DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Valproic acid

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000085	Mitotic g2 phase	Decreases phenotype	PMID:23527032
GO:0000226	Microtubule cytoskeleton organization	Decreases phenotype	PMID:33823148
GO:0000724	Double-strand break repair via homologous recombination	Increases phenotype	PMID:24913804
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:24812151
GO:0001678	Cellular glucose homeostasis	Affects phenotype	PMID:38296531
GO:0001755	Neural crest cell migration	Decreases phenotype	PMID:26238599
GO:0001893	Maternal placenta development	Decreases phenotype	PMID:32437819
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:24812151; PMID:34420476
GO:0002539	Prostaglandin production involved in inflammatory response	Increases phenotype	PMID:33823148
GO:0003810	Protein-glutamine gamma-glutamyltransferase activity	Decreases phenotype	PMID:34420476
GO:0004032	Alditol:nadp+ 1-oxidoreductase activity	Increases phenotype	PMID:25504687
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:25304967
GO:0004053	Arginase activity	Increases phenotype	PMID:34309930
GO:0004063	Aryldialkylphosphatase activity	Decreases phenotype	PMID:32662911
GO:0004089	Carbonate dehydratase activity	Decreases phenotype	PMID:34309930
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:25304967; PMID:25504687; PMID:32662911
GO:0004396	Hexokinase activity	Decreases phenotype	PMID:28266800
GO:0004402	Histone acetyltransferase activity	Decreases phenotype	PMID:27381264
GO:0004407	Histone deacetylase activity	Decreases phenotype	PMID:33770205
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:34309930; PMID:34309959
GO:0004602	Glutathione peroxidase activity	Affects phenotype	PMID:25504687; PMID:28988495; PMID:31760073; PMID:32662911; PMID:34309930; PMID:34309959; PMID:34420476
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:25504687; PMID:28988495; PMID:34309930; PMID:34309959; PMID:34420476; PMID:35090963
GO:0005249	Voltage-gated potassium channel activity	Decreases phenotype	PMID:26348896
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:32662911
GO:0006054	N-acetylneuraminate metabolic process	Affects phenotype	PMID:25304967
GO:0006099	Tricarboxylic acid cycle	Decreases phenotype	PMID:24442146
GO:0006304	Dna modification	Increases phenotype	PMID:30404997
GO:0006306	Dna methylation	Affects phenotype	PMID:28853863
GO:0006309	Apoptotic dna fragmentation	Affects phenotype	PMID:19060243; PMID:22814014
GO:0006536	Glutamate metabolic process	Affects phenotype	PMID:37357844
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:35156134
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:33007364; PMID:33007364; PMID:39147356; PMID:33901630; PMID:34778935; PMID:39147356; PMID:39423997
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:25504687; PMID:26921665; PMID:29968957; PMID:30273971; PMID:32662911; PMID:32662911; PMID:34309959; PMID:33007364; PMID:34309930; PMID:34309959; PMID:37357844
GO:0006750	Glutathione biosynthetic process	Affects phenotype	PMID:30426164
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:25716160
GO:0006776	Vitamin a metabolic process	Affects phenotype	PMID:35594946
GO:0006805	Xenobiotic metabolic process	Affects phenotype	PMID:25745819
GO:0006811	Monoatomic ion transport	Increases phenotype	PMID:2167745
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:34748853; PMID:35156134
GO:0006879	Cellular iron ion homeostasis	Affects phenotype	PMID:39147356
GO:0006915	Apoptotic process	Affects phenotype	PMID:11281642; PMID:17653085; PMID:19006566; PMID:19060243; PMID:19351772; PMID:21067264; PMID:21737646; PMID:24812151; PMID:25130820; PMID:26865186; PMID:29225137; PMID:32167238; PMID:34658283
GO:0006935	Chemotaxis	Decreases phenotype	PMID:29845424
GO:0006954	Inflammatory response	Increases phenotype	PMID:17994530
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:29845424
GO:0006979	Response to oxidative stress	Affects phenotype	PMID:19006566; PMID:19351772; PMID:20679181
GO:0007049	Cell cycle	Decreases phenotype	PMID:17653085; PMID:19351772; PMID:21737646
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:28762043
GO:0007625	Grooming behavior	Decreases phenotype	PMID:35254616; PMID:37207798
GO:0007631	Feeding behavior	Affects phenotype	PMID:31085223
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:31760073
