Toluene-2,4-diamine


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
100020791 ALDH1A4 Increases expression PMID:17070881
101 ADAM8 Increases expression PMID:20713471
10232 MSLN Increases expression PMID:20713471
1026 CDKN1A Increases expression PMID:17070881; PMID:20713471
10274 STAG1 Decreases expression PMID:20713471
10294 DNAJA2 Decreases expression PMID:22016648
10403 NDC80 Increases expression PMID:20713471
10404 CPQ Decreases expression PMID:17070881
10437 IFI30 Increases expression PMID:20713471
10457 GPNMB Increases expression PMID:20713471
10512 SEMA3C Decreases expression PMID:20713471
10615 SPAG5 Increases expression PMID:20713471
10635 RAD51AP1 Increases expression PMID:20713471
10935 PRDX3 Decreases expression PMID:22016648
11004 KIF2C Increases expression PMID:20713471
110454 LY6A Increases expression PMID:20713471
11065 UBE2C Increases expression PMID:20713471
11116 CEP43 Increases expression PMID:20713471
11186 RASSF1 Increases expression PMID:20713471
116496 NIBAN1 Increases expression PMID:20713471
117247 SLC16A10 Decreases expression PMID:17070881
11732 ANK Increases expression PMID:20713471
122769 LRR1 Increases expression PMID:20713471
124599 CD300LB Increases expression PMID:20713471
125972 CALR3 Increases expression PMID:20713471
1272 CNTN1 Increases expression PMID:20713471
128239 IQGAP3 Increases expression PMID:20713471
1290 COL5A2 Decreases expression PMID:20713471
130013 ACMSD Decreases expression PMID:17070881
13531 USP17LA Decreases expression PMID:20713471
13664 EIF1A Decreases expression PMID:20713471
1371 CPOX Increases expression PMID:20713471
1389 CREBL2 Increases expression PMID:20713471
1410 CRYAB Increases expression PMID:17070881
14325 FTL1 Increases expression PMID:22016648
144455 E2F7 Increases expression PMID:20713471
147495 APCDD1 Increases expression PMID:20713471
14958 H1F0 Decreases expression PMID:20713471
14964 H2-D1 Increases expression PMID:20713471
15081 H3F3B Decreases expression PMID:20713471
15122 HBA-A1 Increases expression PMID:20713471
1543 CYP1A1 Increases expression PMID:20713471; PMID:8685904
1544 CYP1A2 Increases expression PMID:8685904
1545 CYP1B1 Increases expression PMID:20713471
1647 GADD45A Increases expression PMID:20713471
1649 DDIT3 Increases expression PMID:22016648
1687 GSDME Increases expression PMID:20713471
171521 CYP2C13 Increases expression PMID:17070881
1728 NQO1 Increases expression PMID:20713471
17311 KITL Increases expression PMID:20713471
174 AFP Increases expression PMID:20713471
1758 DMP1 Increases expression PMID:20713471
1843 DUSP1 Increases expression PMID:20713471
1846 DUSP4 Increases expression PMID:20713471
1848 DUSP6 Increases expression PMID:20713471
18669 ABCB1B Increases expression PMID:17070881
2012 EMP1 Increases expression PMID:20713471
201562 HACD2 Decreases expression PMID:20713471
20210 SAA3 Increases expression PMID:22016648
2052 EPHX1 Increases expression PMID:17070881
20556 SLFN2 Increases expression PMID:20713471
2069 EREG Increases expression PMID:20713471
2115 ETV1 Increases expression PMID:20713471
2119 ETV5 Increases expression PMID:20713471
214 ALCAM Increases expression PMID:20713471
216 ALDH1A1 Increases expression PMID:17070881
2167 FABP4 Decreases expression PMID:22016648
218 ALDH3A1 Increases expression PMID:20713471
2181 ACSL3 Increases expression PMID:17070881
219132 PHF11D Increases expression PMID:20713471
22061 TRP63 Decreases expression PMID:20713471
2224 FDPS Decreases expression PMID:20713471
2272 FHIT Decreases expression PMID:17070881
227835 GTDC1 Decreases expression PMID:20713471
22977 AKR7A3 Increases expression PMID:17070881
23221 RHOBTB2 Increases expression PMID:17070881
23266 ADGRL2 Decreases expression PMID:20713471
23464 GCAT Increases expression PMID:20713471
23491 CES3 Increases expression PMID:20713471
23576 DDAH1 Increases expression PMID:17070881
23612 PHLDA3 Increases expression PMID:17070881
23624 CBLC Increases expression PMID:17070881
23645 PPP1R15A Increases expression PMID:20713471
236537 ZFP352 Decreases expression PMID:20713471
237886 SLFN9 Increases expression PMID:20713471
245109 ZSCAN4C Decreases expression PMID:20713471
