DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Tamoxifen

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000084	Mitotic s phase	Increases phenotype	PMID:30467747; PMID:32530119
GO:0000086	G2/m transition of mitotic cell cycle	Decreases phenotype	PMID:30467747; PMID:30467747; PMID:32530119; PMID:32530119
GO:0000165	Mapk cascade	Increases phenotype	PMID:14645110
GO:0000278	Mitotic cell cycle	Decreases phenotype	PMID:10785588; PMID:30467747; PMID:30664189
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:27395752
GO:0001553	Luteinization	Decreases phenotype	PMID:27395752; PMID:28248286
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:29571322
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:29571322; PMID:29974145
GO:0004364	Glutathione transferase activity	Increases phenotype	PMID:38779996
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:38779996
GO:0004510	Tryptophan 5-monooxygenase activity	Affects phenotype	PMID:28463726
GO:0005262	Calcium channel activity	Affects phenotype	PMID:24205315
GO:0006094	Gluconeogenesis	Decreases phenotype	PMID:21570382
GO:0006096	Glycolytic process	Affects phenotype	PMID:1525059; PMID:21570382
GO:0006106	Fumarate metabolic process	Affects phenotype	PMID:29974145
GO:0006304	Dna modification	Increases phenotype	PMID:25123088
GO:0006306	Dna methylation	Decreases phenotype	PMID:17219426
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:26470790
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:38191086
GO:0006646	Phosphatidylethanolamine biosynthetic process	Affects phenotype	PMID:28138993
GO:0006656	Phosphatidylcholine biosynthetic process	Decreases phenotype	PMID:28138993
GO:0006661	Phosphatidylinositol biosynthetic process	Increases phenotype	PMID:28138993
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:29183790; PMID:32530119
GO:0006805	Xenobiotic metabolic process	Increases phenotype	PMID:29162470
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:31416231
GO:0006811	Monoatomic ion transport	Increases phenotype	PMID:10991979
GO:0006884	Cell volume homeostasis	Increases phenotype	PMID:22108225
GO:0006914	Autophagy	Affects phenotype	PMID:11872957; PMID:18172760; PMID:18172760; PMID:21233418; PMID:20594311
GO:0006915	Apoptotic process	Increases phenotype	PMID:10771088; PMID:10785588; PMID:11356682; PMID:11485825; PMID:12169386; PMID:12602925; PMID:12611458; PMID:12611458; PMID:12721755; PMID:17011908; PMID:17767197; PMID:18172760; PMID:18815881; PMID:21233418; PMID:12721755; PMID:12747936; PMID:12810152; PMID:14649542; PMID:14990993; PMID:15604281; PMID:15604281; PMID:9329022; PMID:15606891; PMID:15748701; PMID:16497877; PMID:17011908; PMID:17186241; PMID:17767197; PMID:18172760; PMID:18790785; PMID:18815881; PMID:19931998; PMID:20594311; PMID:21413024; PMID:23840623; PMID:25301941; PMID:30153467; PMID:30467747; PMID:30980508; PMID:32530119; PMID:38779996; PMID:39561883; PMID:27163517; PMID:30153467; PMID:30467747; PMID:30980508; PMID:32530119; PMID:34463000; PMID:39561883; PMID:9742967; PMID:9888466
GO:0006936	Muscle contraction	Increases phenotype	PMID:28138957
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:30153467
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:31532279; PMID:9888466
GO:0007049	Cell cycle	Increases phenotype	PMID:11485825; PMID:12602925; PMID:14645110; PMID:15665275; PMID:16450001; PMID:17186241; PMID:17767197; PMID:17876043; PMID:20225760; PMID:7753712
GO:0007283	Spermatogenesis	Increases phenotype	PMID:34974146; PMID:8070710
GO:0007565	Female pregnancy	Decreases phenotype	PMID:28248286
GO:0007585	Respiratory gaseous exchange by respiratory system	Decreases phenotype	PMID:29571322
GO:0007613	Memory	Decreases phenotype	PMID:24902786; PMID:37392961
GO:0007614	Short-term memory	Decreases phenotype	PMID:24902786
GO:0007616	Long-term memory	Decreases phenotype	PMID:24902786
GO:0008219	Cell death	Increases phenotype	PMID:10715583; PMID:11034078; PMID:12632256; PMID:12894523; PMID:14645110; PMID:15190103; PMID:16450001; PMID:16497877; PMID:18167132; PMID:19330798; PMID:28322778; PMID:7753712
