| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000045 | Autophagosome assembly | Increases phenotype | PMID:23448468; PMID:24492484; PMID:28419832; PMID:36708882 |
| GO:0000266 | Mitochondrial fission | Affects phenotype | PMID:35158046 |
| GO:0000737 | Dna catabolic process, endonucleolytic | Increases phenotype | PMID:36085217; PMID:38259729 |
| GO:0001501 | Skeletal system development | Affects phenotype | PMID:36174738 |
| GO:0001503 | Ossification | Decreases phenotype | PMID:24872432; PMID:31887396; PMID:37024064 |
| GO:0001516 | Prostaglandin biosynthetic process | Decreases phenotype | PMID:28456544; PMID:28456544; PMID:28963034; PMID:29339218; PMID:28963034; PMID:29339218 |
| GO:0001523 | Retinoid metabolic process | Affects phenotype | PMID:24646710 |
| GO:0001570 | Vasculogenesis | Affects phenotype | PMID:19091803 |
| GO:0001649 | Osteoblast differentiation | Decreases phenotype | PMID:17582586; PMID:24872432 |
| GO:0001654 | Eye development | Affects phenotype | PMID:31690747 |
| GO:0001659 | Temperature homeostasis | Affects phenotype | PMID:29944862; PMID:30248482 |
| GO:0001662 | Behavioral fear response | Increases phenotype | PMID:29944862 |
| GO:0001774 | Microglial cell activation | Increases phenotype | PMID:31954762; PMID:36402194 |
| GO:0001780 | Neutrophil homeostasis | Decreases phenotype | PMID:34808223 |
| GO:0001894 | Tissue homeostasis | Affects phenotype | PMID:27265477 |
| GO:0002027 | Regulation of heart rate | Affects phenotype | PMID:2050169; PMID:7796714 |
| GO:0002121 | Inter-male aggressive behavior | Increases phenotype | PMID:34662589 |
| GO:0002232 | Leukocyte chemotaxis involved in inflammatory response | Increases phenotype | PMID:34405320 |
| GO:0002260 | Lymphocyte homeostasis | Decreases phenotype | PMID:34808223 |
| GO:0002523 | Leukocyte migration involved in inflammatory response | Increases phenotype | PMID:22257724; PMID:24972622; PMID:24972622; PMID:26522475; PMID:29339218; PMID:38341112; PMID:26522475; PMID:26970604; PMID:27983966; PMID:27989594; PMID:27989594; PMID:29704510; PMID:35156864; PMID:28419832; PMID:29339218; PMID:29704510; PMID:35156864; PMID:38341112 |
| GO:0002554 | Serotonin secretion by platelet | Increases phenotype | PMID:8928743 |
| GO:0002693 | Positive regulation of cellular extravasation | Increases phenotype | PMID:24946281 |
| GO:0003015 | Heart process | Affects phenotype | PMID:23500772 |
| GO:0003084 | Positive regulation of systemic arterial blood pressure | Increases phenotype | PMID:25598224 |
| GO:0003300 | Cardiac muscle hypertrophy | Increases phenotype | PMID:25598224; PMID:33645892 |
| GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:39988212 |
| GO:0004030 | Aldehyde dehydrogenase [nad(p)+] activity | Decreases phenotype | PMID:35158046 |
| GO:0004035 | Alkaline phosphatase activity | Increases phenotype | PMID:25859307; PMID:28419832; PMID:28419832; PMID:28797650; PMID:29476730; PMID:28797650; PMID:29085585; PMID:29476730; PMID:30853489; PMID:34565211 |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:27939985; PMID:27989594; PMID:27989594; PMID:29085585; PMID:29704510; PMID:35156864; PMID:28419832; PMID:28419832; PMID:28797650; PMID:29044621; PMID:29476730; PMID:31711802; PMID:34192554; PMID:35143882; PMID:28797650; PMID:29044621; PMID:29085585; PMID:29476730; PMID:29704510; PMID:30248482; PMID:30853489; PMID:30976847; PMID:31785310; PMID:34192554; PMID:35143882; PMID:35156864; PMID:35158046; PMID:37150348; PMID:39988212 |
| GO:0004129 | Cytochrome-c oxidase activity | Decreases phenotype | PMID:27984176 |
| GO:0004197 | Cysteine-type endopeptidase activity | Increases phenotype | PMID:27984176 |
| GO:0004322 | Ferroxidase activity | Decreases phenotype | PMID:26858005 |
| GO:0004364 | Glutathione transferase activity | Affects phenotype | PMID:16540368; PMID:19788401; PMID:20067348; PMID:28442378; PMID:28442378; PMID:35156864; PMID:28797650; PMID:30844427; PMID:32113805; PMID:32151596; PMID:32531310; PMID:32894639; PMID:33314588; PMID:35156864; PMID:37860953 |
| GO:0004457 | Lactate dehydrogenase activity | Increases phenotype | PMID:16208625; PMID:27939985; PMID:27939985; PMID:29694836; PMID:28419832; PMID:28419832; PMID:34192554; PMID:29694836; PMID:30853489; PMID:34192554; PMID:35156864; PMID:35608386 |
| GO:0004602 | Glutathione peroxidase activity | Affects phenotype | PMID:16540368; PMID:20020850; PMID:20020850; PMID:24769256; PMID:35156864; PMID:24769256; PMID:24972622; PMID:28797650; PMID:30844427; PMID:32894639; PMID:33314588; PMID:35156864; PMID:9528125 |
| GO:0004679 | Amp-activated protein kinase activity | Decreases phenotype | PMID:28964808 |
| GO:0004784 | Superoxide dismutase activity | Affects phenotype | PMID:20020850; PMID:20020850; PMID:25111957; PMID:35156864; PMID:36085217; PMID:20067348; PMID:23994557; PMID:28797650; PMID:39988212; PMID:23265624; PMID:23265624; PMID:23994557; PMID:23994557; PMID:25111957; PMID:25637687; PMID:26522475; PMID:26522475; PMID:27474069; PMID:28456544; PMID:28963034; PMID:29339218; PMID:26970604; PMID:26970604; PMID:27983966; PMID:27474069; PMID:27983966; PMID:28115068; PMID:28456544; PMID:28797650; PMID:28963034; PMID:29339218; PMID:30844427; PMID:32531310; PMID:33314588; PMID:33516661; PMID:34474091; PMID:35156864; PMID:36085217; PMID:39988212; PMID:9528125 |
| GO:0005739 | Mitochondrion | Increases phenotype | PMID:35158046 |
| GO:0005776 | Autophagosome | Increases phenotype | PMID:24095927 |
| GO:0006006 | Glucose metabolic process | Affects phenotype | PMID:34470993 |
| GO:0006012 | Galactose metabolic process | Increases phenotype | PMID:29630881 |
| GO:0006067 | Ethanol metabolic process | Affects phenotype | PMID:36207479 |
| GO:0006072 | Glycerol-3-phosphate metabolic process | Increases phenotype | PMID:31974165 |
| GO:0006083 | Acetate metabolic process | Affects phenotype | PMID:39988212 |
| GO:0006089 | Lactate metabolic process | Affects phenotype | PMID:35608386; PMID:39988212 |
| GO:0006094 | Gluconeogenesis | Decreases phenotype | PMID:24275070; PMID:26858005 |
| GO:0006117 | Acetaldehyde metabolic process | Affects phenotype | PMID:39988212 |
