Pentachlorophenol

Target genes for Pentachlorophenol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
PentachlorophenolNR1H3ATG_DR4_LXR_CIS_dn
PentachlorophenolCCL26BSK_4H_Eotaxin3_down
PentachlorophenolCREB3ATG_CRE_CIS_up
PentachlorophenolCEBPBATG_C_EBP_CIS_up
PentachlorophenolCOL3A1BSK_hDFCGF_CollagenIII_down
PentachlorophenolCSF1BSK_hDFCGF_MCSF_down
PentachlorophenolCSF1BSK_LPS_MCSF_down
PentachlorophenolCYP19A1TOX21_Aromatase_Inhibition
PentachlorophenolE2F1ATG_E2F_CIS_dn
PentachlorophenolEGR1ATG_EGR_CIS_up
PentachlorophenolAHRTOX21_AhR_LUC_Agonist
PentachlorophenolAHRATG_Ahr_CIS_up
PentachlorophenolESR1ATG_ERE_CIS_up
PentachlorophenolESR1ATG_ERa_TRANS_up
PentachlorophenolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
PentachlorophenolESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
PentachlorophenolESR1TOX21_ERa_BLA_Antagonist_ratio
PentachlorophenolESR2TOX21_ERb_BLA_Antagonist_ratio
PentachlorophenolESRRATOX21_PGC_ERR_Antagonist
PentachlorophenolESRRATOX21_ERR_Antagonist
PentachlorophenolETS1ATG_Ets_CIS_dn
PentachlorophenolFOXO1ATG_FoxO_CIS_dn
PentachlorophenolFOXO3ATG_FoxO_CIS_dn
PentachlorophenolFOSATG_AP_1_CIS_up
PentachlorophenolGLI1ATG_GLI_CIS_up
PentachlorophenolNR3C1TOX21_GR_BLA_Antagonist_ratio
PentachlorophenolHIF1AATG_HIF1a_CIS_up
PentachlorophenolHLA-DRABSK_BE3C_HLADR_down
PentachlorophenolHLA-DRABSK_3C_HLADR_down
PentachlorophenolONECUT1ATG_HNF6_CIS_up
PentachlorophenolHSF1ATG_HSE_CIS_up
PentachlorophenolICAM1BSK_KF3CT_ICAM1_down
PentachlorophenolIL1ABSK_BE3C_IL1a_down
PentachlorophenolCXCL10BSK_hDFCGF_IP10_down
PentachlorophenolCXCL10BSK_KF3CT_IP10_down
PentachlorophenolCXCL10BSK_BE3C_IP10_down
PentachlorophenolIRF1ATG_ISRE_CIS_dn
PentachlorophenolARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
PentachlorophenolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
PentachlorophenolARTOX21_AR_BLA_Antagonist_ratio
PentachlorophenolARACEA_AR_antagonist_80hr
PentachlorophenolJUNATG_AP_1_CIS_up
PentachlorophenolSMAD1ATG_BRE_CIS_up
PentachlorophenolCXCL9BSK_BE3C_MIG_down
PentachlorophenolCXCL9BSK_hDFCGF_MIG_down
PentachlorophenolMMP9BSK_KF3CT_MMP9_down
PentachlorophenolMTF1ATG_MRE_CIS_up
PentachlorophenolMYCATG_Myc_CIS_up
PentachlorophenolNFIAATG_NFI_CIS_up
PentachlorophenolNFE2L2ATG_NRF2_ARE_CIS_up
PentachlorophenolNFE2L2TOX21_ARE_BLA_agonist_ratio
PentachlorophenolNFKB1ATG_NF_kB_CIS_up
PentachlorophenolNRF1ATG_NRF1_CIS_dn
PentachlorophenolSERPINE1BSK_hDFCGF_PAI1_down
PentachlorophenolSERPINE1BSK_BE3C_PAI1_down
PentachlorophenolPAX6ATG_Pax6_CIS_up
PentachlorophenolLEF1ATG_TCF_b_cat_CIS_dn
PentachlorophenolPGRTOX21_PR_BLA_Antagonist_ratio
