Busulfan


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0006308 Dna catabolic process Affects phenotype PMID:16882877
GO:0006741 Nadp biosynthetic process Affects phenotype PMID:32416107
GO:0006914 Autophagy Affects phenotype PMID:38220133
GO:0006915 Apoptotic process Increases phenotype PMID:35533795
GO:0007033 Vacuole organization Increases phenotype PMID:35533795
GO:0007283 Spermatogenesis Decreases phenotype PMID:1058559; PMID:16903937; PMID:32416107; PMID:35533795; PMID:38123000; PMID:39081119
GO:0007286 Spermatid development Decreases phenotype PMID:39081119
GO:0008219 Cell death Increases phenotype PMID:15786497
GO:0008283 Cell population proliferation Decreases phenotype PMID:15786497; PMID:16882877
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28578006
GO:0016042 Lipid catabolic process Affects phenotype PMID:32416107
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:37597760
GO:0036098 Male germ-line stem cell population maintenance Decreases phenotype PMID:28578006
GO:0044237 Cellular metabolic process Decreases phenotype PMID:35533795; PMID:38123000
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:34097952
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:28578006
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:38220133
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:38123000
GO:0070994 Detection of oxidative stress Increases phenotype PMID:38123000
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:32416107; PMID:38220133
GO:0090398 Cellular senescence Increases phenotype PMID:16882877
GO:0097368 Establishment of sertoli cell barrier Affects phenotype PMID:35533795
GO:0097707 Ferroptosis Increases phenotype PMID:32416107
GO:0097722 Sperm motility Decreases phenotype PMID:32416107; PMID:35533795; PMID:38123000; PMID:39081119
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:38220133
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:26524245
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.