DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Caffeine

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:31306741
GO:0000084	Mitotic s phase	Affects phenotype	PMID:33971260
GO:0000085	Mitotic g2 phase	Affects phenotype	PMID:31597699
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:11278490; PMID:32910239
GO:0000278	Mitotic cell cycle	Decreases phenotype	PMID:32910239; PMID:6449284
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:35964836
GO:0001503	Ossification	Decreases phenotype	PMID:30423288; PMID:31874197; PMID:31874197
GO:0001570	Vasculogenesis	Decreases phenotype	PMID:31756439
GO:0001649	Osteoblast differentiation	Decreases phenotype	PMID:31874197
GO:0002027	Regulation of heart rate	Increases phenotype	PMID:15060505; PMID:1528938; PMID:4014015; PMID:8998252; PMID:15653753; PMID:19052555; PMID:8354027; PMID:8363291; PMID:917720
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:29055810; PMID:30528684
GO:0004053	Arginase activity	Increases phenotype	PMID:37865952
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:29249184
GO:0004364	Glutathione transferase activity	Increases phenotype	PMID:30776459
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:25486098
GO:0004517	Nitric-oxide synthase activity	Decreases phenotype	PMID:29447158
GO:0004679	Amp-activated protein kinase activity	Decreases phenotype	PMID:30555576
GO:0005776	Autophagosome	Increases phenotype	PMID:38759937
GO:0006119	Oxidative phosphorylation	Affects phenotype	PMID:7803452
GO:0006163	Purine nucleotide metabolic process	Affects phenotype	PMID:37865952
GO:0006171	Camp biosynthetic process	Affects phenotype	PMID:30555576; PMID:30825513
GO:0006182	Cgmp biosynthetic process	Decreases phenotype	PMID:29447158
GO:0006196	Amp catabolic process	Increases phenotype	PMID:37865952
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:10967407; PMID:12907610; PMID:9098629
GO:0006536	Glutamate metabolic process	Increases phenotype	PMID:35917217
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:29249184
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:29800656; PMID:30825513; PMID:30825513
GO:0006700	C21-steroid hormone biosynthetic process	Decreases phenotype	PMID:29343424
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:29249184; PMID:30555576
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:29407385
GO:0006809	Nitric oxide biosynthetic process	Affects phenotype	PMID:26852703; PMID:29447158
GO:0006811	Monoatomic ion transport	Increases phenotype	PMID:7803452
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:34453993; PMID:35964836
GO:0006914	Autophagy	Increases phenotype	PMID:21081844; PMID:22927544; PMID:38759937
GO:0006915	Apoptotic process	Increases phenotype	PMID:10797495; PMID:10967407; PMID:11835680; PMID:12205293; PMID:21561856; PMID:12378022; PMID:12811820; PMID:12395097; PMID:12907610; PMID:16351796; PMID:16522534; PMID:17145898; PMID:17188726; PMID:17664435; PMID:18179623; PMID:21505179; PMID:18201823; PMID:18440285; PMID:19242509; PMID:19325779; PMID:19490937; PMID:19996588; PMID:21081844; PMID:21229324; PMID:21561856; PMID:26339337; PMID:31756439; PMID:7593128; PMID:8402636; PMID:9098629; PMID:9459166
GO:0006954	Inflammatory response	Increases phenotype	PMID:29249184; PMID:37865952
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:30842367; PMID:33971260
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:19325779; PMID:19490937
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:30528684; PMID:30776459
GO:0007029	Endoplasmic reticulum organization	Decreases phenotype	PMID:30776459
GO:0007049	Cell cycle	Increases phenotype	PMID:11754638; PMID:11835680; PMID:12101394; PMID:12791511; PMID:12811820; PMID:15126379; PMID:18444173; PMID:19996588; PMID:21081844; PMID:21229324; PMID:3756902; PMID:6449284; PMID:7593128; PMID:8402636; PMID:9098629; PMID:9458082
GO:0007095	Mitotic g2 dna damage checkpoint signaling	Increases phenotype	PMID:24792323
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:28298333
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:33372294
GO:0007382	Specification of segmental identity, maxillary segment	Decreases phenotype	PMID:31756439
GO:0007420	Brain development	Decreases phenotype	PMID:31756439
GO:0007507	Heart development	Decreases phenotype	PMID:31756439
GO:0007565	Female pregnancy	Decreases phenotype	PMID:27112524
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:29249184
GO:0008217	Regulation of blood pressure	Increases phenotype	PMID:10463623; PMID:11310517; PMID:11576153; PMID:12240665; PMID:14573329; PMID:1528938; PMID:15696321; PMID:16278361; PMID:16541243; PMID:17087778; PMID:17126666; PMID:19052555; PMID:2437789; PMID:2583079; PMID:3046816; PMID:3354444; PMID:4014015; PMID:6353897; PMID:6635107; PMID:8405011; PMID:8998252; PMID:9638033; PMID:9655769; PMID:11509481; PMID:12434259; PMID:8354027; PMID:12457274; PMID:15060505; PMID:8529334; PMID:15060505; PMID:1860718; PMID:3020089; PMID:3046816; PMID:8354027; PMID:9631984
