Phenobarbital


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28414157
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28414157
GO:0004364 Glutathione transferase activity Affects phenotype PMID:19788401; PMID:27048571; PMID:28414157; PMID:28414157; PMID:9794803
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157
GO:0006094 Gluconeogenesis Decreases phenotype PMID:8665939
GO:0006260 Dna replication Increases phenotype PMID:25145657; PMID:32435917
GO:0006306 Dna methylation Increases phenotype PMID:24157574; PMID:33549593
GO:0006309 Apoptotic dna fragmentation Decreases phenotype PMID:8640813
GO:0006749 Glutathione metabolic process Affects phenotype PMID:35358606
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:24493665; PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:24021950; PMID:25745819; PMID:35597399; PMID:6135573
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:28414157
GO:0006811 Monoatomic ion transport Increases phenotype PMID:2167745
GO:0006915 Apoptotic process Increases phenotype PMID:10449034; PMID:17963809; PMID:24090815; PMID:26865186; PMID:8640813; PMID:9230198
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27048571; PMID:29777724; PMID:30842367
GO:0006979 Response to oxidative stress Increases phenotype PMID:10817630
GO:0007268 Chemical synaptic transmission Affects phenotype PMID:12694808
GO:0008206 Bile acid metabolic process Affects phenotype PMID:28495587
GO:0008219 Cell death Increases phenotype PMID:19437554; PMID:24493665
GO:0008283 Cell population proliferation Increases phenotype PMID:17963809; PMID:33398415; PMID:35881160; PMID:19437554; PMID:23626729; PMID:24025784; PMID:24090815; PMID:24157574; PMID:28414157; PMID:28495587; PMID:33398415; PMID:34813904; PMID:39909212
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:24449422; PMID:29244179
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32949729
GO:0008361 Regulation of cell size Increases phenotype PMID:3426617
GO:0009825 Multidimensional cell growth Increases phenotype PMID:32320717
GO:0010942 Positive regulation of cell death Increases phenotype PMID:1933335; PMID:9215992
GO:0016042 Lipid catabolic process Increases phenotype PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157; PMID:35113675; PMID:35358606
GO:0016401 Palmitoyl-coa oxidase activity Decreases phenotype PMID:32320717
GO:0016712 Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Increases phenotype PMID:29425889; PMID:32320717
GO:0018158 Protein oxidation Increases phenotype PMID:27048571
GO:0018411 Protein glucuronidation Increases phenotype PMID:36549901
GO:0018685 Alkane 1-monooxygenase activity Decreases phenotype PMID:32320717
GO:0019627 Urea metabolic process Affects phenotype PMID:35113675
GO:0030199 Collagen fibril organization Affects phenotype PMID:34796763
GO:0030307 Positive regulation of cell growth Increases phenotype PMID:31465819
GO:0032125 Micronucleus organization Increases phenotype PMID:30842367
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:27427493
GO:0032770 Positive regulation of monooxygenase activity Increases phenotype PMID:32320717
GO:0036211 Protein modification process Increases phenotype PMID:6547179
GO:0042168 Heme metabolic process Affects phenotype PMID:35113675
GO:0042178 Xenobiotic catabolic process Increases phenotype PMID:7483660; PMID:7483660; PMID:9817083; PMID:9929512; PMID:9817083; PMID:9929512
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:23439660; PMID:31465819
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:39909212
GO:0043971 Histone h3-k18 acetylation Increases phenotype PMID:28495587
GO:0046034 Atp metabolic process Increases phenotype PMID:32320717; PMID:32949729
GO:0046449 Creatinine metabolic process Affects phenotype PMID:35113675
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:10817630; PMID:8638846
GO:0046620 Regulation of organ growth Increases phenotype PMID:9121950
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:29548889; PMID:29548889; PMID:31465819
GO:0047962 Glycine n-benzoyltransferase activity Increases phenotype PMID:2818615
GO:0050649 Testosterone 6-beta-hydroxylase activity Increases phenotype PMID:32320717
GO:0051354 Negative regulation of oxidoreductase activity Affects phenotype PMID:32320717
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:24493665
GO:0060013 Righting reflex Decreases phenotype PMID:29944862; PMID:29944862; PMID:37115471; PMID:37115471
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:31270302
GO:0070633 Transepithelial transport Decreases phenotype PMID:18063342
GO:0070989 Oxidative demethylation Increases phenotype PMID:28218408
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24025784; PMID:24486436
GO:0071897 Dna biosynthetic process Increases phenotype PMID:27530964; PMID:29142176
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:23665940; PMID:23665940; PMID:24025784; PMID:24025784; PMID:24493665; PMID:35358606
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:28495587
GO:0090592 Dna synthesis involved in dna replication Increases phenotype PMID:28520973; PMID:31465819; PMID:29425889; PMID:29425889; PMID:32027962; PMID:29548889; PMID:31465819; PMID:32027962; PMID:32320717
GO:0098657 Import into cell Affects phenotype PMID:36216988
GO:0098781 Ncrna transcription Increases phenotype PMID:28541575
GO:1900064 Positive regulation of peroxisome organization Increases phenotype PMID:25786523
GO:1901113 Erythromycin metabolic process Increases phenotype PMID:16844145
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:30633929
GO:2000573 Positive regulation of dna biosynthetic process Increases phenotype PMID:28218408
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:19760798
GO:2001169 Regulation of atp biosynthetic process Affects phenotype PMID:32027962
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.