GO:0008283	Cell population proliferation	Increases phenotype	PMID:10505046; PMID:11485825; PMID:11735166; PMID:12169386; PMID:12602925; PMID:12611458; PMID:17186241; PMID:17876043; PMID:20225760; PMID:2386944; PMID:2846159; PMID:3458212; PMID:6542011; PMID:12632256; PMID:12894523; PMID:1333883; PMID:15642790; PMID:15665275; PMID:15750629; PMID:16263272; PMID:1661414; PMID:1661414; PMID:21513275; PMID:17186241; PMID:17219426; PMID:17458902; PMID:24213142; PMID:30664189; PMID:17572228; PMID:17876043; PMID:18066117; PMID:18066117; PMID:6542011; PMID:8110496; PMID:18575591; PMID:18575591; PMID:21513275; PMID:9714066; PMID:19031437; PMID:19549922; PMID:19874578; PMID:20225760; PMID:20302909; PMID:20535544; PMID:21413024; PMID:21513275; PMID:21513275; PMID:24758408; PMID:25301941; PMID:22138011; PMID:28763032; PMID:23786776; PMID:2386944; PMID:24758408; PMID:25301941; PMID:27163517; PMID:2936615; PMID:30664189; PMID:3458212; PMID:7588234; PMID:7923186; PMID:8110496; PMID:9888466
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:22108225; PMID:28811679; PMID:32171938; PMID:34270681; PMID:34821461; PMID:9224209
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:21687957; PMID:22037685; PMID:23159075; PMID:32497533; PMID:34821461
GO:0008584	Male gonad development	Decreases phenotype	PMID:23213263
GO:0008585	Female gonad development	Decreases phenotype	PMID:28248286
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:27089845
GO:0008654	Phospholipid biosynthetic process	Affects phenotype	PMID:28138993; PMID:28552552
GO:0009086	Methionine biosynthetic process	Affects phenotype	PMID:29974145
GO:0010694	Positive regulation of alkaline phosphatase activity	Increases phenotype	PMID:27159630
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:15545282
GO:0010825	Positive regulation of centrosome duplication	Increases phenotype	PMID:27998958
GO:0010918	Positive regulation of mitochondrial membrane potential	Increases phenotype	PMID:15545282
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:15545282; PMID:23397584
GO:0014734	Skeletal muscle hypertrophy	Increases phenotype	PMID:29571322
GO:0016049	Cell growth	Decreases phenotype	PMID:30153467
GO:0019249	Lactate biosynthetic process	Decreases phenotype	PMID:29974145
GO:0019432	Triglyceride biosynthetic process	Decreases phenotype	PMID:28138993
GO:0019722	Calcium-mediated signaling	Increases phenotype	PMID:11034078; PMID:11034078; PMID:15604281; PMID:11034078; PMID:17011908; PMID:12632256; PMID:17011908; PMID:21413024
GO:0019853	L-ascorbic acid biosynthetic process	Decreases phenotype	PMID:29974145
GO:0022832	Voltage-gated channel activity	Affects phenotype	PMID:33512997
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:29571322
GO:0030282	Bone mineralization	Decreases phenotype	PMID:29571322
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:34821461
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:34270681; PMID:34821461
GO:0030520	Intracellular estrogen receptor signaling pathway	Increases phenotype	PMID:36513145
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:29445054
GO:0032049	Cardiolipin biosynthetic process	Increases phenotype	PMID:28138993
GO:0032148	Activation of protein kinase b activity	Increases phenotype	PMID:34821461
GO:0032735	Positive regulation of interleukin-12 production	Increases phenotype	PMID:28811679
GO:0032792	Negative regulation of creb transcription factor activity	Increases phenotype	PMID:37392961
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:15545282
GO:0034383	Low-density lipoprotein particle clearance	Affects phenotype	PMID:27358406
GO:0034440	Lipid oxidation	Increases phenotype	PMID:29183790; PMID:38779996
GO:0035847	Uterine epithelium development	Increases phenotype	PMID:24487097
GO:0036164	Cell-abiotic substrate adhesion	Decreases phenotype	PMID:33024228
GO:0040011	Locomotion	Affects phenotype	PMID:29571322
GO:0040015	Negative regulation of multicellular organism growth	Increases phenotype	PMID:30672060
GO:0042307	Positive regulation of protein import into nucleus	Increases phenotype	PMID:27358406
GO:0042311	Vasodilation	Increases phenotype	PMID:21092740
GO:0042412	Taurine biosynthetic process	Decreases phenotype	PMID:29974145
GO:0042420	Dopamine catabolic process	Affects phenotype	PMID:28463726
GO:0042422	Norepinephrine catabolic process	Affects phenotype	PMID:28463726
GO:0042429	Serotonin catabolic process	Affects phenotype	PMID:28463726
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:12628514
GO:0042755	Eating behavior	Affects phenotype	PMID:38191086
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:21413024; PMID:22646800; PMID:34821461; PMID:35468944
GO:0043066	Negative regulation of apoptotic process	Increases phenotype	PMID:34821461
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:15149724; PMID:15196704; PMID:30467747; PMID:30980508; PMID:31576639; PMID:32530119; PMID:39561883; PMID:22905168; PMID:29940172; PMID:30467747; PMID:30980508; PMID:31576639; PMID:32530119; PMID:34463000; PMID:39561883
