DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Endosulfan

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0001556	Oocyte maturation	Increases phenotype	PMID:30266436
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:26714676
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:24299906
GO:0004407	Histone deacetylase activity	Increases phenotype	PMID:29054638
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:30502743
GO:0004784	Superoxide dismutase activity	Affects phenotype	PMID:24299906; PMID:24299906; PMID:29702342; PMID:29702342; PMID:30502743; PMID:32044604; PMID:34856488
GO:0006006	Glucose metabolic process	Increases phenotype	PMID:31520823
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:30502743
GO:0006094	Gluconeogenesis	Affects phenotype	PMID:29702342
GO:0006105	Succinate metabolic process	Increases phenotype	PMID:29702342; PMID:30502743
GO:0006522	Alanine metabolic process	Affects phenotype	PMID:30502743
GO:0006525	Arginine metabolic process	Affects phenotype	PMID:30502743
GO:0006528	Asparagine metabolic process	Affects phenotype	PMID:30502743
GO:0006531	Aspartate metabolic process	Affects phenotype	PMID:30502743
GO:0006536	Glutamate metabolic process	Affects phenotype	PMID:30502743
GO:0006537	Glutamate biosynthetic process	Increases phenotype	PMID:29702342
GO:0006541	Glutamine metabolic process	Affects phenotype	PMID:30502743
GO:0006542	Glutamine biosynthetic process	Affects phenotype	PMID:29702342
GO:0006544	Glycine metabolic process	Affects phenotype	PMID:30502743
GO:0006549	Isoleucine metabolic process	Affects phenotype	PMID:30502743
GO:0006551	Leucine metabolic process	Affects phenotype	PMID:30502743
GO:0006553	Lysine metabolic process	Affects phenotype	PMID:30502743
GO:0006558	L-phenylalanine metabolic process	Affects phenotype	PMID:30502743
GO:0006560	Proline metabolic process	Affects phenotype	PMID:30502743
GO:0006566	Threonine metabolic process	Affects phenotype	PMID:30502743
GO:0006570	Tyrosine metabolic process	Affects phenotype	PMID:30502743
GO:0006577	Amino-acid betaine metabolic process	Affects phenotype	PMID:30502743
GO:0006601	Creatine biosynthetic process	Decreases phenotype	PMID:29702342
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:27092634
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:29702342
GO:0006809	Nitric oxide biosynthetic process	Decreases phenotype	PMID:28273962
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:26187449
GO:0006915	Apoptotic process	Increases phenotype	PMID:17309119; PMID:26714676; PMID:28161397; PMID:28161397; PMID:29705383; PMID:30796443
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:29705383
GO:0007566	Embryo implantation	Decreases phenotype	PMID:25486513
GO:0008219	Cell death	Affects phenotype	PMID:29391264
GO:0008283	Cell population proliferation	Affects phenotype	PMID:24832206; PMID:26714676; PMID:29705383; PMID:34856488
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:25486513; PMID:29054638
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:34089567
GO:0008652	Amino acid biosynthetic process	Affects phenotype	PMID:29702342
GO:0008753	Nadph dehydrogenase (quinone) activity	Increases phenotype	PMID:25199686
GO:0009069	Serine family amino acid metabolic process	Affects phenotype	PMID:30502743
GO:0009085	Lysine biosynthetic process	Increases phenotype	PMID:29702342
GO:0009086	Methionine biosynthetic process	Affects phenotype	PMID:29702342
GO:0009097	Isoleucine biosynthetic process	Increases phenotype	PMID:29702342
GO:0009099	Valine biosynthetic process	Increases phenotype	PMID:29702342
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:29054638; PMID:35114330
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:30796443
GO:0010823	Negative regulation of mitochondrion organization	Increases phenotype	PMID:34089567
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:36513242
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25363902; PMID:26615145; PMID:40434365
GO:0014054	Positive regulation of gamma-aminobutyric acid secretion	Increases phenotype	PMID:28975519
GO:0015942	Formate metabolic process	Affects phenotype	PMID:30502743
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:24299906; PMID:29702342; PMID:30502743; PMID:32044604
GO:0016049	Cell growth	Decreases phenotype	PMID:29705383
GO:0016525	Negative regulation of angiogenesis	Decreases phenotype	PMID:31029737
GO:0016925	Protein sumoylation	Increases phenotype	PMID:30426790
GO:0018158	Protein oxidation	Increases phenotype	PMID:27092634
