Formaldehyde


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:37584494
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:37584494
GO:0002027 Regulation of heart rate Affects phenotype PMID:36706861; PMID:36758786
GO:0002228 Natural killer cell mediated immunity Decreases phenotype PMID:24060340
GO:0002248 Connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:29758289
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:1683282; PMID:29758289
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:29758289; PMID:36706861
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:27020608; PMID:28422384
GO:0002859 Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Affects phenotype PMID:24060340
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23059809; PMID:39142364
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:23059809; PMID:23059809; PMID:31823256; PMID:29315975; PMID:39142364
GO:0006089 Lactate metabolic process Affects phenotype PMID:33259821
GO:0006096 Glycolytic process Affects phenotype PMID:37638564
GO:0006281 Dna repair Affects phenotype PMID:23649840
GO:0006304 Dna modification Increases phenotype PMID:27941166; PMID:28373009
GO:0006606 Protein import into nucleus Affects phenotype PMID:36534342
GO:0006749 Glutathione metabolic process Affects phenotype PMID:31823256; PMID:33259821
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:24733833; PMID:30395894
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24733833
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:33259821
GO:0006884 Cell volume homeostasis Affects phenotype PMID:36706861
GO:0006915 Apoptotic process Increases phenotype PMID:22186232; PMID:24140967; PMID:30600586; PMID:36534342; PMID:37584494
GO:0006954 Inflammatory response Increases phenotype PMID:29315975; PMID:30395894
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:22186232; PMID:23059809
GO:0007507 Heart development Affects phenotype PMID:36758786
GO:0007612 Learning Affects phenotype PMID:30395894
GO:0007613 Memory Affects phenotype PMID:30395894
GO:0008219 Cell death Increases phenotype PMID:17551412; PMID:30395894; PMID:33259821; PMID:39142364
GO:0008283 Cell population proliferation Decreases phenotype PMID:25821186; PMID:27339418; PMID:30236600
GO:0008285 Negative regulation of cell population proliferation Affects phenotype PMID:23649840
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:24142868
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:25821186
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23649840; PMID:28373009; PMID:29860525
GO:0016042 Lipid catabolic process Increases phenotype PMID:23059809; PMID:29315975; PMID:31823256; PMID:33259821
GO:0016477 Cell migration Increases phenotype PMID:30236600
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:39992237
GO:0019233 Sensory perception of pain Increases phenotype PMID:22236721; PMID:34896366
GO:0030101 Natural killer cell activation Affects phenotype PMID:25157974
GO:0030199 Collagen fibril organization Decreases phenotype PMID:29758289
GO:0030217 T cell differentiation Affects phenotype PMID:1683282
GO:0030534 Adult behavior Affects phenotype PMID:30395894
GO:0030854 Positive regulation of granulocyte differentiation Increases phenotype PMID:27020608
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:27664576
GO:0032609 Type ii interferon production Decreases phenotype PMID:25157974
GO:0032611 Interleukin-1 beta production Increases phenotype PMID:23671638
GO:0032613 Interleukin-10 production Increases phenotype PMID:25157974
GO:0032633 Interleukin-4 production Increases phenotype PMID:23671638; PMID:25157974
GO:0032637 Interleukin-8 production Decreases phenotype PMID:25157974
GO:0032689 Negative regulation of type ii interferon production Affects phenotype PMID:24060340
GO:0032824 Negative regulation of natural killer cell differentiation Affects phenotype PMID:24060340
GO:0034440 Lipid oxidation Increases phenotype PMID:39142364
GO:0034614 Cellular response to reactive oxygen species Increases phenotype PMID:29758289
GO:0034728 Nucleosome organization Decreases phenotype PMID:28937961
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:24140967
GO:0035491 Positive regulation of leukotriene production involved in inflammatory response Increases phenotype PMID:39992237
GO:0035944 Perforin production Decreases phenotype PMID:24060340
GO:0036336 Dendritic cell migration Increases phenotype PMID:39992237
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:28373009
GO:0042113 B cell activation Affects phenotype PMID:25157974
GO:0042310 Vasoconstriction Increases phenotype PMID:30974163; PMID:39067042
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23359814; PMID:37263556
GO:0043303 Mast cell degranulation Increases phenotype PMID:29758289
GO:0043966 Histone h3 acetylation Affects phenotype PMID:28937961
GO:0043970 Histone h3-k9 acetylation Decreases phenotype PMID:28937961
GO:0043983 Histone h4-k12 acetylation Affects phenotype PMID:28937961
GO:0044065 Regulation of respiratory system process Affects phenotype PMID:23871789
GO:0044154 Histone h3-k14 acetylation Decreases phenotype PMID:28937961
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31823256; PMID:33233951; PMID:33259821; PMID:36534342; PMID:37584494
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:33233951
GO:0045023 G0 to g1 transition Affects phenotype PMID:37584494
GO:0045333 Cellular respiration Decreases phenotype PMID:36116563; PMID:37638564
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:23359814; PMID:37105513
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:37105513
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:27941166
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:22186232
GO:0045953 Negative regulation of natural killer cell mediated cytotoxicity Affects phenotype PMID:24060340
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:31823256; PMID:37638564
GO:0046292 Formaldehyde metabolic process Affects phenotype PMID:30255327
GO:0046293 Formaldehyde biosynthetic process Increases phenotype PMID:31494693
GO:0048266 Behavioral response to pain Increases phenotype PMID:30261224
GO:0050671 Positive regulation of lymphocyte proliferation Increases phenotype PMID:20677212
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:39992237
GO:0061366 Behavioral response to chemical pain Increases phenotype PMID:19027877; PMID:19027877; PMID:29499192; PMID:29499192
GO:0061368 Behavioral response to formalin induced pain Increases phenotype PMID:15315263; PMID:15315263; PMID:28422384; PMID:18164607; PMID:27277137; PMID:27899695; PMID:28422384
GO:0070212 Protein poly-adp-ribosylation Affects phenotype PMID:22479348
GO:0070628 Proteasome binding Increases phenotype PMID:35504338
GO:0070814 Hydrogen sulfide biosynthetic process Decreases phenotype PMID:23359814
GO:0070989 Oxidative demethylation Increases phenotype PMID:8498088
GO:0070994 Detection of oxidative stress Increases phenotype PMID:36706861
GO:0071169 Establishment of protein localization to chromatin Affects phenotype PMID:36534342
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33259821; PMID:37584494
GO:0072672 Neutrophil extravasation Increases phenotype PMID:23671638
GO:0072682 Eosinophil extravasation Increases phenotype PMID:23671638
GO:0097531 Mast cell migration Increases phenotype PMID:39992237
GO:0097707 Ferroptosis Increases phenotype PMID:33259821
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:29860525
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:27020608
GO:1902035 Positive regulation of hematopoietic stem cell proliferation Increases phenotype PMID:28373009
GO:1902107 Positive regulation of leukocyte differentiation Decreases phenotype PMID:27020608
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:37584494
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27339418; PMID:29758289; PMID:30236600
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28373009
GO:2000318 Positive regulation of t-helper 17 type immune response Increases phenotype PMID:29758289
GO:2000553 Positive regulation of t-helper 2 cell cytokine production Increases phenotype PMID:29758289
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:24142868
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.