX_H295R_ESTRONE_dn
MyclobutanilESR1CEETOX_H295R_ESTRADIOL_dn
MyclobutanilNACEETOX_H295R_TESTO_dn
MyclobutanilNACEETOX_H295R_ESTRONE_dn
MyclobutanilNACEETOX_H295R_ESTRADIOL_dn
MyclobutanilARCEETOX_H295R_TESTO_dn
MyclobutanilARCEETOX_H295R_ANDR_dn
MyclobutanilNR3C2CEETOX_H295R_DOC_dn
MyclobutanilNR3C2CEETOX_H295R_11DCORT_dn
MyclobutanilNR3C2CEETOX_H295R_CORTISOL_dn
MyclobutanilNTRK1NVS_ENZ_hTrkA
MyclobutanilSERPINE1BSK_hDFCGF_PAI1_down
MyclobutanilPGRCEETOX_H295R_OHPROG_dn
MyclobutanilPGRTOX21_PR_BLA_Antagonist_ratio
MyclobutanilPGRCEETOX_H295R_OHPREG_dn
MyclobutanilPLAURBSK_CASM3C_uPAR_down
MyclobutanilUGT1A1CLD_UGT1A1_24hr
MyclobutanilPTGER2BSK_LPS_PGE2_up
MyclobutanilRARAATG_RARa_TRANS_up
MyclobutanilRARAATG_DR5_CIS_up
MyclobutanilRARBATG_DR5_CIS_up
MyclobutanilRARGATG_DR5_CIS_up
MyclobutanilSLC6A3NVS_TR_hDAT
MyclobutanilCYP4F12NVS_ADME_hCYP4F12_Activator
MyclobutanilSREBF1ATG_SREBP_CIS_up
MyclobutanilTSPONVS_MP_hPBR
MyclobutanilTSHRTOX21_TSHR_Antagonist_ratio
MyclobutanilNR1H2ATG_DR4_LXR_CIS_dn
MyclobutanilUSF1ATG_E_Box_CIS_dn
MyclobutanilVDRATG_VDRE_CIS_up
MyclobutanilNACEETOX_H295R_TESTO_dn
MyclobutanilNACEETOX_H295R_ANDR_dn
MyclobutanilNR1I2ATG_PXRE_CIS_up
MyclobutanilNR1I3TOX21_CAR_Agonist

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.