Triflumizol

Target genes for Triflumizol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
TriflumizolNR1H3ATG_DR4_LXR_CIS_dn
TriflumizolNACEETOX_H295R_PROG_up
TriflumizolESR1CEETOX_H295R_TESTO_dn
TriflumizolESR1CEETOX_H295R_ESTRADIOL_dn
TriflumizolESR1CEETOX_H295R_ESTRONE_dn
TriflumizolNACEETOX_H295R_ANDR_dn
TriflumizolNACEETOX_H295R_TESTO_dn
TriflumizolCCL26BSK_4H_Eotaxin3_down
TriflumizolCOL3A1BSK_hDFCGF_CollagenIII_down
TriflumizolCSF1BSK_LPS_MCSF_down
TriflumizolCSF1BSK_hDFCGF_MCSF_down
TriflumizolCSF1BSK_CASM3C_MCSF_down
TriflumizolCYP1A1CLD_CYP1A1_24hr
TriflumizolCYP1A1NVS_ADME_hCYP1A1
TriflumizolCYP1A1CLD_CYP1A1_48hr
TriflumizolCYP1A1CLD_CYP1A1_6hr
TriflumizolCYP1A2NVS_ADME_hCYP1A2
TriflumizolCYP1A2CLD_CYP1A2_24hr
TriflumizolCYP1A2CLD_CYP1A2_6hr
TriflumizolCYP1A2CLD_CYP1A2_48hr
TriflumizolCYP2B6CLD_CYP2B6_6hr
TriflumizolCYP2B6NVS_ADME_hCYP2B6
TriflumizolCYP2C19NVS_ADME_hCYP2C19
TriflumizolCYP2C8NVS_ADME_hCYP2C8
TriflumizolCYP2C9NVS_ADME_hCYP2C9
TriflumizolCYP2C18NVS_ADME_hCYP2C18
TriflumizolCYP2D6NVS_ADME_hCYP2D6
TriflumizolCYP2J2NVS_ADME_hCYP2J2
TriflumizolCYP3A4NVS_ADME_hCYP3A4
TriflumizolCYP3A4CLD_CYP3A4_48hr
TriflumizolCYP3A4CLD_CYP3A4_24hr
TriflumizolCYP19A1TOX21_Aromatase_Inhibition
TriflumizolCYP19A1NVS_ADME_hCYP19A1
TriflumizolCYP24A1TOX21_VDR_BLA_antagonist_ratio
TriflumizolDIO1NHEERL_MED_hDIO1_dn
TriflumizolDRD1NVS_GPCR_hDRD1
TriflumizolEGFRBSK_hDFCGF_EGFR_up
TriflumizolEGR1ATG_EGR_CIS_up
TriflumizolSLC29A1NVS_TR_hAdoT
TriflumizolESR1CEETOX_H295R_ESTRADIOL_dn
TriflumizolESR1OT_ERa_EREGFP_0480
TriflumizolESR1CEETOX_H295R_ESTRONE_dn
TriflumizolESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
TriflumizolESR1OT_ERa_EREGFP_0120
TriflumizolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
TriflumizolESR1ATG_ERE_CIS_up
TriflumizolESR1TOX21_ERa_BLA_Antagonist_ratio
TriflumizolESR2CEETOX_H295R_ESTRADIOL_dn
TriflumizolESR2TOX21_ERb_BLA_Antagonist_ratio
TriflumizolESR2CEETOX_H295R_ESTRONE_dn
TriflumizolESRRATOX21_ERR_Antagonist
TriflumizolESRRATOX21_PGC_ERR_Antagonist
TriflumizolF3BSK_LPS_TissueFactor_down
TriflumizolF3BSK_3C_TissueFactor_down
TriflumizolFOSATG_AP_1_CIS_up
TriflumizolGLI1ATG_GLI_CIS_up
TriflumizolNR3C1NVS_NR_hGR
TriflumizolNR3C1TOX21_GR_BLA_Antagonist_ratio
TriflumizolNR3C1TOX21_GR_BLA_Agonist_ratio
TriflumizolNR3C1CEETOX_H295R_11DCORT_dn
TriflumizolNR3C1CEETOX_H295R_CORTISOL_dn
