Indole-3-carbinol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:32070777
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:33118390; PMID:34085558
GO:0001525 Angiogenesis Decreases phenotype PMID:29775573
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:29775573
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:29775573
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:29775573
GO:0002726 Positive regulation of t cell cytokine production Affects phenotype PMID:24200994
GO:0004111 Creatine kinase activity Increases phenotype PMID:29775573
GO:0004364 Glutathione transferase activity Affects phenotype PMID:29775573; PMID:9794803
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:29775573
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:29775573
GO:0005747 Mitochondrial respiratory chain complex i Decreases phenotype PMID:37150287
GO:0005751 Mitochondrial respiratory chain complex iv Decreases phenotype PMID:37150287
GO:0005757 Mitochondrial permeability transition pore complex Increases phenotype PMID:37150287
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:28619389
GO:0006701 Progesterone biosynthetic process Increases phenotype PMID:28619389
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:28619389
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:29775573
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:29775573
GO:0006915 Apoptotic process Affects phenotype PMID:24257414; PMID:29775573; PMID:29992829; PMID:33118390; PMID:34085558
GO:0006974 Cellular response to dna damage stimulus Affects phenotype PMID:17582584; PMID:29775573; PMID:29992829
GO:0007049 Cell cycle Decreases phenotype PMID:15611077; PMID:18023427
GO:0008210 Estrogen metabolic process Affects phenotype PMID:17297389
GO:0008283 Cell population proliferation Affects phenotype PMID:18023427; PMID:24257414; PMID:29775573; PMID:33118390; PMID:34085558
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29472718
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:37150287
GO:0016042 Lipid catabolic process Increases phenotype PMID:28619389; PMID:29269057; PMID:29775573
GO:0016049 Cell growth Decreases phenotype PMID:29775573
GO:0016477 Cell migration Increases phenotype PMID:28619389
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:28619389
GO:0032729 Positive regulation of type ii interferon production Affects phenotype PMID:24200994
GO:0032743 Positive regulation of interleukin-2 production Affects phenotype PMID:24200994
GO:0032755 Positive regulation of interleukin-6 production Affects phenotype PMID:24200994
GO:0032760 Positive regulation of tumor necrosis factor production Affects phenotype PMID:24200994
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:29775573
GO:0042102 Positive regulation of t cell proliferation Affects phenotype PMID:24200994
GO:0042541 Hemoglobin biosynthetic process Affects phenotype PMID:29775573
GO:0044237 Cellular metabolic process Decreases phenotype PMID:29992829; PMID:32070777; PMID:33118390; PMID:34085558
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:34085558
GO:0045023 G0 to g1 transition Affects phenotype PMID:32070777; PMID:33118390; PMID:34085558
GO:0050870 Positive regulation of t cell activation Affects phenotype PMID:24200994
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37150287
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:29775573
GO:0060444 Branching involved in mammary gland duct morphogenesis Increases phenotype PMID:27178563
GO:0060763 Mammary duct terminal end bud growth Increases phenotype PMID:27178563
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28619389
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:33118390; PMID:34085558
GO:0097272 Ammonium homeostasis Decreases phenotype PMID:37150287
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:32070777; PMID:33118390; PMID:34085558
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:29775573
GO:1903788 Positive regulation of glutathione biosynthetic process Increases phenotype PMID:37150287
GO:1903925 Response to bisphenol a Affects phenotype PMID:27178563
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.