Prochloraz

Target genes for Prochloraz is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ProchlorazNACEETOX_H295R_PROG_up
ProchlorazESR1CEETOX_H295R_TESTO_dn
ProchlorazESR1CEETOX_H295R_ESTRONE_dn
ProchlorazESR1CEETOX_H295R_ESTRADIOL_dn
ProchlorazNACEETOX_H295R_ANDR_dn
ProchlorazNACEETOX_H295R_TESTO_dn
ProchlorazCREB3ATG_CRE_CIS_up
ProchlorazCOL3A1BSK_hDFCGF_CollagenIII_down
ProchlorazCSF1BSK_LPS_MCSF_down
ProchlorazCSF1BSK_hDFCGF_MCSF_down
ProchlorazADRA2CNVS_GPCR_hAdra2C
ProchlorazCYP1A1NVS_ADME_hCYP1A1
ProchlorazCYP1A1CLD_CYP1A1_48hr
ProchlorazCYP1A1CLD_CYP1A1_24hr
ProchlorazCYP1A1CLD_CYP1A1_6hr
ProchlorazCYP1A2CLD_CYP1A2_6hr
ProchlorazCYP1A2NVS_ADME_hCYP1A2
ProchlorazCYP1A2CLD_CYP1A2_48hr
ProchlorazCYP1A2CLD_CYP1A2_24hr
ProchlorazCYP1B1NVS_ADME_hCYP1B1
ProchlorazCYP2A6NVS_ADME_hCYP2A6_Activator
ProchlorazCYP2B6CLD_CYP2B6_6hr
ProchlorazCYP2B6CLD_CYP2B6_24hr
ProchlorazCYP2B6NVS_ADME_hCYP2B6
ProchlorazCYP2B6CLD_CYP2B6_48hr
ProchlorazCYP2C19NVS_ADME_hCYP2C19
ProchlorazCYP2C8NVS_ADME_hCYP2C8
ProchlorazCYP2C9NVS_ADME_hCYP2C9
ProchlorazCYP2C18NVS_ADME_hCYP2C18
ProchlorazCYP2D6NVS_ADME_hCYP2D6
ProchlorazCYP2E1NVS_ADME_hCYP2E1
ProchlorazCYP2J2NVS_ADME_hCYP2J2
ProchlorazCYP3A4CLD_CYP3A4_48hr
ProchlorazCYP3A4CLD_CYP3A4_24hr
ProchlorazCYP19A1NVS_ADME_hCYP19A1
ProchlorazCYP19A1TOX21_Aromatase_Inhibition
ProchlorazEGFRBSK_hDFCGF_EGFR_down
ProchlorazAHRATG_Ahr_CIS_up
ProchlorazAHRTOX21_AhR_LUC_Agonist
ProchlorazSLC29A1NVS_TR_hAdoT
ProchlorazESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ProchlorazESR1TOX21_ERa_BLA_Antagonist_ratio
ProchlorazESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ProchlorazESR1CEETOX_H295R_ESTRADIOL_dn
ProchlorazESR1CEETOX_H295R_ESTRONE_dn
ProchlorazESR2CEETOX_H295R_ESTRADIOL_dn
ProchlorazESR2TOX21_ERb_BLA_Antagonist_ratio
ProchlorazESR2CEETOX_H295R_ESTRONE_dn
ProchlorazESRRATOX21_PGC_ERR_Antagonist
ProchlorazESRRATOX21_ERR_Antagonist
ProchlorazSIRT2NVS_ENZ_hSIRT2
ProchlorazFOSATG_AP_1_CIS_up
ProchlorazGATA1ATG_GATA_CIS_dn
ProchlorazNR3C1TOX21_GR_BLA_Antagonist_ratio
ProchlorazNR3C1CEETOX_H295R_11DCORT_dn
ProchlorazNR3C1NVS_NR_hGR
ProchlorazNR3C1CEETOX_H295R_DOC_up
ProchlorazNR3C1CEETOX_H295R_CORTISOL_dn
ProchlorazNR3C1CEETOX_H295R_CORTIC_up
ProchlorazHLA-DRABSK_3C_HLADR_down
ProchlorazHLA-DRABSK_BE3C_HLADR_down
ProchlorazHTR5ANVS_GPCR_h5HT5A
ProchlorazHTR7NVS_GPCR_h5HT7
ProchlorazICAM1BSK_KF3CT_ICAM1_up
ProchlorazIL1ABSK_BE3C_IL1a_down
ProchlorazIL6BSK_CASM3C_IL6_up
ProchlorazCXCL8BSK_SAg_IL8_down
ProchlorazCXCL10BSK_BE3C_IP10_down
ProchlorazCXCL10BSK_hDFCGF_IP10_down
ProchlorazARACEA_AR_antagonist_80hr
ProchlorazARCEETOX_H295R_TESTO_dn
ProchlorazAROT_AR_ARSRC1_0480
ProchlorazARTOX21_AR_BLA_Antagonist_ratio
ProchlorazARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ProchlorazARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ProchlorazARNVS_NR_hAR