GO:0008219	Cell death	Affects phenotype	PMID:11278490; PMID:12101394; PMID:3756902
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:12811820; PMID:15126379; PMID:16522534; PMID:17145898; PMID:19996588; PMID:21081844; PMID:21229324; PMID:31306741
GO:0008284	Positive regulation of cell population proliferation	Decreases phenotype	PMID:34590332
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:30555576
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:24239806
GO:0009411	Response to uv	Decreases phenotype	PMID:30555576
GO:0009636	Response to toxic substance	Affects phenotype	PMID:24211539
GO:0009790	Embryo development	Affects phenotype	PMID:31756439
GO:0010470	Regulation of gastrulation	Affects phenotype	PMID:28184906
GO:0010737	Protein kinase a signaling	Decreases phenotype	PMID:35917217
GO:0010801	Negative regulation of peptidyl-threonine phosphorylation	Affects phenotype	PMID:30555576
GO:0010906	Regulation of glucose metabolic process	Affects phenotype	PMID:24321341
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:28089782; PMID:30098389
GO:0010972	Negative regulation of g2/m transition of mitotic cell cycle	Increases phenotype	PMID:21840268
GO:0014049	Positive regulation of glutamate secretion	Increases phenotype	PMID:35917217
GO:0014054	Positive regulation of gamma-aminobutyric acid secretion	Increases phenotype	PMID:35917217
GO:0014808	Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Increases phenotype	PMID:25937560
GO:0015793	Glycerol transmembrane transport	Increases phenotype	PMID:2307116
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:10094584; PMID:11508705; PMID:14684395; PMID:8005843; PMID:16395657; PMID:7256787; PMID:29249184; PMID:7018802
GO:0016049	Cell growth	Affects phenotype	PMID:36807623
GO:0018158	Protein oxidation	Affects phenotype	PMID:30098389; PMID:30555576
GO:0018212	Peptidyl-tyrosine modification	Increases phenotype	PMID:30098389
GO:0019222	Regulation of metabolic process	Affects phenotype	PMID:31568846
GO:0019229	Regulation of vasoconstriction	Affects phenotype	PMID:29447158
GO:0019432	Triglyceride biosynthetic process	Affects phenotype	PMID:30776459
GO:0019722	Calcium-mediated signaling	Increases phenotype	PMID:10797495; PMID:11566509; PMID:18172213; PMID:7585891
GO:0021915	Neural tube development	Decreases phenotype	PMID:31756439
GO:0030154	Cell differentiation	Affects phenotype	PMID:31711903
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:30098389
GO:0032125	Micronucleus organization	Increases phenotype	PMID:30842367
GO:0032496	Response to lipopolysaccharide	Increases phenotype	PMID:29055810; PMID:29958987
GO:0032836	Glomerular basement membrane development	Affects phenotype	PMID:31306741
GO:0033314	Mitotic dna replication checkpoint signaling	Decreases phenotype	PMID:29074359
GO:0033555	Multicellular organismal response to stress	Affects phenotype	PMID:24321341
GO:0034440	Lipid oxidation	Affects phenotype	PMID:30555576; PMID:33372294; PMID:37865952
GO:0034656	Nucleobase-containing small molecule catabolic process	Decreases phenotype	PMID:28465162
GO:0035115	Embryonic forelimb morphogenesis	Affects phenotype	PMID:31756439
GO:0035116	Embryonic hindlimb morphogenesis	Decreases phenotype	PMID:31756439
GO:0035261	External genitalia morphogenesis	Decreases phenotype	PMID:28111094
GO:0035810	Positive regulation of urine volume	Affects phenotype	PMID:16847703; PMID:7564894; PMID:21076499
GO:0035812	Renal sodium excretion	Increases phenotype	PMID:16847703
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:30776459
GO:0036211	Protein modification process	Increases phenotype	PMID:25486098
GO:0036276	Response to antidepressant	Increases phenotype	PMID:29107002; PMID:29107002; PMID:29882086; PMID:29882086
GO:0040018	Positive regulation of multicellular organism growth	Affects phenotype	PMID:28111094; PMID:28843594; PMID:31568846
GO:0042178	Xenobiotic catabolic process	Increases phenotype	PMID:19215233; PMID:27917125
GO:0042305	Specification of segmental identity, mandibular segment	Decreases phenotype	PMID:31756439
GO:0042310	Vasoconstriction	Increases phenotype	PMID:1528938; PMID:23177664; PMID:23177664; PMID:8932688; PMID:8932688
GO:0042311	Vasodilation	Increases phenotype	PMID:17126666; PMID:17309447; PMID:2225701; PMID:25356826; PMID:8354027
GO:0042391	Regulation of membrane potential	Decreases phenotype	PMID:21615388
GO:0042402	Cellular biogenic amine catabolic process	Decreases phenotype	PMID:28465162
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:34590332; PMID:35917217
GO:0043262	Adp phosphatase activity	Decreases phenotype	PMID:28465162
GO:0043970	Histone h3-k9 acetylation	Decreases phenotype	PMID:24717552; PMID:32663519
GO:0043974	Histone h3-k27 acetylation	Increases phenotype	PMID:30776459; PMID:30776459; PMID:30825513; PMID:30825513
