Malathion


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000080 Mitotic g1 phase Increases phenotype PMID:30769050
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:30769050
GO:0001556 Oocyte maturation Increases phenotype PMID:30266436
GO:0001675 Acrosome assembly Affects phenotype PMID:36336997
GO:0001776 Leukocyte homeostasis Decreases phenotype PMID:33510276; PMID:36370973
GO:0002260 Lymphocyte homeostasis Decreases phenotype PMID:39798862
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:32495713
GO:0002675 Positive regulation of acute inflammatory response Increases phenotype PMID:34262720
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:25180440
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:25180440; PMID:36370973
GO:0004104 Cholinesterase activity Decreases phenotype PMID:36370973
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:23774768
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:25180440
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:25180440
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:25180440; PMID:30769050; PMID:32120800
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:25180440; PMID:32120800; PMID:36336997
GO:0005980 Glycogen catabolic process Increases phenotype PMID:21783476
GO:0006096 Glycolytic process Increases phenotype PMID:21783476
GO:0006304 Dna modification Increases phenotype PMID:27941166
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:19607909
GO:0006554 Lysine catabolic process Increases phenotype PMID:30673264
GO:0006558 L-phenylalanine metabolic process Increases phenotype PMID:30673264
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:36370973
GO:0006650 Glycerophospholipid metabolic process Increases phenotype PMID:30673264
GO:0006749 Glutathione metabolic process Increases phenotype PMID:28987951; PMID:30673264; PMID:32120800; PMID:34778934
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25180440; PMID:27214522; PMID:30769050
GO:0006915 Apoptotic process Increases phenotype PMID:12505448; PMID:19607909; PMID:29027213; PMID:30769050
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:29027213; PMID:29741206
GO:0006979 Response to oxidative stress Increases phenotype PMID:16865556; PMID:19607909
GO:0007283 Spermatogenesis Decreases phenotype PMID:30409133
GO:0007286 Spermatid development Decreases phenotype PMID:30409133
GO:0007596 Blood coagulation Decreases phenotype PMID:27214522
GO:0007626 Locomotory behavior Increases phenotype PMID:39798862
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:23774768
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:36370973
GO:0008283 Cell population proliferation Affects phenotype PMID:11401758; PMID:24333466; PMID:25684042; PMID:27214522
GO:0009064 Glutamine family amino acid metabolic process Increases phenotype PMID:30673264
GO:0009085 Lysine biosynthetic process Increases phenotype PMID:30673264
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:34516295
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:30409133
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:39798862
GO:0010942 Positive regulation of cell death Increases phenotype PMID:30409133; PMID:30673264
GO:0014042 Positive regulation of neuron maturation Increases phenotype PMID:39798862
GO:0014053 Negative regulation of gamma-aminobutyric acid secretion Increases phenotype PMID:39798862
GO:0014063 Negative regulation of serotonin secretion Increases phenotype PMID:39798862
GO:0015937 Coenzyme a biosynthetic process Increases phenotype PMID:30673264
GO:0016042 Lipid catabolic process Increases phenotype PMID:25180440; PMID:32120800
GO:0016049 Cell growth Decreases phenotype PMID:30769050
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:23774768
GO:0019369 Arachidonic acid metabolic process Increases phenotype PMID:30673264
GO:0019530 Taurine metabolic process Increases phenotype PMID:30673264
GO:0030220 Platelet formation Decreases phenotype PMID:27214522
GO:0033603 Positive regulation of dopamine secretion Increases phenotype PMID:39798862
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:33510276
GO:0034440 Lipid oxidation Increases phenotype PMID:27941166; PMID:28987951; PMID:30409133
GO:0035041 Sperm dna decondensation Increases phenotype PMID:30409133
GO:0043039 Trna aminoacylation Increases phenotype PMID:30673264
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:39798862
GO:0043277 Apoptotic cell clearance Increases phenotype PMID:8812242
GO:0044237 Cellular metabolic process Decreases phenotype PMID:32069766; PMID:32120800; PMID:34778934
GO:0045023 G0 to g1 transition Decreases phenotype PMID:30769050
GO:0045333 Cellular respiration Decreases phenotype PMID:23774768
GO:0045444 Fat cell differentiation Increases phenotype PMID:36370973
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:30409133
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:27941166
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:30769050
GO:0046058 Camp metabolic process Affects phenotype PMID:29143548
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:16865556; PMID:18035420
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:30409133
GO:0046986 Negative regulation of hemoglobin biosynthetic process Increases phenotype PMID:33510276
GO:0050665 Hydrogen peroxide biosynthetic process Decreases phenotype PMID:23774768
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:29027213
GO:0070668 Positive regulation of mast cell proliferation Increases phenotype PMID:33510276
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:32120800
GO:0097531 Mast cell migration Increases phenotype PMID:34262720
GO:0097722 Sperm motility Decreases phenotype PMID:32495713
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:30409133
GO:1901605 Alpha-amino acid metabolic process Increases phenotype PMID:30673264
GO:1901668 Regulation of superoxide dismutase activity Affects phenotype PMID:30673264
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:28987951; PMID:30409133
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:30409133
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30769050
GO:1905220 Negative regulation of platelet formation Increases phenotype PMID:33510276
GO:1905517 Macrophage migration Increases phenotype PMID:32495713
GO:1905867 Epididymis development Affects phenotype PMID:32495713
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:30409133
GO:2000848 Positive regulation of corticosteroid hormone secretion Increases phenotype PMID:39798862
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.