PentachlorophenolPLATBSK_BE3C_tPA_down
PentachlorophenolPLAUBSK_BE3C_uPA_down
PentachlorophenolPLAURBSK_4H_uPAR_down
PentachlorophenolPLAURBSK_3C_uPAR_down
PentachlorophenolPLAURBSK_BE3C_uPAR_down
PentachlorophenolPOU2F1ATG_Oct_MLP_CIS_up
PentachlorophenolPPARAATG_PPARa_TRANS_up
PentachlorophenolPPARAATG_PPRE_CIS_up
PentachlorophenolPPARDATG_PPARd_TRANS_up
PentachlorophenolPPARDATG_PPRE_CIS_up
PentachlorophenolPPARDTOX21_PPARd_BLA_antagonist_ratio
PentachlorophenolPPARGATG_PPARg_TRANS_up
PentachlorophenolPPARGATG_PPRE_CIS_up
PentachlorophenolPPARGTOX21_PPARg_BLA_antagonist_ratio
PentachlorophenolRARAATG_DR5_CIS_up
PentachlorophenolRARBATG_DR5_CIS_up
PentachlorophenolRARGATG_DR5_CIS_up
PentachlorophenolRARGATG_RARg_TRANS_up
PentachlorophenolRORAATG_RORE_CIS_up
PentachlorophenolRORBATG_RORE_CIS_up
PentachlorophenolRORCATG_RORE_CIS_up
PentachlorophenolCCL2BSK_SAg_MCP1_down
PentachlorophenolCCL2BSK_3C_MCP1_down
PentachlorophenolCCL2BSK_LPS_MCP1_down
PentachlorophenolSELEBSK_LPS_Eselectin_down
PentachlorophenolSELEBSK_3C_Eselectin_down
PentachlorophenolSELPBSK_4H_Pselectin_down
PentachlorophenolSLC5A5NIS_RAIU_inhibition
PentachlorophenolSOX1ATG_Sox_CIS_up
PentachlorophenolSP1ATG_Sp1_CIS_up
PentachlorophenolSREBF1ATG_SREBP_CIS_up
PentachlorophenolSTAT3ATG_STAT3_CIS_dn
PentachlorophenolTCF7ATG_TCF_b_cat_CIS_dn
PentachlorophenolTCF7L2ATG_TCF_b_cat_CIS_dn
PentachlorophenolTFAP2AATG_AP_2_CIS_dn
PentachlorophenolTFAP2BATG_AP_2_CIS_dn
PentachlorophenolTGFB1ATG_TGFb_CIS_up
PentachlorophenolTIMP2BSK_KF3CT_TIMP2_down
PentachlorophenolTP53ATG_p53_CIS_up
PentachlorophenolTP53TOX21_p53_BLA_p4_ratio
PentachlorophenolTP53TOX21_p53_BLA_p1_ratio
PentachlorophenolTP53TOX21_p53_BLA_p5_ratio
PentachlorophenolTP53TOX21_p53_BLA_p3_ratio
PentachlorophenolTP53TOX21_p53_BLA_p2_ratio
PentachlorophenolNR1H2ATG_DR4_LXR_CIS_dn
PentachlorophenolUSF1ATG_E_Box_CIS_up
PentachlorophenolVCAM1BSK_LPS_VCAM1_down
PentachlorophenolVCAM1BSK_3C_VCAM1_down
PentachlorophenolVCAM1BSK_4H_VCAM1_down
PentachlorophenolVCAM1BSK_hDFCGF_VCAM1_down
PentachlorophenolVDRATG_VDRE_CIS_up
PentachlorophenolVDRATG_VDR_TRANS_up
PentachlorophenolXBP1ATG_Xbp1_CIS_up
PentachlorophenolTCF7L1ATG_TCF_b_cat_CIS_dn
PentachlorophenolTFAP2DATG_AP_2_CIS_dn
PentachlorophenolNR1I2ATG_PXR_TRANS_up
PentachlorophenolNR1I2ATG_PXRE_CIS_up
PentachlorophenolCD38BSK_SAg_CD38_down
PentachlorophenolCD40BSK_SAg_CD40_down
PentachlorophenolCD40BSK_LPS_CD40_down
PentachlorophenolCD69BSK_SAg_CD69_down
PentachlorophenolNR1I3ATG_PBREM_CIS_up
PentachlorophenolNR1I3TOX21_CAR_Agonist
PentachlorophenolNR1H4ATG_FXR_TRANS_up
PentachlorophenolNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.