| GO:0006119 | Oxidative phosphorylation | Decreases phenotype | PMID:1036417 |
| GO:0006171 | Camp biosynthetic process | Increases phenotype | PMID:29802914; PMID:35143882 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:14598302; PMID:17869084; PMID:19919524; PMID:25637687; PMID:29803612 |
| GO:0006383 | Transcription by rna polymerase iii | Increases phenotype | PMID:32418914 |
| GO:0006497 | Protein lipidation | Increases phenotype | PMID:35066094 |
| GO:0006520 | Amino acid metabolic process | Affects phenotype | PMID:38341112 |
| GO:0006536 | Glutamate metabolic process | Affects phenotype | PMID:33068620 |
| GO:0006556 | S-adenosylmethionine biosynthetic process | Affects phenotype | PMID:16540368 |
| GO:0006577 | Amino-acid betaine metabolic process | Affects phenotype | PMID:38341112 |
| GO:0006606 | Protein import into nucleus | Affects phenotype | PMID:31887396 |
| GO:0006629 | Lipid metabolic process | Affects phenotype | PMID:33645892 |
| GO:0006631 | Fatty acid metabolic process | Affects phenotype | PMID:34470993; PMID:38341112 |
| GO:0006633 | Fatty acid biosynthetic process | Increases phenotype | PMID:29630881 |
| GO:0006636 | Unsaturated fatty acid biosynthetic process | Affects phenotype | PMID:25029343 |
| GO:0006641 | Triglyceride metabolic process | Affects phenotype | PMID:31711802; PMID:35143882; PMID:37271273; PMID:39862944; PMID:31912162; PMID:32237978; PMID:32237978; PMID:34192554; PMID:34995708; PMID:39862944; PMID:32535229; PMID:34470993; PMID:33645892; PMID:33645892; PMID:35156864; PMID:34192554; PMID:34474091; PMID:34995708; PMID:35156864; PMID:37271273; PMID:39862944 |
| GO:0006693 | Prostaglandin metabolic process | Affects phenotype | PMID:38341112 |
| GO:0006695 | Cholesterol biosynthetic process | Affects phenotype | PMID:24746831; PMID:24746831; PMID:24853400; PMID:26115886; PMID:26115886; PMID:27989594; PMID:28442378; PMID:29940154; PMID:26115886; PMID:27989594; PMID:29940154; PMID:26858005; PMID:27939985; PMID:27939985; PMID:29940154; PMID:27989594; PMID:28442378; PMID:29044621; PMID:29044621; PMID:29476730; PMID:29476730; PMID:29940154 |
| GO:0006699 | Bile acid biosynthetic process | Increases phenotype | PMID:24853400; PMID:28095641; PMID:28095641; PMID:30976847 |
| GO:0006700 | C21-steroid hormone biosynthetic process | Decreases phenotype | PMID:29524503 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:20020850; PMID:20020850; PMID:32894639; PMID:35156864; PMID:36085217; PMID:20020850; PMID:35156864; PMID:36085217; PMID:21525764; PMID:22486562; PMID:24296114; PMID:24337826; PMID:24972622; PMID:24972622; PMID:33301711; PMID:25645596; PMID:26747958; PMID:27198676; PMID:30372842; PMID:32006539; PMID:32151596; PMID:32360496; PMID:32894639; PMID:33017621; PMID:33017621; PMID:34192554; PMID:39988212; PMID:33301711; PMID:33516661; PMID:34192554; PMID:34192554; PMID:39988212; PMID:34346143; PMID:34405320; PMID:34474091; PMID:35156864; PMID:35526736; PMID:35595033; PMID:36085217; PMID:37860953; PMID:39988212 |
| GO:0006750 | Glutathione biosynthetic process | Increases phenotype | PMID:10830784; PMID:16540368; PMID:17433488; PMID:17433488; PMID:19325051; PMID:19325051; PMID:22257724; PMID:22257724; PMID:26522475; PMID:27474069; PMID:29339218; PMID:22257724; PMID:27474069; PMID:23265624; PMID:23265624; PMID:23994557; PMID:23994557; PMID:23994557; PMID:25162931; PMID:28419832; PMID:28797650; PMID:24769256; PMID:24769256; PMID:25111957; PMID:25859307; PMID:29085585; PMID:25111957; PMID:25162931; PMID:25455889; PMID:25637687; PMID:25859307; PMID:25859307; PMID:29085585; PMID:26522475; PMID:27474069; PMID:27545833; PMID:27780710; PMID:28115068; PMID:28419832; PMID:28797650; PMID:29085585; PMID:29339218; PMID:30844427; PMID:32531310; PMID:9528125 |
| GO:0006754 | Atp biosynthetic process | Decreases phenotype | PMID:29704510 |
| GO:0006801 | Superoxide metabolic process | Increases phenotype | PMID:37860953 |
| GO:0006809 | Nitric oxide biosynthetic process | Affects phenotype | PMID:26970604; PMID:27265477; PMID:28456544; PMID:28456544; PMID:28963034; PMID:29339218; PMID:28882574; PMID:28963034; PMID:29339218; PMID:30844427 |
| GO:0006810 | Transport | Affects phenotype | PMID:22666445 |
| GO:0006874 | Cellular calcium ion homeostasis | Affects phenotype | PMID:33516933 |
| GO:0006879 | Cellular iron ion homeostasis | Affects phenotype | PMID:33017621 |
| GO:0006914 | Autophagy | Affects phenotype | PMID:21410490; PMID:24892905 |
| GO:0006915 | Apoptotic process | Affects phenotype | PMID:12106828; PMID:12218695; PMID:12700235; PMID:14598302; PMID:14598302; PMID:16237857; PMID:15146544; PMID:16237857; PMID:17299812; PMID:17869084; PMID:17869084; PMID:21410490; PMID:19088804; PMID:19919524; PMID:20067348; PMID:20067348; PMID:23832548; PMID:25455889; PMID:28119953; PMID:31785310; PMID:37271273; PMID:21410490; PMID:22892342; PMID:23832548; PMID:24582693; PMID:24582693; PMID:34346143; PMID:35158046; PMID:24769256; PMID:24972622; PMID:25455889; PMID:26033013; PMID:26470730; PMID:27338645; PMID:27983966; PMID:28119953; PMID:28427893; PMID:28427893; PMID:33516933; PMID:29044621; PMID:29476730; PMID:29800586; PMID:29803612; PMID:33516933; PMID:34346143; PMID:35158046; PMID:37271273; PMID:9637713 |
| GO:0006950 | Response to stress | Increases phenotype | PMID:32497709 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:26769846; PMID:26769846; PMID:29476730; PMID:34192554; PMID:28689299; PMID:29476730; PMID:34192554; PMID:34547370 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:17351912; PMID:25354798; PMID:26109895; PMID:26629949; PMID:27984176; PMID:28115068; PMID:28442378; PMID:29803612; PMID:33645892; PMID:34346143 |
| GO:0006979 | Response to oxidative stress | Increases phenotype | PMID:11747978; PMID:11747978; PMID:12508366; PMID:12508366; PMID:14598302; PMID:22530035; PMID:24646710; PMID:9637713 |
| GO:0007005 | Mitochondrion organization | Decreases phenotype | PMID:22257724; PMID:33017621; PMID:34470993; PMID:35066094 |
| GO:0007006 | Mitochondrial membrane organization | Decreases phenotype | PMID:37142061 |
