DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Arsenite

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:28636814; PMID:31781319
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:35964836
GO:0001510	Rna methylation	Affects phenotype	PMID:39405678
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:34453993; PMID:35964836
GO:0001837	Epithelial to mesenchymal transition	Increases phenotype	PMID:35124418
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:36791901; PMID:37442281; PMID:39405678
GO:0003729	Mrna binding	Affects phenotype	PMID:32406909
GO:0003730	Mrna 3'-utr binding	Increases phenotype	PMID:23824327
GO:0004096	Catalase activity	Decreases phenotype	PMID:39798443
GO:0004197	Cysteine-type endopeptidase activity	Increases phenotype	PMID:23968587
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:29572906
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:29324385; PMID:39798443
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:34339004; PMID:39798443
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:29596344; PMID:31935557; PMID:32030632; PMID:34339004; PMID:39798443
GO:0005977	Glycogen metabolic process	Affects phenotype	PMID:31935557
GO:0006006	Glucose metabolic process	Affects phenotype	PMID:31935557
GO:0006096	Glycolytic process	Increases phenotype	PMID:38485781
GO:0006304	Dna modification	Increases phenotype	PMID:22572560; PMID:29572906; PMID:38563870
GO:0006338	Chromatin remodeling	Increases phenotype	PMID:25281835; PMID:34453993
GO:0006412	Translation	Decreases phenotype	PMID:23086926; PMID:23824327; PMID:32406909; PMID:34390821
GO:0006413	Translational initiation	Decreases phenotype	PMID:23396362; PMID:23824327
GO:0006480	N-terminal protein amino acid methylation	Increases phenotype	PMID:23978223
GO:0006520	Amino acid metabolic process	Affects phenotype	PMID:38703806
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:36534342
GO:0006611	Protein export from nucleus	Affects phenotype	PMID:33129825
GO:0006635	Fatty acid beta-oxidation	Decreases phenotype	PMID:39620
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:34339004
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:28688901; PMID:28688901; PMID:32030632; PMID:31272005; PMID:32030632; PMID:34339004; PMID:36343453; PMID:36791901
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:24024143; PMID:29324385; PMID:29596344
GO:0006805	Xenobiotic metabolic process	Affects phenotype	PMID:25194983
GO:0006839	Mitochondrial transport	Decreases phenotype	PMID:24315374
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:26677073; PMID:34453993; PMID:35964836; PMID:37659621
GO:0006909	Phagocytosis	Decreases phenotype	PMID:28499612
GO:0006914	Autophagy	Increases phenotype	PMID:33097607; PMID:34929507
GO:0006915	Apoptotic process	Increases phenotype	PMID:11848479; PMID:12803490; PMID:22463588; PMID:23396362; PMID:26677073; PMID:29596344; PMID:32443253; PMID:32980394; PMID:37046073
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:24190502; PMID:29324385; PMID:32030632
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:25547999; PMID:9057100
GO:0007611	Learning or memory	Decreases phenotype	PMID:29982692
GO:0007631	Feeding behavior	Affects phenotype	PMID:37442281
GO:0008219	Cell death	Increases phenotype	PMID:22463588; PMID:26375285; PMID:34390821; PMID:37442281
GO:0008283	Cell population proliferation	Affects phenotype	PMID:23744399; PMID:24473123; PMID:26677073; PMID:28444938; PMID:35124418; PMID:38485781; PMID:38563870
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:28688901; PMID:31773452
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:24960579; PMID:29566083; PMID:29572906
GO:0009060	Aerobic respiration	Increases phenotype	PMID:28956099
GO:0010606	Positive regulation of cytoplasmic mrna processing body assembly	Increases phenotype	PMID:25409157
GO:0010823	Negative regulation of mitochondrion organization	Increases phenotype	PMID:24960579
GO:0010825	Positive regulation of centrosome duplication	Increases phenotype	PMID:28739695
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:25547999
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:16479312; PMID:25567531; PMID:30177839
GO:0010976	Positive regulation of neuron projection development	Increases phenotype	PMID:25547999
GO:0014852	Regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction	Affects phenotype	PMID:24960579
GO:0015700	Arsenite transport	Decreases phenotype	PMID:29324385
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:29324385; PMID:34339004
GO:0016049	Cell growth	Decreases phenotype	PMID:23534459; PMID:29324385; PMID:29596344
GO:0016078	Trna catabolic process	Increases phenotype	PMID:23086926