TriflumizolNR3C1CEETOX_H295R_DOC_up
TriflumizolGSTA2CLD_GSTA2_48hr
TriflumizolHLA-DRABSK_BE3C_HLADR_down
TriflumizolHLA-DRABSK_3C_HLADR_down
TriflumizolHSF1TOX21_HSE_BLA_agonist_ratio
TriflumizolICAM1BSK_3C_ICAM1_down
TriflumizolICAM1BSK_KF3CT_ICAM1_down
TriflumizolIL1ABSK_LPS_IL1a_down
TriflumizolIL1ABSK_KF3CT_IL1a_down
TriflumizolIL1ABSK_BE3C_IL1a_down
TriflumizolCXCL8BSK_hDFCGF_IL8_down
TriflumizolCXCL8BSK_LPS_IL8_down
TriflumizolCXCL8BSK_3C_IL8_down
TriflumizolCXCL8BSK_SAg_IL8_down
TriflumizolCXCL10BSK_KF3CT_IP10_down
TriflumizolCXCL10BSK_hDFCGF_IP10_down
TriflumizolCXCL10BSK_BE3C_IP10_down
TriflumizolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
TriflumizolARNVS_NR_hAR
TriflumizolARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
TriflumizolARACEA_AR_antagonist_80hr
TriflumizolAROT_AR_ARSRC1_0960
TriflumizolARCEETOX_H295R_TESTO_dn
TriflumizolARCEETOX_H295R_ANDR_dn
TriflumizolAROT_AR_ARSRC1_0480
TriflumizolARTOX21_AR_BLA_Antagonist_ratio
TriflumizolJUNATG_AP_1_CIS_up
TriflumizolJUNTOX21_AP1_BLA_Agonist_ratio
TriflumizolKDRBSK_4H_VEGFRII_down
TriflumizolESR1CEETOX_H295R_ESTRADIOL_dn
TriflumizolESR1CEETOX_H295R_ESTRONE_dn
TriflumizolESR1CEETOX_H295R_TESTO_dn
TriflumizolFOSTOX21_AP1_BLA_Agonist_ratio
TriflumizolNACEETOX_H295R_ESTRADIOL_dn
TriflumizolNACEETOX_H295R_ESTRONE_dn
TriflumizolNACEETOX_H295R_TESTO_dn
TriflumizolSMAD1ATG_BRE_CIS_up
TriflumizolARCEETOX_H295R_ANDR_dn
TriflumizolARCEETOX_H295R_TESTO_dn
TriflumizolCXCL9BSK_hDFCGF_MIG_down
TriflumizolCXCL9BSK_BE3C_MIG_down
TriflumizolCXCL9BSK_SAg_MIG_down
TriflumizolCXCL9BSK_CASM3C_MIG_down
TriflumizolCXCL9BSK_3C_MIG_down
TriflumizolNR3C2CEETOX_H295R_DOC_up
TriflumizolNR3C2CEETOX_H295R_11DCORT_dn
TriflumizolNR3C2CEETOX_H295R_CORTISOL_dn
TriflumizolMMP1BSK_BE3C_MMP1_down
TriflumizolMMP1BSK_hDFCGF_MMP1_down
TriflumizolMMP9NVS_ENZ_hMMP9
TriflumizolMMP9BSK_KF3CT_MMP9_down
TriflumizolNFE2L2ATG_NRF2_ARE_CIS_up
TriflumizolNFE2L2TOX21_ARE_BLA_agonist_ratio
TriflumizolOPRM1NVS_GPCR_hOpiate_mu
TriflumizolSERPINE1BSK_hDFCGF_PAI1_down
TriflumizolSERPINE1BSK_BE3C_PAI1_down
TriflumizolPDE4ANVS_ENZ_hPDE4A1
TriflumizolPGRCEETOX_H295R_OHPROG_dn
TriflumizolPGRTOX21_PR_BLA_Antagonist_ratio
TriflumizolPGRCEETOX_H295R_PROG_up
TriflumizolPGRNVS_NR_hPR
TriflumizolPGRCEETOX_H295R_OHPREG_dn
TriflumizolABCB1CLD_ABCB1_24hr