| GO:0007009 | Plasma membrane organization | Affects phenotype | PMID:29803612 |
| GO:0007029 | Endoplasmic reticulum organization | Affects phenotype | PMID:34470993 |
| GO:0007033 | Vacuole organization | Increases phenotype | PMID:34470993 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | Decreases phenotype | PMID:25549548 |
| GO:0007268 | Chemical synaptic transmission | Affects phenotype | PMID:12702707 |
| GO:0007283 | Spermatogenesis | Decreases phenotype | PMID:25637669 |
| GO:0007420 | Brain development | Affects phenotype | PMID:31690747 |
| GO:0007507 | Heart development | Affects phenotype | PMID:19091803 |
| GO:0007584 | Response to nutrient | Affects phenotype | PMID:26185205 |
| GO:0007613 | Memory | Decreases phenotype | PMID:29800586; PMID:30844427; PMID:32360496 |
| GO:0007614 | Short-term memory | Affects phenotype | PMID:30098312 |
| GO:0007616 | Long-term memory | Affects phenotype | PMID:30098312 |
| GO:0007623 | Circadian rhythm | Affects phenotype | PMID:32437693 |
| GO:0007625 | Grooming behavior | Increases phenotype | PMID:27126842 |
| GO:0007628 | Adult walking behavior | Affects phenotype | PMID:34864093 |
| GO:0007631 | Feeding behavior | Affects phenotype | PMID:34864093 |
| GO:0008137 | Nadh dehydrogenase (ubiquinone) activity | Affects phenotype | PMID:22257724; PMID:27984176 |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:22257724 |
| GO:0008202 | Steroid metabolic process | Affects phenotype | PMID:34454011; PMID:34454011; PMID:38341112; PMID:38341112 |
| GO:0008203 | Cholesterol metabolic process | Affects phenotype | PMID:31711802; PMID:35143882; PMID:37271273; PMID:39862944; PMID:32535229; PMID:32535229; PMID:33645892; PMID:32535229; PMID:33645892; PMID:35156864; PMID:33645892; PMID:34192554; PMID:34192554; PMID:39862944; PMID:34474091; PMID:35156864; PMID:37271273; PMID:39862944 |
| GO:0008206 | Bile acid metabolic process | Affects phenotype | PMID:34217791; PMID:35149083; PMID:35429548 |
| GO:0008211 | Glucocorticoid metabolic process | Affects phenotype | PMID:32535229 |
| GO:0008217 | Regulation of blood pressure | Affects phenotype | PMID:2050169; PMID:3234469; PMID:7796714; PMID:3358882; PMID:7995640 |
| GO:0008219 | Cell death | Increases phenotype | PMID:11981770; PMID:22257724; PMID:23448468; PMID:25881548; PMID:26177723; PMID:26970604; PMID:27939985; PMID:28119953; PMID:28385499; PMID:29704510; PMID:33017621; PMID:33516661 |
| GO:0008283 | Cell population proliferation | Affects phenotype | PMID:11981770; PMID:12218695; PMID:12544013; PMID:12700235; PMID:15255942; PMID:16770775; PMID:17582586; PMID:23544149; PMID:24201001; PMID:24374569; PMID:24769256; PMID:27989594; PMID:26033013; PMID:26033013; PMID:29704510; PMID:28763032; PMID:32418914; PMID:29803612; PMID:31954762; PMID:32418914; PMID:34565211 |
| GO:0008284 | Positive regulation of cell population proliferation | Increases phenotype | PMID:29432896; PMID:29769550; PMID:32198086 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:23770283; PMID:29524503; PMID:30373287; PMID:31226463; PMID:32151596; PMID:32151596; PMID:35595033; PMID:32497709; PMID:34405320; PMID:34405320; PMID:35595033; PMID:35595033; PMID:37898230 |
| GO:0008331 | High voltage-gated calcium channel activity | Increases phenotype | PMID:27905406 |
| GO:0008343 | Adult feeding behavior | Decreases phenotype | PMID:32360496; PMID:34547370 |
| GO:0008344 | Adult locomotory behavior | Increases phenotype | PMID:30319688; PMID:34864093; PMID:34662589; PMID:34864093 |
| GO:0008361 | Regulation of cell size | Affects phenotype | PMID:24492484 |
| GO:0008542 | Visual learning | Decreases phenotype | PMID:30844427 |
| GO:0008610 | Lipid biosynthetic process | Increases phenotype | PMID:24275070; PMID:27939985; PMID:27939985; PMID:30976847; PMID:27989594; PMID:27989594; PMID:28442378; PMID:28419832; PMID:28442378; PMID:29704510; PMID:30976847 |
| GO:0008652 | Amino acid biosynthetic process | Affects phenotype | PMID:26109895 |
| GO:0008654 | Phospholipid biosynthetic process | Increases phenotype | PMID:12850777; PMID:28442378 |
| GO:0009101 | Glycoprotein biosynthetic process | Decreases phenotype | PMID:27983966 |
| GO:0009435 | Nad biosynthetic process | Decreases phenotype | PMID:27984176 |
| GO:0009790 | Embryo development | Affects phenotype | PMID:19091803 |
| GO:0010035 | Response to inorganic substance | Decreases phenotype | PMID:27840117 |
| GO:0010172 | Embryonic body morphogenesis | Decreases phenotype | PMID:26074427 |
| GO:0010452 | Histone h3-k36 methylation | Decreases phenotype | PMID:29018328 |
| GO:0010459 | Negative regulation of heart rate | Affects phenotype | PMID:23500772 |
| GO:0010460 | Positive regulation of heart rate | Increases phenotype | PMID:26074427 |
| GO:0010508 | Positive regulation of autophagy | Increases phenotype | PMID:37898230 |
| GO:0010718 | Positive regulation of epithelial to mesenchymal transition | Increases phenotype | PMID:38880189 |
| GO:0010759 | Positive regulation of macrophage chemotaxis | Increases phenotype | PMID:34405320; PMID:35526736 |
| GO:0010801 | Negative regulation of peptidyl-threonine phosphorylation | Affects phenotype | PMID:35526736 |
| GO:0010884 | Positive regulation of lipid storage | Increases phenotype | PMID:27795452 |
| GO:0010890 | Positive regulation of sequestering of triglyceride | Increases phenotype | PMID:32492475 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:28062356; PMID:29432896; PMID:31059573 |
| GO:0014002 | Astrocyte development | Decreases phenotype | PMID:16770775 |
| GO:0015920 | Lipopolysaccharide transport | Increases phenotype | PMID:28964808 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:16540368; PMID:17299812; PMID:17433488; PMID:17433488; PMID:19325051; PMID:19325051; PMID:22257724; PMID:22486562; PMID:23265624; PMID:25029343; PMID:25029343; PMID:30844427; PMID:25455889; PMID:25455889; PMID:27984176; PMID:28419832; PMID:28797650; PMID:28882574; PMID:25637687; PMID:26854922; PMID:26970604; PMID:26970604; PMID:27983966; PMID:27474069; PMID:27474069; PMID:28456544; PMID:28963034; PMID:29339218; PMID:27983966; PMID:27984176; PMID:28115068; PMID:28419832; PMID:28456544; PMID:28797650; PMID:28849987; PMID:28963034; PMID:29044621; PMID:29085585; PMID:29085585; PMID:35156864; PMID:29339218; PMID:29704510; PMID:29803612; PMID:30844427; PMID:32360496; PMID:32531310; PMID:32894639; PMID:32894639; PMID:34346143; PMID:33017621; PMID:33301711; PMID:33314588; PMID:33516661; PMID:33645892; PMID:34346143; PMID:34346143; PMID:35158046; PMID:34474091; PMID:35156864; PMID:35158046; PMID:9528125 |
