Fludioxonil

Target genes for Fludioxonil is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
FludioxonilNR1H3ATG_DR4_LXR_CIS_dn
FludioxonilCCL26BSK_4H_Eotaxin3_down
FludioxonilCREB3ATG_CRE_CIS_up
FludioxonilCEBPBATG_C_EBP_CIS_up
FludioxonilCSF1BSK_LPS_MCSF_down
FludioxonilCSF1BSK_hDFCGF_MCSF_down
FludioxonilCYP1A1CLD_CYP1A1_48hr
FludioxonilCYP1A1CLD_CYP1A1_6hr
FludioxonilCYP1A1CLD_CYP1A1_24hr
FludioxonilCYP1A2CLD_CYP1A2_48hr
FludioxonilCYP1A2CLD_CYP1A2_6hr
FludioxonilCYP1A2CLD_CYP1A2_24hr
FludioxonilCYP1A2NVS_ADME_hCYP1A2
FludioxonilCYP2B6CLD_CYP2B6_6hr
FludioxonilCYP2B6CLD_CYP2B6_24hr
FludioxonilCYP2B6CLD_CYP2B6_48hr
FludioxonilCYP2E1NVS_ADME_hCYP2E1
FludioxonilCYP19A1TOX21_Aromatase_Inhibition
FludioxonilCYP24A1TOX21_VDR_BLA_antagonist_ratio
FludioxonilDRD4NVS_GPCR_hDRD4.4
FludioxonilEGR1ATG_EGR_CIS_up
FludioxonilAHRTOX21_AhR_LUC_Agonist
FludioxonilAHRATG_Ahr_CIS_up
FludioxonilESR1OT_ER_ERaERa_1440
FludioxonilESR1ATG_ERa_TRANS_up
FludioxonilESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
FludioxonilESR1OT_ER_ERaERb_0480
FludioxonilESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
FludioxonilESR1ATG_ERE_CIS_up
FludioxonilESR1OT_ER_ERaERb_1440
FludioxonilESR1TOX21_ERa_BLA_Agonist_ratio
FludioxonilESR1TOX21_ERa_BLA_Antagonist_ratio
FludioxonilESR2OT_ER_ERbERb_0480
FludioxonilESR2OT_ER_ERaERb_0480
FludioxonilESR2OT_ER_ERaERb_1440
FludioxonilESR2OT_ER_ERbERb_1440
FludioxonilESR2TOX21_ERb_BLA_Antagonist_ratio
FludioxonilESRRATOX21_ERR_Antagonist
FludioxonilESRRATOX21_PGC_ERR_Antagonist
FludioxonilETS1ATG_Ets_CIS_dn
FludioxonilGATA1ATG_GATA_CIS_dn
FludioxonilNR3C1NVS_NR_hGR
FludioxonilNR3C1TOX21_GR_BLA_Antagonist_ratio
FludioxonilHIF1AATG_HIF1a_CIS_up
FludioxonilHLA-DRABSK_3C_HLADR_down
FludioxonilHLA-DRABSK_CASM3C_HLADR_up
FludioxonilIL1ABSK_LPS_IL1a_down
FludioxonilCXCL8BSK_SAg_IL8_down
FludioxonilCXCL8BSK_3C_IL8_down
FludioxonilIRF1ATG_ISRE_CIS_dn
FludioxonilARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
FludioxonilARTOX21_AR_BLA_Antagonist_ratio
FludioxonilARACEA_AR_antagonist_80hr
FludioxonilARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
FludioxonilSMAD1ATG_BRE_CIS_up
FludioxonilMMP1BSK_hDFCGF_MMP1_up
FludioxonilMTF1ATG_MRE_CIS_up
FludioxonilNFE2L2ATG_NRF2_ARE_CIS_up
FludioxonilNR4A2ATG_NURR1_TRANS_up
FludioxonilPGRTOX21_PR_BLA_Antagonist_ratio
FludioxonilPLAURBSK_4H_uPAR_down
FludioxonilPLAURBSK_3C_uPAR_down
FludioxonilPOU2F1ATG_Oct_MLP_CIS_up
FludioxonilPPARAATG_PPRE_CIS_up
FludioxonilPPARDATG_PPRE_CIS_up
FludioxonilPPARGATG_PPARg_TRANS_up
FludioxonilPPARGTOX21_PPARg_BLA_antagonist_ratio
FludioxonilPPARGATG_PPRE_CIS_up
FludioxonilRARAATG_RARa_TRANS_up
FludioxonilRARAATG_DR5_CIS_up
FludioxonilRARBATG_DR5_CIS_up
FludioxonilRARGATG_DR5_CIS_up
FludioxonilRORAATG_RORE_CIS_up
FludioxonilRORBATG_RORE_CIS_up
FludioxonilRORCATG_RORE_CIS_up
FludioxonilRXRATOX21_RXR_BLA_Agonist_ratio
FludioxonilRXRBATG_RXRb_TRANS_up
FludioxonilCCL2BSK_LPS_MCP1_down
FludioxonilCCL2BSK_3C_MCP1_down
FludioxonilCCL2BSK_SAg_MCP1_down
FludioxonilSELPBSK_4H_Pselectin_down
FludioxonilSOX1ATG_Sox_CIS_up
FludioxonilSP1ATG_Sp1_CIS_up
FludioxonilSTAT3ATG_STAT3_CIS_dn
FludioxonilTFAP2AATG_AP_2_CIS_dn
FludioxonilTFAP2BATG_AP_2_CIS_dn
FludioxonilTHBDBSK_CASM3C_Thrombomodulin_up
FludioxonilTNFBSK_LPS_TNFa_down
FludioxonilTP53TOX21_p53_BLA_p1_ratio
FludioxonilTP53TOX21_p53_BLA_p2_ratio
FludioxonilTP53TOX21_p53_BLA_p3_ratio
FludioxonilTP53TOX21_p53_BLA_p4_ratio
FludioxonilTP53TOX21_p53_BLA_p5_ratio
FludioxonilNR1H2ATG_DR4_LXR_CIS_dn
FludioxonilUSF1ATG_E_Box_CIS_dn
FludioxonilVCAM1BSK_4H_VCAM1_down
FludioxonilVCAM1BSK_hDFCGF_VCAM1_down
FludioxonilVCAM1BSK_LPS_VCAM1_down
FludioxonilVDRTOX21_VDR_BLA_antagonist_ratio
FludioxonilVDRATG_VDRE_CIS_up
FludioxonilXBP1ATG_Xbp1_CIS_up
FludioxonilTFAP2DATG_AP_2_CIS_dn
FludioxonilNR1I2ATG_PXRE_CIS_up
FludioxonilCD38BSK_SAg_CD38_down
FludioxonilCD40BSK_LPS_CD40_down
FludioxonilCD40BSK_SAg_CD40_down
FludioxonilCD69BSK_SAg_CD69_down
FludioxonilNR1I3TOX21_CAR_Agonist
FludioxonilNR1I3ATG_PBREM_CIS_up
FludioxonilNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.