DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Ochratoxin A

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000084	Mitotic s phase	Increases phenotype	PMID:31154016; PMID:31276768; PMID:31678613
GO:0000086	G2/m transition of mitotic cell cycle	Increases phenotype	PMID:30763683; PMID:39117293
GO:0000266	Mitochondrial fission	Increases phenotype	PMID:38546835
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:31276768
GO:0000280	Nuclear division	Decreases phenotype	PMID:37162024
GO:0000422	Autophagy of mitochondrion	Increases phenotype	PMID:24755393
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:39117293
GO:0001765	Membrane raft assembly	Decreases phenotype	PMID:34101318
GO:0001774	Microglial cell activation	Increases phenotype	PMID:24792326
GO:0001819	Positive regulation of cytokine production	Increases phenotype	PMID:28935500
GO:0002522	Leukocyte migration involved in immune response	Increases phenotype	PMID:36227364
GO:0002537	Nitric oxide production involved in inflammatory response	Increases phenotype	PMID:25532488
GO:0002639	Positive regulation of immunoglobulin production	Increases phenotype	PMID:28935500
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:36227364
GO:0004364	Glutathione transferase activity	Increases phenotype	PMID:37633472
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:27923682
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:26861962; PMID:27923682; PMID:36397609
GO:0005978	Glycogen biosynthetic process	Increases phenotype	PMID:27923682
GO:0006099	Tricarboxylic acid cycle	Decreases phenotype	PMID:32835834
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:27923682
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:34101318; PMID:38896176; PMID:39053875
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:30291945
GO:0006754	Atp biosynthetic process	Affects phenotype	PMID:27597255; PMID:30876885
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:27597255; PMID:34748853
GO:0006914	Autophagy	Increases phenotype	PMID:24755393
GO:0006915	Apoptotic process	Increases phenotype	PMID:20108032; PMID:24120684; PMID:25002221; PMID:25002221; PMID:32617660; PMID:30120945; PMID:30763683; PMID:31154016; PMID:33465424; PMID:37162024; PMID:38546835; PMID:39947449
GO:0006954	Inflammatory response	Increases phenotype	PMID:32617660; PMID:33543323
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:24525463; PMID:27193732; PMID:30120945
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:11701387
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:38546835
GO:0007033	Vacuole organization	Increases phenotype	PMID:27923682; PMID:32468156
GO:0007631	Feeding behavior	Affects phenotype	PMID:27923682
GO:0008152	Metabolic process	Affects phenotype	PMID:34126166
GO:0008219	Cell death	Increases phenotype	PMID:1987662; PMID:26505656; PMID:26861962; PMID:26505656; PMID:27153755; PMID:26861962; PMID:27153755; PMID:28710020; PMID:30428381; PMID:30428381; PMID:31678613; PMID:31678613; PMID:32905824
GO:0008283	Cell population proliferation	Affects phenotype	PMID:23172667; PMID:24120684; PMID:25002221; PMID:28286205; PMID:29126803; PMID:31154016; PMID:31276768; PMID:31678613
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:38301995
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:30559759; PMID:32835834; PMID:34101318
GO:0008360	Regulation of cell shape	Affects phenotype	PMID:28286205; PMID:29673704
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:27422291; PMID:39299375
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25532488; PMID:27422291; PMID:28951292
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:27923682; PMID:30291945
GO:0016049	Cell growth	Decreases phenotype	PMID:30120945; PMID:30291945; PMID:30716354
GO:0016477	Cell migration	Affects phenotype	PMID:31276768
GO:0018158	Protein oxidation	Increases phenotype	PMID:25532488
GO:0019627	Urea metabolic process	Affects phenotype	PMID:39053875
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:27923682
GO:0031323	Regulation of cellular metabolic process	Affects phenotype	PMID:30559759
GO:0032125	Micronucleus organization	Increases phenotype	PMID:32910239; PMID:38301995; PMID:39947449
GO:0032148	Activation of protein kinase b activity	Decreases phenotype	PMID:34101318
GO:0032964	Collagen biosynthetic process	Increases phenotype	PMID:25091173
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:27422291
GO:0034263	Positive regulation of autophagy in response to er overload	Increases phenotype	PMID:36058351
GO:0034440	Lipid oxidation	Increases phenotype	PMID:25532488; PMID:34101318; PMID:38546835; PMID:38896176; PMID:39053875
GO:0035265	Organ growth	Decreases phenotype	PMID:28321044
GO:0036444	Calcium import into the mitochondrion	Increases phenotype	PMID:31154016
GO:0042632	Cholesterol homeostasis	Decreases phenotype	PMID:34101318
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:27422291; PMID:34101318; PMID:36058351