| GO:0016049 | Cell growth | Decreases phenotype | PMID:26177723; PMID:29694836; PMID:29704510 |
| GO:0016160 | Amylase activity | Increases phenotype | PMID:30248482 |
| GO:0016298 | Lipase activity | Increases phenotype | PMID:30248482 |
| GO:0016477 | Cell migration | Affects phenotype | PMID:26014148; PMID:35038560 |
| GO:0016505 | Peptidase activator activity involved in apoptotic process | Increases phenotype | PMID:27270636 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:18506933; PMID:20020850; PMID:24296114; PMID:25029343; PMID:29803612; PMID:33645892 |
| GO:0018212 | Peptidyl-tyrosine modification | Increases phenotype | PMID:25029343; PMID:27984176 |
| GO:0019368 | Fatty acid elongation, unsaturated fatty acid | Affects phenotype | PMID:24498295 |
| GO:0019432 | Triglyceride biosynthetic process | Increases phenotype | PMID:12036955; PMID:24746831; PMID:26769846; PMID:26858005; PMID:27984176; PMID:28131861; PMID:28882574; PMID:24746831; PMID:26115886; PMID:26115886; PMID:27989594; PMID:28442378; PMID:29940154; PMID:26115886; PMID:27989594; PMID:29940154; PMID:26769846; PMID:26858005; PMID:27939985; PMID:27939985; PMID:29940154; PMID:27984176; PMID:27989594; PMID:28131861; PMID:28442378; PMID:28882574; PMID:29044621; PMID:29476730; PMID:29940154 |
| GO:0019674 | Nad metabolic process | Increases phenotype | PMID:32087266 |
| GO:0019827 | Stem cell population maintenance | Affects phenotype | PMID:27693003 |
| GO:0019852 | L-ascorbic acid metabolic process | Affects phenotype | PMID:20020850 |
| GO:0021506 | Anterior neuropore closure | Decreases phenotype | PMID:25354798; PMID:26074427; PMID:26629949 |
| GO:0021537 | Telencephalon development | Decreases phenotype | PMID:28397836 |
| GO:0021542 | Dentate gyrus development | Decreases phenotype | PMID:23544149 |
| GO:0021766 | Hippocampus development | Decreases phenotype | PMID:23544149 |
| GO:0021915 | Neural tube development | Affects phenotype | PMID:19091803; PMID:19091803; PMID:34492310 |
| GO:0022008 | Neurogenesis | Decreases phenotype | PMID:31954762; PMID:34547370 |
| GO:0022408 | Negative regulation of cell-cell adhesion | Increases phenotype | PMID:29109170 |
| GO:0023041 | Neuronal signal transduction | Decreases phenotype | PMID:33068620 |
| GO:0030032 | Lamellipodium assembly | Increases phenotype | PMID:34687774 |
| GO:0030041 | Actin filament polymerization | Increases phenotype | PMID:16105861 |
| GO:0030154 | Cell differentiation | Increases phenotype | PMID:19919524 |
| GO:0030199 | Collagen fibril organization | Increases phenotype | PMID:20465419; PMID:33645892; PMID:37271273 |
| GO:0030203 | Glycosaminoglycan metabolic process | Increases phenotype | PMID:30543783 |
| GO:0030262 | Apoptotic nuclear changes | Increases phenotype | PMID:29069573 |
| GO:0030263 | Apoptotic chromosome condensation | Increases phenotype | PMID:37024064 |
| GO:0030264 | Nuclear fragmentation involved in apoptotic nuclear change | Increases phenotype | PMID:32151596 |
| GO:0030282 | Bone mineralization | Affects phenotype | PMID:31887396 |
| GO:0030335 | Positive regulation of cell migration | Increases phenotype | PMID:38880189 |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | Increases phenotype | PMID:29617878 |
| GO:0030900 | Forebrain development | Affects phenotype | PMID:19091803 |
| GO:0030901 | Midbrain development | Affects phenotype | PMID:19091803 |
| GO:0030902 | Hindbrain development | Affects phenotype | PMID:19091803 |
| GO:0031394 | Positive regulation of prostaglandin biosynthetic process | Decreases phenotype | PMID:25289771 |
| GO:0031914 | Negative regulation of synaptic plasticity | Increases phenotype | PMID:32497709 |
| GO:0031948 | Positive regulation of glucocorticoid biosynthetic process | Decreases phenotype | PMID:26188107 |
| GO:0031987 | Locomotion involved in locomotory behavior | Increases phenotype | PMID:19091803; PMID:31524960; PMID:23291223; PMID:23643753; PMID:29018328; PMID:31524960 |
| GO:0032125 | Micronucleus organization | Increases phenotype | PMID:29362861; PMID:36372259 |
| GO:0032147 | Activation of protein kinase activity | Decreases phenotype | PMID:28964808 |
| GO:0032148 | Activation of protein kinase b activity | Decreases phenotype | PMID:31226463 |
| GO:0032330 | Regulation of chondrocyte differentiation | Affects phenotype | PMID:29617878 |
| GO:0032430 | Positive regulation of phospholipase a2 activity | Increases phenotype | PMID:8928743 |
| GO:0032755 | Positive regulation of interleukin-6 production | Affects phenotype | PMID:22280800; PMID:24239723 |
| GO:0032760 | Positive regulation of tumor necrosis factor production | Affects phenotype | PMID:24239723 |
| GO:0032914 | Positive regulation of transforming growth factor beta1 production | Affects phenotype | PMID:24239723 |
| GO:0032956 | Regulation of actin cytoskeleton organization | Affects phenotype | PMID:38880189 |
| GO:0032964 | Collagen biosynthetic process | Increases phenotype | PMID:28442378 |
| GO:0032967 | Positive regulation of collagen biosynthetic process | Increases phenotype | PMID:22280800; PMID:30543783 |
| GO:0033344 | Cholesterol efflux | Increases phenotype | PMID:17478430 |
| GO:0033603 | Positive regulation of dopamine secretion | Increases phenotype | PMID:26711020 |
| GO:0034383 | Low-density lipoprotein particle clearance | Decreases phenotype | PMID:28442378 |
| GO:0034384 | High-density lipoprotein particle clearance | Increases phenotype | PMID:28442378 |
| GO:0034389 | Lipid droplet organization | Increases phenotype | PMID:27837167 |