GO:0016477	Cell migration	Decreases phenotype	PMID:31272005
GO:0016567	Protein ubiquitination	Increases phenotype	PMID:29324385
GO:0019627	Urea metabolic process	Affects phenotype	PMID:38703806
GO:0019722	Calcium-mediated signaling	Decreases phenotype	PMID:12803490
GO:0030101	Natural killer cell activation	Increases phenotype	PMID:33301752
GO:0030182	Neuron differentiation	Decreases phenotype	PMID:31272005
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:38703806; PMID:38703806; PMID:39405678; PMID:39405678
GO:0030262	Apoptotic nuclear changes	Increases phenotype	PMID:35964836
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:28688901; PMID:31773452
GO:0031589	Cell-substrate adhesion	Decreases phenotype	PMID:35124418; PMID:38563870
GO:0032043	Mitochondrial dna catabolic process	Increases phenotype	PMID:25547999
GO:0032125	Micronucleus organization	Increases phenotype	PMID:9057100
GO:0032148	Activation of protein kinase b activity	Increases phenotype	PMID:28952001
GO:0032227	Negative regulation of synaptic transmission, dopaminergic	Increases phenotype	PMID:29982692
GO:0032780	Negative regulation of atp-dependent activity	Increases phenotype	PMID:26677073
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:24960579
GO:0032963	Collagen metabolic process	Affects phenotype	PMID:38703806
GO:0033192	Calmodulin-dependent protein phosphatase activity	Decreases phenotype	PMID:22564430
GO:0034063	Stress granule assembly	Increases phenotype	PMID:23279204; PMID:23279204; PMID:34244458; PMID:34390821; PMID:34469566; PMID:23824327; PMID:34244458; PMID:34390821; PMID:34469566; PMID:36534342; PMID:38734221
GO:0034440	Lipid oxidation	Increases phenotype	PMID:29572906; PMID:36791901; PMID:39798443
GO:0035733	Hepatic stellate cell activation	Increases phenotype	PMID:31513886
GO:0038001	Paracrine signaling	Increases phenotype	PMID:31513886
GO:0042116	Macrophage activation	Increases phenotype	PMID:33080309; PMID:35777529
GO:0042541	Hemoglobin biosynthetic process	Increases phenotype	PMID:23369756
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:34339004
GO:0042593	Glucose homeostasis	Affects phenotype	PMID:28952001
GO:0042756	Drinking behavior	Affects phenotype	PMID:37442281
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:15316071; PMID:24457827
GO:0043984	Histone h4-k16 acetylation	Decreases phenotype	PMID:25281835; PMID:28837777
GO:0044127	Regulation of development of symbiont in host	Affects phenotype	PMID:26529668
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:22447124; PMID:22463588; PMID:23968587; PMID:31272005; PMID:31934280; PMID:32030632; PMID:32443253; PMID:32980394; PMID:34453993; PMID:34678219; PMID:34929507; PMID:35964836; PMID:38485781; PMID:38630284; PMID:38703806; PMID:39798443
GO:0044255	Cellular lipid metabolic process	Affects phenotype	PMID:30376133
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:31616959; PMID:35124418; PMID:38485781
GO:0044399	Multi-species biofilm formation	Affects phenotype	PMID:26529668
GO:0044754	Autolysosome	Increases phenotype	PMID:31781319
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:28688901
GO:0045666	Positive regulation of neuron differentiation	Increases phenotype	PMID:25547999
GO:0045725	Positive regulation of glycogen biosynthetic process	Increases phenotype	PMID:28952001
GO:0045919	Positive regulation of cytolysis	Increases phenotype	PMID:29572906
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:23744399; PMID:24184494
GO:0045931	Positive regulation of mitotic cell cycle	Increases phenotype	PMID:28688901
GO:0046459	Short-chain fatty acid metabolic process	Affects phenotype	PMID:36791901
GO:0048027	Mrna 5'-utr binding	Increases phenotype	PMID:23824327
GO:0048709	Oligodendrocyte differentiation	Decreases phenotype	PMID:31272005
GO:0051000	Positive regulation of nitric-oxide synthase activity	Increases phenotype	PMID:28688901
GO:0051091	Positive regulation of dna-binding transcription factor activity	Increases phenotype	PMID:11299744; PMID:30177839
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:30177839
GO:0051173	Positive regulation of nitrogen compound metabolic process	Increases phenotype	PMID:26529668
GO:0051348	Negative regulation of transferase activity	Affects phenotype	PMID:29572906
GO:0051560	Mitochondrial calcium ion homeostasis	Affects phenotype	PMID:34453993
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:23744399; PMID:26677073; PMID:35964836
GO:0051973	Positive regulation of telomerase activity	Affects phenotype	PMID:27470698
GO:0055088	Lipid homeostasis	Affects phenotype	PMID:30376133
GO:0060212	Negative regulation of nuclear-transcribed mrna poly(a) tail shortening	Increases phenotype	PMID:25446091
