Benzene


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000723 Telomere maintenance Decreases phenotype PMID:19772576
GO:0001510 Rna methylation Increases phenotype PMID:36306860
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:28733890; PMID:31381583; PMID:31988427; PMID:33749080; PMID:35092719; PMID:39842622; PMID:38866309; PMID:38914192
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:33749080; PMID:39842622
GO:0002260 Lymphocyte homeostasis Affects phenotype PMID:33749080; PMID:39842622
GO:0002262 Myeloid cell homeostasis Affects phenotype PMID:39842622
GO:0002521 Leukocyte differentiation Decreases phenotype PMID:15576619
GO:0003870 5-aminolevulinate synthase activity Increases phenotype PMID:3344524
GO:0004197 Cysteine-type endopeptidase activity Affects phenotype PMID:22960397
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:35661779
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:35090963
GO:0006304 Dna modification Increases phenotype PMID:28373009
GO:0006306 Dna methylation Decreases phenotype PMID:26341289
GO:0006520 Amino acid metabolic process Affects phenotype PMID:38866309
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:38866309
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33749080; PMID:35661779
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:24733833
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24733833
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:35661779
GO:0006915 Apoptotic process Increases phenotype PMID:22960397; PMID:36306860
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:30567741; PMID:31381583
GO:0007005 Mitochondrion organization Affects phenotype PMID:35661779
GO:0007088 Regulation of mitotic nuclear division Decreases phenotype PMID:23138419
GO:0007283 Spermatogenesis Decreases phenotype PMID:36306860
GO:0007596 Blood coagulation Decreases phenotype PMID:33749080
GO:0008283 Cell population proliferation Affects phenotype PMID:27339418; PMID:27853917
GO:0009437 Carnitine metabolic process Affects phenotype PMID:38866309
GO:0010942 Positive regulation of cell death Increases phenotype PMID:28373009
GO:0016042 Lipid catabolic process Affects phenotype PMID:33749080; PMID:35661779
GO:0020027 Hemoglobin metabolic process Affects phenotype PMID:35092719; PMID:35661779
GO:0030097 Hemopoiesis Affects phenotype PMID:31988427; PMID:33749080; PMID:35661779; PMID:35661779; PMID:38914192; PMID:38866309; PMID:38914192
GO:0030218 Erythrocyte differentiation Decreases phenotype PMID:30567741
GO:0030220 Platelet formation Decreases phenotype PMID:31988427; PMID:33749080; PMID:35092719
GO:0030851 Granulocyte differentiation Decreases phenotype PMID:15576619
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:33502539
GO:0032125 Micronucleus organization Increases phenotype PMID:30567741; PMID:31381583
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:31381583
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:30567741; PMID:32293364; PMID:35092719; PMID:38866309; PMID:35661779; PMID:38866309; PMID:38914192
GO:0035702 Monocyte homeostasis Affects phenotype PMID:33749080
GO:0035855 Megakaryocyte development Affects phenotype PMID:33749080
GO:0036344 Platelet morphogenesis Decreases phenotype PMID:15576619
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:28373009
GO:0042118 Endothelial cell activation Increases phenotype PMID:34718823
GO:0042129 Regulation of t cell proliferation Affects phenotype PMID:35090963
GO:0042540 Hemoglobin catabolic process Increases phenotype PMID:28373009
GO:0042541 Hemoglobin biosynthetic process Decreases phenotype PMID:33749080
GO:0042593 Glucose homeostasis Affects phenotype PMID:30346588
GO:0043436 Oxoacid metabolic process Affects phenotype PMID:38866309
GO:0043576 Regulation of respiratory gaseous exchange Affects phenotype PMID:25108490
GO:0044237 Cellular metabolic process Increases phenotype PMID:22960397; PMID:27853917
GO:0046034 Atp metabolic process Affects phenotype PMID:27853917; PMID:35090963; PMID:35661779
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:20338863
GO:0046651 Lymphocyte proliferation Decreases phenotype PMID:30567741
GO:0048872 Homeostasis of number of cells Affects phenotype PMID:35661779
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:35661779
GO:0060218 Hematopoietic stem cell differentiation Affects phenotype PMID:35661779
GO:0061518 Microglial cell proliferation Increases phenotype PMID:37084897
GO:0070265 Necrotic cell death Increases phenotype PMID:22960397
GO:0070661 Leukocyte proliferation Decreases phenotype PMID:30567741; PMID:38866309
GO:0070994 Detection of oxidative stress Increases phenotype PMID:33749080; PMID:35090963
GO:0071425 Hematopoietic stem cell proliferation Affects phenotype PMID:30567741
GO:0071838 Cell proliferation in bone marrow Affects phenotype PMID:33749080
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33749080
GO:0072672 Neutrophil extravasation Increases phenotype PMID:34718823
GO:0097009 Energy homeostasis Decreases phenotype PMID:33502539
GO:0097386 Glial cell projection Increases phenotype PMID:37084897
GO:0097707 Ferroptosis Increases phenotype PMID:35661779
GO:0097722 Sperm motility Decreases phenotype PMID:36306860
GO:0140113 Extracellular microvesicle biogenesis Increases phenotype PMID:34624356
GO:1902035 Positive regulation of hematopoietic stem cell proliferation Increases phenotype PMID:28373009
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27339418
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28373009
GO:1903561 Extracellular vesicle Increases phenotype PMID:34044057
GO:2000078 Positive regulation of type b pancreatic cell development Increases phenotype PMID:33502539
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.