| GO:0034440 | Lipid oxidation | Increases phenotype | PMID:18506933; PMID:18506933; PMID:24972622; PMID:25289771; PMID:38341112; PMID:20020850; PMID:20020850; PMID:27795452; PMID:36085217; PMID:20067348; PMID:24946281; PMID:35526736; PMID:37271273; PMID:39988212; PMID:24296114; PMID:24946281; PMID:24972622; PMID:24972622; PMID:38341112; PMID:25289771; PMID:25478868; PMID:25478868; PMID:32006539; PMID:25637669; PMID:25637669; PMID:36085217; PMID:25645596; PMID:25645596; PMID:35595033; PMID:26747301; PMID:26747958; PMID:27795452; PMID:27795452; PMID:36085217; PMID:30368987; PMID:30368987; PMID:36085217; PMID:30372842; PMID:30664321; PMID:32006539; PMID:35526736; PMID:35526736; PMID:37271273; PMID:39988212; PMID:35595033; PMID:36085217; PMID:37271273; PMID:37860953; PMID:38341112; PMID:39988212 |
| GO:0034447 | Very-low-density lipoprotein particle clearance | Decreases phenotype | PMID:28442378 |
| GO:0034599 | Cellular response to oxidative stress | Increases phenotype | PMID:28935932 |
| GO:0034650 | Cortisol metabolic process | Affects phenotype | PMID:34454011 |
| GO:0034773 | Histone h4-k20 trimethylation | Increases phenotype | PMID:28285099 |
| GO:0034976 | Response to endoplasmic reticulum stress | Affects phenotype | PMID:24224909 |
| GO:0035176 | Social behavior | Decreases phenotype | PMID:27126842; PMID:30143782 |
| GO:0035264 | Multicellular organism growth | Decreases phenotype | PMID:30943441 |
| GO:0035633 | Maintenance of blood-brain barrier | Decreases phenotype | PMID:33516661 |
| GO:0035640 | Exploration behavior | Affects phenotype | PMID:27126842; PMID:30143782 |
| GO:0035641 | Locomotory exploration behavior | Affects phenotype | PMID:34492310 |
| GO:0035733 | Hepatic stellate cell activation | Increases phenotype | PMID:37271273 |
| GO:0035810 | Positive regulation of urine volume | Increases phenotype | PMID:15314997 |
| GO:0035860 | Glial cell-derived neurotrophic factor receptor signaling pathway | Decreases phenotype | PMID:29548890 |
| GO:0036123 | Histone h3-k9 dimethylation | Affects phenotype | PMID:30143782 |
| GO:0036124 | Histone h3-k9 trimethylation | Affects phenotype | PMID:24899502; PMID:28285099 |
| GO:0036211 | Protein modification process | Increases phenotype | PMID:20020850; PMID:24946281; PMID:24946281; PMID:28119953; PMID:28119953 |
| GO:0036343 | Psychomotor behavior | Decreases phenotype | PMID:26778759; PMID:30943441 |
| GO:0038001 | Paracrine signaling | Increases phenotype | PMID:27765815 |
| GO:0040015 | Negative regulation of multicellular organism growth | Increases phenotype | PMID:29317476; PMID:29317476; PMID:34405320; PMID:34405320 |
| GO:0042045 | Epithelial fluid transport | Decreases phenotype | PMID:35526736 |
| GO:0042098 | T cell proliferation | Decreases phenotype | PMID:28843478 |
| GO:0042178 | Xenobiotic catabolic process | Increases phenotype | PMID:9817083 |
| GO:0042311 | Vasodilation | Increases phenotype | PMID:3358882; PMID:7763124 |
| GO:0042360 | Vitamin e metabolic process | Affects phenotype | PMID:20020850 |
| GO:0042417 | Dopamine metabolic process | Affects phenotype | PMID:34590183 |
| GO:0042554 | Superoxide anion generation | Increases phenotype | PMID:17351912; PMID:23544086; PMID:34474091 |
| GO:0042587 | Glycogen granule | Increases phenotype | PMID:34470993 |
| GO:0042593 | Glucose homeostasis | Decreases phenotype | PMID:30248482; PMID:35713687 |
| GO:0042632 | Cholesterol homeostasis | Decreases phenotype | PMID:27795452; PMID:29317476; PMID:29317476; PMID:34405320; PMID:29548890; PMID:30372842; PMID:31226463; PMID:29548890; PMID:31075344; PMID:30372842; PMID:30372842; PMID:31075344; PMID:31226463; PMID:31075344; PMID:31226463; PMID:34405320; PMID:35713687; PMID:37023972 |
| GO:0042743 | Hydrogen peroxide metabolic process | Affects phenotype | PMID:22486562; PMID:33314588; PMID:33516661 |
| GO:0042755 | Eating behavior | Affects phenotype | PMID:35227807 |
| GO:0042756 | Drinking behavior | Increases phenotype | PMID:28397836; PMID:31550440; PMID:32360496; PMID:34547370; PMID:35227807; PMID:35713687 |
| GO:0042791 | 5s class rrna transcription by rna polymerase iii | Increases phenotype | PMID:32198086 |
| GO:0042797 | Trna transcription by rna polymerase iii | Increases phenotype | PMID:32198086 |
| GO:0043032 | Positive regulation of macrophage activation | Increases phenotype | PMID:35526736 |
| GO:0043045 | Dna methylation involved in embryo development | Decreases phenotype | PMID:23544149 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:21525764; PMID:23770283; PMID:24224909; PMID:24946281; PMID:24946281; PMID:32492475; PMID:35526736; PMID:25645596; PMID:25927324; PMID:27033740; PMID:28962519; PMID:31226463; PMID:32151596; PMID:32492475; PMID:35526736; PMID:35639301; PMID:37406968; PMID:39521100 |
| GO:0043123 | Positive regulation of i-kappab kinase/nf-kappab signaling | Increases phenotype | PMID:24239723; PMID:35526736 |
| GO:0043408 | Regulation of mapk cascade | Affects phenotype | PMID:22530035; PMID:25226407 |
| GO:0043410 | Positive regulation of mapk cascade | Increases phenotype | PMID:36453646 |
| GO:0043497 | Regulation of protein heterodimerization activity | Affects phenotype | PMID:29205397 |
| GO:0043525 | Positive regulation of neuron apoptotic process | Increases phenotype | PMID:32497709 |
| GO:0043569 | Negative regulation of insulin-like growth factor receptor signaling pathway | Increases phenotype | PMID:29524503 |
| GO:0043583 | Ear development | Affects phenotype | PMID:19091803 |
| GO:0043584 | Nose development | Affects phenotype | PMID:19091803 |
| GO:0043603 | Amide metabolic process | Affects phenotype | PMID:38341112 |
| GO:0043970 | Histone h3-k9 acetylation | Increases phenotype | PMID:24899502; PMID:31887396 |
| GO:0043974 | Histone h3-k27 acetylation | Increases phenotype | PMID:28285099; PMID:31887396 |
| GO:0043984 | Histone h4-k16 acetylation | Increases phenotype | PMID:28285099 |
| GO:0044237 | Cellular metabolic process | Affects phenotype | PMID:19778255; PMID:32061760; PMID:33516933; PMID:32418914; PMID:33516933; PMID:34192554; PMID:34192554; PMID:34474091; PMID:34346143; PMID:34346143; PMID:35158046; PMID:39988212; PMID:34474091; PMID:34687774; PMID:34864093; PMID:34995708; PMID:35066094; PMID:35149083; PMID:35158046; PMID:35478211; PMID:37271273; PMID:38341112; PMID:39862944 |