GO:0044154	Histone h3-k14 acetylation	Affects phenotype	PMID:24717552; PMID:30776459; PMID:30776459; PMID:30825513; PMID:30825513
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:33971260
GO:0044242	Cellular lipid catabolic process	Affects phenotype	PMID:25486098
GO:0044849	Estrous cycle	Decreases phenotype	PMID:28111094
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:33971260
GO:0045333	Cellular respiration	Increases phenotype	PMID:7803452
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:21840268
GO:0046058	Camp metabolic process	Increases phenotype	PMID:35917217
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:29249184; PMID:37865952
GO:0046620	Regulation of organ growth	Affects phenotype	PMID:28843594
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:29343424
GO:0046622	Positive regulation of organ growth	Decreases phenotype	PMID:28111094
GO:0048730	Epidermis morphogenesis	Decreases phenotype	PMID:30555576
GO:0048807	Female genitalia morphogenesis	Decreases phenotype	PMID:28111094
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:29055810
GO:0050850	Positive regulation of calcium-mediated signaling	Increases phenotype	PMID:29394407
GO:0051216	Cartilage development	Affects phenotype	PMID:38759937
GO:0051881	Regulation of mitochondrial membrane potential	Decreases phenotype	PMID:21081844; PMID:30377735; PMID:33971260; PMID:7803452
GO:0060348	Bone development	Affects phenotype	PMID:31874197
GO:0060453	Regulation of gastric acid secretion	Affects phenotype	PMID:28696284
GO:0061053	Somite development	Affects phenotype	PMID:31756439
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:33372294
GO:0070265	Necrotic cell death	Increases phenotype	PMID:33372294
GO:0070814	Hydrogen sulfide biosynthetic process	Decreases phenotype	PMID:29447158
GO:0071481	Cellular response to x-ray	Increases phenotype	PMID:11278490
GO:0071599	Otic vesicle development	Decreases phenotype	PMID:31756439
GO:0072015	Podocyte development	Affects phenotype	PMID:31306741
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:33372294; PMID:33971260; PMID:35964836
GO:0072678	T cell migration	Increases phenotype	PMID:36807623
GO:0090181	Regulation of cholesterol metabolic process	Affects phenotype	PMID:24321341
GO:0090205	Positive regulation of cholesterol metabolic process	Increases phenotype	PMID:29958987
GO:0090207	Regulation of triglyceride metabolic process	Affects phenotype	PMID:24321341
GO:0090305	Nucleic acid phosphodiester bond hydrolysis	Increases phenotype	PMID:9511736
GO:0090398	Cellular senescence	Increases phenotype	PMID:22927544
GO:0090400	Stress-induced premature senescence	Decreases phenotype	PMID:30555576
GO:0090403	Oxidative stress-induced premature senescence	Increases phenotype	PMID:30555576
GO:0097577	Sequestering of iron ion	Increases phenotype	PMID:28465162
GO:0097578	Sequestering of copper ion	Increases phenotype	PMID:28465162
GO:0098817	Evoked excitatory postsynaptic potential	Increases phenotype	PMID:34536444
GO:0098868	Bone growth	Decreases phenotype	PMID:30423288
GO:0099537	Trans-synaptic signaling	Decreases phenotype	PMID:34536444
GO:0120029	Proton export across plasma membrane	Increases phenotype	PMID:28525714; PMID:28696284
GO:0140042	Lipid droplet formation	Affects phenotype	PMID:30776459; PMID:37046073
GO:0140657	Atp-dependent activity	Increases phenotype	PMID:37865952
GO:0150063	Visual system development	Decreases phenotype	PMID:31756439
GO:1902603	Carnitine transmembrane transport	Decreases phenotype	PMID:28298333
GO:1902794	Sirna-independent facultative heterochromatin formation	Increases phenotype	PMID:30555576
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:31597699; PMID:33971260
GO:1903408	Positive regulation of p-type sodium:potassium-exchanging transporter activity	Increases phenotype	PMID:28465162
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:30555576; PMID:34590332
GO:1904179	Positive regulation of adipose tissue development	Decreases phenotype	PMID:28111094
GO:1904457	Positive regulation of neuronal action potential	Increases phenotype	PMID:34536444
GO:1905037	Autophagosome organization	Increases phenotype	PMID:38759937
GO:1905069	Allantois development	Decreases phenotype	PMID:31756439
GO:1990034	Calcium ion export across plasma membrane	Increases phenotype	PMID:25799571
GO:1990845	Adaptive thermogenesis	Increases phenotype	PMID:4011637
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:30555576
GO:2000854	Positive regulation of corticosterone secretion	Increases phenotype	PMID:29343424; PMID:29958987
GO:2000859	Negative regulation of aldosterone secretion	Increases phenotype	PMID:29343424
GO:2000866	Positive regulation of estradiol secretion	Increases phenotype	PMID:28111094
GO:2001171	Positive regulation of atp biosynthetic process	Decreases phenotype	PMID:26921665

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.