3,4-Methylenedioxymethamphetamine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:26610922
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:36138126
GO:0001774 Microglial cell activation Increases phenotype PMID:24299738
GO:0003084 Positive regulation of systemic arterial blood pressure Affects phenotype PMID:29198060
GO:0005391 P-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:36104498
GO:0006101 Citrate metabolic process Affects phenotype PMID:30255327
GO:0006106 Fumarate metabolic process Affects phenotype PMID:30255327
GO:0006108 Malate metabolic process Affects phenotype PMID:30255327
GO:0006117 Acetaldehyde metabolic process Affects phenotype PMID:30255327
GO:0006532 Aspartate biosynthetic process Decreases phenotype PMID:30255327
GO:0006537 Glutamate biosynthetic process Decreases phenotype PMID:30255327
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:24101030
GO:0006897 Endocytosis Increases phenotype PMID:32186374
GO:0006915 Apoptotic process Increases phenotype PMID:29105552
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:23820845; PMID:27255387
GO:0007033 Vacuole organization Increases phenotype PMID:32186374
GO:0007616 Long-term memory Affects phenotype PMID:24595967
GO:0007626 Locomotory behavior Increases phenotype PMID:25370842
GO:0008219 Cell death Increases phenotype PMID:24101030; PMID:26610922
GO:0008283 Cell population proliferation Decreases phenotype PMID:24101030; PMID:24177245
GO:0009636 Response to toxic substance Affects phenotype PMID:24211539
GO:0010460 Positive regulation of heart rate Affects phenotype PMID:29198060
GO:0010635 Regulation of mitochondrial fusion Affects phenotype PMID:24595818
GO:0010940 Positive regulation of necrotic cell death Affects phenotype PMID:23820845
GO:0010942 Positive regulation of cell death Increases phenotype PMID:24211539; PMID:27373168
GO:0014062 Regulation of serotonin secretion Affects phenotype PMID:25370842
GO:0018928 Methyl ethyl ketone metabolic process Affects phenotype PMID:30255327
GO:0019226 Transmission of nerve impulse Affects phenotype PMID:28167133
GO:0019896 Axonal transport of mitochondrion Decreases phenotype PMID:24595818
GO:0021846 Cell proliferation in forebrain Decreases phenotype PMID:27373168
GO:0031650 Regulation of heat generation Affects phenotype PMID:24595820
GO:0031652 Positive regulation of heat generation Increases phenotype PMID:25370842; PMID:30923810
GO:0035641 Locomotory exploration behavior Affects phenotype PMID:24595820
GO:0042310 Vasoconstriction Increases phenotype PMID:27079619; PMID:30448555
GO:0043005 Neuron projection Decreases phenotype PMID:26610922
GO:0043065 Positive regulation of apoptotic process Affects phenotype PMID:23820845
GO:0044237 Cellular metabolic process Decreases phenotype PMID:32186374
GO:0046034 Atp metabolic process Affects phenotype PMID:23820845
GO:0046292 Formaldehyde metabolic process Affects phenotype PMID:30255327
GO:0051447 Negative regulation of meiotic cell cycle Decreases phenotype PMID:28087314
GO:0051464 Positive regulation of cortisol secretion Increases phenotype PMID:24190587
GO:0051612 Negative regulation of serotonin uptake Affects phenotype PMID:24211539
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:24101030
GO:0060096 Serotonin secretion, neurotransmission Increases phenotype PMID:24595820
GO:0070994 Detection of oxidative stress Increases phenotype PMID:36138126
GO:0071419 Cellular response to amphetamine Increases phenotype PMID:23820845
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24101030
GO:0090140 Regulation of mitochondrial fission Affects phenotype PMID:24595818
GO:1900535 Palmitic acid biosynthetic process Increases phenotype PMID:30255327
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:27773601
GO:1903189 Glyoxal metabolic process Affects phenotype PMID:30255327
GO:1903296 Positive regulation of glutamate secretion, neurotransmission Increases phenotype PMID:27773601
GO:1990138 Neuron projection extension Decreases phenotype PMID:32186374
GO:2000987 Positive regulation of behavioral fear response Increases phenotype PMID:24190587
GO:2001025 Positive regulation of response to drug Increases phenotype PMID:27773601
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:27255387
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.