| GO:0044242 | Cellular lipid catabolic process | Increases phenotype | PMID:21999510; PMID:24065054 |
| GO:0044319 | Wound healing, spreading of cells | Decreases phenotype | PMID:38341112 |
| GO:0044648 | Histone h3-k4 dimethylation | Increases phenotype | PMID:35149083 |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | Affects phenotype | PMID:18506933; PMID:25478868; PMID:36535314 |
| GO:0045454 | Cell redox homeostasis | Decreases phenotype | PMID:26185205; PMID:28849987; PMID:30368987; PMID:32151596; PMID:37023972; PMID:37499997 |
| GO:0045597 | Positive regulation of cell differentiation | Affects phenotype | PMID:3180082 |
| GO:0045600 | Positive regulation of fat cell differentiation | Increases phenotype | PMID:32171850 |
| GO:0045722 | Positive regulation of gluconeogenesis | Increases phenotype | PMID:23544086 |
| GO:0045766 | Positive regulation of angiogenesis | Increases phenotype | PMID:27840117 |
| GO:0045807 | Positive regulation of endocytosis | Increases phenotype | PMID:26733986 |
| GO:0045834 | Positive regulation of lipid metabolic process | Increases phenotype | PMID:32151596; PMID:32171850 |
| GO:0045851 | Ph reduction | Decreases phenotype | PMID:34405320 |
| GO:0045870 | Positive regulation of single stranded viral rna replication via double stranded dna intermediate | Increases phenotype | PMID:26733986 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Increases phenotype | PMID:23378141; PMID:26033013 |
| GO:0045954 | Positive regulation of natural killer cell mediated cytotoxicity | Decreases phenotype | PMID:6694728 |
| GO:0046034 | Atp metabolic process | Affects phenotype | PMID:35158046 |
| GO:0046058 | Camp metabolic process | Increases phenotype | PMID:29802914 |
| GO:0046186 | Acetaldehyde biosynthetic process | Increases phenotype | PMID:17299812; PMID:23448468 |
| GO:0046187 | Acetaldehyde catabolic process | Affects phenotype | PMID:30248482 |
| GO:0046209 | Nitric oxide metabolic process | Affects phenotype | PMID:32360496; PMID:33314588; PMID:33516661; PMID:35156864; PMID:38341112 |
| GO:0046330 | Positive regulation of jnk cascade | Increases phenotype | PMID:32151596 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:11125845; PMID:11747978; PMID:11747978; PMID:16865776; PMID:2576368; PMID:36453646; PMID:9503478; PMID:14598302; PMID:16865776; PMID:2576368; PMID:2634830; PMID:27198676; PMID:35863473; PMID:36453646; PMID:6316840 |
| GO:0046483 | Heterocycle metabolic process | Affects phenotype | PMID:38341112 |
| GO:0046621 | Negative regulation of organ growth | Increases phenotype | PMID:30368987 |
| GO:0046622 | Positive regulation of organ growth | Increases phenotype | PMID:29317476; PMID:29769550; PMID:37898230 |
| GO:0046654 | Tetrahydrofolate biosynthetic process | Affects phenotype | PMID:24498295 |
| GO:0046847 | Filopodium assembly | Increases phenotype | PMID:34687774 |
| GO:0046849 | Bone remodeling | Decreases phenotype | PMID:22892342 |
| GO:0046960 | Sensitization | Affects phenotype | PMID:23291223; PMID:23291223; PMID:29084627; PMID:29084627 |
| GO:0047810 | D-alanine:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:25859307 |
| GO:0048009 | Insulin-like growth factor receptor signaling pathway | Affects phenotype | PMID:24275070 |
| GO:0048149 | Behavioral response to ethanol | Increases phenotype | PMID:18276852; PMID:28194850; PMID:28397836; PMID:35713687; PMID:39988212 |
| GO:0048468 | Cell development | Affects phenotype | PMID:35227807 |
| GO:0048469 | Cell maturation | Increases phenotype | PMID:28882574 |
| GO:0048666 | Neuron development | Decreases phenotype | PMID:16770775 |
| GO:0048874 | Host-mediated regulation of intestinal microbiota composition | Increases phenotype | PMID:35526736 |
| GO:0050405 | [acetyl-coa carboxylase] kinase activity | Decreases phenotype | PMID:35526736 |
| GO:0050665 | Hydrogen peroxide biosynthetic process | Increases phenotype | PMID:26220687; PMID:30844427 |
| GO:0050768 | Negative regulation of neurogenesis | Increases phenotype | PMID:32497709 |
| GO:0050769 | Positive regulation of neurogenesis | Decreases phenotype | PMID:26747301 |
| GO:0050890 | Cognition | Decreases phenotype | PMID:33516661; PMID:35863473 |
| GO:0050996 | Positive regulation of lipid catabolic process | Increases phenotype | PMID:37142061; PMID:37499997 |
| GO:0051059 | Nf-kappab binding | Decreases phenotype | PMID:11781286 |
| GO:0051216 | Cartilage development | Affects phenotype | PMID:36174738 |
| GO:0051348 | Negative regulation of transferase activity | Affects phenotype | PMID:32151596 |
| GO:0051480 | Regulation of cytosolic calcium ion concentration | Affects phenotype | PMID:26033013 |
| GO:0051481 | Negative regulation of cytosolic calcium ion concentration | Decreases phenotype | PMID:25549548 |
| GO:0051560 | Mitochondrial calcium ion homeostasis | Affects phenotype | PMID:35158046 |
| GO:0051568 | Histone h3-k4 methylation | Increases phenotype | PMID:35149083 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Decreases phenotype | PMID:21410490; PMID:22257724; PMID:26033013; PMID:26033013; PMID:29704510; PMID:28115068; PMID:29803612; PMID:34474091; PMID:35158046; PMID:9637713 |
| GO:0051882 | Mitochondrial depolarization | Increases phenotype | PMID:37142061 |
| GO:0051901 | Positive regulation of mitochondrial depolarization | Increases phenotype | PMID:32151596 |
| GO:0055070 | Copper ion homeostasis | Affects phenotype | PMID:26858005 |
| GO:0055071 | Manganese ion homeostasis | Affects phenotype | PMID:34590183 |
| GO:0055072 | Iron ion homeostasis | Decreases phenotype | PMID:34590183; PMID:34864093; PMID:35595033 |
| GO:0055074 | Calcium ion homeostasis | Affects phenotype | PMID:29704510 |
| GO:0055088 | Lipid homeostasis | Affects phenotype | PMID:36535314 |
| GO:0060013 | Righting reflex | Decreases phenotype | PMID:29944862 |
| GO:0060173 | Limb development | Affects phenotype | PMID:19091803; PMID:36174738 |
| GO:0060267 | Positive regulation of respiratory burst | Increases phenotype | PMID:28935932 |
