DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Cyclophosphamide

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000086	G2/m transition of mitotic cell cycle	Increases phenotype	PMID:32087850
GO:0000104	Succinate dehydrogenase activity	Decreases phenotype	PMID:36198566
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:3657842
GO:0000902	Cell morphogenesis	Decreases phenotype	PMID:34715073
GO:0001541	Ovarian follicle development	Decreases phenotype	PMID:31557371; PMID:35429547; PMID:36154502; PMID:39952379
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:31557371; PMID:38825044; PMID:39952379
GO:0002260	Lymphocyte homeostasis	Affects phenotype	PMID:29168405
GO:0002446	Neutrophil mediated immunity	Decreases phenotype	PMID:37853057
GO:0002449	Lymphocyte mediated immunity	Decreases phenotype	PMID:37853057
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:30506662; PMID:32456565; PMID:35762198; PMID:36154502; PMID:36198566; PMID:37690746
GO:0002526	Acute inflammatory response	Increases phenotype	PMID:22099998
GO:0002690	Positive regulation of leukocyte chemotaxis	Increases phenotype	PMID:23666265
GO:0003810	Protein-glutamine gamma-glutamyltransferase activity	Affects phenotype	PMID:33992719
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:23488790
GO:0004035	Alkaline phosphatase activity	Affects phenotype	PMID:29753871; PMID:33992719; PMID:33992719; PMID:34748891; PMID:34748891
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Affects phenotype	PMID:29753871; PMID:29753871; PMID:30506662; PMID:30506662; PMID:33992719; PMID:33992719; PMID:34748891; PMID:34748891
GO:0004096	Catalase activity	Decreases phenotype	PMID:39952379
GO:0004129	Cytochrome-c oxidase activity	Decreases phenotype	PMID:36198566
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:26615121; PMID:33992719; PMID:34748891
GO:0004457	Lactate dehydrogenase activity	Affects phenotype	PMID:32197949; PMID:33992719
GO:0004591	Oxoglutarate dehydrogenase (succinyl-transferring) activity	Decreases phenotype	PMID:36198566
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:25753322; PMID:25753322; PMID:33992719; PMID:34748891; PMID:29753871; PMID:33992719; PMID:34748891; PMID:34748891; PMID:36198566; PMID:36198566
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:26615121; PMID:29753871; PMID:32456565; PMID:34748891; PMID:34748891; PMID:36198566; PMID:35762198; PMID:36198566; PMID:38278497; PMID:38740238; PMID:39952379
GO:0004833	Tryptophan 2,3-dioxygenase activity	Increases phenotype	PMID:34748891
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:23542512
GO:0006182	Cgmp biosynthetic process	Decreases phenotype	PMID:37263553
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:10393266; PMID:11723234
GO:0006533	Aspartate catabolic process	Affects phenotype	PMID:23542512
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:23542512; PMID:29168405; PMID:32197949; PMID:32456565; PMID:33992719; PMID:33992719; PMID:34748891; PMID:34748891; PMID:35762198; PMID:38278497; PMID:39952379
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:25753322; PMID:26615121; PMID:29753871; PMID:37419146
GO:0006829	Zinc ion transport	Increases phenotype	PMID:27281708
GO:0006915	Apoptotic process	Increases phenotype	PMID:10393266; PMID:10766175; PMID:11723234; PMID:12227071; PMID:15217956; PMID:15582267; PMID:16166447; PMID:17434952; PMID:20417958; PMID:17898787; PMID:18034189; PMID:18202011; PMID:18339125; PMID:20417958; PMID:20665104; PMID:21315284; PMID:25779342; PMID:29168405; PMID:32846153; PMID:34658283; PMID:36154502; PMID:36941454; PMID:39079574; PMID:8870961; PMID:9166702; PMID:9764839
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:23702825; PMID:34627991; PMID:30842367; PMID:31479713; PMID:32846153; PMID:32846153; PMID:34627991; PMID:34762139
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:19539803; PMID:19539803; PMID:23542512; PMID:20661687; PMID:23542512; PMID:31779506
GO:0007049	Cell cycle	Affects phenotype	PMID:2492079
GO:0007137	Meiotic metaphase ii	Decreases phenotype	PMID:35429547
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:32197949
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:34715073; PMID:34715073; PMID:39079574; PMID:36063855; PMID:39079574; PMID:6788612; PMID:8312451
GO:0007286	Spermatid development	Decreases phenotype	PMID:27466211; PMID:32197949
GO:0007613	Memory	Decreases phenotype	PMID:37419146
GO:0007616	Long-term memory	Decreases phenotype	PMID:31651976
GO:0008121	Ubiquinol-cytochrome-c reductase activity	Decreases phenotype	PMID:36198566
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:36198566
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:36198566
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:32456565; PMID:32456565; PMID:36154502; PMID:36154502; PMID:39952379
GO:0008234	Cysteine-type peptidase activity	Increases phenotype	PMID:36941454
