Captan

Target genes for Captan is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
CaptanHDAC6NVS_ENZ_hHDAC6
CaptanCOL3A1BSK_hDFCGF_CollagenIII_down
CaptanCSF1BSK_LPS_MCSF_down
CaptanCSF1BSK_hDFCGF_MCSF_down
CaptanCSF1BSK_CASM3C_MCSF_down
CaptanCYP1A2NVS_ADME_hCYP1A2
CaptanCYP2A6NVS_ADME_hCYP2A6
CaptanCYP2C19NVS_ADME_hCYP2C19
CaptanCYP2C9NVS_ADME_hCYP2C9
CaptanCYP19A1TOX21_Aromatase_Inhibition
CaptanCYP24A1TOX21_VDR_BLA_antagonist_ratio
CaptanDIO1NHEERL_MED_hDIO1_dn
CaptanDRD1NVS_GPCR_hDRD1
CaptanDRD2NVS_GPCR_hDRD2s
CaptanAGTR1NVS_GPCR_hAT1
CaptanEGFRBSK_hDFCGF_EGFR_up
CaptanEGR1ATG_EGR_CIS_dn
CaptanESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
CaptanESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
CaptanESR1TOX21_ERa_BLA_Antagonist_ratio
CaptanESR2TOX21_ERb_BLA_Antagonist_ratio
CaptanESRRATOX21_ERR_Antagonist
CaptanESRRATOX21_PGC_ERR_Antagonist
CaptanF3BSK_LPS_TissueFactor_down
CaptanSIRT2NVS_ENZ_hSIRT2
CaptanSIRT3NVS_ENZ_hSIRT3
CaptanSIRT1NVS_ENZ_hSIRT1
CaptanNR3C1NVS_NR_hGR
CaptanNR3C1TOX21_GR_BLA_Antagonist_ratio
CaptanHIF1ATOX21_HRE_BLA_Agonist_ratio
CaptanHLA-DRABSK_BE3C_HLADR_down
CaptanHLA-DRABSK_3C_HLADR_down
CaptanHLA-DRABSK_CASM3C_HLADR_down
CaptanHSF1TOX21_HSE_BLA_agonist_ratio
CaptanHTR5ANVS_GPCR_h5HT5A
CaptanHTR7NVS_GPCR_h5HT7
CaptanICAM1BSK_KF3CT_ICAM1_down
CaptanIL1ABSK_BE3C_IL1a_down
CaptanIL1ABSK_KF3CT_IL1a_down
CaptanIL1ABSK_LPS_IL1a_down
CaptanIL6BSK_CASM3C_IL6_down
CaptanCXCL8BSK_hDFCGF_IL8_down
CaptanCXCL8BSK_LPS_IL8_down
CaptanCXCL8BSK_CASM3C_IL8_down
CaptanCXCL8BSK_SAg_IL8_down
CaptanCXCL10BSK_BE3C_IP10_down
CaptanCXCL10BSK_hDFCGF_IP10_down
CaptanCXCL10BSK_KF3CT_IP10_down
CaptanARACEA_AR_antagonist_80hr
CaptanARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
CaptanAROT_AR_ARSRC1_0960
CaptanARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
CaptanAROT_AR_ARSRC1_0480
CaptanARTOX21_AR_BLA_Antagonist_ratio
CaptanJUNTOX21_AP1_BLA_Agonist_ratio
CaptanFOSTOX21_AP1_BLA_Agonist_ratio
CaptanCXCL9BSK_CASM3C_MIG_down
CaptanCXCL9BSK_BE3C_MIG_down
CaptanCXCL9BSK_hDFCGF_MIG_down
CaptanMMP1BSK_BE3C_MMP1_down
CaptanMMP1BSK_hDFCGF_MMP1_down
CaptanMMP9BSK_KF3CT_MMP9_down
CaptanNFE2L2TOX21_ARE_BLA_agonist_ratio
CaptanNPY1RNVS_GPCR_hNPY1
CaptanOPRM1NVS_GPCR_hOpiate_mu
CaptanSERPINE1BSK_BE3C_PAI1_down
CaptanSERPINE1BSK_hDFCGF_PAI1_down
CaptanPGRTOX21_PR_BLA_Antagonist_ratio
CaptanPLATBSK_BE3C_tPA_down
CaptanPLAUBSK_BE3C_uPA_down
CaptanPLAUBSK_KF3CT_uPA_down
CaptanPLAURBSK_BE3C_uPAR_down
CaptanPLAURBSK_CASM3C_uPAR_down
CaptanPPARDTOX21_PPARd_BLA_antagonist_ratio
CaptanPPARGTOX21_PPARg_BLA_antagonist_ratio
CaptanPTENNVS_ENZ_hPTEN
CaptanPTPN2NVS_ENZ_hPTPN2
CaptanPTPN9NVS_ENZ_hPTPN9
CaptanSAA1BSK_CASM3C_SAA_down
CaptanCCL2BSK_KF3CT_MCP1_down
CaptanCCL2BSK_CASM3C_MCP1_down
CaptanSELEBSK_3C_Eselectin_down
CaptanSELEBSK_LPS_Eselectin_down
CaptanSELEBSK_SAg_Eselectin_down
CaptanSELPBSK_4H_Pselectin_down
CaptanSLC5A5NIS_RAIU_inhibition
CaptanTACR2NVS_GPCR_hNK2
CaptanTGFB1BSK_KF3CT_TGFb1_down
CaptanTGFB1BSK_BE3C_TGFb1_down
CaptanTIMP2BSK_KF3CT_TIMP2_down
CaptanTNFBSK_LPS_TNFa_down
CaptanTP53APR_HepG2_p53Act_24h_up
CaptanTP53TOX21_p53_BLA_p2_ratio
CaptanTP53TOX21_p53_BLA_p3_ratio
CaptanTP53TOX21_p53_BLA_p1_ratio
CaptanTP53TOX21_p53_BLA_p5_ratio
CaptanTSHRTOX21_TSHR_Antagonist_ratio
CaptanTSHRTOX21_TSHR_Agonist_ratio
CaptanVCAM1BSK_3C_VCAM1_down
CaptanVCAM1BSK_LPS_VCAM1_down
CaptanVCAM1BSK_CASM3C_VCAM1_down
CaptanVCAM1BSK_4H_VCAM1_down
CaptanVCAM1BSK_hDFCGF_VCAM1_down
CaptanVDRTOX21_VDR_BLA_antagonist_ratio
CaptanHDAC3NVS_ENZ_hHDAC3
CaptanCD38BSK_SAg_CD38_down
CaptanCD40BSK_LPS_CD40_down
CaptanNR1I3TOX21_CAR_Antagonist
CaptanNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.