2,2',6,6'-Tetrachlorobisphenol A

Target genes for 2,2',6,6'-Tetrachlorobisphenol A is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
2,2',6,6'-Tetrachlorobisphenol ANR1H3ATG_DR4_LXR_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ACCL26BSK_4H_Eotaxin3_down
2,2',6,6'-Tetrachlorobisphenol ACOL3A1BSK_hDFCGF_CollagenIII_down
2,2',6,6'-Tetrachlorobisphenol ACSF1BSK_hDFCGF_MCSF_down
2,2',6,6'-Tetrachlorobisphenol ACSF1BSK_CASM3C_MCSF_down
2,2',6,6'-Tetrachlorobisphenol ACSF1BSK_LPS_MCSF_down
2,2',6,6'-Tetrachlorobisphenol ACYP2C19NVS_ADME_hCYP2C19
2,2',6,6'-Tetrachlorobisphenol ACYP2C9NVS_ADME_hCYP2C9
2,2',6,6'-Tetrachlorobisphenol ACYP19A1TOX21_Aromatase_Inhibition
2,2',6,6'-Tetrachlorobisphenol ADIO1NHEERL_MED_hDIO1_dn
2,2',6,6'-Tetrachlorobisphenol AEGFRBSK_hDFCGF_EGFR_up
2,2',6,6'-Tetrachlorobisphenol AEGR1ATG_EGR_CIS_up
2,2',6,6'-Tetrachlorobisphenol AESR1TOX21_ERa_BLA_Antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol AESR1TOX21_ERa_BLA_Agonist_ratio
2,2',6,6'-Tetrachlorobisphenol AESR1ATG_ERa_TRANS_up
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ERa_EREGFP_0480
2,2',6,6'-Tetrachlorobisphenol AESR1ATG_ERE_CIS_up
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ER_ERaERa_0480
2,2',6,6'-Tetrachlorobisphenol AESR1NVS_NR_hER
2,2',6,6'-Tetrachlorobisphenol AESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
2,2',6,6'-Tetrachlorobisphenol AESR1TOX21_ERa_LUC_VM7_Agonist
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ER_ERaERb_0480
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ER_ERaERa_1440
2,2',6,6'-Tetrachlorobisphenol AESR1ACEA_ER_80hr
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ERa_EREGFP_0120
2,2',6,6'-Tetrachlorobisphenol AESR1OT_ER_ERaERb_1440
2,2',6,6'-Tetrachlorobisphenol AESR2TOX21_ERb_BLA_Antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol AESR2OT_ER_ERaERb_0480
2,2',6,6'-Tetrachlorobisphenol AESR2OT_ER_ERaERb_1440
2,2',6,6'-Tetrachlorobisphenol AESRRAATG_ERRa_TRANS_dn
2,2',6,6'-Tetrachlorobisphenol AF3BSK_3C_TissueFactor_down
2,2',6,6'-Tetrachlorobisphenol AF3BSK_CASM3C_TissueFactor_down
2,2',6,6'-Tetrachlorobisphenol AF3BSK_LPS_TissueFactor_down
2,2',6,6'-Tetrachlorobisphenol AGATA1ATG_GATA_CIS_dn
2,2',6,6'-Tetrachlorobisphenol AGLI1ATG_GLI_CIS_up
2,2',6,6'-Tetrachlorobisphenol ANR3C1TOX21_GR_BLA_Antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol ANR3C1NVS_NR_hGR
2,2',6,6'-Tetrachlorobisphenol AHLA-DRABSK_3C_HLADR_down
2,2',6,6'-Tetrachlorobisphenol AHLA-DRABSK_BE3C_HLADR_down
2,2',6,6'-Tetrachlorobisphenol AHLA-DRABSK_CASM3C_HLADR_down
2,2',6,6'-Tetrachlorobisphenol AHSF1ATG_HSE_CIS_up
2,2',6,6'-Tetrachlorobisphenol AICAM1BSK_3C_ICAM1_down
2,2',6,6'-Tetrachlorobisphenol AICAM1BSK_KF3CT_ICAM1_down
2,2',6,6'-Tetrachlorobisphenol AIL1ABSK_BE3C_IL1a_down
2,2',6,6'-Tetrachlorobisphenol AIL1ABSK_LPS_IL1a_down
2,2',6,6'-Tetrachlorobisphenol AIL1ABSK_KF3CT_IL1a_down
2,2',6,6'-Tetrachlorobisphenol AIL6BSK_CASM3C_IL6_down