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:31760073
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:33007364; PMID:33007364; PMID:39147356; PMID:39147356
GO:0008217	Regulation of blood pressure	Decreases phenotype	PMID:20679181
GO:0008219	Cell death	Increases phenotype	PMID:17184924; PMID:17479365; PMID:22131109; PMID:26378038
GO:0008283	Cell population proliferation	Increases phenotype	PMID:17351657; PMID:17994530; PMID:19099629; PMID:25130820; PMID:19351772; PMID:19440698; PMID:20646843; PMID:21067264; PMID:21737646; PMID:23562654; PMID:25130820; PMID:25137620; PMID:31711903; PMID:33991534; PMID:34420476
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:25815518
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:22580532; PMID:32949729; PMID:34537371; PMID:34742744; PMID:37210002
GO:0008344	Adult locomotory behavior	Decreases phenotype	PMID:29778792
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:25716160; PMID:27089845; PMID:30426164
GO:0008611	Ether lipid biosynthetic process	Decreases phenotype	PMID:29877216
GO:0008652	Amino acid biosynthetic process	Decreases phenotype	PMID:24442146
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:25745980
GO:0009100	Glycoprotein metabolic process	Affects phenotype	PMID:34309930
GO:0009410	Response to xenobiotic stimulus	Increases phenotype	PMID:34537371
GO:0009448	Gamma-aminobutyric acid metabolic process	Affects phenotype	PMID:37357844
GO:0009636	Response to toxic substance	Affects phenotype	PMID:23179753
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:25446377
GO:0010884	Positive regulation of lipid storage	Increases phenotype	PMID:28762043
GO:0010918	Positive regulation of mitochondrial membrane potential	Affects phenotype	PMID:25446377; PMID:25745980; PMID:28762043
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:35543257
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:22580532; PMID:25446377; PMID:25745980; PMID:27015953; PMID:28001369; PMID:28762043
GO:0010977	Negative regulation of neuron projection development	Increases phenotype	PMID:29261810; PMID:30578912
GO:0014045	Establishment of endothelial blood-brain barrier	Decreases phenotype	PMID:32240654
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28988495; PMID:31760073; PMID:32662911; PMID:33007364; PMID:34309930
GO:0016049	Cell growth	Decreases phenotype	PMID:23562654; PMID:25091725; PMID:29225137; PMID:29845424; PMID:30426164
GO:0016477	Cell migration	Decreases phenotype	PMID:29845424; PMID:34658283
GO:0016505	Peptidase activator activity involved in apoptotic process	Increases phenotype	PMID:24913804
GO:0016525	Negative regulation of angiogenesis	Increases phenotype	PMID:37207908
GO:0018158	Protein oxidation	Increases phenotype	PMID:31760073; PMID:32662911; PMID:32662911; PMID:34309959; PMID:34309930; PMID:34309959
GO:0019226	Transmission of nerve impulse	Increases phenotype	PMID:26348896
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:30003287
GO:0021542	Dentate gyrus development	Affects phenotype	PMID:33150595
GO:0030154	Cell differentiation	Increases phenotype	PMID:23562654; PMID:31711903
GO:0030182	Neuron differentiation	Decreases phenotype	PMID:22131109; PMID:29775723
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:24812151; PMID:34309930
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:29225137
GO:0030308	Negative regulation of cell growth	Increases phenotype	PMID:37210002
GO:0031987	Locomotion involved in locomotory behavior	Increases phenotype	PMID:31760073; PMID:37357844
GO:0032000	Positive regulation of fatty acid beta-oxidation	Decreases phenotype	PMID:24442146
GO:0032922	Circadian regulation of gene expression	Increases phenotype	PMID:29229235
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:28762043
GO:0034440	Lipid oxidation	Increases phenotype	PMID:25304967; PMID:25504687; PMID:29968957; PMID:30273971; PMID:37357844
GO:0035176	Social behavior	Decreases phenotype	PMID:29427782; PMID:29510222; PMID:30404997; PMID:32526256; PMID:35594946; PMID:37357844; PMID:29510222; PMID:32526256; PMID:35254616; PMID:35594946; PMID:36535311; PMID:37207798; PMID:37357844
GO:0035640	Exploration behavior	Decreases phenotype	PMID:32526256; PMID:35594946; PMID:35594946
GO:0035733	Hepatic stellate cell activation	Increases phenotype	PMID:24812151
