Dichlorvos


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001774 Microglial cell activation Increases phenotype PMID:24369695
GO:0001809 Positive regulation of type iv hypersensitivity Decreases phenotype PMID:14631503
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24369695
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Affects phenotype PMID:39733793
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:39733793
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Affects phenotype PMID:39733793
GO:0004096 Catalase activity Decreases phenotype PMID:39733793
GO:0004364 Glutathione transferase activity Increases phenotype PMID:25895260
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:39733793
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:25895260; PMID:27180203; PMID:39733793
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:25895260; PMID:27180203; PMID:29098328; PMID:39733793
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:39733793
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:39733793
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:39733793
GO:0006749 Glutathione metabolic process Increases phenotype PMID:25891459; PMID:29143438; PMID:39733793
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:24231740; PMID:25895260; PMID:27180203
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:24231740
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24369695
GO:0006915 Apoptotic process Increases phenotype PMID:27365043
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:24231740; PMID:24369695
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:39733793
GO:0008219 Cell death Increases phenotype PMID:24231740
GO:0008283 Cell population proliferation Decreases phenotype PMID:24231740
GO:0009449 Gamma-aminobutyric acid biosynthetic process Decreases phenotype PMID:27899289
GO:0010942 Positive regulation of cell death Increases phenotype PMID:29143438; PMID:29893964; PMID:40434365
GO:0010960 Magnesium ion homeostasis Affects phenotype PMID:39733793
GO:0016042 Lipid catabolic process Increases phenotype PMID:24231740; PMID:25895260; PMID:27180203; PMID:29098328
GO:0018158 Protein oxidation Increases phenotype PMID:27180203
GO:0034440 Lipid oxidation Increases phenotype PMID:25891459; PMID:26814074; PMID:29143438; PMID:39733793
GO:0035399 Helper t cell enhancement of b cell mediated immune response Decreases phenotype PMID:14631503
GO:0036211 Protein modification process Increases phenotype PMID:24231740
GO:0042427 Serotonin biosynthetic process Increases phenotype PMID:27899289
GO:0042554 Superoxide anion generation Increases phenotype PMID:29098328
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:39733793
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:26814074; PMID:29893964
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:24369695; PMID:29893964
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:39733793
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:33574433
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:24231740
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:29143438
GO:0055064 Chloride ion homeostasis Affects phenotype PMID:39733793
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:39733793
GO:0055075 Potassium ion homeostasis Affects phenotype PMID:39733793
GO:0055078 Sodium ion homeostasis Affects phenotype PMID:39733793
GO:0055081 Monoatomic anion homeostasis Affects phenotype PMID:39733793
GO:0070265 Necrotic cell death Increases phenotype PMID:39733793
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24231740
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24231740
GO:0097214 Positive regulation of lysosomal membrane permeability Increases phenotype PMID:29143438
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:29143438
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:25891459; PMID:26814074
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:29143438
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24369695; PMID:25895260
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29143438; PMID:29893964
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.