2,2',6,6'-Tetrachlorobisphenol ACXCL8BSK_LPS_IL8_down
2,2',6,6'-Tetrachlorobisphenol ACXCL8BSK_hDFCGF_IL8_down
2,2',6,6'-Tetrachlorobisphenol ACXCL8BSK_SAg_IL8_down
2,2',6,6'-Tetrachlorobisphenol ACXCL8BSK_3C_IL8_down
2,2',6,6'-Tetrachlorobisphenol ACXCL10BSK_hDFCGF_IP10_down
2,2',6,6'-Tetrachlorobisphenol ACXCL10BSK_BE3C_IP10_down
2,2',6,6'-Tetrachlorobisphenol ACXCL10BSK_KF3CT_IP10_down
2,2',6,6'-Tetrachlorobisphenol AIRF1ATG_ISRE_CIS_dn
2,2',6,6'-Tetrachlorobisphenol AARACEA_AR_antagonist_80hr
2,2',6,6'-Tetrachlorobisphenol AAROT_AR_ARSRC1_0960
2,2',6,6'-Tetrachlorobisphenol AARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
2,2',6,6'-Tetrachlorobisphenol AARNVS_NR_hAR
2,2',6,6'-Tetrachlorobisphenol AARTOX21_AR_BLA_Antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol AJUNTOX21_AP1_BLA_Agonist_ratio
2,2',6,6'-Tetrachlorobisphenol AKDRBSK_4H_VEGFRII_down
2,2',6,6'-Tetrachlorobisphenol AFOSTOX21_AP1_BLA_Agonist_ratio
2,2',6,6'-Tetrachlorobisphenol ACXCL9BSK_CASM3C_MIG_down
2,2',6,6'-Tetrachlorobisphenol ACXCL9BSK_hDFCGF_MIG_down
2,2',6,6'-Tetrachlorobisphenol ACXCL9BSK_3C_MIG_down
2,2',6,6'-Tetrachlorobisphenol ACXCL9BSK_BE3C_MIG_down
2,2',6,6'-Tetrachlorobisphenol ACXCL9BSK_SAg_MIG_down
2,2',6,6'-Tetrachlorobisphenol AMMP1BSK_BE3C_MMP1_down
2,2',6,6'-Tetrachlorobisphenol AMMP1BSK_hDFCGF_MMP1_down
2,2',6,6'-Tetrachlorobisphenol AMMP9BSK_KF3CT_MMP9_down
2,2',6,6'-Tetrachlorobisphenol AMTF1ATG_MRE_CIS_up
2,2',6,6'-Tetrachlorobisphenol AMYBATG_Myb_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ANFE2L2TOX21_ARE_BLA_agonist_ratio
2,2',6,6'-Tetrachlorobisphenol ANFKB1ATG_NF_kB_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ANR4A2ATG_NURR1_TRANS_up
2,2',6,6'-Tetrachlorobisphenol ASERPINE1BSK_hDFCGF_PAI1_down
2,2',6,6'-Tetrachlorobisphenol APAX6ATG_Pax6_CIS_up
2,2',6,6'-Tetrachlorobisphenol ALEF1ATG_TCF_b_cat_CIS_dn
2,2',6,6'-Tetrachlorobisphenol APGRTOX21_PR_BLA_Antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol APIK3CANVS_ENZ_hPI3Ka
2,2',6,6'-Tetrachlorobisphenol APLAUBSK_KF3CT_uPA_down
2,2',6,6'-Tetrachlorobisphenol APLAUBSK_BE3C_uPA_down
2,2',6,6'-Tetrachlorobisphenol APLAURBSK_BE3C_uPAR_down
2,2',6,6'-Tetrachlorobisphenol APLAURBSK_3C_uPAR_down
2,2',6,6'-Tetrachlorobisphenol APLAURBSK_CASM3C_uPAR_down
2,2',6,6'-Tetrachlorobisphenol APLAURBSK_4H_uPAR_down
2,2',6,6'-Tetrachlorobisphenol APPARANVS_NR_hPPARa
2,2',6,6'-Tetrachlorobisphenol APPARAATG_PPARa_TRANS_dn
2,2',6,6'-Tetrachlorobisphenol APPARDTOX21_PPARd_BLA_antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol APPARGNVS_NR_hPPARg
2,2',6,6'-Tetrachlorobisphenol APPARGATG_PPARg_TRANS_up
2,2',6,6'-Tetrachlorobisphenol APPARGTOX21_PPARg_BLA_antagonist_ratio
2,2',6,6'-Tetrachlorobisphenol APTGER2BSK_LPS_PGE2_down
2,2',6,6'-Tetrachlorobisphenol ARARAATG_RARa_TRANS_dn
2,2',6,6'-Tetrachlorobisphenol ARXRAOT_NURR1_NURR1RXRa_1440
2,2',6,6'-Tetrachlorobisphenol ARXRAOT_NURR1_NURR1RXRa_0480
2,2',6,6'-Tetrachlorobisphenol ARXRBATG_RXRb_TRANS_up