TriflumizolPLATBSK_BE3C_tPA_down
TriflumizolPLAUBSK_BE3C_uPA_down
TriflumizolPLAUBSK_KF3CT_uPA_down
TriflumizolPLAURBSK_3C_uPAR_down
TriflumizolPLAURBSK_4H_uPAR_down
TriflumizolPLAURBSK_BE3C_uPAR_down
TriflumizolPPARAATG_PPRE_CIS_up
TriflumizolPPARDATG_PPRE_CIS_up
TriflumizolPPARDTOX21_PPARd_BLA_antagonist_ratio
TriflumizolPPARGNVS_NR_hPPARg
TriflumizolPPARGATG_PPRE_CIS_up
TriflumizolPPARGATG_PPARg_TRANS_up
TriflumizolPPARGTOX21_PPARg_BLA_Agonist_ratio
TriflumizolRARAATG_DR5_CIS_up
TriflumizolRARAATG_RARa_TRANS_up
TriflumizolRARBATG_DR5_CIS_up
TriflumizolRARGATG_DR5_CIS_up
TriflumizolCCL2BSK_LPS_MCP1_down
TriflumizolCCL2BSK_SAg_MCP1_down
TriflumizolCCL2BSK_KF3CT_MCP1_down
TriflumizolCCL2BSK_3C_MCP1_down
TriflumizolCCL2BSK_CASM3C_MCP1_down
TriflumizolCCL2BSK_4H_MCP1_down
TriflumizolSELEBSK_3C_Eselectin_down
TriflumizolSELEBSK_LPS_Eselectin_down
TriflumizolSELEBSK_SAg_Eselectin_down
TriflumizolSELPBSK_4H_Pselectin_down
TriflumizolSLC5A5NIS_RAIU_inhibition
TriflumizolSLC6A3NVS_TR_hDAT
TriflumizolSREBF1ATG_SREBP_CIS_up
TriflumizolTGFB1BSK_BE3C_TGFb1_down
TriflumizolTGFB1BSK_KF3CT_TGFb1_down
TriflumizolTHBDBSK_3C_Thrombomodulin_up
TriflumizolTHBDBSK_CASM3C_Thrombomodulin_up
TriflumizolTSPONVS_MP_hPBR
TriflumizolTIMP1BSK_hDFCGF_TIMP1_down
TriflumizolTIMP2BSK_KF3CT_TIMP2_down
TriflumizolTNFBSK_LPS_TNFa_down
TriflumizolTP53TOX21_p53_BLA_p3_ratio
TriflumizolTP53TOX21_p53_BLA_p5_ratio
TriflumizolTP53TOX21_p53_BLA_p2_ratio
TriflumizolTP53TOX21_p53_BLA_p1_ratio
TriflumizolTP53TOX21_p53_BLA_p4_ratio
TriflumizolTSHRTOX21_TSHR_Agonist_ratio
TriflumizolNR1H2ATG_DR4_LXR_CIS_dn
TriflumizolVCAM1BSK_3C_VCAM1_down
TriflumizolVCAM1BSK_hDFCGF_VCAM1_down
TriflumizolVCAM1BSK_CASM3C_VCAM1_down
TriflumizolVCAM1BSK_4H_VCAM1_down
TriflumizolVCAM1BSK_LPS_VCAM1_down
TriflumizolVDRTOX21_VDR_BLA_antagonist_ratio
TriflumizolNACEETOX_H295R_TESTO_dn
TriflumizolNACEETOX_H295R_ANDR_dn
TriflumizolNR1I2ATG_PXRE_CIS_up
TriflumizolABCG2CLD_ABCG2_24hr
TriflumizolABCG2CLD_ABCG2_48hr
TriflumizolCD38BSK_SAg_CD38_down
TriflumizolCD40BSK_SAg_CD40_down
TriflumizolCD40BSK_LPS_CD40_down
TriflumizolCD69BSK_SAg_CD69_down
TriflumizolNR1I3NVS_NR_hCAR_Antagonist
TriflumizolNR1I3TOX21_CAR_Agonist
TriflumizolNR1H4OT_FXR_FXRSRC1_0480
TriflumizolNR1H4OT_FXR_FXRSRC1_1440
TriflumizolNR1H4TOX21_FXR_BLA_antagonist_ratio

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.