ProchlorazAROT_AR_ARSRC1_0960
ProchlorazARCEETOX_H295R_ANDR_dn
ProchlorazJUNATG_AP_1_CIS_up
ProchlorazKCNH2NVS_IC_hKhERGCh
ProchlorazESR1CEETOX_H295R_ESTRADIOL_dn
ProchlorazESR1CEETOX_H295R_ESTRONE_dn
ProchlorazESR1CEETOX_H295R_TESTO_dn
ProchlorazNACEETOX_H295R_ESTRADIOL_dn
ProchlorazNACEETOX_H295R_TESTO_dn
ProchlorazNACEETOX_H295R_ESTRONE_dn
ProchlorazSMAD1ATG_BRE_CIS_up
ProchlorazARCEETOX_H295R_TESTO_dn
ProchlorazARCEETOX_H295R_ANDR_dn
ProchlorazCXCL9BSK_SAg_MIG_down
ProchlorazNR3C2CEETOX_H295R_CORTISOL_dn
ProchlorazNR3C2CEETOX_H295R_DOC_up
ProchlorazNR3C2CEETOX_H295R_11DCORT_dn
ProchlorazNR3C2CEETOX_H295R_CORTIC_up
ProchlorazMMP1NVS_ENZ_hMMP1
ProchlorazMTF1ATG_MRE_CIS_up
ProchlorazNFIAATG_NFI_CIS_up
ProchlorazNFE2L2ATG_NRF2_ARE_CIS_up
ProchlorazNFE2L2TOX21_ARE_BLA_agonist_ratio
ProchlorazOPRD1NVS_GPCR_hOpiate_D1
ProchlorazOPRM1NVS_GPCR_hOpiate_mu
ProchlorazSERPINE1BSK_hDFCGF_PAI1_down
ProchlorazSERPINE1BSK_BE3C_PAI1_down
ProchlorazPDE4ANVS_ENZ_hPDE4A1
ProchlorazPGRCEETOX_H295R_OHPREG_dn
ProchlorazPGRNVS_NR_hPR
ProchlorazPGRCEETOX_H295R_PROG_up
ProchlorazPGRTOX21_PR_BLA_Antagonist_ratio
ProchlorazABCB1CLD_ABCB1_24hr
ProchlorazABCB1CLD_ABCB1_48hr
ProchlorazPLAUBSK_BE3C_uPA_down
ProchlorazPOU2F1ATG_Oct_MLP_CIS_up
ProchlorazPPARDTOX21_PPARd_BLA_antagonist_ratio
ProchlorazPTGER2BSK_LPS_PGE2_up
ProchlorazRARAATG_DR5_CIS_up
ProchlorazRARAATG_RARa_TRANS_up
ProchlorazRARBATG_DR5_CIS_up
ProchlorazRARGATG_DR5_CIS_up
ProchlorazRXRAOT_NURR1_NURR1RXRa_1440
ProchlorazRXRAOT_NURR1_NURR1RXRa_0480
ProchlorazCCL2BSK_SAg_MCP1_down
ProchlorazCCL2BSK_4H_MCP1_down
ProchlorazSELEBSK_SAg_Eselectin_down
ProchlorazSELPBSK_4H_Pselectin_down
ProchlorazSLC5A5NIS_RAIU_inhibition
ProchlorazSLC6A2NVS_TR_hNET
ProchlorazSLC6A3NVS_TR_hDAT
ProchlorazSLC6A4NVS_TR_hSERT
ProchlorazSP1ATG_Sp1_CIS_up
ProchlorazSREBF1ATG_SREBP_CIS_up
ProchlorazTHBDBSK_3C_Thrombomodulin_up
ProchlorazTHBDBSK_CASM3C_Thrombomodulin_up
ProchlorazTSPONVS_MP_hPBR
ProchlorazTHRANVS_NR_hTRa_Antagonist
ProchlorazTNFBSK_LPS_TNFa_down
ProchlorazTP53TOX21_p53_BLA_p5_ratio
ProchlorazTP53TOX21_p53_BLA_p3_ratio
ProchlorazTP53TOX21_p53_BLA_p4_ratio
ProchlorazTP53TOX21_p53_BLA_p2_ratio
ProchlorazTSHRTOX21_TSHR_Agonist_ratio
ProchlorazVDRATG_VDRE_CIS_up
ProchlorazNACEETOX_H295R_TESTO_dn
ProchlorazNACEETOX_H295R_ANDR_dn
ProchlorazXBP1ATG_Xbp1_CIS_up
ProchlorazPDE5ANVS_ENZ_hPDE5
ProchlorazNR1I2ATG_PXR_TRANS_up
ProchlorazNR1I2ATG_PXRE_CIS_up
ProchlorazABCG2CLD_ABCG2_48hr
ProchlorazCD38BSK_SAg_CD38_down
ProchlorazCD40BSK_SAg_CD40_down
ProchlorazCD40BSK_LPS_CD40_down
ProchlorazCD69BSK_SAg_CD69_down
ProchlorazNR1I3NVS_NR_hCAR_Antagonist
ProchlorazNR1I3ATG_PBREM_CIS_up
ProchlorazNR1I3TOX21_CAR_Agonist
ProchlorazNR1H4TOX21_FXR_BLA_antagonist_ratio
ProchlorazNR1H4OT_FXR_FXRSRC1_1440
ProchlorazNR1H4OT_FXR_FXRSRC1_0480

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.