2,2',6,6'-Tetrachlorobisphenol ASAA1BSK_CASM3C_SAA_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_4H_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_CASM3C_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_LPS_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_SAg_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_KF3CT_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ACCL2BSK_3C_MCP1_down
2,2',6,6'-Tetrachlorobisphenol ASELEBSK_3C_Eselectin_down
2,2',6,6'-Tetrachlorobisphenol ASELEBSK_SAg_Eselectin_down
2,2',6,6'-Tetrachlorobisphenol ASELEBSK_LPS_Eselectin_down
2,2',6,6'-Tetrachlorobisphenol ASELPBSK_4H_Pselectin_down
2,2',6,6'-Tetrachlorobisphenol ASLC6A3NVS_TR_hDAT
2,2',6,6'-Tetrachlorobisphenol ASOX1ATG_Sox_CIS_up
2,2',6,6'-Tetrachlorobisphenol ASTAT3ATG_STAT3_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ATCF7ATG_TCF_b_cat_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ATCF7L2ATG_TCF_b_cat_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ATGFB1BSK_BE3C_TGFb1_up
2,2',6,6'-Tetrachlorobisphenol ATGFB1BSK_KF3CT_TGFb1_down
2,2',6,6'-Tetrachlorobisphenol ATHBDBSK_3C_Thrombomodulin_up
2,2',6,6'-Tetrachlorobisphenol ATHBDBSK_CASM3C_Thrombomodulin_up
2,2',6,6'-Tetrachlorobisphenol ATIMP1BSK_hDFCGF_TIMP1_down
2,2',6,6'-Tetrachlorobisphenol ATIMP2BSK_KF3CT_TIMP2_down
2,2',6,6'-Tetrachlorobisphenol ATNFBSK_LPS_TNFa_down
2,2',6,6'-Tetrachlorobisphenol ATP53TOX21_p53_BLA_p5_ratio
2,2',6,6'-Tetrachlorobisphenol ATP53TOX21_p53_BLA_p2_ratio
2,2',6,6'-Tetrachlorobisphenol ATP53TOX21_p53_BLA_p3_ratio
2,2',6,6'-Tetrachlorobisphenol ATP53TOX21_p53_BLA_p4_ratio
2,2',6,6'-Tetrachlorobisphenol ATP53TOX21_p53_BLA_p1_ratio
2,2',6,6'-Tetrachlorobisphenol ATP53ATG_p53_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ANR1H2ATG_DR4_LXR_CIS_dn
2,2',6,6'-Tetrachlorobisphenol AVCAM1BSK_hDFCGF_VCAM1_down
2,2',6,6'-Tetrachlorobisphenol AVCAM1BSK_4H_VCAM1_down
2,2',6,6'-Tetrachlorobisphenol AVCAM1BSK_CASM3C_VCAM1_down
2,2',6,6'-Tetrachlorobisphenol AVCAM1BSK_LPS_VCAM1_down
2,2',6,6'-Tetrachlorobisphenol AVCAM1BSK_3C_VCAM1_down
2,2',6,6'-Tetrachlorobisphenol AVDRATG_VDRE_CIS_up
2,2',6,6'-Tetrachlorobisphenol ATCF7L1ATG_TCF_b_cat_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ANR1I2ATG_PXRE_CIS_up
2,2',6,6'-Tetrachlorobisphenol ANR1I2ATG_PXR_TRANS_up
2,2',6,6'-Tetrachlorobisphenol ANR1I2NVS_NR_hPXR
2,2',6,6'-Tetrachlorobisphenol ACD38BSK_SAg_CD38_down
2,2',6,6'-Tetrachlorobisphenol ACD40BSK_LPS_CD40_down
2,2',6,6'-Tetrachlorobisphenol ACD40BSK_SAg_CD40_down
2,2',6,6'-Tetrachlorobisphenol ACD69BSK_SAg_CD69_down
2,2',6,6'-Tetrachlorobisphenol ANR1H4OT_FXR_FXRSRC1_0480
2,2',6,6'-Tetrachlorobisphenol ANR1H4ATG_FXR_TRANS_up
2,2',6,6'-Tetrachlorobisphenol ANR1H4OT_FXR_FXRSRC1_1440
2,2',6,6'-Tetrachlorobisphenol ANR1H4ATG_IR1_CIS_dn
2,2',6,6'-Tetrachlorobisphenol ANR1H4TOX21_FXR_BLA_antagonist_ratio
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.