Flusilazole

Target genes for Flusilazole is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
FlusilazoleNR1H3ATG_DR4_LXR_CIS_dn
FlusilazoleESR1CEETOX_H295R_ESTRADIOL_dn
FlusilazoleESR1CEETOX_H295R_ESTRONE_dn
FlusilazoleCEBPBATG_C_EBP_CIS_up
FlusilazoleCHRM3NVS_GPCR_hM3
FlusilazoleCHRM4NVS_GPCR_hM4
FlusilazoleCSF1BSK_LPS_MCSF_down
FlusilazoleCSF1BSK_hDFCGF_MCSF_down
FlusilazoleCYP1A1CLD_CYP1A1_24hr
FlusilazoleCYP1A1CLD_CYP1A1_48hr
FlusilazoleCYP1A1NVS_ADME_hCYP1A1
FlusilazoleCYP1A2CLD_CYP1A2_48hr
FlusilazoleCYP1A2CLD_CYP1A2_24hr
FlusilazoleCYP2A6NVS_ADME_hCYP2A6
FlusilazoleCYP2B6CLD_CYP2B6_48hr
FlusilazoleCYP2B6NVS_ADME_hCYP2B6
FlusilazoleCYP2B6CLD_CYP2B6_24hr
FlusilazoleCYP2B6CLD_CYP2B6_6hr
FlusilazoleCYP2C19NVS_ADME_hCYP2C19
FlusilazoleCYP2C9NVS_ADME_hCYP2C9
FlusilazoleCYP2C18NVS_ADME_hCYP2C18
FlusilazoleCYP3A4CLD_CYP3A4_48hr
FlusilazoleCYP3A4CLD_CYP3A4_24hr
FlusilazoleCYP19A1NVS_ADME_hCYP19A1
FlusilazoleCYP19A1TOX21_Aromatase_Inhibition
FlusilazoleCYP24A1TOX21_VDR_BLA_antagonist_ratio
FlusilazoleEGR1ATG_EGR_CIS_up
FlusilazoleESR1TOX21_ERa_BLA_Antagonist_ratio
FlusilazoleESR1CEETOX_H295R_ESTRADIOL_dn
FlusilazoleESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
FlusilazoleESR1ATG_ERa_TRANS_up
FlusilazoleESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
FlusilazoleESR1CEETOX_H295R_ESTRONE_dn
FlusilazoleESR2CEETOX_H295R_ESTRADIOL_dn
FlusilazoleESR2CEETOX_H295R_ESTRONE_dn
FlusilazoleESR2TOX21_ERb_BLA_Antagonist_ratio
FlusilazoleESRRATOX21_ERR_Antagonist
FlusilazoleESRRATOX21_PGC_ERR_Antagonist
FlusilazoleSIRT3NVS_ENZ_hSIRT3
FlusilazoleFOSATG_AP_1_CIS_up
FlusilazoleNR3C1TOX21_GR_BLA_Antagonist_ratio
FlusilazoleNR3C1NVS_NR_hGR
FlusilazoleGSTA2CLD_GSTA2_24hr
FlusilazoleGSTA2CLD_GSTA2_48hr
FlusilazoleHIF1AATG_HIF1a_CIS_up
FlusilazoleHSF1ATG_HSE_CIS_up
FlusilazoleHTR5ANVS_GPCR_h5HT5A
FlusilazoleHTR7NVS_GPCR_h5HT7
FlusilazoleIL1ABSK_LPS_IL1a_up
FlusilazoleCXCL8BSK_SAg_IL8_down
FlusilazoleAROT_AR_ARSRC1_0480
FlusilazoleARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
FlusilazoleARNVS_NR_hAR
FlusilazoleARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
FlusilazoleARTOX21_AR_BLA_Antagonist_ratio
FlusilazoleARACEA_AR_antagonist_80hr
FlusilazoleAROT_AR_ARSRC1_0960
