Dicofol

Target genes for Dicofol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
DicofolCCL26BSK_4H_Eotaxin3_down
DicofolCOL3A1BSK_hDFCGF_CollagenIII_down
DicofolCSF1BSK_LPS_MCSF_down
DicofolCSF1BSK_CASM3C_MCSF_down
DicofolCSF1BSK_hDFCGF_MCSF_down
DicofolCYP1A1CLD_CYP1A1_48hr
DicofolCYP1A1CLD_CYP1A1_24hr
DicofolCYP2B6CLD_CYP2B6_6hr
DicofolCYP2B6CLD_CYP2B6_48hr
DicofolCYP2B6CLD_CYP2B6_24hr
DicofolCYP2C19NVS_ADME_hCYP2C19
DicofolCYP2C9CLD_CYP2C9_48hr
DicofolCYP3A4CLD_CYP3A4_24hr
DicofolCYP3A4CLD_CYP3A4_48hr
DicofolCYP3A4CLD_CYP3A4_6hr
DicofolCYP19A1TOX21_Aromatase_Inhibition
DicofolDIO1NHEERL_MED_hDIO1_dn
DicofolEGFRBSK_hDFCGF_EGFR_down
DicofolESR1TOX21_ERa_BLA_Antagonist_ratio
DicofolESR1OT_ER_ERaERb_1440
DicofolESR1OT_ER_ERaERa_0480
DicofolESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
DicofolESR1OT_ER_ERaERb_0480
DicofolESR2OT_ER_ERaERb_1440
DicofolESR2OT_ER_ERbERb_1440
DicofolESR2OT_ER_ERbERb_0480
DicofolESR2OT_ER_ERaERb_0480
DicofolF3BSK_LPS_TissueFactor_down
DicofolF3BSK_3C_TissueFactor_down
DicofolATF6TOX21_ESRE_BLA_ratio
DicofolNR3C1NVS_NR_hGR
DicofolNR3C1TOX21_GR_BLA_Antagonist_ratio
DicofolHIF1ATOX21_HRE_BLA_Agonist_ratio
DicofolHLA-DRABSK_3C_HLADR_down
DicofolHLA-DRABSK_BE3C_HLADR_down
DicofolHSF1TOX21_HSE_BLA_agonist_ratio
DicofolICAM1BSK_3C_ICAM1_down
DicofolICAM1BSK_KF3CT_ICAM1_down
DicofolIL1ABSK_BE3C_IL1a_down
DicofolIL1ABSK_LPS_IL1a_down
DicofolIL1ABSK_KF3CT_IL1a_down
DicofolCXCL8BSK_SAg_IL8_down
DicofolCXCL8BSK_CASM3C_IL8_down
DicofolCXCL8BSK_LPS_IL8_down
DicofolCXCL8BSK_3C_IL8_down
DicofolCXCL8BSK_hDFCGF_IL8_down
DicofolCXCL10BSK_KF3CT_IP10_down
DicofolCXCL10BSK_BE3C_IP10_down
DicofolCXCL10BSK_hDFCGF_IP10_down
DicofolARTOX21_AR_BLA_Antagonist_ratio
DicofolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
DicofolAROT_AR_ARSRC1_0960
DicofolAROT_AR_ARSRC1_0480
DicofolARNVS_NR_hAR
DicofolARACEA_AR_antagonist_80hr
DicofolJUNTOX21_AP1_BLA_Agonist_ratio
DicofolKDRBSK_4H_VEGFRII_down
DicofolFOSTOX21_AP1_BLA_Agonist_ratio
DicofolCXCL9BSK_3C_MIG_down
DicofolCXCL9BSK_hDFCGF_MIG_down
DicofolCXCL9BSK_SAg_MIG_down
DicofolCXCL9BSK_CASM3C_MIG_down
DicofolCXCL9BSK_BE3C_MIG_down
DicofolMMP1BSK_hDFCGF_MMP1_down
DicofolMMP1BSK_BE3C_MMP1_down
DicofolMMP9BSK_KF3CT_MMP9_down
DicofolNFE2L2TOX21_ARE_BLA_agonist_ratio
DicofolNFKB1TOX21_NFkB_BLA_agonist_ratio
DicofolSERPINE1BSK_hDFCGF_PAI1_down
DicofolSERPINE1BSK_BE3C_PAI1_down
DicofolPGRTOX21_PR_BLA_Antagonist_ratio
DicofolPLATBSK_BE3C_tPA_down
DicofolPLAUBSK_KF3CT_uPA_down
DicofolPLAUBSK_BE3C_uPA_down
DicofolPLAURBSK_BE3C_uPAR_down
DicofolPLAURBSK_CASM3C_uPAR_down
DicofolPLAURBSK_3C_uPAR_down
DicofolPLAURBSK_4H_uPAR_down
DicofolPPARGTOX21_PPARg_BLA_Agonist_ratio
DicofolPTGER2BSK_LPS_PGE2_down
DicofolSAA1BSK_CASM3C_SAA_down
DicofolCCL2BSK_3C_MCP1_down
DicofolCCL2BSK_LPS_MCP1_down
DicofolCCL2BSK_KF3CT_MCP1_down
DicofolCCL2BSK_SAg_MCP1_down
DicofolCCL2BSK_4H_MCP1_down
DicofolCCL2BSK_CASM3C_MCP1_down
DicofolSELEBSK_LPS_Eselectin_down
DicofolSELEBSK_SAg_Eselectin_down
DicofolSELEBSK_3C_Eselectin_down
DicofolSELPBSK_4H_Pselectin_down
DicofolSLC5A5NIS_RAIU_inhibition
DicofolSLC6A3NVS_TR_hDAT
DicofolSULT2A1CLD_SULT2A_24hr
DicofolSULT2A1CLD_SULT2A_48hr
DicofolTGFB1BSK_BE3C_TGFb1_down
DicofolTGFB1BSK_KF3CT_TGFb1_down
DicofolTHBDBSK_CASM3C_Thrombomodulin_down
DicofolTHBDBSK_3C_Thrombomodulin_up
DicofolTIMP1BSK_hDFCGF_TIMP1_down
DicofolTIMP2BSK_KF3CT_TIMP2_down
DicofolTNFBSK_LPS_TNFa_down
DicofolTP53APR_HepG2_p53Act_24h_dn
DicofolTP53APR_HepG2_p53Act_1h_up
DicofolTP53TOX21_p53_BLA_p1_ratio
DicofolTP53TOX21_p53_BLA_p5_ratio
DicofolTP53TOX21_p53_BLA_p3_ratio
DicofolTSHRTOX21_TSHR_Antagonist_ratio
DicofolVCAM1BSK_hDFCGF_VCAM1_down
DicofolVCAM1BSK_CASM3C_VCAM1_down
DicofolVCAM1BSK_LPS_VCAM1_down
DicofolVCAM1BSK_3C_VCAM1_down
DicofolVCAM1BSK_4H_VCAM1_down
DicofolNR1I2ATG_PXRE_CIS_up
DicofolCD38BSK_SAg_CD38_down
DicofolCD40BSK_SAg_CD40_down
DicofolCD40BSK_LPS_CD40_down
DicofolCD69BSK_SAg_CD69_down
DicofolNR1I3TOX21_CAR_Agonist
DicofolNR1H4OT_FXR_FXRSRC1_1440
DicofolNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.