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:30153467; PMID:32530119; PMID:32530119
GO:0044849	Estrous cycle	Decreases phenotype	PMID:27395752
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:30467747; PMID:30467747; PMID:30980508; PMID:32530119; PMID:30980508; PMID:32530119
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:15545282
GO:0045795	Positive regulation of cell volume	Increases phenotype	PMID:21792908; PMID:22108225; PMID:22108225
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:30153467; PMID:30153467; PMID:30467747; PMID:30980508; PMID:32530119; PMID:30467747; PMID:30467747; PMID:30980508; PMID:32530119; PMID:30467747; PMID:32530119; PMID:30980508; PMID:32530119
GO:0046058	Camp metabolic process	Affects phenotype	PMID:27936172
GO:0046323	Glucose import	Affects phenotype	PMID:38779996
GO:0046466	Membrane lipid catabolic process	Affects phenotype	PMID:17283165; PMID:1884432; PMID:31532279; PMID:8494544
GO:0046620	Regulation of organ growth	Affects phenotype	PMID:27395752
GO:0046622	Positive regulation of organ growth	Affects phenotype	PMID:27395752
GO:0046649	Lymphocyte activation	Decreases phenotype	PMID:19031437
GO:0046716	Muscle cell cellular homeostasis	Affects phenotype	PMID:29571322
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:35468944
GO:0051298	Centrosome duplication	Increases phenotype	PMID:36384894
GO:0051881	Regulation of mitochondrial membrane potential	Decreases phenotype	PMID:14990993; PMID:17283165; PMID:20225760; PMID:27089845; PMID:32530119
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:21413024
GO:0051898	Negative regulation of protein kinase b signaling	Increases phenotype	PMID:37392961
GO:0055119	Relaxation of cardiac muscle	Affects phenotype	PMID:24205315
GO:0060004	Reflex	Decreases phenotype	PMID:25595991
GO:0060065	Uterus development	Decreases phenotype	PMID:28248286
GO:0060326	Cell chemotaxis	Decreases phenotype	PMID:32530119
GO:0070265	Necrotic cell death	Increases phenotype	PMID:29571322; PMID:29974145
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:27358406
GO:0070782	Phosphatidylserine exposure on apoptotic cell surface	Increases phenotype	PMID:15545282
GO:0070873	Regulation of glycogen metabolic process	Affects phenotype	PMID:30672060
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:24486436
GO:0071466	Cellular response to xenobiotic stimulus	Increases phenotype	PMID:32497533
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:32530119; PMID:34463000; PMID:38779996
GO:0086003	Cardiac muscle cell contraction	Affects phenotype	PMID:24205315
GO:0090327	Negative regulation of locomotion involved in locomotory behavior	Increases phenotype	PMID:29183790
GO:0097327	Response to antineoplastic agent	Increases phenotype	PMID:26078298; PMID:32001260
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:38191086
GO:0140354	Lipid import into cell	Increases phenotype	PMID:35944649
GO:1900087	Positive regulation of g1/s transition of mitotic cell cycle	Increases phenotype	PMID:34821461
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:29183790
GO:1902476	Chloride transmembrane transport	Affects phenotype	PMID:21792908; PMID:22108225; PMID:22108225
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:21413024
GO:1902608	Positive regulation of large conductance calcium-activated potassium channel activity	Increases phenotype	PMID:21413024
GO:1902941	Regulation of voltage-gated chloride channel activity	Affects phenotype	PMID:33512997
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:38779996
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:27089845; PMID:30153467
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:34821461
GO:1903709	Uterine gland development	Affects phenotype	PMID:24487097; PMID:27395752
GO:1903999	Negative regulation of eating behavior	Increases phenotype	PMID:30672060
GO:1904109	Positive regulation of cholesterol import	Increases phenotype	PMID:35944649
GO:1905602	Positive regulation of receptor-mediated endocytosis involved in cholesterol transport	Increases phenotype	PMID:35944649
GO:1905867	Epididymis development	Affects phenotype	PMID:34974146
GO:2000134	Negative regulation of g1/s transition of mitotic cell cycle	Increases phenotype	PMID:34821461
GO:2000386	Positive regulation of ovarian follicle development	Decreases phenotype	PMID:28248286
GO:2001024	Negative regulation of response to drug	Increases phenotype	PMID:34821461
GO:2001200	Positive regulation of dendritic cell differentiation	Increases phenotype	PMID:28811679

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.