GO:0060317	Cardiac epithelial to mesenchymal transition	Decreases phenotype	PMID:26354774
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:31781319; PMID:38485781
GO:0060390	Regulation of smad protein signal transduction	Affects phenotype	PMID:26354774
GO:0061179	Negative regulation of insulin secretion involved in cellular response to glucose stimulus	Increases phenotype	PMID:28956099
GO:0061909	Autophagosome-lysosome fusion	Decreases phenotype	PMID:31781319
GO:0062029	Positive regulation of stress granule assembly	Increases phenotype	PMID:24183723; PMID:25409157; PMID:26115353
GO:0070372	Regulation of erk1 and erk2 cascade	Decreases phenotype	PMID:25145660
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:23618899; PMID:25493652
GO:0070509	Calcium ion import	Affects phenotype	PMID:31332465
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:22240577; PMID:32030632; PMID:36791901
GO:0071243	Cellular response to arsenic-containing substance	Affects phenotype	PMID:31355259; PMID:37759824
GO:0071478	Cellular response to radiation	Increases phenotype	PMID:28739695
GO:0071493	Cellular response to uv-b	Affects phenotype	PMID:22463588
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24184494; PMID:31781319; PMID:31935557; PMID:32030632; PMID:32980394; PMID:33451022; PMID:34453993; PMID:34798142; PMID:35964836; PMID:35964836; PMID:37659621; PMID:36343453; PMID:37659621; PMID:38630284
GO:0072676	Lymphocyte migration	Increases phenotype	PMID:36791901
GO:0080009	Mrna methylation	Increases phenotype	PMID:29982692
GO:0090398	Cellular senescence	Increases phenotype	PMID:39405678
GO:0097272	Ammonium homeostasis	Affects phenotype	PMID:38703806
GO:0098609	Cell-cell adhesion	Increases phenotype	PMID:31781319; PMID:32076005
GO:0099156	Cell-cell signaling via exosome	Increases phenotype	PMID:31513886
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:35777529
GO:1900182	Positive regulation of protein localization to nucleus	Increases phenotype	PMID:29572906
GO:1901485	Positive regulation of transcription factor catabolic process	Increases phenotype	PMID:25493652
GO:1901605	Alpha-amino acid metabolic process	Increases phenotype	PMID:26529668
GO:1901671	Positive regulation of superoxide dismutase activity	Increases phenotype	PMID:28688901; PMID:29572906
GO:1901684	Arsenate ion transmembrane transport	Decreases phenotype	PMID:11509741
GO:1902310	Positive regulation of peptidyl-serine dephosphorylation	Increases phenotype	PMID:24942733
GO:1902883	Negative regulation of response to oxidative stress	Increases phenotype	PMID:24960579
GO:1903071	Positive regulation of er-associated ubiquitin-dependent protein catabolic process	Increases phenotype	PMID:25701757
GO:1903180	Negative regulation of dopamine biosynthetic process	Increases phenotype	PMID:29982692
GO:1903209	Positive regulation of oxidative stress-induced cell death	Increases phenotype	PMID:25701757
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:23744399
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:25547999; PMID:27470698
GO:1903599	Positive regulation of autophagy of mitochondrion	Increases phenotype	PMID:24960579
GO:1903608	Protein localization to cytoplasmic stress granule	Increases phenotype	PMID:23341463
GO:1903626	Positive regulation of dna catabolic process	Increases phenotype	PMID:29572906
GO:1903703	Enterocyte differentiation	Affects phenotype	PMID:38563870
GO:1904206	Positive regulation of skeletal muscle hypertrophy	Increases phenotype	PMID:24960579
GO:1905267	Endonucleolytic cleavage involved in trna processing	Increases phenotype	PMID:29431851
GO:1905538	Polysome binding	Affects phenotype	PMID:32406909
GO:1905898	Positive regulation of response to endoplasmic reticulum stress	Increases phenotype	PMID:25547999
GO:1990051	Activation of protein kinase c activity	Increases phenotype	PMID:9057100
GO:1990182	Exosomal secretion	Increases phenotype	PMID:31513886
GO:1990266	Neutrophil migration	Increases phenotype	PMID:36791901
GO:1990428	Mirna transport	Increases phenotype	PMID:33080309
GO:1990764	Myofibroblast contraction	Increases phenotype	PMID:38703806
GO:1990922	Hepatic stellate cell proliferation	Increases phenotype	PMID:31513886
GO:2000277	Positive regulation of oxidative phosphorylation uncoupler activity	Increases phenotype	PMID:24960579
GO:2000324	Positive regulation of glucocorticoid receptor signaling pathway	Increases phenotype	PMID:2298732
GO:2000376	Positive regulation of oxygen metabolic process	Increases phenotype	PMID:24960579
GO:2000573	Positive regulation of dna biosynthetic process	Increases phenotype	PMID:28688901

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.