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:10766175; PMID:17898787; PMID:18202011; PMID:18339125; PMID:31587870; PMID:36154502; PMID:8312451; PMID:9200187
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:10601799; PMID:30500380; PMID:30500380; PMID:33811995; PMID:32505695; PMID:33811995
GO:0009566	Fertilization	Decreases phenotype	PMID:31557371; PMID:31557371; PMID:39079574; PMID:39079574
GO:0009790	Embryo development	Decreases phenotype	PMID:31557371
GO:0010692	Regulation of alkaline phosphatase activity	Affects phenotype	PMID:23542512
GO:0010694	Positive regulation of alkaline phosphatase activity	Increases phenotype	PMID:23488790
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:37955270
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25860621; PMID:27633142; PMID:27836570; PMID:32197949
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:26615121; PMID:29168405; PMID:29753871; PMID:32615180; PMID:33992719; PMID:33992719; PMID:34748891; PMID:34748891; PMID:35762198; PMID:36031164
GO:0016049	Cell growth	Decreases phenotype	PMID:34658283; PMID:39426530
GO:0016209	Antioxidant activity	Decreases phenotype	PMID:37419146; PMID:38211767
GO:0016477	Cell migration	Decreases phenotype	PMID:34658283
GO:0016615	Malate dehydrogenase activity	Decreases phenotype	PMID:36198566
GO:0016788	Hydrolase activity, acting on ester bonds	Decreases phenotype	PMID:25082528
GO:0018158	Protein oxidation	Increases phenotype	PMID:29168405; PMID:32197949; PMID:34715073; PMID:37690746
GO:0019233	Sensory perception of pain	Increases phenotype	PMID:29129814
GO:0019471	4-hydroxyproline metabolic process	Affects phenotype	PMID:33737140
GO:0019481	L-alanine catabolic process, by transamination	Affects phenotype	PMID:23542512
GO:0019627	Urea metabolic process	Affects phenotype	PMID:36198566
GO:0020027	Hemoglobin metabolic process	Affects phenotype	PMID:32129080
GO:0030154	Cell differentiation	Increases phenotype	PMID:18339125
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:38278497
GO:0030218	Erythrocyte differentiation	Affects phenotype	PMID:32129080
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:38278497; PMID:39209270
GO:0031052	Programmed dna elimination by chromosome breakage	Increases phenotype	PMID:30439388
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:29445054
GO:0031987	Locomotion involved in locomotory behavior	Decreases phenotype	PMID:39209270
GO:0032125	Micronucleus organization	Increases phenotype	PMID:23702825; PMID:30842367; PMID:30944280; PMID:31479713; PMID:32087850; PMID:32846153; PMID:34762139; PMID:35568224
GO:0033754	Indoleamine 2,3-dioxygenase activity	Increases phenotype	PMID:34748891
GO:0033764	Steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor	Decreases phenotype	PMID:32197949
GO:0034101	Erythrocyte homeostasis	Affects phenotype	PMID:32129080
GO:0034440	Lipid oxidation	Increases phenotype	PMID:23542512; PMID:25446862; PMID:25451569; PMID:32456565; PMID:34715073; PMID:36198566; PMID:37690746; PMID:38278497; PMID:38740238; PMID:39952379
GO:0034976	Response to endoplasmic reticulum stress	Increases phenotype	PMID:36063855
GO:0035092	Sperm dna condensation	Decreases phenotype	PMID:34715073
GO:0035126	Post-embryonic genitalia morphogenesis	Decreases phenotype	PMID:34715073
GO:0035696	Monocyte extravasation	Increases phenotype	PMID:36031164
GO:0042310	Vasoconstriction	Increases phenotype	PMID:39378958
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:34748891
GO:0042448	Progesterone metabolic process	Affects phenotype	PMID:36154502
GO:0042585	Germinal vesicle	Affects phenotype	PMID:35429547
GO:0042640	Anagen	Decreases phenotype	PMID:30760223
GO:0042743	Hydrogen peroxide metabolic process	Affects phenotype	PMID:23488790
GO:0042770	Signal transduction in response to dna damage	Increases phenotype	PMID:30500380
GO:0042994	Cytoplasmic sequestering of transcription factor	Increases phenotype	PMID:32197949
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:22010212; PMID:30500380; PMID:37263553; PMID:37419146
GO:0043114	Regulation of vascular permeability	Affects phenotype	PMID:39378958
GO:0043117	Positive regulation of vascular permeability	Increases phenotype	PMID:39378958
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:31479713; PMID:31587870; PMID:32846153; PMID:33737021; PMID:34658283; PMID:38740238
GO:0045123	Cellular extravasation	Increases phenotype	PMID:36031164
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:37419146; PMID:38211767; PMID:38825044
GO:0045820	Negative regulation of glycolytic process	Affects phenotype	PMID:32197949
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:32087850
GO:0046058	Camp metabolic process	Affects phenotype	PMID:32456565
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:32456565; PMID:33992719; PMID:34748891; PMID:34748891; PMID:38278497
GO:0046370	Fructose biosynthetic process	Decreases phenotype	PMID:39239657
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:36198566