GO:0043553	Negative regulation of phosphatidylinositol 3-kinase activity	Increases phenotype	PMID:34101318
GO:0043970	Histone h3-k9 acetylation	Affects phenotype	PMID:29098329
GO:0043971	Histone h3-k18 acetylation	Decreases phenotype	PMID:29098329
GO:0043972	Histone h3-k23 acetylation	Decreases phenotype	PMID:29098329
GO:0043974	Histone h3-k27 acetylation	Decreases phenotype	PMID:29098329
GO:0043977	Histone h2a-k5 acetylation	Decreases phenotype	PMID:29098329
GO:0043980	Histone h2b-k12 acetylation	Decreases phenotype	PMID:29098329
GO:0043981	Histone h4-k5 acetylation	Decreases phenotype	PMID:29098329
GO:0043982	Histone h4-k8 acetylation	Decreases phenotype	PMID:29098329
GO:0043983	Histone h4-k12 acetylation	Decreases phenotype	PMID:29098329
GO:0043984	Histone h4-k16 acetylation	Decreases phenotype	PMID:29098329
GO:0044154	Histone h3-k14 acetylation	Decreases phenotype	PMID:29098329
GO:0044237	Cellular metabolic process	Affects phenotype	PMID:31276768; PMID:31678613; PMID:31678613; PMID:32659470; PMID:34481902; PMID:32617660; PMID:36587836; PMID:32659470; PMID:33465424; PMID:34126166; PMID:34748853; PMID:36587836; PMID:38896176
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:31154016; PMID:31276768; PMID:31678613; PMID:39117293
GO:0045333	Cellular respiration	Decreases phenotype	PMID:1987662
GO:0045627	Positive regulation of t-helper 1 cell differentiation	Increases phenotype	PMID:28935500
GO:0045786	Negative regulation of cell cycle	Increases phenotype	PMID:36058351
GO:0045821	Positive regulation of glycolytic process	Increases phenotype	PMID:32835834
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:24525463; PMID:28286205; PMID:30428381; PMID:30763683; PMID:31154016; PMID:31678613
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:34126166; PMID:34126166; PMID:38546835; PMID:39053875; PMID:38546835; PMID:39053875; PMID:39053875
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:11701387; PMID:1987662
GO:0046622	Positive regulation of organ growth	Decreases phenotype	PMID:24243707
GO:0050996	Positive regulation of lipid catabolic process	Increases phenotype	PMID:39299375
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:26861962; PMID:27193732; PMID:27597255; PMID:31154016; PMID:31678613; PMID:31678613; PMID:34481902
GO:0055072	Iron ion homeostasis	Affects phenotype	PMID:39053875
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:31154016
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:26314263
GO:0070062	Extracellular exosome	Increases phenotype	PMID:34481902
GO:0070265	Necrotic cell death	Increases phenotype	PMID:29126803; PMID:32468156; PMID:36227364; PMID:39053875; PMID:39947449
GO:0070266	Necroptotic process	Increases phenotype	PMID:38546835
GO:0070269	Pyroptosis	Increases phenotype	PMID:33543323
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:27346841; PMID:27597255; PMID:38546835
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:25218026; PMID:34015425; PMID:34481902; PMID:34748853; PMID:36587836; PMID:39947449
GO:0090156	Cellular sphingolipid homeostasis	Decreases phenotype	PMID:34101318
GO:0090398	Cellular senescence	Increases phenotype	PMID:28286205
GO:0140639	Positive regulation of pyroptosis	Increases phenotype	PMID:39299375
GO:1900103	Positive regulation of endoplasmic reticulum unfolded protein response	Increases phenotype	PMID:36058351
GO:1900182	Positive regulation of protein localization to nucleus	Increases phenotype	PMID:32835834
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:34101318; PMID:39299375
GO:1901671	Positive regulation of superoxide dismutase activity	Decreases phenotype	PMID:25532488
GO:1901987	Regulation of cell cycle phase transition	Affects phenotype	PMID:37633472
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:39117293
GO:1903209	Positive regulation of oxidative stress-induced cell death	Increases phenotype	PMID:35543154
GO:1903284	Positive regulation of glutathione peroxidase activity	Decreases phenotype	PMID:25532488
GO:1903303	Negative regulation of pyruvate kinase activity	Increases phenotype	PMID:32835834
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:26861962; PMID:28286205; PMID:30120945; PMID:30291945; PMID:31678613
GO:1903427	Negative regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:37633472
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:34101318; PMID:35543154; PMID:38812125
GO:1903787	Negative regulation of glutathione biosynthetic process	Increases phenotype	PMID:38812125; PMID:39299375
GO:1905168	Positive regulation of double-strand break repair via homologous recombination	Increases phenotype	PMID:24243707
GO:1990182	Exosomal secretion	Increases phenotype	PMID:34481902
GO:2000615	Regulation of histone h3-k9 acetylation	Affects phenotype	PMID:30559759
GO:2000616	Negative regulation of histone h3-k9 acetylation	Increases phenotype	PMID:30559759
GO:2000617	Positive regulation of histone h3-k9 acetylation	Increases phenotype	PMID:30559759

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.