2530 FUT8 Increases expression PMID:20713471
253017 TECRL Decreases expression PMID:20713471
255394 TCP11L2 Decreases expression PMID:20713471
258353 OR2AT1 Decreases expression PMID:17070881
25976 TIPARP Increases expression PMID:20713471
25994 HIGD1A Increases expression PMID:20713471
26011 TENM4 Increases expression PMID:20713471
2643 GCH1 Increases expression PMID:20713471
2644 GCHFR Increases expression PMID:20713471
26471 NUPR1 Affects expression PMID:17070881; PMID:20713471
26586 CKAP2 Increases expression PMID:20713471
2697 GJA1 Increases expression PMID:20713471
27316 RBMX Decreases expression PMID:20713471
2817 GPC1 Increases expression PMID:20713471
283431 GAS2L3 Increases expression PMID:20713471
286905 CYP4F5 Increases expression PMID:17070881
2892 GRIA3 Increases expression PMID:17070881
28951 TRIB2 Increases expression PMID:20713471
2944 GSTM1 Increases expression PMID:17070881
3014 H2AX Decreases expression PMID:20713471
3157 HMGCS1 Decreases expression PMID:20713471
3159 HMGA1 Increases expression PMID:20713471
3161 HMMR Increases expression PMID:20713471
3295 HSD17B4 Increases expression PMID:22016648
332 BIRC5 Increases expression PMID:20713471
3326 HSP90AB1 Decreases expression PMID:22016648
336 APOA2 Decreases expression PMID:17070881
337 APOA4 Decreases expression PMID:17070881
345 APOC3 Decreases expression PMID:17070881
3491 CCN1 Decreases expression PMID:20713471
3516 RBPJ Increases expression PMID:20713471
353322 ANKRD37 Decreases expression PMID:20713471
355 FAS Increases expression PMID:17070881
3559 IL2RA Increases expression PMID:17070881
3594 IL12RB1 Increases expression PMID:20713471
3604 TNFRSF9 Increases expression PMID:20713471
3720 JARID2 Decreases expression PMID:20713471
3725 JUN Increases expression PMID:20713471
3776 KCNK2 Increases expression PMID:20713471
3783 KCNN4 Increases expression PMID:20713471
378938 MALAT1 Increases expression PMID:20713471
3855 KRT7 Increases expression PMID:20713471
3957 LGALS2 Increases expression PMID:20713471
3976 LIF Increases expression PMID:20713471
4001 LMNB1 Increases expression PMID:20713471
4061 LY6E Increases expression PMID:20713471
4071 TM4SF1 Increases expression PMID:20713471
4072 EPCAM Increases expression PMID:17070881
4172 MCM3 Increases expression PMID:20713471
4174 MCM5 Increases expression PMID:20713471
4189 DNAJB9 Increases expression PMID:20713471
4255 MGMT Increases expression PMID:17070881; PMID:22084566
4314 MMP3 Increases expression PMID:20713471
4318 MMP9 Increases expression PMID:20713471
4322 MMP13 Increases expression PMID:20713471
4597 MVD Decreases expression PMID:20713471
4641 MYO1C Increases expression PMID:20713471
4689 NCF4 Increases expression PMID:20713471
4942 OAT Decreases expression PMID:22016648
4969 OGN Decreases expression PMID:20713471
5027 P2RX7 Decreases expression PMID:20713471
50484 RRM2B Increases expression PMID:21704725
5052 PRDX1 Increases expression PMID:22016648
5054 SERPINE1 Increases expression PMID:22016648
5099 PCDH7 Decreases expression PMID:20713471
51166 AADAT Increases expression PMID:22016648
51382 ATP6V1D Increases expression PMID:17070881
51512 GTSE1 Increases expression PMID:20713471
5224 PGAM2 Increases expression PMID:22016648
5251 PHEX Increases expression PMID:20713471
52673 TCSTV6A Decreases expression PMID:20713471
53827 FXYD5 Increases expression PMID:20713471
54192 PBSN Increases expression PMID:17070881
5422 POLA1 Increases expression PMID:20713471
54443 ANLN Increases expression PMID:20713471
54510 PCDH18 Decreases expression PMID:20713471
54829 ASPN Decreases expression PMID:20713471
54892 NCAPG2 Increases expression PMID:20713471
55080 TAPBPL Increases expression PMID:20713471
55143 CDCA8 Increases expression PMID:20713471
55144 LRRC8D Increases expression PMID:20713471
55220 KLHDC8A Increases expression PMID:20713471
55247 NEIL3 Increases expression PMID:20713471
55723 ASF1B Increases expression PMID:20713471
55789 DEPDC1B Increases expression PMID:20713471
55872 PBK Increases expression PMID:20713471
55959 SULF2 Increases expression PMID:17070881
56288 PARD3 Decreases expression PMID:20713471
56778 LY6C Increases expression PMID:20713471