GO:0035815	Positive regulation of renal sodium excretion	Increases phenotype	PMID:28693025
GO:0035936	Testosterone secretion	Decreases phenotype	PMID:37505509
GO:0036268	Swimming	Decreases phenotype	PMID:29427782
GO:0036444	Calcium import into the mitochondrion	Increases phenotype	PMID:31760073
GO:0040018	Positive regulation of multicellular organism growth	Decreases phenotype	PMID:29427782; PMID:32437819
GO:0042116	Macrophage activation	Increases phenotype	PMID:28184907
GO:0042129	Regulation of t cell proliferation	Affects phenotype	PMID:35090963
GO:0042267	Natural killer cell mediated cytotoxicity	Increases phenotype	PMID:32060585
GO:0042307	Positive regulation of protein import into nucleus	Decreases phenotype	PMID:24154490
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:30426164
GO:0042572	Retinol metabolic process	Affects phenotype	PMID:32526256
GO:0042756	Drinking behavior	Affects phenotype	PMID:31085223
GO:0042919	Benzoate transport	Decreases phenotype	PMID:8140053
GO:0043005	Neuron projection	Decreases phenotype	PMID:37210002
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:25815518; PMID:28762043; PMID:34742744
GO:0043966	Histone h3 acetylation	Affects phenotype	PMID:22711276; PMID:22723015; PMID:23378038; PMID:24200999; PMID:25769527; PMID:25815518; PMID:27237783; PMID:28743636; PMID:29225137; PMID:29778792; PMID:29845424; PMID:30897286
GO:0043967	Histone h4 acetylation	Affects phenotype	PMID:24200999; PMID:25769527; PMID:26378038; PMID:29778792; PMID:29845424
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:32167238; PMID:32623605; PMID:33007364; PMID:33901630; PMID:34658283; PMID:34748853; PMID:38296531
GO:0045176	Apical protein localization	Decreases phenotype	PMID:31368504
GO:0045333	Cellular respiration	Decreases phenotype	PMID:32623605
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:30273971
GO:0045651	Positive regulation of macrophage differentiation	Increases phenotype	PMID:28184907
GO:0045665	Negative regulation of neuron differentiation	Increases phenotype	PMID:29261810
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:22580532; PMID:29845424
GO:0046034	Atp metabolic process	Affects phenotype	PMID:32949729; PMID:35090963
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:28988495; PMID:32662911; PMID:34309930
GO:0046323	Glucose import	Increases phenotype	PMID:38296531
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:23378038
GO:0046415	Urate metabolic process	Decreases phenotype	PMID:29968957
GO:0046449	Creatinine metabolic process	Decreases phenotype	PMID:17994530; PMID:29968957
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:35543257
GO:0047833	D-sorbitol dehydrogenase (acceptor) activity	Increases phenotype	PMID:25504687
GO:0048021	Regulation of melanin biosynthetic process	Affects phenotype	PMID:23001511
GO:0048060	Negative gravitaxis	Decreases phenotype	PMID:29427782
GO:0048266	Behavioral response to pain	Decreases phenotype	PMID:37357844
GO:0048312	Intracellular distribution of mitochondria	Affects phenotype	PMID:25446377
GO:0048386	Positive regulation of retinoic acid receptor signaling pathway	Decreases phenotype	PMID:27693483
GO:0048666	Neuron development	Decreases phenotype	PMID:35254616
GO:0048672	Positive regulation of collateral sprouting	Increases phenotype	PMID:23378038
GO:0048863	Stem cell differentiation	Decreases phenotype	PMID:25393219; PMID:32205227
GO:0048872	Homeostasis of number of cells	Affects phenotype	PMID:23527032
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:35543257
GO:0050767	Regulation of neurogenesis	Affects phenotype	PMID:23527032
GO:0050768	Negative regulation of neurogenesis	Affects phenotype	PMID:24896083
GO:0050885	Neuromuscular process controlling balance	Affects phenotype	PMID:37357844
GO:0051149	Positive regulation of muscle cell differentiation	Affects phenotype	PMID:24896083
GO:0051402	Neuron apoptotic process	Increases phenotype	PMID:37357844
GO:0051881	Regulation of mitochondrial membrane potential	Decreases phenotype	PMID:19060243; PMID:27089845; PMID:30426164; PMID:31760073
GO:0051897	Positive regulation of protein kinase b signaling	Decreases phenotype	PMID:25453207
GO:0051938	L-glutamate import	Affects phenotype	PMID:29778792
GO:0055007	Cardiac muscle cell differentiation	Decreases phenotype	PMID:31445079
GO:0055072	Iron ion homeostasis	Affects phenotype	PMID:39147356