| GO:0060291 | Long-term synaptic potentiation | Decreases phenotype | PMID:30143782 |
| GO:0060323 | Head morphogenesis | Decreases phenotype | PMID:26074427 |
| GO:0060348 | Bone development | Decreases phenotype | PMID:27338645; PMID:31887396 |
| GO:0060392 | Negative regulation of smad protein signal transduction | Increases phenotype | PMID:29617878 |
| GO:0060545 | Positive regulation of necroptotic process | Increases phenotype | PMID:24946281; PMID:37898230 |
| GO:0060613 | Fat pad development | Decreases phenotype | PMID:29317476 |
| GO:0060729 | Intestinal epithelial structure maintenance | Decreases phenotype | PMID:35526736 |
| GO:0061053 | Somite development | Decreases phenotype | PMID:25354798; PMID:26074427; PMID:26629949 |
| GO:0061179 | Negative regulation of insulin secretion involved in cellular response to glucose stimulus | Increases phenotype | PMID:32087266 |
| GO:0061436 | Establishment of skin barrier | Decreases phenotype | PMID:26778740 |
| GO:0061518 | Microglial cell proliferation | Affects phenotype | PMID:30098312; PMID:34547370 |
| GO:0061744 | Motor behavior | Affects phenotype | PMID:33068620 |
| GO:0061975 | Articular cartilage development | Decreases phenotype | PMID:29617878 |
| GO:0070164 | Negative regulation of adiponectin secretion | Affects phenotype | PMID:24412557 |
| GO:0070165 | Positive regulation of adiponectin secretion | Affects phenotype | PMID:24412557 |
| GO:0070212 | Protein poly-adp-ribosylation | Increases phenotype | PMID:26383632; PMID:29317476; PMID:29339456 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:28689299; PMID:29704510; PMID:35156864; PMID:31785310; PMID:35156864 |
| GO:0070266 | Necroptotic process | Increases phenotype | PMID:26769846; PMID:34474091 |
| GO:0070328 | Triglyceride homeostasis | Decreases phenotype | PMID:27688165; PMID:27688165; PMID:28964808; PMID:35526736; PMID:27795452; PMID:28935932; PMID:28935932; PMID:28964808; PMID:29317476; PMID:34405320; PMID:35526736; PMID:28964808; PMID:29317476; PMID:30372842; PMID:34405320; PMID:35526736; PMID:35713687; PMID:36535314; PMID:37023972 |
| GO:0070372 | Regulation of erk1 and erk2 cascade | Affects phenotype | PMID:25226407 |
| GO:0070374 | Positive regulation of erk1 and erk2 cascade | Increases phenotype | PMID:32151596 |
| GO:0070577 | Lysine-acetylated histone binding | Decreases phenotype | PMID:34454011 |
| GO:0070857 | Regulation of bile acid biosynthetic process | Affects phenotype | PMID:24498295 |
| GO:0070932 | Histone h3 deacetylation | Increases phenotype | PMID:29069573 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:20067348; PMID:20067348; PMID:24892905; PMID:25162931; PMID:25455889; PMID:39862944; PMID:24892905; PMID:25162931; PMID:25029343; PMID:25455889; PMID:26522475; PMID:34346143; PMID:37150348; PMID:39862944 |
| GO:0070997 | Neuron death | Increases phenotype | PMID:32360496; PMID:36402194 |
| GO:0071407 | Cellular response to organic cyclic compound | Decreases phenotype | PMID:32199159 |
| GO:0071441 | Negative regulation of histone h3-k14 acetylation | Increases phenotype | PMID:31075344 |
| GO:0071442 | Positive regulation of histone h3-k14 acetylation | Increases phenotype | PMID:29548890 |
| GO:0071500 | Cellular response to nitrosative stress | Increases phenotype | PMID:28935932 |
| GO:0071901 | Negative regulation of protein serine/threonine kinase activity | Increases phenotype | PMID:27688165 |
| GO:0071902 | Positive regulation of protein serine/threonine kinase activity | Affects phenotype | PMID:20224005 |
| GO:0072089 | Stem cell proliferation | Decreases phenotype | PMID:16770775 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:22530035; PMID:24201001; PMID:33017621; PMID:34192554; PMID:34346143; PMID:34474091; PMID:34864093; PMID:35158046; PMID:35478211; PMID:37271273 |
| GO:0080134 | Regulation of response to stress | Affects phenotype | PMID:24498295 |
| GO:0080182 | Histone h3-k4 trimethylation | Increases phenotype | PMID:24899502; PMID:28285099 |
| GO:0086003 | Cardiac muscle cell contraction | Affects phenotype | PMID:31059573 |
| GO:0090036 | Regulation of protein kinase c signaling | Affects phenotype | PMID:22530035 |
| GO:0090071 | Negative regulation of ribosome biogenesis | Increases phenotype | PMID:39521100 |
| GO:0090074 | Negative regulation of protein homodimerization activity | Increases phenotype | PMID:29205397 |
| GO:0090185 | Negative regulation of kidney development | Increases phenotype | PMID:29548890 |
| GO:0090326 | Positive regulation of locomotion involved in locomotory behavior | Increases phenotype | PMID:32497709 |
| GO:0097043 | Histone h3-k56 acetylation | Increases phenotype | PMID:28285099 |
| GO:0097198 | Histone h3-k36 trimethylation | Decreases phenotype | PMID:29018328 |
| GO:0097205 | Renal filtration | Decreases phenotype | PMID:29548890 |
| GO:0097342 | Ripoptosome | Increases phenotype | PMID:34474091 |
| GO:0097676 | Histone h3-k36 dimethylation | Decreases phenotype | PMID:29018328 |
| GO:0097707 | Ferroptosis | Increases phenotype | PMID:33017621 |
| GO:0098706 | Iron ion import across cell outer membrane | Increases phenotype | PMID:24746831 |
| GO:0140042 | Lipid droplet formation | Increases phenotype | PMID:26858005; PMID:27984176; PMID:28119953; PMID:28882574; PMID:28935932; PMID:29317476; PMID:31711802; PMID:31912162; PMID:32237978; PMID:34995708; PMID:39862944; PMID:28882574; PMID:28935932; PMID:29044621; PMID:29317476; PMID:29476730; PMID:29476730; PMID:29940154; PMID:29630881; PMID:29630881; PMID:37271273; PMID:31912162; PMID:32237978; PMID:33017621; PMID:34474091; PMID:34995708; PMID:35429548; PMID:37024064; PMID:37271273; PMID:39862944 |
| GO:0140112 | Extracellular vesicle biogenesis | Increases phenotype | PMID:38259729 |
| GO:0140460 | Response to gram-negative bacterium | Affects phenotype | PMID:39251147 |
| GO:0150032 | Positive regulation of protein localization to lysosome | Increases phenotype | PMID:35595033 |
| GO:0150063 | Visual system development | Affects phenotype | PMID:19091803 |
| GO:0160020 | Positive regulation of ferroptosis | Increases phenotype | PMID:35595033 |
