Bisphenol A

Target genes for Bisphenol A is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Bisphenol ANR1H3ATG_DR4_LXR_CIS_dn
Bisphenol AESR1CEETOX_H295R_TESTO_dn
Bisphenol ANACEETOX_H295R_ANDR_dn
Bisphenol ANACEETOX_H295R_TESTO_dn
Bisphenol ACREB3ATG_CRE_CIS_up
Bisphenol ALTB4RNVS_GPCR_hLTB4_BLT1
Bisphenol ACOL3A1BSK_hDFCGF_CollagenIII_down
Bisphenol AADORA1NVS_GPCR_hAdoRA1
Bisphenol ACSNK1DNVS_ENZ_hCK1D
Bisphenol AADRB1NVS_GPCR_hAdrb1
Bisphenol ACYP1A1NVS_ADME_hCYP1A1
Bisphenol ACYP1A1CLD_CYP1A1_6hr
Bisphenol ACYP1A2CLD_CYP1A2_6hr
Bisphenol ACYP2B6NVS_ADME_hCYP2B6
Bisphenol ACYP2B6CLD_CYP2B6_6hr
Bisphenol ACYP2C19NVS_ADME_hCYP2C19_Activator
Bisphenol ACYP2C9NVS_ADME_hCYP2C9
Bisphenol ACYP2C18NVS_ADME_hCYP2C18
Bisphenol ACYP2J2NVS_ADME_hCYP2J2
Bisphenol ADRD1NVS_GPCR_hDRD1
Bisphenol AEGR1ATG_EGR_CIS_up
Bisphenol AAHRATG_Ahr_CIS_up
Bisphenol AESR1TOX21_ERa_BLA_Antagonist_ratio
Bisphenol AESR1NVS_NR_hER
Bisphenol AESR1ACEA_ER_80hr
Bisphenol AESR1OT_ER_ERaERa_1440
Bisphenol AESR1ATG_ERa_TRANS_up
Bisphenol AESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
Bisphenol AESR1ATG_ERE_CIS_up
Bisphenol AESR1OT_ERa_EREGFP_0120
Bisphenol AESR1TOX21_ERa_BLA_Agonist_ratio
Bisphenol AESR1TOX21_ERa_LUC_VM7_Agonist
Bisphenol AESR1OT_ER_ERaERa_0480
Bisphenol AESR1OT_ER_ERaERb_0480
Bisphenol AESR1OT_ERa_EREGFP_0480
Bisphenol AESR1OT_ER_ERaERb_1440
Bisphenol AESR2OT_ER_ERbERb_0480
Bisphenol AESR2OT_ER_ERaERb_0480
Bisphenol AESR2OT_ER_ERaERb_1440
Bisphenol AESR2OT_ER_ERbERb_1440
Bisphenol AESR2TOX21_ERb_BLA_Antagonist_ratio
Bisphenol AESRRATOX21_PGC_ERR_Antagonist
Bisphenol AESRRATOX21_ERR_Antagonist
Bisphenol AFOSATG_AP_1_CIS_up
Bisphenol ANR3C1TOX21_GR_BLA_Antagonist_ratio
Bisphenol ANR3C1NVS_NR_hGR
Bisphenol AHSF1ATG_HSE_CIS_up
Bisphenol AHTR6NVS_GPCR_h5HT6
Bisphenol AHTR7NVS_GPCR_h5HT7
Bisphenol AIRF1ATG_ISRE_CIS_dn
Bisphenol AARCEETOX_H295R_ANDR_dn
Bisphenol AARNVS_NR_hAR
Bisphenol AAROT_AR_ARSRC1_0960
Bisphenol AARCEETOX_H295R_TESTO_dn
Bisphenol AARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Bisphenol AARTOX21_AR_BLA_Antagonist_ratio
Bisphenol AARACEA_AR_antagonist_80hr
Bisphenol AARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
Bisphenol AJUNATG_AP_1_CIS_up