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:30426164
GO:0055078	Sodium ion homeostasis	Increases phenotype	PMID:28693025
GO:0060135	Maternal process involved in female pregnancy	Decreases phenotype	PMID:32437819
GO:0060322	Head development	Affects phenotype	PMID:28635121
GO:0060326	Cell chemotaxis	Decreases phenotype	PMID:34658283
GO:0061029	Eyelid development in camera-type eye	Decreases phenotype	PMID:29427782
GO:0061518	Microglial cell proliferation	Increases phenotype	PMID:33823148
GO:0061744	Motor behavior	Affects phenotype	PMID:33991534
GO:0061890	Positive regulation of astrocyte activation	Increases phenotype	PMID:33823148
GO:0070265	Necrotic cell death	Increases phenotype	PMID:17994530; PMID:34420476; PMID:24812151; PMID:34420476
GO:0070368	Positive regulation of hepatocyte differentiation	Increases phenotype	PMID:25084468
GO:0070577	Lysine-acetylated histone binding	Increases phenotype	PMID:28743636
GO:0070633	Transepithelial transport	Decreases phenotype	PMID:8140053
GO:0070932	Histone h3 deacetylation	Decreases phenotype	PMID:29229235
GO:0070933	Histone h4 deacetylation	Decreases phenotype	PMID:29229235
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:24486436; PMID:35090963; PMID:39147356
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:32167238; PMID:33007364; PMID:34309930; PMID:34309959; PMID:34748853; PMID:35156134
GO:0090326	Positive regulation of locomotion involved in locomotory behavior	Decreases phenotype	PMID:28610743
GO:0090398	Cellular senescence	Increases phenotype	PMID:21067264
GO:0090557	Establishment of endothelial intestinal barrier	Decreases phenotype	PMID:32240654
GO:0090648	Response to environmental enrichment	Decreases phenotype	PMID:30404997
GO:0099610	Action potential initiation	Decreases phenotype	PMID:36375636
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:33007364; PMID:33007364; PMID:39147356; PMID:33901630; PMID:33901630; PMID:39147356; PMID:37046073; PMID:39147356
GO:0140059	Dendrite arborization	Decreases phenotype	PMID:33991534
GO:0140253	Cell-cell fusion	Increases phenotype	PMID:37385477
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:32240654
GO:1900111	Positive regulation of histone h3-k9 dimethylation	Decreases phenotype	PMID:25815518
GO:1900535	Palmitic acid biosynthetic process	Increases phenotype	PMID:30003287
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:23378038
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:24896083; PMID:33823148
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:30273971
GO:1901726	Negative regulation of histone deacetylase activity	Increases phenotype	PMID:24896083; PMID:27693483
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:27089845; PMID:27381264; PMID:30426164; PMID:31760073
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Affects phenotype	PMID:25745980; PMID:28762043
GO:1903980	Positive regulation of microglial cell activation	Increases phenotype	PMID:30404997; PMID:31369746
GO:1904105	Positive regulation of convergent extension involved in gastrulation	Decreases phenotype	PMID:27693483
GO:1904447	Folate import across plasma membrane	Increases phenotype	PMID:29223574
GO:1904456	Negative regulation of neuronal action potential	Increases phenotype	PMID:29596924
GO:1904846	Negative regulation of establishment of bipolar cell polarity	Decreases phenotype	PMID:31368504
GO:1990138	Neuron projection extension	Increases phenotype	PMID:23378038
GO:1990911	Response to psychosocial stress	Decreases phenotype	PMID:33823148
GO:1990962	Xenobiotic transport across blood-brain barrier	Decreases phenotype	PMID:2117062
GO:2000292	Regulation of defecation	Affects phenotype	PMID:32526256
GO:2000616	Negative regulation of histone h3-k9 acetylation	Increases phenotype	PMID:36535311
GO:2000617	Positive regulation of histone h3-k9 acetylation	Increases phenotype	PMID:28184907
GO:2000726	Negative regulation of cardiac muscle cell differentiation	Increases phenotype	PMID:34537371
GO:2000736	Regulation of stem cell differentiation	Affects phenotype	PMID:25247782
GO:2000987	Positive regulation of behavioral fear response	Increases phenotype	PMID:31369746
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:29501571; PMID:33147516
GO:2001171	Positive regulation of atp biosynthetic process	Decreases phenotype	PMID:26921665

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.