| GO:1900015 | Regulation of cytokine production involved in inflammatory response | Affects phenotype | PMID:24239723 |
| GO:1900017 | Positive regulation of cytokine production involved in inflammatory response | Increases phenotype | PMID:25927324; PMID:28852734 |
| GO:1900111 | Positive regulation of histone h3-k9 dimethylation | Increases phenotype | PMID:29802914 |
| GO:1900181 | Negative regulation of protein localization to nucleus | Increases phenotype | PMID:32492475 |
| GO:1900182 | Positive regulation of protein localization to nucleus | Increases phenotype | PMID:27765815 |
| GO:1900744 | Regulation of p38mapk cascade | Affects phenotype | PMID:25226407 |
| GO:1900745 | Positive regulation of p38mapk cascade | Increases phenotype | PMID:24412557; PMID:27270636; PMID:32151596 |
| GO:1901097 | Negative regulation of autophagosome maturation | Increases phenotype | PMID:34405320 |
| GO:1901525 | Negative regulation of mitophagy | Increases phenotype | PMID:35595033 |
| GO:1901666 | Positive regulation of nad+ adp-ribosyltransferase activity | Increases phenotype | PMID:26383632 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Increases phenotype | PMID:23500772; PMID:24569067; PMID:27198676; PMID:32151596 |
| GO:1901671 | Positive regulation of superoxide dismutase activity | Affects phenotype | PMID:24296114; PMID:25289771; PMID:31374322 |
| GO:1901676 | Positive regulation of histone h3-k27 acetylation | Increases phenotype | PMID:29548890 |
| GO:1901687 | Glutathione derivative biosynthetic process | Increases phenotype | PMID:24296114 |
| GO:1901727 | Positive regulation of histone deacetylase activity | Increases phenotype | PMID:29069573 |
| GO:1902093 | Positive regulation of flagellated sperm motility | Decreases phenotype | PMID:25637669 |
| GO:1902255 | Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | Increases phenotype | PMID:27270636 |
| GO:1902260 | Negative regulation of delayed rectifier potassium channel activity | Increases phenotype | PMID:28284858 |
| GO:1902512 | Positive regulation of apoptotic dna fragmentation | Increases phenotype | PMID:27270636 |
| GO:1902690 | Positive regulation of nad metabolic process | Increases phenotype | PMID:29317476 |
| GO:1903169 | Regulation of calcium ion transmembrane transport | Affects phenotype | PMID:31059573 |
| GO:1903283 | Negative regulation of glutathione peroxidase activity | Increases phenotype | PMID:32151596 |
| GO:1903284 | Positive regulation of glutathione peroxidase activity | Affects phenotype | PMID:24296114; PMID:25289771; PMID:31374322 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Increases phenotype | PMID:22257724; PMID:23265624; PMID:26177723; PMID:28115068; PMID:29362861; PMID:29704510 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:20705415; PMID:21525764; PMID:25449124; PMID:25645596; PMID:25645596; PMID:28062356; PMID:35595033; PMID:26079697; PMID:28062356; PMID:28062356; PMID:32151596; PMID:35595033; PMID:31059573; PMID:32151596; PMID:34405320; PMID:35595033; PMID:35639301; PMID:36535314; PMID:37142061 |
| GO:1904007 | Positive regulation of phospholipase d activity | Increases phenotype | PMID:8928743 |
| GO:1904178 | Negative regulation of adipose tissue development | Increases phenotype | PMID:34116071 |
| GO:1904345 | Negative regulation of gastric mucosal blood circulation | Increases phenotype | PMID:11567657 |
| GO:1904808 | Positive regulation of protein oxidation | Increases phenotype | PMID:35639301 |
| GO:1904973 | Positive regulation of viral translation | Increases phenotype | PMID:26733986 |
| GO:1990266 | Neutrophil migration | Increases phenotype | PMID:26769846 |
| GO:1990708 | Conditioned place preference | Increases phenotype | PMID:29944862 |
| GO:1990812 | Growth cone filopodium | Decreases phenotype | PMID:34687774 |
| GO:2000065 | Negative regulation of cortisol biosynthetic process | Increases phenotype | PMID:29524503 |
| GO:2000252 | Negative regulation of feeding behavior | Increases phenotype | PMID:27126842; PMID:34116071 |
| GO:2000304 | Positive regulation of ceramide biosynthetic process | Increases phenotype | PMID:20224005 |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | Increases phenotype | PMID:24569067 |
| GO:2000391 | Positive regulation of neutrophil extravasation | Increases phenotype | PMID:28935932; PMID:28935932; PMID:35526736; PMID:35526736 |
| GO:2000480 | Negative regulation of camp-dependent protein kinase activity | Increases phenotype | PMID:24582693; PMID:29802914 |
| GO:2000481 | Positive regulation of camp-dependent protein kinase activity | Increases phenotype | PMID:29802914 |
| GO:2000491 | Positive regulation of hepatic stellate cell activation | Increases phenotype | PMID:30543783 |
| GO:2000616 | Negative regulation of histone h3-k9 acetylation | Increases phenotype | PMID:29802914; PMID:31075344 |
| GO:2000617 | Positive regulation of histone h3-k9 acetylation | Increases phenotype | PMID:20705415; PMID:29548890 |
| GO:2000748 | Positive regulation of defecation rhythm | Increases phenotype | PMID:32497709 |
| GO:2000774 | Positive regulation of cellular senescence | Increases phenotype | PMID:34405320 |
| GO:2000786 | Positive regulation of autophagosome assembly | Increases phenotype | PMID:29524503; PMID:35595033; PMID:36535314 |
| GO:2000853 | Negative regulation of corticosterone secretion | Increases phenotype | PMID:31075344 |
| GO:2000854 | Positive regulation of corticosterone secretion | Affects phenotype | PMID:26188107; PMID:29802914; PMID:31075344 |
| GO:2000863 | Positive regulation of estrogen secretion | Increases phenotype | PMID:29769550 |
| GO:2001025 | Positive regulation of response to drug | Increases phenotype | PMID:24337826 |
| GO:2001057 | Reactive nitrogen species metabolic process | Increases phenotype | PMID:30372842 |
| GO:2001170 | Negative regulation of atp biosynthetic process | Increases phenotype | PMID:32087266 |
| GO:2001272 | Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | Increases phenotype | PMID:29069573 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.