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:14641813; PMID:20621952; PMID:31779506; PMID:20661687; PMID:23488790; PMID:31779506; PMID:3435898; PMID:35906875; PMID:37419146
GO:0046620	Regulation of organ growth	Decreases phenotype	PMID:10393266
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:32197949; PMID:34715073
GO:0046882	Negative regulation of follicle-stimulating hormone secretion	Increases phenotype	PMID:39239657
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:37419146
GO:0050890	Cognition	Decreases phenotype	PMID:39209270
GO:0050996	Positive regulation of lipid catabolic process	Increases phenotype	PMID:37263553; PMID:38211767
GO:0051301	Cell division	Decreases phenotype	PMID:34425170
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:36198566
GO:0051899	Membrane depolarization	Increases phenotype	PMID:36198566
GO:0055072	Iron ion homeostasis	Affects phenotype	PMID:32129080
GO:0060073	Micturition	Increases phenotype	PMID:32615180
GO:0060326	Cell chemotaxis	Decreases phenotype	PMID:34658283
GO:0061002	Negative regulation of dendritic spine morphogenesis	Increases phenotype	PMID:29228376
GO:0061003	Positive regulation of dendritic spine morphogenesis	Increases phenotype	PMID:31651976
GO:0061366	Behavioral response to chemical pain	Increases phenotype	PMID:16450293; PMID:16450293; PMID:29129814; PMID:29129814
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:39079574
GO:0061518	Microglial cell proliferation	Increases phenotype	PMID:11276054
GO:0070141	Response to uv-a	Increases phenotype	PMID:2018979
GO:0070265	Necrotic cell death	Increases phenotype	PMID:30506662; PMID:32846153; PMID:35762198
GO:0070341	Fat cell proliferation	Increases phenotype	PMID:38348709
GO:0070665	Positive regulation of leukocyte proliferation	Decreases phenotype	PMID:27737899
GO:0070962	Positive regulation of neutrophil mediated killing of bacterium	Decreases phenotype	PMID:27737899
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:37690746; PMID:38740238; PMID:39209270
GO:0071425	Hematopoietic stem cell proliferation	Decreases phenotype	PMID:38348709
GO:0071838	Cell proliferation in bone marrow	Decreases phenotype	PMID:38348709
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:23488790; PMID:36198566; PMID:37863343; PMID:39952379
GO:0097327	Response to antineoplastic agent	Decreases phenotype	PMID:25351371
GO:0140591	Nuclear envelope budding	Increases phenotype	PMID:35568224
GO:0150020	Basal dendrite arborization	Decreases phenotype	PMID:31651976
GO:0150023	Apical dendrite arborization	Decreases phenotype	PMID:31651976
GO:1901224	Positive regulation of nik/nf-kappab signaling	Increases phenotype	PMID:22099998
GO:1901318	Negative regulation of flagellated sperm motility	Increases phenotype	PMID:32197949; PMID:34715073
GO:1901670	Negative regulation of superoxide dismutase activity	Affects phenotype	PMID:23542512
GO:1901671	Positive regulation of superoxide dismutase activity	Affects phenotype	PMID:25451569
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:25446862; PMID:27303909; PMID:34715073
GO:1902552	Negative regulation of catalase activity	Affects phenotype	PMID:23542512
GO:1903223	Positive regulation of oxidative stress-induced neuron death	Increases phenotype	PMID:37419146
GO:1903284	Positive regulation of glutathione peroxidase activity	Decreases phenotype	PMID:25446862
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:31557371
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:32197949; PMID:37419146
GO:1903787	Negative regulation of glutathione biosynthetic process	Increases phenotype	PMID:38211767
GO:1904808	Positive regulation of protein oxidation	Increases phenotype	PMID:23488790
GO:1905628	Negative regulation of serotonin biosynthetic process	Increases phenotype	PMID:37419146
GO:1990414	Replication-born double-strand break repair via sister chromatid exchange	Increases phenotype	PMID:22342611
GO:2000180	Negative regulation of androgen biosynthetic process	Affects phenotype	PMID:32197949
GO:2000355	Negative regulation of ovarian follicle development	Increases phenotype	PMID:38825044
GO:2000379	Positive regulation of reactive oxygen species metabolic process	Affects phenotype	PMID:23542512
GO:2000387	Regulation of antral ovarian follicle growth	Decreases phenotype	PMID:38825044
GO:2000391	Positive regulation of neutrophil extravasation	Increases phenotype	PMID:25451569
GO:2000844	Negative regulation of testosterone secretion	Increases phenotype	PMID:32197949; PMID:39239657
GO:2000845	Positive regulation of testosterone secretion	Decreases phenotype	PMID:25446862
GO:2000865	Negative regulation of estradiol secretion	Increases phenotype	PMID:39239657
GO:2000866	Positive regulation of estradiol secretion	Increases phenotype	PMID:39239657
GO:2001057	Reactive nitrogen species metabolic process	Affects phenotype	PMID:32615180
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:30500380
GO:2001290	Hydroperoxide metabolic process	Affects phenotype	PMID:33992719

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