Bisphenol AESR1CEETOX_H295R_TESTO_dn
Bisphenol ANACEETOX_H295R_TESTO_dn
Bisphenol AARCEETOX_H295R_ANDR_dn
Bisphenol AARCEETOX_H295R_TESTO_dn
Bisphenol AMMP3NVS_ENZ_hMMP3
Bisphenol AMMP13NVS_ENZ_hMMP13
Bisphenol AMTF1ATG_MRE_CIS_up
Bisphenol ANFE2L2ATG_NRF2_ARE_CIS_up
Bisphenol ANFE2L2TOX21_ARE_BLA_agonist_ratio
Bisphenol ANTRK1NVS_ENZ_hTrkA
Bisphenol AOPRD1NVS_GPCR_hOpiate_D1
Bisphenol AOPRM1NVS_GPCR_hOpiate_mu
Bisphenol APAX6ATG_Pax6_CIS_up
Bisphenol ALEF1ATG_TCF_b_cat_CIS_dn
Bisphenol APGRNVS_NR_hPR
Bisphenol APGRTOX21_PR_BLA_Antagonist_ratio
Bisphenol APIK3CANVS_ENZ_hPI3Ka
Bisphenol APOU2F1ATG_Oct_MLP_CIS_up
Bisphenol APPARANVS_NR_hPPARa
Bisphenol APPARAATG_PPRE_CIS_up
Bisphenol APPARDTOX21_PPARd_BLA_antagonist_ratio
Bisphenol APPARDATG_PPRE_CIS_up
Bisphenol APPARGTOX21_PPARg_BLA_antagonist_ratio
Bisphenol APPARGATG_PPRE_CIS_up
Bisphenol APTGER2BSK_LPS_PGE2_down
Bisphenol ARARAATG_DR5_CIS_up
Bisphenol ARARBATG_DR5_CIS_up
Bisphenol ARARGATG_DR5_CIS_up
Bisphenol ASLC5A5NIS_RAIU_inhibition
Bisphenol ASLC6A2NVS_TR_hNET
Bisphenol ASLC6A3NVS_TR_hDAT
Bisphenol ACYP4F12NVS_ADME_hCYP4F12
Bisphenol ASREBF1ATG_SREBP_CIS_up
Bisphenol ATBXA2RNVS_GPCR_hTXA2
Bisphenol ATCF7ATG_TCF_b_cat_CIS_dn
Bisphenol ATCF7L2ATG_TCF_b_cat_CIS_dn
Bisphenol ATFAP2AATG_AP_2_CIS_dn
Bisphenol ATFAP2BATG_AP_2_CIS_dn
Bisphenol ATP53TOX21_p53_BLA_p4_ratio
Bisphenol ATP53ATG_p53_CIS_dn
Bisphenol ATP53TOX21_p53_BLA_p2_ratio
Bisphenol ATSHRTOX21_TSHR_Agonist_ratio
Bisphenol ANR1H2ATG_DR4_LXR_CIS_dn
Bisphenol AVCAM1BSK_hDFCGF_VCAM1_down
Bisphenol AVCAM1BSK_LPS_VCAM1_down
Bisphenol AVDRATG_VDRE_CIS_up
Bisphenol ANACEETOX_H295R_ANDR_dn
Bisphenol ANACEETOX_H295R_TESTO_dn
Bisphenol AXBP1ATG_Xbp1_CIS_up
Bisphenol ATCF7L1ATG_TCF_b_cat_CIS_dn
Bisphenol ATFAP2DATG_AP_2_CIS_dn
Bisphenol ANR1I2ATG_PXRE_CIS_up
Bisphenol ANR1I2NVS_NR_hPXR
Bisphenol ANR1I2ATG_PXR_TRANS_up
Bisphenol ACD40BSK_SAg_CD40_down
Bisphenol ANR1I3NVS_NR_hCAR_Antagonist
Bisphenol ANR1I3ATG_PBREM_CIS_up
Bisphenol ANR1I3TOX21_CAR_Agonist
Bisphenol ANR1H4OT_FXR_FXRSRC1_1440
Bisphenol ANR1H4NVS_NR_hFXR_Antagonist
Bisphenol ANR1H4TOX21_FXR_BLA_antagonist_ratio
Bisphenol ANR1H4OT_FXR_FXRSRC1_0480

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.