| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000902 | Cell morphogenesis | Affects phenotype | PMID:37840363 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:35908932 |
| GO:0002639 | Positive regulation of immunoglobulin production | Increases phenotype | PMID:27869817 |
| GO:0003958 | Nadph-hemoprotein reductase activity | Increases phenotype | PMID:27091720 |
| GO:0004035 | Alkaline phosphatase activity | Affects phenotype | PMID:16025432; PMID:33063951 |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | Affects phenotype | PMID:32623939; PMID:33063951; PMID:39214269 |
| GO:0004111 | Creatine kinase activity | Increases phenotype | PMID:39214269 |
| GO:0004364 | Glutathione transferase activity | Increases phenotype | PMID:18678235; PMID:21801490; PMID:23033690; PMID:27091720; PMID:31476248; PMID:33063951; PMID:35243731 |
| GO:0004457 | Lactate dehydrogenase activity | Affects phenotype | PMID:32623939; PMID:33063951; PMID:39214269 |
| GO:0004602 | Glutathione peroxidase activity | Affects phenotype | PMID:24995432; PMID:25744308; PMID:31476248; PMID:31476248; PMID:33759307; PMID:33063951; PMID:33347680; PMID:33347680; PMID:35243731; PMID:37840363; PMID:33347680; PMID:37840363; PMID:33759307; PMID:35243731; PMID:37840363 |
| GO:0004784 | Superoxide dismutase activity | Decreases phenotype | PMID:24995432; PMID:25744308; PMID:31476248; PMID:31476248; PMID:33759307; PMID:32662567; PMID:33063951; PMID:33347680; PMID:33347680; PMID:35243731; PMID:37840363; PMID:33347680; PMID:37840363; PMID:33759307; PMID:35243731; PMID:37840363 |
| GO:0005243 | Gap junction channel activity | Decreases phenotype | PMID:36863560 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:24995432 |
| GO:0006417 | Regulation of translation | Affects phenotype | PMID:39910959 |
| GO:0006606 | Protein import into nucleus | Affects phenotype | PMID:33347680 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:18678235; PMID:18678235; PMID:32623939; PMID:33063951; PMID:21801490; PMID:21801490; PMID:33347680; PMID:35243731; PMID:37840363; PMID:21801490; PMID:35243731; PMID:37840363; PMID:23033690; PMID:31476248; PMID:31476248; PMID:33759307; PMID:32623939; PMID:32623939; PMID:33063951; PMID:32662567; PMID:33063951; PMID:33347680; PMID:33347680; PMID:37840363; PMID:33759307; PMID:34896434; PMID:35243731; PMID:37840363 |
| GO:0006750 | Glutathione biosynthetic process | Decreases phenotype | PMID:24995432; PMID:25744308 |
| GO:0006809 | Nitric oxide biosynthetic process | Increases phenotype | PMID:16025432; PMID:24995432 |
| GO:0006915 | Apoptotic process | Decreases phenotype | PMID:31332895; PMID:34896434 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:23835587; PMID:39214269 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:23717041; PMID:25448685 |
| GO:0008219 | Cell death | Increases phenotype | PMID:12734332; PMID:35908932 |
| GO:0008283 | Cell population proliferation | Increases phenotype | PMID:27091720; PMID:29663660; PMID:37352108; PMID:38299738; PMID:39214269 |
| GO:0008284 | Positive regulation of cell population proliferation | Increases phenotype | PMID:23835587; PMID:26945725 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:29555536 |
| GO:0008360 | Regulation of cell shape | Affects phenotype | PMID:29663660 |
| GO:0008610 | Lipid biosynthetic process | Increases phenotype | PMID:30027798 |
| GO:0009636 | Response to toxic substance | Affects phenotype | PMID:35364107 |
| GO:0010820 | Positive regulation of t cell chemotaxis | Increases phenotype | PMID:27869817 |
| GO:0015020 | Glucuronosyltransferase activity | Decreases phenotype | PMID:27091720 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:25744308; PMID:31476248; PMID:32662567; PMID:33063951; PMID:33347680; PMID:33347680; PMID:35243731; PMID:33347706; PMID:33759307; PMID:35243731 |
| GO:0016887 | Atp hydrolysis activity | Decreases phenotype | PMID:27091720 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:27091720; PMID:32623939 |
| GO:0019319 | Hexose biosynthetic process | Increases phenotype | PMID:27091720 |
| GO:0019627 | Urea metabolic process | Affects phenotype | PMID:32623939 |