GO:0019226	Transmission of nerve impulse	Affects phenotype	PMID:38599286
GO:0019249	Lactate biosynthetic process	Decreases phenotype	PMID:29702342
GO:0019413	Acetate biosynthetic process	Increases phenotype	PMID:29702342
GO:0022414	Reproductive process	Affects phenotype	PMID:31550491
GO:0030036	Actin cytoskeleton organization	Decreases phenotype	PMID:30090376
GO:0032125	Micronucleus organization	Increases phenotype	PMID:29705383
GO:0033148	Positive regulation of intracellular estrogen receptor signaling pathway	Increases phenotype	PMID:26139245
GO:0034199	Activation of protein kinase a activity	Decreases phenotype	PMID:34089567
GO:0034440	Lipid oxidation	Increases phenotype	PMID:25363902; PMID:27092634
GO:0042412	Taurine biosynthetic process	Affects phenotype	PMID:29702342
GO:0042425	Choline biosynthetic process	Increases phenotype	PMID:29702342
GO:0042448	Progesterone metabolic process	Affects phenotype	PMID:30502743
GO:0042866	Pyruvate biosynthetic process	Decreases phenotype	PMID:29702342
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:30090376; PMID:36513242
GO:0043985	Histone h4-r3 methylation	Increases phenotype	PMID:29054638
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:38599286
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:32044604; PMID:32413665
GO:0045727	Positive regulation of translation	Increases phenotype	PMID:35137321
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:26714676; PMID:29705383
GO:0046101	Hypoxanthine biosynthetic process	Increases phenotype	PMID:29702342
GO:0046102	Inosine metabolic process	Affects phenotype	PMID:30502743
GO:0046107	Uracil biosynthetic process	Increases phenotype	PMID:29702342
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:32044604
GO:0046622	Positive regulation of organ growth	Increases phenotype	PMID:28935589
GO:0048662	Negative regulation of smooth muscle cell proliferation	Decreases phenotype	PMID:31029737
GO:0048863	Stem cell differentiation	Decreases phenotype	PMID:32205227
GO:0051497	Negative regulation of stress fiber assembly	Increases phenotype	PMID:28108160
GO:0051726	Regulation of cell cycle	Increases phenotype	PMID:30090376
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:26714676
GO:0051894	Positive regulation of focal adhesion assembly	Decreases phenotype	PMID:28108160
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:30056177
GO:0060135	Maternal process involved in female pregnancy	Decreases phenotype	PMID:31029737
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:32044604; PMID:32413665
GO:0060749	Mammary gland alveolus development	Increases phenotype	PMID:28935589
GO:0060763	Mammary duct terminal end bud growth	Increases phenotype	PMID:28935589
GO:0061038	Uterus morphogenesis	Decreases phenotype	PMID:31029737
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:30502743
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:34856488
GO:0071629	Cytoplasm protein quality control by the ubiquitin-proteasome system	Decreases phenotype	PMID:23988235
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:25199686; PMID:32044604
GO:0098874	Spike train	Decreases phenotype	PMID:29432603
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:27092634
GO:1901386	Negative regulation of voltage-gated calcium channel activity	Increases phenotype	PMID:24913802; PMID:26187449
GO:1901671	Positive regulation of superoxide dismutase activity	Decreases phenotype	PMID:25363902
GO:1902466	Positive regulation of histone h3-k27 trimethylation	Increases phenotype	PMID:29054638
GO:1903142	Positive regulation of establishment of endothelial barrier	Decreases phenotype	PMID:28108160
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:28273962
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:25363902; PMID:27092634; PMID:34089567
GO:1903709	Uterine gland development	Decreases phenotype	PMID:26911934
GO:1904027	Negative regulation of collagen fibril organization	Decreases phenotype	PMID:31029737
GO:1904028	Positive regulation of collagen fibril organization	Increases phenotype	PMID:28935589
GO:1904303	Positive regulation of maternal process involved in parturition	Increases phenotype	PMID:31029737
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:30796443
GO:2000844	Negative regulation of testosterone secretion	Increases phenotype	PMID:34089567
GO:2000866	Positive regulation of estradiol secretion	Decreases phenotype	PMID:28935589
GO:2001269	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Increases phenotype	PMID:30796443

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.