FlusilazoleJUNATG_AP_1_CIS_up
FlusilazoleESR1CEETOX_H295R_ESTRADIOL_dn
FlusilazoleESR1CEETOX_H295R_ESTRONE_dn
FlusilazoleNACEETOX_H295R_ESTRONE_dn
FlusilazoleNACEETOX_H295R_ESTRADIOL_dn
FlusilazoleSMAD1ATG_BRE_CIS_up
FlusilazoleMMP9NVS_ENZ_hMMP9_Activator
FlusilazoleMTF1ATG_MRE_CIS_up
FlusilazoleNFIAATG_NFI_CIS_up
FlusilazoleNFE2L2ATG_NRF2_ARE_CIS_up
FlusilazoleNFE2L2TOX21_ARE_BLA_agonist_ratio
FlusilazoleNRF1ATG_NRF1_CIS_dn
FlusilazoleOPRM1NVS_GPCR_hOpiate_mu
FlusilazolePAX6ATG_Pax6_CIS_up
FlusilazolePDE4ANVS_ENZ_hPDE4A1
FlusilazolePGRCEETOX_H295R_OHPROG_dn
FlusilazolePGRNVS_NR_hPR
FlusilazolePGRTOX21_PR_BLA_Antagonist_ratio
FlusilazoleABCB1CLD_ABCB1_24hr
FlusilazoleABCB1CLD_ABCB1_48hr
FlusilazolePOU2F1ATG_Oct_MLP_CIS_up
FlusilazolePPARAATG_PPRE_CIS_up
FlusilazolePPARDTOX21_PPARd_BLA_antagonist_ratio
FlusilazolePPARDATG_PPRE_CIS_up
FlusilazolePPARGATG_PPARg_TRANS_up
FlusilazolePPARGATG_PPRE_CIS_up
FlusilazolePTGER2BSK_LPS_PGE2_up
FlusilazoleRARAATG_DR5_CIS_up
FlusilazoleRARAATG_RARa_TRANS_up
FlusilazoleRARBATG_DR5_CIS_up
FlusilazoleRARGATG_DR5_CIS_up
FlusilazoleRORAATG_RORE_CIS_up
FlusilazoleRORBATG_RORE_CIS_up
FlusilazoleRORCATG_RORE_CIS_up
FlusilazoleCCL2BSK_SAg_MCP1_down
FlusilazoleCCL2BSK_4H_MCP1_down
FlusilazoleSELEBSK_LPS_Eselectin_down
FlusilazoleSELEBSK_SAg_Eselectin_down
FlusilazoleSLC5A5NIS_RAIU_inhibition
FlusilazoleSLC6A2NVS_TR_hNET
FlusilazoleSLC6A3NVS_TR_hDAT
FlusilazoleSREBF1ATG_SREBP_CIS_up
FlusilazoleSTAT3ATG_STAT3_CIS_up
FlusilazoleSULT2A1CLD_SULT2A_24hr
FlusilazoleTHBDBSK_CASM3C_Thrombomodulin_up
FlusilazoleTSPONVS_MP_hPBR
FlusilazoleTP53TOX21_p53_BLA_p2_ratio
FlusilazoleTP53TOX21_p53_BLA_p4_ratio
FlusilazoleNR1H2ATG_DR4_LXR_CIS_dn
FlusilazoleUSF1ATG_E_Box_CIS_dn
FlusilazoleVDRATG_VDRE_CIS_up
FlusilazoleVDRTOX21_VDR_BLA_antagonist_ratio
FlusilazoleNR1I2ATG_PXR_TRANS_up
FlusilazoleNR1I2ATG_PXRE_CIS_up
FlusilazoleABCG2CLD_ABCG2_48hr
FlusilazoleCD38BSK_SAg_CD38_down
FlusilazoleCD40BSK_SAg_CD40_down
FlusilazoleNR1I3ATG_PBREM_CIS_up
FlusilazoleNR1I3TOX21_CAR_Agonist
FlusilazoleNR1I3NVS_NR_hCAR_Antagonist
FlusilazoleNR1H4OT_FXR_FXRSRC1_0480
FlusilazoleNR1H4TOX21_FXR_BLA_antagonist_ratio
FlusilazoleNR1H4ATG_IR1_CIS_dn

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