| GO:0019825 | Oxygen binding | Increases phenotype | PMID:27091720 |
| GO:0019852 | L-ascorbic acid metabolic process | Affects phenotype | PMID:31476248; PMID:31476248; PMID:33759307; PMID:32662567; PMID:33063951; PMID:33347680; PMID:33347680; PMID:35243731; PMID:33347680; PMID:35243731; PMID:37840363; PMID:33759307; PMID:35243731; PMID:37840363 |
| GO:0030154 | Cell differentiation | Increases phenotype | PMID:38299738 |
| GO:0030199 | Collagen fibril organization | Increases phenotype | PMID:39214269 |
| GO:0034440 | Lipid oxidation | Increases phenotype | PMID:21801490; PMID:21801490; PMID:37840363; PMID:23033690; PMID:32623939; PMID:37840363 |
| GO:0040015 | Negative regulation of multicellular organism growth | Increases phenotype | PMID:23033690 |
| GO:0042360 | Vitamin e metabolic process | Affects phenotype | PMID:21801490; PMID:21801490; PMID:33347680; PMID:35243731; PMID:37840363; PMID:31476248; PMID:31476248; PMID:33759307; PMID:32662567; PMID:33347680; PMID:33347680; PMID:37840363; PMID:33759307; PMID:35243731; PMID:37840363 |
| GO:0042554 | Superoxide anion generation | Increases phenotype | PMID:24995432 |
| GO:0043616 | Keratinocyte proliferation | Decreases phenotype | PMID:38299738 |
| GO:0044242 | Cellular lipid catabolic process | Increases phenotype | PMID:24995432 |
| GO:0044319 | Wound healing, spreading of cells | Increases phenotype | PMID:29663660 |
| GO:0045454 | Cell redox homeostasis | Affects phenotype | PMID:30027798 |
| GO:0045618 | Positive regulation of keratinocyte differentiation | Increases phenotype | PMID:27869817 |
| GO:0046209 | Nitric oxide metabolic process | Affects phenotype | PMID:32623939; PMID:33063951; PMID:33063951 |
| GO:0046415 | Urate metabolic process | Affects phenotype | PMID:32623939 |
| GO:0046449 | Creatinine metabolic process | Affects phenotype | PMID:32623939 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:30027798; PMID:34972512; PMID:6413056 |
| GO:0046621 | Negative regulation of organ growth | Increases phenotype | PMID:23033690 |
| GO:0046622 | Positive regulation of organ growth | Increases phenotype | PMID:29877212 |
| GO:0046827 | Positive regulation of protein export from nucleus | Increases phenotype | PMID:21294050 |
| GO:0047823 | D-glutamyltransferase activity | Affects phenotype | PMID:33063951 |
| GO:0051347 | Positive regulation of transferase activity | Increases phenotype | PMID:21801490 |
| GO:0051348 | Negative regulation of transferase activity | Affects phenotype | PMID:21801490; PMID:23033690 |
| GO:0051882 | Mitochondrial depolarization | Increases phenotype | PMID:35908932 |
| GO:0060384 | Innervation | Increases phenotype | PMID:27869817 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:39214269 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:39214269 |
| GO:0072089 | Stem cell proliferation | Decreases phenotype | PMID:38299738 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:25697376; PMID:35908932 |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | Decreases phenotype | PMID:25478867 |
| GO:0097237 | Cellular response to toxic substance | Increases phenotype | PMID:29502735 |
| GO:0097531 | Mast cell migration | Increases phenotype | PMID:37352108 |
| GO:0098754 | Detoxification | Increases phenotype | PMID:21801490 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Increases phenotype | PMID:21801490; PMID:23033690; PMID:34972512 |
| GO:1902034 | Negative regulation of hematopoietic stem cell proliferation | Increases phenotype | PMID:32553695 |
| GO:1903283 | Negative regulation of glutathione peroxidase activity | Increases phenotype | PMID:21801490; PMID:23033690 |
| GO:1903284 | Positive regulation of glutathione peroxidase activity | Increases phenotype | PMID:21801490 |
| GO:1903604 | Cytochrome metabolic process | Affects phenotype | PMID:37840363 |
| GO:1903605 | Cytochrome biosynthetic process | Increases phenotype | PMID:30027798 |
| GO:2000354 | Regulation of ovarian follicle development | Affects phenotype | PMID:24576726 |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | Decreases phenotype | PMID:25478867 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.