5737 PTGFR Decreases expression PMID:20713471
57405 SPC25 Increases expression PMID:20713471
5743 PTGS2 Increases expression PMID:20713471
57561 ARRDC3 Increases expression PMID:20713471
5777 PTPN6 Increases expression PMID:20713471
5806 PTX3 Decreases expression PMID:20713471
581 BAX Increases expression PMID:17070881
5817 PVR Increases expression PMID:20713471
58504 ARHGAP22 Increases expression PMID:20713471
5888 RAD51 Increases expression PMID:20713471
59345 GNB4 Increases expression PMID:20713471
5935 RBM3 Increases expression PMID:20713471
5983 RFC3 Increases expression PMID:20713471
5984 RFC4 Increases expression PMID:20713471
60401 EDA2R Increases expression PMID:20713471
6241 RRM2 Increases expression PMID:20713471
6347 CCL2 Increases expression PMID:20713471
6355 CCL8 Increases expression PMID:20713471
6376 CX3CL1 Increases expression PMID:20713471
63979 FIGNL1 Increases expression PMID:20713471
64108 RTP4 Increases expression PMID:20713471
64393 ZMAT3 Increases expression PMID:17070881
6462 SHBG Increases expression PMID:3199457
64782 AEN Increases expression PMID:17070881
653145 ANXA8 Increases expression PMID:20713471
6590 SLPI Increases expression PMID:20713471
6647 SOD1 Decreases expression PMID:22016648
6690 SPINK1 Decreases expression PMID:17070881
6713 SQLE Decreases expression PMID:20713471
6822 SULT2A1 Decreases expression PMID:17070881
6906 SERPINA7 Increases expression PMID:17070881
7077 TIMP2 Decreases expression PMID:22016648
7083 TK1 Increases expression PMID:20713471
7103 TSPAN8 Increases expression PMID:20713471
7139 TNNT2 Increases expression PMID:20713471
7153 TOP2A Increases expression PMID:20713471
716 C1S Increases expression PMID:20713471
7163 TPD52 Increases expression PMID:20713471
730 C7 Increases expression PMID:17070881
7378 UPP1 Increases expression PMID:20713471
7498 XDH Increases expression PMID:20713471
7832 BTG2 Increases expression PMID:17070881; PMID:20713471
79094 CHAC1 Increases expression PMID:20713471
79682 CENPU Increases expression PMID:20713471
79733 E2F8 Increases expression PMID:20713471
79783 SUGCT Decreases expression PMID:17070881
79801 SHCBP1 Increases expression PMID:20713471
80031 SEMA6D Increases expression PMID:20713471
80349 SKIC8 Increases expression PMID:20713471
80381 CD276 Increases expression PMID:17070881
8061 FOSL1 Increases expression PMID:20713471
8091 HMGA2 Increases expression PMID:20713471
81030 ZBP1 Increases expression PMID:20713471
81572 PDRG1 Increases expression PMID:20713471
81620 CDT1 Increases expression PMID:20713471
8294 H4C9 Decreases expression PMID:20713471
8318 CDC45 Increases expression PMID:20713471
836 CASP3 Increases expression PMID:20713471
8365 H4C8 Decreases expression PMID:20713471
84296 GINS4 Increases expression PMID:20713471
8438 RAD54L Increases expression PMID:20713471
8445 DYRK2 Decreases expression PMID:20713471
84456 L3MBTL3 Decreases expression PMID:20713471
84722 PSRC1 Increases expression PMID:20713471
8482 SEMA7A Increases expression PMID:20713471
8630 HSD17B6 Decreases expression PMID:17070881
8732 RNGTT Decreases expression PMID:20713471
8870 IER3 Increases expression PMID:20713471
890 CCNA2 Increases expression PMID:20713471
900 CCNG1 Increases expression PMID:17070881
9037 SEMA5A Increases expression PMID:20713471
90637 ZFAND2A Increases expression PMID:20713471
9096 TBX18 Decreases expression PMID:20713471
9120 SLC16A6 Increases expression PMID:20713471
9133 CCNB2 Increases expression PMID:20713471
91543 RSAD2 Increases expression PMID:20713471
9156 EXO1 Increases expression PMID:20713471
9173 IL1RL1 Increases expression PMID:20713471
9221 NOLC1 Increases expression PMID:20713471
9315 NREP Decreases expression PMID:20713471
93893 PCDHB22 Decreases expression PMID:20713471
94103 ORMDL3 Increases expression PMID:20713471
9507 ADAMTS4 Increases expression PMID:20713471
9510 ADAMTS1 Decreases expression PMID:20713471
962 CD48 Increases expression PMID:20713471
9700 ESPL1 Increases expression PMID:20713471
978 CDA Increases expression PMID:20713471
9824 ARHGAP11A Increases expression PMID:20713471
990 CDC6 Increases expression PMID:20713471
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.